H. M. Cochemé

发表

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

Irene Papatheodorou, Janet M Thornton, Linda Partridge, 2011, Molecular systems biology.

Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species

A. M. James, H. M. Cochemé, Robin A. J. Smith, 2005, Journal of Biological Chemistry.

Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

W. Lieb, C. Kaleta, A. Franke, 2020, Cell metabolism.

Enhancing autophagy by redox regulation extends lifespan in Drosophila

A. M. James, L. Partridge, H. M. Cochemé, 2019, bioRxiv.

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

K. Bryson, W. Lieb, C. Kaleta, 2019, Cell.

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

T. P. Neufeld, J. Thornton, L. Partridge, 2020, PLoS genetics.

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

Edward T Chouchani, L. Partridge, H. M. Cochemé, 2016, Cell metabolism.

Resource Assessing the Mitochondr ial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry Graphical Abstract Highlights

Edward T Chouchani, L. Partridge, H. M. Cochemé, 2016 .

Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.

H. Senn, H. M. Cochemé, D. Aksentijević, 2015, Free radical biology & medicine.

Using exomarkers to assess mitochondrial reactive species in vivo.

Edward T Chouchani, H. M. Cochemé, Robin A. J. Smith, 2014, Biochimica et biophysica acta.

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

L. Partridge, H. M. Cochemé, Robin A. J. Smith, 2012, Nature Protocols.

Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

A. Dominiczak, C. Hamilton, H. M. Cochemé, 2009, Hypertension.

Mitochondria as a source of reactive oxygen species

H. M. Cochemé, M. Murphy, 2009 .

Fasting , but Not Aging , Dra matically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster Graphical Abstract Highlights

Edward T Chouchani, L. Partridge, H. M. Cochemé, 2015 .

Mitochondrial pharmacology.

H. M. Cochemé, Robin A. J. Smith, R. Hartley, 2012, Trends in pharmacological sciences.

Redox signalling and ageing: insights from Drosophila

H. M. Cochemé, Claudia Lennicke, Helena M. Cochemé, 2020, Biochemical Society transactions.

Click-PEGylation – A mobility shift approach to assess the redox state of cysteines in candidate proteins

H. M. Cochemé, Ellen L. Robb, M. Murphy, 2017, Free radical biology & medicine.

Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.

H. M. Cochemé, Robin A. J. Smith, M. Murphy, 2003, Biochemical Society transactions.

Can antioxidants be effective therapeutics?

H. M. Cochemé, M. Murphy, Helena M. Cochemé, 2010, Current opinion in investigational drugs.

Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat*

H. M. Cochemé, M. Murphy, Michael P Murphy, 2008, Journal of Biological Chemistry.

Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria.

H. M. Cochemé, M. Murphy, 2009, Methods in enzymology.

Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing

H. M. Cochemé, M. Murphy, A. James, 2005, Mechanisms of Ageing and Development.

Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

T. Hurd, H. M. Cochemé, Robin A. J. Smith, 2005, Biochemistry (Moscow).

Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants

H. M. Cochemé, Robin A. J. Smith, A. Logan, 2015, Tetrahedron.

A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic.

H. M. Cochemé, Robin A. J. Smith, A. Logan, 2012, Chemistry & biology.

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

David Weinkove, David Gems, Nicholas D.E. Greene, 2013, Cell.

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

L. Partridge, M. Singer, D. Gems, 2011, Cell metabolism.

Redox metabolism: ROS as specific molecular regulators of cell signaling and function.

H. M. Cochemé, Claudia Lennicke, Helena M. Cochemé, 2021, Molecular cell.

Redox regulation of the insulin signalling pathway

H. M. Cochemé, Claudia Lennicke, Helena M. Cochemé, 2021, Redox biology.

Mitochondrial targeting of quinones: therapeutic implications.

J. Trnka, H. M. Cochemé, Robin A. J. Smith, 2007, Mitochondrion.

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

L. Partridge, H. M. Cochemé, M. Murphy, 2015, Cell reports.

Oxidative stress and life histories: unresolved issues and current needs

J. Speakman, T. Kirkwood, S. Ozanne, 2015, Ecology and evolution.

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

J. Hardy, L. Partridge, K. Bhatia, 2015, Brain : a journal of neurology.

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

J. Thornton, L. Partridge, D. Ivanov, 2017, PLoS genetics.

Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation

E. R. Taylor, C. Cooper, H. M. Cochemé, 2003, Journal of Biological Chemistry.

Mitochondrial redox signalling at a glance

H. M. Cochemé, M. Murphy, Helena M. Cochemé, 2012, Journal of Cell Science.

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.

D. Rubinsztein, H. M. Cochemé, Robin A. J. Smith, 2010, Free radical biology & medicine.

Mitochondria‐Targeted Antioxidants in the Treatment of Disease

J. Trnka, H. M. Cochemé, Robin A. J. Smith, 2008, Annals of the New York Academy of Sciences.

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

Linda Partridge, Kathryn S Lilley, Edward T Chouchani, 2013, Nature Medicine.

Myostatin-like proteins regulate synaptic function and neuronal morphology

L. Partridge, H. M. Cochemé, J. Steinert, 2017, Development.

Sugar-induced dysregulation of purine metabolism impacts lifespan

H. M. Cochemé, Claudia Lennicke, Eliano Dos Santos, 2020, Aging.

Loss of PLA 2 G 6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

J. Hardy, L. Partridge, K. Bhatia, 2015 .

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

L. Partridge, H. M. Cochemé, Robin A. J. Smith, 2016, Cell metabolism.

Oxidative stress and life histories: unresolved issues and current needs

J. Speakman, T. Kirkwood, S. Ozanne, 2015 .

Ecology, Evolution and Organismal Biology Publications Ecology, Evolution and Organismal Biology Oxidative Stress and Life Histories: Unresolved Issues and Current Needs Oxidative Stress and Life Histories: Unresolved Issues and Current Needs

J. Speakman, T. Kirkwood, Speakman, 2022 .

Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

A. Dominiczak, C. Hamilton, H. M. Cochemé, 2009, Hypertension.