E. Harhaj

发表

Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway.

Noula Shembade, E. Harhaj, 2011, Future virology.

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.

E. Harhaj, G. Xiao, S. Sun, 2001, Molecular cell.

Activation of NF-κB/Rel by Tax involves degradation of IκBα and is blocked by a proteasome inhibitor

E. Harhaj, Shao-Cong Sun, S. Maggirwar, 1995 .

Regulation of NF‐κB by deubiquitinases

V. Dixit, E. Harhaj, Vishva M. Dixit, 2012, Immunological reviews.

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

Noula Shembade, E. Harhaj, Derek W. Abbott, 2011, Nature Immunology.

A20 inhibition of NFκB and inflammation: Targeting E2:E3 ubiquitin enzyme complexes

Noula Shembade, E. Harhaj, 2010, Cell cycle.

Role of post-translational modifications of HTLV-1 Tax in NF-κB activation.

Noula Shembade, E. Harhaj, 2010, World journal of biological chemistry.

Essential role for TAX1BP1 in the termination of TNF‐α‐, IL‐1‐ and LPS‐mediated NF‐κB and JNK signaling

Noula Shembade, E. Harhaj, D. Liebl, 2007 .

Receptors and Adaptors for

E. Harhaj, Cong Sun, 2006 .

Receptors and Adaptors for NF-κB Signaling

E. Harhaj, Shao-Cong Sun, 2006 .

Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses

Xia Chen, E. Harhaj, Xiaoying Wang, 2017, Cellular & Molecular Immunology.

Constitutive Dephosphorylation and Activation of a Member of the Nuclear Factor of Activated T Cells, NF-AT1, in Tax-expressing and Type I Human T-cell Leukemia Virus-infected Human T Cells*

E. Harhaj, S. Sun, Shao-Cong Sun, 1997, The Journal of Biological Chemistry.

Bcl-3 expression and nuclear translocation are induced by granulocyte-macrophage colony-stimulating factor and erythropoietin in proliferating human erythroid precursors.

E. Harhaj, S. Sun, B. Miller, 1998, Blood.

Somatic mutagenesis studies of NF-κB signaling in human T cells: evidence for an essential role of IKKγ in NF-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

E. Harhaj, G. Xiao, Shao-Cong Sun, 2000, Oncogene.

Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein.

E. Harhaj, G. Xiao, S. Sun, 2000, Oncogene.

p 50 by a Putative Nuclear Export Signal and Regulation of RelA Subcellular Localization

E. Harhaj, Shao-Cong Sun, 1999 .

Regulation of RelA Subcellular Localization by a Putative Nuclear Export Signal and p50

E. Harhaj, Shao-Cong Sun, 1999, Molecular and Cellular Biology.

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha.

E. Harhaj, G. Xiao, S. Sun, 2001, The EMBO journal.

TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS

Noula Shembade, E. Harhaj, S. Balachandran, 2016, Molecular and Cellular Biology.

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity.

E. Harhaj, K. Hansen, M. Dzieciatkowska, 2016, Human molecular genetics.

An RNA Interference Screen Identifies the Deubiquitinase STAMBPL1 as a Critical Regulator of Human T-Cell Leukemia Virus Type 1 Tax Nuclear Export and NF-κB Activation

E. Harhaj, A. Lavorgna, 2012, Journal of Virology.

HSP90 Protects the Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Oncoprotein from Proteasomal Degradation To Support NF-κB Activation and HTLV-1 Replication

E. Harhaj, Linlin Gao, 2013, Journal of Virology.

Involvement of NF-AT in Type I Human T-cell Leukemia Virus Tax-mediated Fas Ligand Promoter Transactivation*

E. Harhaj, S. Sun, Shao-Cong Sun, 1998, The Journal of Biological Chemistry.

NF‐κB signaling mechanisms in HTLV‐1‐induced adult T‐cell leukemia/lymphoma

E. Harhaj, C. Giam, 2018, The FEBS journal.

Peroxisomes support human herpesvirus 8 latency by stabilizing the viral oncogenic protein vFLIP via the MAVS-TRAF complex

E. Harhaj, Yeeun Choi, Y. Choi, 2018, PLoS pathogens.

Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.

F. Sutterwala, Y. Wan, R. Flavell, 2006, Immunity.

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway.

E. Harhaj, Shao-Cong Sun, B. Wigdahl, 2005, Virology.

The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling

E. Harhaj, Linlin Gao, Soratree Charoenthongtrakul, 2012, Cellular and Molecular Immunology.

NF-κB-inducing Kinase and IκB Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF-κB Activation*

E. Zandi, M. Karin, E. Harhaj, 1998, The Journal of Biological Chemistry.

Human T Cell Leukemia Virus Type 1 Tax Inhibits Innate Antiviral Signaling via NF-κB-Dependent Induction of SOCS1

Noula Shembade, E. Harhaj, Qinjie Zhou, 2011, Journal of Virology.

HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

G. Barber, Noula Shembade, E. Harhaj, 2011, Retrovirology.

EBV LMP1: New and shared pathways to NF-κB activation

E. Harhaj, A. Lavorgna, Alfonso Lavorgna, 2012, Proceedings of the National Academy of Sciences.

IKKγ Serves as a Docking Subunit of the IκB Kinase (IKK) and Mediates Interaction of IKK with the Human T-cell Leukemia Virus Tax Protein*

E. Harhaj, Shao-Cong Sun, 1999, The Journal of Biological Chemistry.

IKKi: a novel regulator of Act1, IL-17 signaling and pulmonary inflammation

Noula Shembade, E. Harhaj, 2011, Cellular and Molecular Immunology.

Multifaceted roles of TAX1BP1 in autophagy

E. Harhaj, S. Suklabaidya, Y. Choi, 2022, Autophagy.

SHARPINing the knowledge of TCR signal control

E. Harhaj, F. Pan, Melissa D. Bowman, 2016, Nature Immunology.

Phosphorylation of the selective autophagy receptor TAX1BP1 by canonical and noncanonical IκB kinases promotes its lysosomal localization and clearance of MAVS aggregates

E. Harhaj, Chaoxia He, J. White, 2021, bioRxiv.

The Serine/Threonine Phosphatase Inhibitor Calyculin A Induces Rapid Degradation of IκBβ

E. Harhaj, Shao-Cong Sun, 1997, The Journal of Biological Chemistry.

CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers

E. Harhaj, S. Sun, S. Maggirwar, 1996, Molecular and cellular biology.

Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factors

E. Harhaj, S. Sun, S. Maggirwar, 1997, Molecular and cellular biology.

Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis

E. Harhaj, B. Wigdahl, K. Barmak, 2003, Journal of NeuroVirology.

Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration.

E. Harhaj, B. Wigdahl, T. Alefantis, 2003, Virology.

Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-κB activation?

E. Harhaj, A. Lavorgna, 2013, Future virology.

IkappaB kinases serve as a target of CD28 signaling.

E. Harhaj, S. Sun, 1998, The Journal of biological chemistry.

ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling*

E. Harhaj, S. Ley, A. Ma, 2011, The Journal of Biological Chemistry.

The serine/threonine phosphatase inhibitor calyculin A induces rapid degradation of IkappaBbeta. Requirement of both the N- and C-terminal sequences.

E. Harhaj, S. Sun, 1997, The Journal of biological chemistry.

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.

Noula Shembade, E. Harhaj, D. Liebl, 2007, The EMBO journal.

Regulation of human T-cell leukemia virus type 1 antisense promoter by myocyte enhancer factor-2C in the context of adult T-cell leukemia and lymphoma

F. Kashanchi, Julie Joseph, E. Harhaj, 2022, Haematologica.

TAX1BP1 and A20 Inhibit Antiviral Signaling by Targeting TBK1-IKKi Kinases*

G. Barber, E. Harhaj, K. Parvatiyar, 2010, The Journal of Biological Chemistry.

Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

Noula Shembade, E. Harhaj, A. Ma, 2010, Science.

Regulation of NF-κB signaling by the A20 deubiquitinase

Noula Shembade, E. Harhaj, 2012, Cellular and Molecular Immunology.

Deubiquitinases in the regulation of NF-κB signaling

V. Dixit, E. Harhaj, 2011, Cell Research.

The ubiquitin‐editing enzyme A20 requires RNF11 to downregulate NF‐κB signalling

Noula Shembade, E. Harhaj, Nicole S. Harhaj, 2009, The EMBO journal.

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

N. Copeland, N. Jenkins, Noula Shembade, 2008, Nature Immunology.

Lymphotropic Viruses: Chronic Inflammation and Induction of Cancers

Noula Shembade, E. Harhaj, 2020, Biology.

Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III.

Joel D Martin, E. Harhaj, M. Nonnemacher, 2006, DNA and cell biology.

Regulation of inflammatory and antiviral signaling by A20.

E. Harhaj, K. Parvatiyar, 2011, Microbes and infection.

Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation*

E. Harhaj, Shao-Cong Sun, Minying Zhang, 2004, Journal of Biological Chemistry.

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

E. Harhaj, G. Xiao, Shao-Cong Sun, 2001 .

Regulation of HTLV-1 Tax Stability, Cellular Trafficking and NF-κB Activation by the Ubiquitin-Proteasome Pathway

E. Harhaj, Alfonso Lavorgna, Edward William Harhaj, 2014, Viruses.

Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation

E. Harhaj, G. Xiao, Shao-Cong Sun, 1999, Oncogene.

Retroviral oncoprotein Tax induces processing of NF‐κB2/p100 in T cells: evidence for the involvement of IKKα

E. Harhaj, G. Xiao, A. Fong, 2001 .

IκB Kinases Serve as a Target of CD28 Signaling*

E. Harhaj, Shao-Cong Sun, 1998, The Journal of Biological Chemistry.

Activation of NF-κB by Phosphatase Inhibitors Involves the Phosphorylation of IκBα at Phosphatase 2A-sensitive Sites (*)

E. Harhaj, Shao-Cong Sun, S. Maggirwar, 1995, The Journal of Biological Chemistry.

MEF-2 isoforms' (A-D) roles in development and tumorigenesis

E. Harhaj, Zafar K. Khan, P. Jain, 2019, Oncotarget.

The Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Requires the Ubiquitin-Conjugating Enzyme Ubc13 for NF-κB Activation

S. Akira, Masahiro Yamamoto, Noula Shembade, 2007, Journal of Virology.

Domain-specific Interaction with the IκB Kinase (IKK) Regulatory Subunit IKKγ Is an Essential Step in Tax-mediated Activation of IKK*

E. Harhaj, G. Xiao, Shao-Cong Sun, 2000, The Journal of Biological Chemistry.

Activation of I-κB kinase by the HTLV type 1 Tax protein: Mechanistic insights into the adaptor function of IKKγ

E. Harhaj, G. Xiao, Shao-Cong Sun, 2000 .

Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB

E. Harhaj, Linlin Gao, M. Sehgal, 2015, Retrovirology.

Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.

E. Harhaj, G. Xiao, S. Sun, 2000, The Journal of biological chemistry.

NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation.

E. Zandi, M. Karin, E. Harhaj, 1998, The Journal of biological chemistry.

HTLV-1 Tax Stabilizes MCL-1 via TRAF6-Dependent K63-Linked Polyubiquitination to Promote Cell Survival and Transformation

E. Harhaj, Y. Choi, 2014, PLoS pathogens.

Secretion of the Human T Cell Leukemia Virus Type I Transactivator Protein Tax*

E. Harhaj, B. Wigdahl, T. Alefantis, 2005, Journal of Biological Chemistry.

Mechanisms of Oncogenesis by HTLV-1 Tax

E. Harhaj, Suchitra Mohanty, 2020, Pathogens.

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation

E. Harhaj, Teng Han, Suchitra Mohanty, 2020, bioRxiv.

IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma.

I. Lossos, L. Ratner, E. Harhaj, 2007, Blood.

Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses

E. Harhaj, Y. Choi, 2014, Frontiers in Biology.

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon*

J. Hiscott, E. Harhaj, Qinjie Zhou, 2015, The Journal of Biological Chemistry.

Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells

E. Harhaj, Shao-Cong Sun, M. Uhlik, 1999, Oncogene.

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

P. Scacheri, E. Harhaj, Derek W. Abbott, 2009, Current Biology.

Oncogenic Human T-Cell Lymphotropic Virus Type 1 Tax Suppression of Primary Innate Immune Signaling Pathways

G. Barber, E. Harhaj, S. Balachandran, 2015, Journal of Virology.

Over-representation of MEF-2 isoforms (A/C) is associated with HTLV-1-induced acute ATLL and their recruitment to 3’LTR facilitates HBZ expression from the antisense promoter via interactions with Menin and Jun D

F. Kashanchi, Julie Joseph, E. Harhaj, 2021 .

Characterization of a Nuclear Export Signal within the Human T Cell Leukemia Virus Type I Transactivator Protein Tax*

E. Harhaj, B. Wigdahl, T. Alefantis, 2003, Journal of Biological Chemistry.

Elucidating dynamic protein-protein interactions and ubiquitination in NF-κB signaling pathways.

Noula Shembade, E. Harhaj, 2015, Methods in molecular biology.

Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides.

E. Harhaj, C. Harding, S. Joyce, 1999, Journal of immunology.

Occupied by Low-Affinity Peptides Processing-Deficient RMAS Cells Are Transporter Associated with Antigen Molecules Expressed bybThermolabile H-2 K

E. Harhaj, C. Harding, S. Joyce, 1999 .

IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein.

E. Harhaj, S. Sun, S C Sun, 1999, The Journal of biological chemistry.

A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation

M. Matsuoka, E. Harhaj, A. Lavorgna, 2015, Retrovirology.

A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation

M. Matsuoka, E. Harhaj, A. Lavorgna, 2014, PLoS pathogens.

Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor.

E. Harhaj, S. Sun, S. Maggirwar, 1995, Oncogene.

RING Finger Protein 11 Targets TBK1/IKKi Kinases to Inhibit Antiviral Signaling

E. Harhaj, Linlin Gao, Kislay Parvatiyar, 2013, PloS one.

Anchors Away for Ubiquitin Chains

E. Harhaj, K. Parvatiyar, 2010, Science.

Essential role for TAX 1 BP 1 in the termination of TNF-a-, IL-1-and LPS-mediated NF-j B and JNK signaling

Noula Shembade, E. Harhaj, D. Liebl, 2013 .

Mechanisms of persistent NF-kappaB activation by HTLV-I tax.

E. Harhaj, Nicole S. Harhaj, 2005, IUBMB life.

Deregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients.

E. Harhaj, B. Janic, W. Harrington, 2007, Virology.

Activation of NF-κB by the Human T Cell Leukemia Virus Type I Tax Oncoprotein Is Associated with Ubiquitin-dependent Relocalization of IκB Kinase*

E. Harhaj, Shao-Cong Sun, Nicole S. Harhaj, 2006, Journal of Biological Chemistry.

Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase.

E. Harhaj, Shao-Cong Sun, Nicole S. Harhaj, 2007, The Journal of biological chemistry.

The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.

S. Akira, Masahiro Yamamoto, Noula Shembade, 2007, Journal of virology.

Mechanisms of Persistent NF‐κB Activation by HTLV‐I Tax

E. Harhaj, Edward W. Harhaj, Nicole S. Harhaj, 2005 .

A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation

M. Matsuoka, E. Harhaj, A. Lavorgna, 2015, Retrovirology.

A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation

M. Matsuoka, E. Harhaj, A. Lavorgna, 2014, Retrovirology.

Mechanisms of Innate Immune Sensing of HTLV-1 and Viral Immune Evasion

E. Harhaj, Suchitra Mohanty, Suchitra Mohanty, 2023, Pathogens.

Differential effects of IκB molecules on tat-mediated transactivation of HIV-1 LTR

E. Harhaj, Shao-Cong Sun, J. Blaney, 1996 .

Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells.

E. Harhaj, S. Sun, S. Maggirwar, 1996, Oncogene.