J. Guevara-Aguirre

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Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

Federica Madia, Pinchas Cohen, Valter D. Longo, 2011, Science Translational Medicine.

Recombinant human insulin-like growth factor I has significant anabolic effects in adults with growth hormone receptor deficiency: studies on protein, glucose, and lipid metabolism.

N. Mauras, J. Guevara-Aguirre, A. Rini, 2000, The Journal of clinical endocrinology and metabolism.

Leptin concentrations in GH deficiency: the effect of GH insensitivity.

P. Marzullo, J. Guevara-Aguirre, A. Colao, 2002, The Journal of clinical endocrinology and metabolism.

Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans

George W. Hafzalla, P. Thompson, M. Mather, 2017, The Journal of Neuroscience.

Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome.

F Ullrich, G. B. Schaefer, J. Guevara-Aguirre, 1994, Journal of medical genetics.

Growth hormone modulates Trypanosoma cruzi infection in vitro.

J. Guevara-Aguirre, J. Kopchick, M. Grijalva, 2022, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

IGF-I deficiency and enhanced insulin sensitivity due to a mutated growth hormone receptor gene in humans

J. Guevara-Aguirre, Alexandra Guevara, A. W. Gavilanes, 2020, Molecular and Cellular Endocrinology.

Insulin resistance depends on GH counter-regulation in two syndromes of short stature.

J. Guevara-Aguirre, Alexandra Guevara, M. Bahamonde, 2017, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Growth hormone receptor deficiency in Ecuador.

U. Francke, J. Guevara-Aguirre, A. Rosenbloom, 1999, The Journal of clinical endocrinology and metabolism.

Lessons from the Genetics of Laron Syndrome

J. Guevara-Aguirre, A. Rosenbloom, 1998, Trends in Endocrinology & Metabolism.

Growth hormone insensitivity.

J. Guevara-Aguirre, R. Rosenfeld, 1997, Current therapy in endocrinology and metabolism.

Growth hormone (GH) insensitivity due to primary GH receptor deficiency.

J. Guevara-Aguirre, A. Rosenbloom, R. Rosenfeld, 1994, Endocrine reviews.

Growth Hormone Receptor Deficiency (Laron Syndrome): Clinical and Genetic Characteristics

J. Guevara-Aguirre, A. Rosenbloom, R. Rosenfeld, 1991, Acta paediatrica Scandinavica. Supplement.

Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations.

J. Guevara-Aguirre, A. Rosenbloom, R. Rosenfeld, 1993, The Journal of clinical endocrinology and metabolism.

Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome.

J. Guevara-Aguirre, A. Rosenbloom, R. Rosenfeld, 1993, The Journal of clinical endocrinology and metabolism.

GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.

R. de Cabo, J. Guevara-Aguirre, P. Balasubramanian, 2015, The Journal of clinical endocrinology and metabolism.

WHO and national lists of essential medicines in Mexico, Central and South America, and the Caribbean: are they adequate to promote paediatric endocrinology and diabetes care?

J. Guevara-Aguirre, J. Chanoine, Amanda Rowlands, 2016, BMJ Global Health.

J. Guevara-Aguirre, M. Guevara-Aguirre, Jannette Saavedra, 2013, The Journal of clinical endocrinology and metabolism.

Growth hormone (GH) insensitivity and insulin-like growth factor-I deficiency in Inuit subjects and an Ecuadorian cohort: functional studies of two codon 180 GH receptor gene mutations.

B. Little, V. Hwa, J. Guevara-Aguirre, 2008, The Journal of clinical endocrinology and metabolism.

Bone Mineral, Histomorphometry, and Body Composition in Adults with Growth Hormone Receptor Deficiency

R. Marcus, S. Ott, L. Bachrach, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement

G. Brabant, L. Cohen, S. Radovick, 2022, European journal of endocrinology.

Branding of subjects affected with genetic syndromes of severe short stature in developing countries

J. Guevara-Aguirre, Alexandra Guevara, C. Guevara, 2020, BMJ Case Reports.

A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood-onset diabetes.

Michael H. Guo, H. Ostrer, Yiping Shen, 2014, The Journal of clinical endocrinology and metabolism.

The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3.

R. Baxter, J. Guevara-Aguirre, A. Rosenbloom, 1993, The Journal of clinical endocrinology and metabolism.

IGF-I regulates the age-dependent signaling peptide humanin

P. Cohen, Changhan Lee, J. Guevara-Aguirre, 2014, Aging cell.

Kinetics of insulin-like growth factor (IGF) and IGF-binding protein responses to a single dose of growth hormone.

D. Powell, J. Guevara-Aguirre, S. Durham, 1997, The Journal of clinical endocrinology and metabolism.

Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity.

J. Guevara-Aguirre, V. Longo, E. Terán, 2020, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Insulin-Like Growth Factor Treatment of Growth Disorders

J. Guevara-Aguirre, A. Rosenbloom, Martinez, 2015 .

Controversy in clinical endocrinology: reclassification of insulin-like growth factor I production and action disorders.

J. Guevara-Aguirre, A. Rosenbloom, 2006, The Journal of clinical endocrinology and metabolism.

Serum levels of insulin‐like growth factor binding proteins in Ecuadorean children with growth hormone insensitivity

S. Mohan, J. Guevara-Aguirre, R. Rosenfeld, 1999, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Normal intelligence with severe insulin-like growth factor I deficiency due to growth hormone receptor deficiency: a controlled study in a genetically homogeneous population.

J. Guevara-Aguirre, V. Martinez, A. Rosenbloom, 1998, The Journal of clinical endocrinology and metabolism.

Two-year treatment of growth hormone (GH) receptor deficiency with recombinant insulin-like growth factor I in 22 children: comparison of two dosage levels and to GH-treated GH deficiency.

J. Guevara-Aguirre, V. Martinez, A. Rosenbloom, 1997, The Journal of clinical endocrinology and metabolism.

Insulin-like growth factor I--an important intrauterine growth factor.

J. Guevara-Aguirre, 1996, The New England journal of medicine.

The IGF-I generation test revisited: a marker of GH sensitivity.

J. Guevara-Aguirre, C. Burren, R. Rosenfeld, 2001, The Journal of clinical endocrinology and metabolism.

Effects of heterozygosity for the E180 splice mutation causing growth hormone receptor deficiency in Ecuador on IGF-I, IGFBP-3, and stature.

J. Guevara-Aguirre, M. Guevara-Aguirre, A. Rosenbloom, 2007, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency.

J. Guevara-Aguirre, V. Martinez, A. Rosenbloom, 1995, The Journal of clinical endocrinology and metabolism.

Pharmacokinetics of recombinant human insulin‐like growth factor I given subcutaneously to healthy volunteers and to patients with growth hormone receptor deficiency

M. Preece, J. Guevara-Aguirre, A. Grahnén, 1993, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Is there heterozygote expression of growth hormone receptor deficiency?

J. Guevara-Aguirre, A. Rosenbloom, R. Rosenfeld, 1994, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Immunoblot studies of the acid‐labile subunit (ALS) in biological fluids, normal human serum and in children with GH deficiency and GH receptor deficiency before and after long‐term therapy with GH or IGF‐I respectively

J. Argente, J. Guevara-Aguirre, Phillip D. K. Lee, 1997, Clinical endocrinology.

Despite higher body fat content, Ecuadorian subjects with Laron syndrome have less insulin resistance and lower incidence of diabetes than their relatives.

J. Guevara-Aguirre, M. Guevara-Aguirre, E. Terán, 2016, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Absence of hypoglycemia in response to varying doses of recombinant human insulin‐like growth factor‐I (rhIGF‐I) in children and adolescents with low serum concentrations of IGF‐I

J. Guevara-Aguirre, M. Guevara-Aguirre, A. Rosenbloom, 2006 .

Absence of hypoglycemia in response to varying doses of recombinant human insulin-like growth factor-I (rhIGF-I) in children and adolescents with low serum concentrations of IGF-I.

J. Guevara-Aguirre, M. Guevara-Aguirre, A. Rosenbloom, 2006, Acta paediatrica.

Use of Recombinant IGF-I in Syndromes of GH Insensitivity

J. Guevara-Aguirre, A. Rosenbloom, R. Rosenfeld, 1995 .

Treatment of growth failure in the absence of GH signaling: The Ecuadorian experience.

J. Guevara-Aguirre, Alexandra Guevara, C. Guevara, 2017, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Body changes in adolescent patients with growth hormone receptor deficiency receiving recombinant human insulin‐like growth factor I and luteinizing hormone‐releasing hormone analogue: preliminary results

L. Bachrach, J. Guevara-Aguirre, V. Martinez, 1994, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Insulin-like growth factor binding protein-3 generation as a measure of GH sensitivity.

J. Guevara-Aguirre, R. Rosenfeld, K. Pratt, 2002, The Journal of clinical endocrinology and metabolism.

Filter paper blood spot assay of human insulin-like growth factor I (IGF-I) and IGF-binding protein-3 and preliminary application in the evaluation of growth hormone status.

J. Guevara-Aguirre, V. Martinez, J. Mistry, 1998, The Journal of clinical endocrinology and metabolism.

Regulation of Serum Insulin‐Like Growth Factors and Their Binding Proteins in Ecuadorean Patients with Growth Hormone Receptor Dysfunction (Growth Hormone Insensitivity)

J. Guevara-Aguirre, A. Rosenbloom, R. Hintz, 1991, Acta paediatrica Scandinavica. Supplement.

Natural history of growth hormone receptor deficiency

L. Bachrach, J. Guevara-Aguirre, V. Martinez, 1999, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Stature in Ecuadorians heterozygous for growth hormone receptor gene E180 splice mutation does not differ from that of homozygous normal relatives.

U. Francke, J. Guevara-Aguirre, A. Rosenbloom, 1998, The Journal of clinical endocrinology and metabolism.

PRISMATIC case: bienvenidos a mi tierra de soledad: from poetry to molecular biology in southern Ecuador.

J. Guevara-Aguirre, A. Rosenbloom, 1994, The Journal of clinical endocrinology and metabolism.

Receptor mutations and haplotypes in growth hormone receptor deficiency: a global survey and identification of the Ecuadorean E180splice mutation in an oriental Jewish patient

U. Francke, J. Guevara-Aguirre, Z. Laron, 1994, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Heart rate increases in patients with growth hormone receptor deficiency treated with insulin‐like growth factor I

J. Guevara-Aguirre, V. Martinez, A. Rosenbloom, 1994, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Diverse growth hormone receptor gene mutations in Laron syndrome.

U. Francke, J. Argente, J. Guevara-Aguirre, 1993, American journal of human genetics.

The impact of Converso Jews on the genomes of modern Latin Americans

H. Ostrer, I. Pe’er, P. Palamara, 2011, Human Genetics.

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

M. Levine, B. Kennedy, E. Crimmins, 2014, Cell metabolism.

Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis

K. Fiebig, J. Guevara-Aguirre, E. Uleryk, 2023, Frontiers in Medicine.

Intrauterine and postnatal growth failure with normal GH/IGF1 axis and insulin-resistant diabetes in a consanguineous kinship.

H. Ostrer, V. Hwa, J. Guevara-Aguirre, 2012, European journal of endocrinology.

Mutation creating a new splice site in the growth hormone receptor genes of 37 Ecuadorean patients with Laron syndrome

U. Francke, J. Guevara-Aguirre, A. Rosenbloom, 1992, Human mutation.

Microheterogeneity of anterior pituitary FSH in the male rat: isoelectric focusing pattern throughout sexual maturation.

J. Guevara-Aguirre, F. Larrea, A. Ulloa-Aguirre, 1986, The Journal of endocrinology.

Divergent metabolic phenotypes in two genetic syndromes of low insulin secretion.

J. Guevara-Aguirre, E. Terán, C. Wasserfall, 2022, Diabetes research and clinical practice.

Insights from the clinical phenotype of subjects with Laron syndrome in Ecuador

J. Guevara-Aguirre, Alexandra Guevara, C. Guevara, 2020, Reviews in Endocrine and Metabolic Disorders.

Assessing insulin sensitivity and resistance in syndromes of severe short stature.

J. Guevara-Aguirre, Jannette Saavedra, E. Terán, 2020, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

GH and GHR signaling in human disease.

J. Guevara-Aguirre, E. Terán, Alexandra Guevara, 2017, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Obesity, diabetes and cancer: insight into the relationship from a cohort with growth hormone receptor deficiency

J. Guevara-Aguirre, A. Rosenbloom, 2014, Diabetologia.

- Aguirre Reduction in Pro-Aging Signaling , Cancer , and Diabetes in Humans Growth Hormone Receptor Deficiency Is Associated with a Major

S. Ingles, R. Cabo, P. Cohen, 2011 .

Ring chromosome 15 – cytogenetics and mapping arrays: a case report and review of the literature

Jesús M. Hernández, J. Guevara-Aguirre, C. Paz-y-Miño, 2018, Journal of Medical Case Reports.

Safety and efficacy of ALRV5XR in men with androgenetic alopecia: A randomised, double-blinded, placebo-controlled clinical trial

K. Fiebig, J. Guevara-Aguirre, C. Piwko, 2021, EClinicalMedicine.

The impact of Converso Jews on the genomes of modern Latin

H. Ostrer, M. Hammer, P. Palamara, 2012 .

Obesity, the Cinderella of Clinical Medicine

J. Guevara-Aguirre, M. Grunauer, 2020, Critical Care Medicine.

Comparison of oral insulin spray and subcutaneous regular insulin at mealtime in type 1 diabetes.

J. Guevara-Aguirre, M. Guevara-Aguirre, A. Rosenbloom, 2007, Diabetes technology & therapeutics.

Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients.

J. Guevara-Aguirre, L. Carlsson, A. Rosenbloom, 1992, The Journal of clinical endocrinology and metabolism.

Medical and Scientific Aspects of Growth Hormone Receptor Deficiency (Laron Syndrome) in Ecuador

J. Guevara-Aguirre, A. Rosenbloom, R. Rosenfeld, 1994 .

Serum profiles of insulin‐like growth factors and their binding proteins in adults with growth hormone receptor deficiency treated with insulin like growth factor I

J. Guevara-Aguirre, F. Diamond, R. Rosenfeld, 1993, Acta paediatrica.

Induced hyperprolactinaemia does not alter FSH binding or ABP secretion in the rat testis.

J. Guevara-Aguirre, F. Larrea, A. Ulloa-Aguirre, 1986, International journal of andrology.

Insulin-Like Growth Factor (IGF) Parameters and Tools for Efficacy: The IGF-I Generation Test in Children

J. Guevara-Aguirre, R. Rosenfeld, C. Buckway, 2005, Hormone Research in Paediatrics.

Reproducibility in Patterns of IGF Generation with Special Reference to Idiopathic Short Stature

J. Guevara-Aguirre, R. Rosenfeld, K. Pratt, 2003, Hormone Research in Paediatrics.

Oral spray insulin in treatment of type 2 diabetes: a comparison of efficacy of the oral spray insulin (Oralin) with subcutaneous (SC) insulin injection, a proof of concept study

J. Guevara-Aguirre, M. Mihic, P. Modi, 2004, Diabetes/metabolism research and reviews.

Accurate Determination of Height Using an Inexpensive Measuring Device

J. Guevara-Aguirre, A. Rosenbloom, F. Diamond, 1994, La Clinica pediatrica.

Growth in growth hormone insensitivity

B. Pollock, J. Guevara-Aguirre, A. Rosenbloom, 1994, Trends in Endocrinology & Metabolism.

The E180splice mutation in the GHR gene causing Laron syndrome: Witness of a Sephardic Jewish exodus from the Iberian Peninsula to the New World?

D. Damiani, E. Pinto, V. Hwa, 2014, American journal of medical genetics. Part A.

Safety and efficacy of ALRV5XR in women with androgenetic alopecia or telogen effluvium: A randomised, double-blinded, placebo-controlled clinical trial

K. Fiebig, J. Guevara-Aguirre, C. Piwko, 2021, EClinicalMedicine.

Physician’s role in prescribing opioids in developing countries

J. Guevara-Aguirre, Jorge A. Roa, Alexandra Guevara, 2019, BMJ Case Reports.

Effects of insulin‐like growth factor I treatment on the molecular distribution of insulin‐like growth factors among different binding proteins

J. Guevara-Aguirre, R. Rosenfeld, M. Vaccarello, 1994, Acta paediatrica (Oslo, Norway : 1992). Supplement.

High growth hormone serum partially protects mice against Trypanosoma cruzi infection

J. Guevara-Aguirre, J. Kopchick, M. Grijalva, 2023, FEBS Open Bio.

Clinical and biochemical characteristics of growth hormone receptor deficiency (Laron syndrome).

M. Savage, J. Guevara-Aguirre, W. Blum, 1992, Acta paediatrica (Oslo, Norway : 1992). Supplement.

GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.

R. de Cabo, J. Guevara-Aguirre, P. Balasubramanian, 2015, The Journal of clinical endocrinology and metabolism.

Beneficial effects of addition of oral spray insulin (Oralin) on insulin secretion and metabolic control in subjects with type 2 diabetes mellitus suboptimally controlled on oral hypoglycemic agents.

J. Guevara-Aguirre, M. Mihic, P. Modi, 2004, Diabetes technology & therapeutics.

Growth Hormone Receptor Deficiency in South America: Colonial History, Molecular Biology, and Growth and Metabolic Insights

J. Guevara-Aguirre, A. Rosenbloom, 2008, Journal of pediatric endocrinology & metabolism : JPEM.