B. Trigatti

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The Scavenger Receptor Class B Type I: An HDL Receptor Involved in Lipid Transport and HDL Dependent Signaling

A. Al-Jarallah, R. Brunet, B. Trigatti, 2010 .

Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model.

B. Trigatti, V. Tedesco, G. Werstuck, 2006, Diabetes.

High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2

B. Trigatti, K. Durham, Kevin M. Chathely, 2018, The Biochemical journal.

Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice

B. Trigatti, A. Yang, Gabriel Gyulay, 2012, Journal of Lipid Research.

A direct role for serum albumin in the cellular uptake of long-chain fatty acids.

G. Gerber, B. Trigatti, G. E. Gerber, 1995, The Biochemical journal.

Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice

Yuan-Yuan Shi, B. Trigatti, V. Tedesco, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

High Density Lipoprotein and Its Precursor Protein Apolipoprotein A1 as Potential Therapeutics to Prevent Anthracycline Associated Cardiotoxicity

B. Trigatti, K. Durham, G. Kluck, 2020, Frontiers in Cardiovascular Medicine.

Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology.

A. Rigotti, M. Krieger, H. Rayburn, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism

A. Rigotti, M. Krieger, B. Trigatti, 2000, Current opinion in lipidology.

Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis

A. Rigotti, M. Krieger, B. Trigatti, 2003, Arteriosclerosis, thrombosis, and vascular biology.

A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism.

A. Rigotti, M. Krieger, H. Rayburn, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells.

J. Capone, B. Trigatti, G. Cox, 2007, Molecular endocrinology.

Hepatic uptake and metabolism of phosphatidylcholine associated with high density lipoproteins.

D. Vance, B. Trigatti, Z. Yao, 2009, Biochimica et biophysica acta.

Loss of SR-BI Expression Leads to the Early Onset of Occlusive Atherosclerotic Coronary Artery Disease, Spontaneous Myocardial Infarctions, Severe Cardiac Dysfunction, and Premature Death in Apolipoprotein E-Deficient Mice

M. Krieger, B. Trigatti, Kaori Sato, 2002, Circulation research.

Scavenger Receptor Class B Type I–Mediated Protection Against Atherosclerosis in LDL Receptor–Negative Mice Involves Its Expression in Bone Marrow–Derived Cells

Scott D Covey, M. Krieger, B. Trigatti, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Pcpe2: A New Partner for SR-B1 in Selective HDL Lipid Uptake.

B. Trigatti, 2021, Arteriosclerosis, thrombosis, and vascular biology.

Modulators of Protein Kinase C Affect SR-BI-Dependent HDL Lipid Uptake in Transfected HepG2 Cells

R. Brunet, B. Trigatti, M. How, 2011, Cholesterol.

Intestinal SR-BI is upregulated in insulin-resistant states and is associated with overproduction of intestinal apoB48-containing lipoproteins.

B. Trigatti, T. Hawke, K. Adeli, 2011, American journal of physiology. Gastrointestinal and liver physiology.

HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner.

B. Trigatti, A. Momen, M. Husain, 2018, American journal of physiology. Heart and circulatory physiology.

Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathwayss⃞ Published, JLR Papers in Press, November 1, 2006.

R. Truant, B. Trigatti, N. McFarlane, 2007, Journal of Lipid Research.

The Efficient Cellular Uptake of High Density Lipoprotein Lipids via Scavenger Receptor Class B Type I Requires Not Only Receptor-mediated Surface Binding but Also Receptor-specific Lipid Transfer Mediated by Its Extracellular Domain*

M. Krieger, B. Trigatti, Jodie L Babitt, 1998, The Journal of Biological Chemistry.

Murine SR-BI, a High Density Lipoprotein Receptor That Mediates Selective Lipid Uptake, Is N-Glycosylated and Fatty Acylated and Colocalizes with Plasma Membrane Caveolae*

Richard G. W. Anderson, A. Rigotti, M. Krieger, 1997, The Journal of Biological Chemistry.

Suppression of NK and CD8+ T cells reduces astrogliosis but accelerates cerebellar dysfunction and shortens life span in a mouse model of Sandhoff disease

B. Trigatti, Suleiman A. Igdoura, Elizabeth J. White, 2017, Journal of Neuroimmunology.

Conversion of Low Density Lipoprotein-associated Phosphatidylcholine to Triacylglycerol by Primary Hepatocytes*

D. Vance, B. Trigatti, R. Lehner, 2008, Journal of Biological Chemistry.

Rare Genetic Variants and High-Density Lipoprotein: Marching to a Different Drum.

R. Hegele, B. Trigatti, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Biochemical Demonstration of the Involvement of Fatty Acyl-CoA Synthetase in Fatty Acid Translocation across the Plasma Membrane*

G. Gerber, B. Trigatti, D. Mangroo, 2004, Journal of Biological Chemistry.

The effect of pomegranate extract on coronary artery atherosclerosis in SR-BI/APOE double knockout mice.

A. Al-Jarallah, B. Trigatti, C. Tenedero, 2013, Atherosclerosis.

Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering

B. Trigatti, R. Austin, C. Tenedero, 2017, Arteriosclerosis, thrombosis, and vascular biology.

Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism*

A. Prat, N. Seidah, G. Paré, 2016, The Journal of Biological Chemistry.

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained

N. Seidah, B. Trigatti, R. Austin, 2018, The Journal of Biological Chemistry.

SR-BI in Bone Marrow Derived Cells Protects Mice from Diet Induced Coronary Artery Atherosclerosis and Myocardial Infarction

B. Trigatti, Suleiman A. Igdoura, P. Yu, 2013, PloS one.

Salsalate reduces atherosclerosis through AMPKβ1 in mice

B. Kemp, B. Trigatti, Vanessa P. Houde, 2021, Molecular metabolism.

Identification of caveolin-1 as a fatty acid binding protein.

G. Gerber, B. Trigatti, R. G. Anderson, 1999, Biochemical and biophysical research communications.

Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells.

M. Krieger, B. Trigatti, R. Demattos, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways.

A. Al-Jarallah, B. Trigatti, 2010, Biochimica et biophysica acta.

The effect of intracellular pH on long-chain fatty acid uptake in 3T3-L1 adipocytes: evidence that uptake involves the passive diffusion of protonated long-chain fatty acids across the plasma membrane.

G. Gerber, B. Trigatti, G. E. Gerber, 1996, The Biochemical journal.

Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states.

B. Trigatti, K. Adeli, Sarah Farr, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Role of the Scavenger Receptor Class B Type I in Lipoprotein Metabolism and Atherosclerosis: Insight from Genetically Altered Mice

B. Trigatti, 2006 .

Rupture of the Atherosclerotic Plaque: Does a Good Animal Model Exist?

A. Rigotti, M. Krieger, B. Trigatti, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis.

D. Dwivedi, B. Trigatti, P. Liaw, 2015, Blood.

Hepatic Lipase Deficiency Delays Atherosclerosis, Myocardial Infarction, and Cardiac Dysfunction and Extends Lifespan in SR-BI/Apolipoprotein E Double Knockout Mice

M. Krieger, B. Trigatti, S. Karackattu, 2005, Arteriosclerosis, thrombosis, and vascular biology.

for High-Density Lipoprotein Lowering in Insulin Resistance and Hypertriglyceridemia Enhanced Cellular Uptake of Remnant High-Density Lipoprotein Particles : A Mechanism

B. Trigatti, G. Lewis, T. Vaisar, 2008 .

Photoaffinity labeling and fatty acid permeation in 3T3-L1 adipocytes.

G. Gerber, B. Trigatti, D. Mangroo, 1991, The Journal of biological chemistry.

Scavenger receptor BI--a cell surface receptor for high density lipoprotein.

A. Rigotti, M. Krieger, B. Trigatti, 1997, Current opinion in lipidology.

Hepatic high-density lipoprotein receptors: Roles in lipoprotein metabolism and potential for therapeutic modulation

B. Trigatti, 2005, Current atherosclerosis reports.

Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B, type I-dependent manner.

Y. D. Deng, B. Trigatti, K. Durham, 2019, American journal of physiology. Heart and circulatory physiology.

Un-JAMming atherosclerotic arteries: JAM-L as a target to attenuate plaque development.

B. Trigatti, B. S. H. Sokeechand, B Sumayyah H Sokeechand, 2019, Clinical science.

PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice.

B. Trigatti, Kevin M. Chathely, P. Yu, 2018, Atherosclerosis.

HDL signaling and protection against coronary artery atherosclerosis in mice

B. Trigatti, M. Fuller, 2015, Journal of biomedical research.

Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice

B. Trigatti, P. Yu, Usama Tahir, 2017, International journal of molecular sciences.

Cholesterol depletion inhibits fatty acid uptake without affecting CD36 or caveolin-1 distribution in adipocytes.

Scott D Covey, G. Gerber, R. Brunet, 2007, Biochemical and biophysical research communications.

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained

N. Seidah, B. Trigatti, R. Austin, 2018, The Journal of Biological Chemistry.

Membrane permeation and intracellular trafficking of long chain fatty acids: insights from Escherichia coli and 3T3-L1 adipocytes.

G. Gerber, B. Trigatti, D. Mangroo, 1995, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice

A. Fox-Robichaud, M. Szewczyk, B. Trigatti, 2018, The Journal of Biological Chemistry.

Good Cholesterol Gone Bad? HDL and COVID-19

B. Trigatti, G. Kluck, Jeong-Ah Yoo, 2021, International journal of molecular sciences.

Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice.

A. Rigotti, M. Krieger, J. Miquel, 2001, Journal of lipid research.

A point mutation in the neu1 promoter recruits an ectopic repressor, Nkx3.2 and results in a mouse model of sialidase deficiency.

A. Fox-Robichaud, B. Trigatti, M. Champigny, 2009, Molecular genetics and metabolism.

Deletion of tumor necrosis factor-α ameliorates neurodegeneration in Sandhoff disease mice.

B. Trigatti, Suleiman A. Igdoura, H. J. Janse van Rensburg, 2013, Human molecular genetics.

Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells

B. Trigatti, A. Ashkar, C. Richards, 2013, Mediators of inflammation.

Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake.

A. Rigotti, B. Trigatti, A Rigotti, 2000, Biochimica et biophysica acta.

The local effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) on the inflammatory atheroma: beyond LDL cholesterol lowering

B. Trigatti, T. Xiong, Alexander S. Qian, 2021, Vessel Plus.

The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice

B. Trigatti, Viktoria Serkis, J. Macri, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Lipoprotein enrichment in orange insoluble particulate matter reproducibly appearing in cryoprecipitate

B. Trigatti, V. Bhakta, W. Sheffield, 2011, Vox sanguinis.

Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent High-Density Lipoprotein Suppression of Necroptosis in Macrophages

B. Trigatti, G. Kluck, Alexander S. Qian, 2022, Arteriosclerosis, thrombosis, and vascular biology.

Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI.

N. Andrews, M. Krieger, C. Brugnara, 2002, Blood.

Data on leukocyte PDZK1 deficiency affecting macrophage apoptosis but not monocyte recruitment, cell proliferation, macrophage abundance or ER stress in atherosclerotic plaques of LDLR deficient mice

B. Trigatti, Kevin M. Chathely, P. Yu, 2018, Data in brief.

Macrophage Apoptosis and Necrotic Core Development in Atherosclerosis: A Rapidly Advancing Field with Clinical Relevance to Imaging and Therapy.

B. Trigatti, L. González, 2017, The Canadian journal of cardiology.

High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists

A. Al-Jarallah, B. Trigatti, Xing Chen, 2014, PloS one.

Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium

B. Trigatti, R. Austin, Ting Xiong, 2023, Frontiers in Physiology.

SR-B1 and PDZK1: partners in HDL regulation

B. Trigatti, 2017, Current opinion in lipidology.

SIALIDASE (NEUl) PROMOTES INTERLEUKIN-6 OVEREXPRESSION OF SIALIDASE (NEUl) PROMOTES INTERLEUKIN-6 INDUCED INFLAMMATION IN HUMAN NEUROGLIA AND MONOCYTIC THP-1 CELLS By:

B. Trigatti, Taryne M. Chong, A. Fiebig, 2017 .

Enhanced Cellular Uptake of Remnant High-Density Lipoprotein Particles: A Mechanism for High-Density Lipoprotein Lowering in Insulin Resistance and Hypertriglyceridemia

Yi Zhang, B. Trigatti, G. Lewis, 2008, Circulation research.

Hyperglycemia Aggravates Diet-Induced Coronary Artery Disease and Myocardial Infarction in SR-B1-Knockout/ApoE-Hypomorphic Mice

B. Trigatti, Melissa E. MacDonald, L. González, 2018, Front. Physiol..

Modifications in perfringolysin O domain 4 alter the cholesterol concentration threshold required for binding.

B. Trigatti, P. Moe, Benjamin B. Johnson, 2012, Biochemistry.

Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity

M. Jordana, B. Trigatti, R. Palanivel, 2014, PloS one.

Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin‐1 Expression

J. Capone, M. Malloy, C. Pullinger, 2013, Journal of the American Heart Association.

A Single Point Mutation in -COP Results in Temperature-sensitive, Lethal Defects in Membrane Transport in a Chinese Hamster Ovary Cell Mutant (*)

M. Krieger, B. Trigatti, M. Penman, 1996, The Journal of Biological Chemistry.

Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice

A. Prat, N. Seidah, B. Trigatti, 2019, JHEP reports.

Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.

F. Sacks, M. Connelly, S. Mora, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Focus on Cardiovascular Disease

F. Sacks, M. Connelly, S. Mora, 2019 .

The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I

R. Truant, B. Trigatti, N. McFarlane, 2007, Molecular membrane biology.

Identification of high affinity membrane-bound fatty acid-binding proteins using a photoreactive fatty acid

G. Gerber, B. Trigatti, D. Mangroo, 1993, Molecular and Cellular Biochemistry.

Interleukin‐15 Contributes to the Regulation of Murine Adipose Tissue and Human Adipocytes

B. Trigatti, A. Ashkar, G. Werstuck, 2010, Obesity.

Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth

B. Trigatti, J. Cutz, G. Steinberg, 2016, Journal of the American Heart Association.

Results Proliferating Macrophages Are Present at Various Stages of Murine Atherosclerotic Lesion Development and in Human Coronary Artery Atherosclerosis

B. Trigatti, J. Cutz, G. Steinberg, 2016 .

Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor

A. Prat, N. Seidah, D. Dwivedi, 2018, Scientific Reports.

Adirect role for serumalbumin inthecellular uptake oflong-chain fatty acids

B. Trigatti, E. Gerber, 1995 .