Heung-Chin Cheng

发表

Regulation and Function of Protein Kinases and Phosphatases

H. Paudel, Heung-Chin Cheng, R. Qi, 2011, Enzyme research.

Prediction of the Repeat Domain Structures and Impact of Parkinsonism‐Associated Variations on Structure and Function of all Functional Domains of Leucine‐Rich Repeat Kinase 2 (LRRK2)

Heung-Chin Cheng, R. Mills, T. Mulhern, 2014, Human mutation.

Analysis of the regulatory and catalytic domains of PTEN‐induced kinase‐1 (PINK1)

Heung-Chin Cheng, R. Mills, J. Culvenor, 2012, Human mutation.

C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)—endogenous negative regulators of Src-family protein kinases

Heung-Chin Cheng, T. Mulhern, Y. Chong, 2005, Growth factors.

Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases

R. Jorissen, Heung-Chin Cheng, R. Mills, 2010, Growth factors.

Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases.

Heung-Chin Cheng, T. Mulhern, Y. Chong, 2005, Biochimica et biophysica acta.

A Novel Non-catalytic Mechanism Employed by the C-terminal Src-homologous Kinase to Inhibit Src-family Kinase Activity*

Heung-Chin Cheng, Hong-Jian Zhu, T. Mulhern, 2004, Journal of Biological Chemistry.

Activation of Src family tyrosine kinases by ferric ions.

R. Norton, G. Baldwin, B. Shehan, 2014, Biochimica et biophysica acta.

Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression

Heung-Chin Cheng, A. Dhillon, A. Chueh, 2015, Frontiers in Biology.

N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Inform Potential Targets for Neuroprotection

A. Dufour, R. Medcalf, Heung-Chin Cheng, 2022, bioRxiv.

The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate.

Heung-Chin Cheng, Hong-Jian Zhu, B. Catimel, 2015, Archives of biochemistry and biophysics.

The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement

M. Parker, C. Morton, R. Dobson, 2020, The Journal of Biological Chemistry.

The Roc‐COR tandem domain of leucine‐rich repeat kinase 2 forms dimers and exhibits conventional Ras‐like GTPase properties

Heung-Chin Cheng, R. Mills, T. Mulhern, 2018, Journal of neurochemistry.

LRRK2: function and dysfunction Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number, and sites of Parkinson's disease mutations

Heung-Chin Cheng, R. Mills, T. Mulhern, 2012 .

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations.

Heung-Chin Cheng, R. Mills, T. Mulhern, 2012, Biochemical Society transactions.

PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis

B. Bay, Heung-Chin Cheng, N. Cheung, 2006, Neuroscience Letters.

Aberrant regulation and function of Src family tyrosine kinases: Their potential contributions to glutamate‐induced neurotoxicity

Heung-Chin Cheng, M. I. Hossain, M. A. Kamaruddin, 2012, Clinical and experimental pharmacology & physiology.

Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.

Heung-Chin Cheng, Hong-Jian Zhu, Joel Chia, 2010, Biochimica et biophysica acta.

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2)

Heung-Chin Cheng, K. Gayler, D. Gunawardana, 2007, Nucleic acids research.

Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase.

Heung-Chin Cheng, Hong-Jian Zhu, R. Wettenhall, 2007, Protein expression and purification.

A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases.

Heung-Chin Cheng, D. Scanlon, W. O’Malley, 2011, Bioorganic & medicinal chemistry letters.

Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.

M. Perugini, R. Dobson, Heung-Chin Cheng, 2010, Protein expression and purification.

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.

A. Purcell, Heung-Chin Cheng, T. Smithgall, 2015, The Journal of Biological Chemistry.

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Ching-Seng Ang, Heung-Chin Cheng, Nicholas A Williamson, 2019, Cell Death & Disease.

PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.

Heung-Chin Cheng, Hong-Jian Zhu, T. Mulhern, 2007, Cellular signalling.

An Atlas of Phosphorylation and Proteolytic Processing Events During Excitotoxic Neuronal Death Reveals New Therapeutic Opportunities

A. Dufour, R. Medcalf, Heung-Chin Cheng, 2020, bioRxiv.

Autophosphorylation Induces Autoactivation and a Decrease in the Src Homology 2 Domain Accessibility of the Lyn Protein Kinase (*)

E. Stanley, M. Hibbs, Heung-Chin Cheng, 1995, The Journal of Biological Chemistry.

In vitro substrate specificity of protein tyrosine kinases

I. Matsuura, Heung-Chin Cheng, Jerry H. Wang, 1993, Molecular and Cellular Biochemistry.

Biochemical aspects of the neuroprotective mechanism of PTEN‐induced kinase‐1 (PINK1)

S. S. Mok, Heung-Chin Cheng, R. Mills, 2008, Journal of Neurochemistry.

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

O. Sieber, M. Foroutan, J. Mariadason, 2021, Oncogene.

Characterization of Two Activated Mutants of Human pp60c-src That Escape c-Src Kinase Regulation by Distinct Mechanisms (*)

Heung-Chin Cheng, Jerry H. Wang, J. Bjorge, 1995, The Journal of Biological Chemistry.

Common in Vitro Substrate Specificity and Differential Src Homology 2 Domain Accessibility Displayed by Two Members of the Src Family of Protein-tyrosine Kinases, c-Src and Hck*

M. Hibbs, Heung-Chin Cheng, A. Dunn, 1998, The Journal of Biological Chemistry.

Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530

Heung-Chin Cheng, Jerry H. Wang, D. Fujita, 1999, Oncogene.

Global Analysis of Human Nonreceptor Tyrosine Kinase Specificity Using High-Density Peptide Microarrays

B. Turk, T. Boggon, V. Hytönen, 2014, Journal of proteome research.

Allosteric networks governing regulation and catalysis of Src‐family protein tyrosine kinases: Implications for disease‐associated kinases

Heung-Chin Cheng, R. Mills, J. Culvenor, 2010, Clinical and experimental pharmacology & physiology.

Csk-homologous kinase

Heung-Chin Cheng, M. I. Hossain, M. A. Kamaruddin, 2006 .

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

G. Ciccotosto, Heung-Chin Cheng, C. Ang, 2019, Cell Death & Disease.

Src family kinases and their role in hematological malignancies

L. Campbell, Heung-Chin Cheng, C. Tam, 2015, Leukemia & lymphoma.

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

B. Turk, Heung-Chin Cheng, Hong-Jian Zhu, 2017, Cell Communication and Signaling.

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.

B. Turk, A. Purcell, Heung-Chin Cheng, 2011, Biochemistry.

C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases*

A. Purcell, Heung-Chin Cheng, T. Smithgall, 2006, Journal of Biological Chemistry.

Phosphomatics: interactive interrogation of substrate-kinase networks in global phosphoproteomics datasets

Michael G Leeming, Sean O'Callaghan, Luana Licata, 2020, Bioinform..

A Truncated Fragment of Src Protein Kinase Generated by Calpain-mediated Cleavage Is a Mediator of Neuronal Death in Excitotoxicity*

A. Hill, G. Dusting, Heung-Chin Cheng, 2013, The Journal of Biological Chemistry.

A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies.

Heung-Chin Cheng, C. Ang, N. Williamson, 2016, Pharmacology & therapeutics.

The GHB analogue HOCPCA improves sensorimotor function after MCAO via CaMKIIα

Heung-Chin Cheng, D. Vivien, A. Clarkson, 2022, bioRxiv.

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide.

M. Perugini, Heung-Chin Cheng, B. Catimel, 2011, The Biochemical journal.

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

C. Masters, A. Hill, S. S. Mok, 2006, Human molecular genetics.

Modulation of the Catalytic Activity of the Src Family Tyrosine Kinase Hck by Autophosphorylation at a Novel Site in the Unique Domain*

Heung-Chin Cheng, A. Dunn, G. Scholz, 2000, The Journal of Biological Chemistry.

Dual role of Src kinase in governing neuronal survival

A. Hill, A. Burgess, Heung-Chin Cheng, 2015, Brain Research.

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

L. Campbell, Heung-Chin Cheng, H. Nandurkar, 2019, Scientific Reports.

A Potent Synthetic Peptide Inhibitor of the CAMP-dvpendent

Heung-Chin Cheng, S. V. Patten, A. Smith, 1986 .

The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα

C. Sobey, Heung-Chin Cheng, D. Vivien, 2023, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Identification and Structure Characterization of a Cdk Inhibitory Peptide Derived from Neuronal-specific Cdk5 Activator*

Mingjie Zhang, S. Ohki, Heung-Chin Cheng, 1999, The Journal of Biological Chemistry.

Synthesis and receptor binding activity of elephant β-endorphin, a β-endorphin homolog with highly potent analgesic activity

Heung-Chin Cheng, D. Yamashiro, 2009 .

An active twenty-amino-acid-residue peptide derived from the inhibitor protein of the cyclic AMP-dependent protein kinase.

A. Smith, H. Cheng, S. M. Van Patten, 1985, The Biochemical journal.

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.

A. Smith, H. Cheng, B. Kemp, 1986, The Journal of biological chemistry.

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

L. Campbell, Heung-Chin Cheng, H. Nandurkar, 2019, Scientific Reports.

Circular dichroic investigations of secondary structure in synthetic peptide inhibitors of cAMP-dependent protein kinase: a model for inhibitory potential.

H. Cheng, D. Walsh, V. Kinzel, 1987, Biochemistry.

Src family kinases and their role in hematological malignancies

L. Campbell, Heung-Chin Cheng, C. Tam, 2015, Leukemia & lymphoma.

N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection

A. Dufour, G. Ciccotosto, R. Medcalf, 2023, Molecular & cellular proteomics : MCP.

N-Terminomic Changes of Neurons During Excitotoxicity Reveals Proteolytic Events Associated with Synaptic Dysfunctions and Potential Targets for Neuroprotection Graphical Abstract Authors

Heung-Chin Cheng, Prasad N. Paradkar, C. Ang, 2022 .

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

B. Turk, Heung-Chin Cheng, Hong-Jian Zhu, 2017, Cell Communication and Signaling.

Biochemical aspects of the neuroprotective mechanism of PTEN‐induced kinase‐1 (PINK1)

S. S. Mok, Heung-Chin Cheng, R. Mills, 2008, Journal of neurochemistry.