J. Kyriakis

发表

Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function

S. Goruppi, J. Iovanna, D. Kong, 2010, Molecular biology of the cell.

Gene 33/RALT Is Induced by Hypoxia in Cardiomyocytes, Where It Promotes Cell Death by Suppressing Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase Survival Signaling

R. Patten, J. Kyriakis, Dazhong Xu, 2006, Molecular and Cellular Biology.

The Mixed Lineage Kinase SPRK Phosphorylates and Activates the Stress-activated Protein Kinase Activator, SEK-1*

L. Zon, J. Avruch, P. Godowski, 1996, The Journal of Biological Chemistry.

Raf-1 activates MAP kinase-kinase

David L. Brautigan, Joseph Avruch, Ulf R. Rapp, 1992, Nature.

Phosphorylation of c-jun mediated by MAP kinases

James R. Woodgett, Joseph Avruch, J. Woodgett, 1991, Nature.

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.

J. Avruch, J. Kyriakis, J M Kyriakis, 2001, Physiological reviews.

Life-or-death decisions

J. Kyriakis, J M Kyriakis, 2001, Nature.

Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.

S. Goruppi, J. Iovanna, S. P. Georgescu, 2011, American journal of physiology. Cell physiology.

Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation.

J. Kyriakis, A. Alessandrini, Herbert Y. Lin, 2003, American journal of physiology. Cell physiology.

MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase*

L. Zon, J. Avruch, M. Katoh, 1997, The Journal of Biological Chemistry.

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

L. Zon, J. Woodgett, J. Avruch, 1995, Nature.

Repression of human heat shock factor 1 activity at control temperature by phosphorylation.

R. Kingston, J. Kyriakis, U. Knauf, 1996, Genes & development.

Faculty Opinions recommendation of Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.

J. Kyriakis, 2007 .

Induction of cyclin D1 by simian virus 40 small tumor antigen.

L. Zon, C. Albanese, K. Rundell, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2

J. Kyriakis, T. Yuasa, D. N. Chadee, 2002, Molecular and Cellular Biology.

Activation of SAPK/JNKs in vitro.

J. Kyriakis, D. N. Chadee, 2010, Methods in molecular biology.

Germinal Center Kinase Is Required for Optimal Jun N-Terminal Kinase Activation by Toll-Like Receptor Agonists and Is Regulated by the Ubiquitin Proteasome System and Agonist-Induced, TRAF6-Dependent Stabilization

J. Kyriakis, J. Zhong, 2004, Molecular and Cellular Biology.

A Novel Role for Mixed Lineage Kinase 3 (MLK3) in B-Raf Activation and Cell proliferation

J. Kyriakis, D. N. Chadee, 2004, Cell cycle.

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

J. Avruch, J. Kyriakis, 1990, The Journal of biological chemistry.

MAP Kinase Pathways

J. Avruch, J. Kyriakis, 2016 .

Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family.

J. Kyriakis, 1999, Gene expression.

Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice

Jen Q. Pan, M. Aronovitz, J. Kyriakis, 2014, Diabetes.

c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo

Yow-Ming C Wang, F. Salituro, P. Tsichlis, 2005, Circulation research.

Insulin stimulates choline acetyltransferase activity in cultured embryonic chicken retina neurons.

J. Kyriakis, R. Hausman, S. Peterson, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Gene 33 Is an Endogenous Inhibitor of Epidermal Growth Factor (EGF) Receptor Signaling and Mediates Dexamethasone-induced Suppression of EGF Function*

J. Kyriakis, Dazhong Xu, A. Makkinje, 2005, Journal of Biological Chemistry.

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

J. Avruch, J. Kyriakis, J. Troppmair, 1994, The Journal of biological chemistry.

Cross‐linking CD40 on B cells preferentially induces stress‐activated protein kinases rather than mitogen‐activated protein kinases.

J. Woodgett, J. Kyriakis, I. Berberich, 1996, The EMBO journal.

Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases.

J. Avruch, L. Heasley, J. Kyriakis, 1992, Molecular endocrinology.

REGULATION OF NUCLEAR TRANSCRIPTION FACTORS BY STRESS SIGNALS

J. Woodgett, J. Avruch, J. Kyriakis, 1995, Clinical and experimental pharmacology & physiology.

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

J. Woodgett, J. Gutkind, J. Kyriakis, 1995, The Journal of Biological Chemistry.

SOK1 Translocates from the Golgi to the Nucleus upon Chemical Anoxia and Induces Apoptotic Cell Death*

J. Kyriakis, T. Force, J. Zalvide, 2008, Journal of Biological Chemistry.

Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.

M. Gayle, J. Kyriakis, T. Bird, 1994, The Journal of biological chemistry.

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase.

J. Avruch, J. Bonventre, J. Kyriakis, 1993, The Journal of biological chemistry.

Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain

L. Silengo, F. Giancotti, E. Hirsch, 2002, The Journal of cell biology.

pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity.

J. Avruch, J. Kyriakis, D. Brautigan, 1991, The Journal of biological chemistry.

Changes in Insulin Binding to Developing Embryonic Chick Neural Retina Cells

J. Kyriakis, R. Hausman, S. Peterson, 1986, Journal of neurochemistry.

An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

J. Avruch, J. Kyriakis, S. Pelech, 1992, The Journal of biological chemistry.

The Stress‐activated Protein Kinases

J. Woodgett, J. Avruch, J. Kyriakis, 1995 .

Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.

J. Avruch, J. Bonventre, J. Kyriakis, 1991, The Journal of biological chemistry.

Activation of the MKK4‐JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2‐β isoform

J. Eriksson, L. Sistonen, J. Kyriakis, 2001, FEBS letters.

Helix-Loop-Helix Protein p8, a Transcriptional Regulator Required for Cardiomyocyte Hypertrophy and Cardiac Fibroblast Matrix Metalloprotease Induction

S. Goruppi, R. Patten, J. Kyriakis, 2006, Molecular and Cellular Biology.

The stress-activated protein kinase subfamily of c-Jun kinases

J. Woodgett, J. Avruch, J. Kyriakis, 1994, Nature.

Advances in Brief Defective Induction of Stress-activated Protein Kinase Activity in Ataxia-Telangiectasia Cells Exposed to Ionizing Radiation 1

Surender, Saleem, R. Weichselbaum, 2006 .

Activation of SAPKs/JNKs and p38s in vitro.

Hong Liu, J. Kyriakis, D. N. Chadee, 2004, Methods in molecular biology.

TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related.

A. Leonardi, J. Kyriakis, C. Shi, 1999, Journal of immunology.

A. Leonardi, J. Kyriakis, C. Shi, 1999 .

Reconstitution of novel signalling cascades responding to cellular stresses.

L. Zon, J. Woodgett, B. Zanke, 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation.

R. Weichselbaum, D. Kufe, S. Kharbanda, 1995, Cancer research.

Inhibition de la proliferation cellulaire via des kinases de lignage melangees

J. Kyriakis, D. N. Chadee, 2004 .

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

L. Zon, S. Grant, M. Birrer, 1996, Nature.

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

L. Zon, J. Woodgett, J. Kyriakis, 1994, Nature.

Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter (*)

J. Bonventre, J. Kyriakis, T. Force, 1995, The Journal of Biological Chemistry.

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

S. Elledge, J. Settleman, J. Avruch, 1993, Nature.

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation*

J. Avruch, J. Kyriakis, 1996, The Journal of Biological Chemistry.

Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.

X. F. Zhang, J. Avruch, G. Tzivion, 2001, Recent progress in hormone research.

Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.

Joseph Avruch, J. Avruch, J. Kyriakis, 2012, Physiological reviews.

Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons

L. Rubin, J. Kyriakis, J. Ham, 1998, The Journal of Neuroscience.

Glucocorticoid receptor–JNK interaction mediates inhibition of the JNK pathway by glucocorticoids

Alejandra Bruna, A. Muñoz, J. Kyriakis, 2003, The EMBO journal.

Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.

M. Skolnick, A. Oliphant, D. Teng, 1997, Cancer research.

Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels and Consequent Suppression of Inhibitory Raf-1 Phosphorylation*♦

J. Kyriakis, G. Kilili, 2010, The Journal of Biological Chemistry.

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

J. Kyriakis, D. N. Chadee, 2004, Nature Cell Biology.

Insulin Regulation of Protein Phosphorylation

J. Avruch, J. Kyriakis, H. Tornqvist, 1990 .

The integration of signaling by multiprotein complexes containing Raf kinases.

J. Kyriakis, 2007, Biochimica et biophysica acta.

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.

R. Hajjar, J. Bonventre, G. Choukroun, 1998, The Journal of clinical investigation.

Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase (SAPK)/Jun NH2-terminal Kinase (JNK) and p38

J. Kyriakis, J. Kehrl, S. Ohno, 1998, The Journal of Biological Chemistry.

Protein kinase cascades activated by stress and inflammatory cytokines

J. Avruch, J. Kyriakis, 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.

Stress-activated protein kinases in cardiovascular disease.

J. Avruch, J. Bonventre, J. Kyriakis, 1996, Circulation research.

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

L. Zon, J. Woodgett, B. Zanke, 1996, Current Biology.

Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein Kinase with Phosphatidylinositol 3-Kinase (*)

R. Weichselbaum, J. Woodgett, J. Avruch, 1995, The Journal of Biological Chemistry.

Activation of the Ste20-like Oxidant Stress Response Kinase-1 during the Initial Stages of Chemical Anoxia-induced Necrotic Cell Death

J. Bonventre, J. Kyriakis, C. Pombo, 1997, The Journal of Biological Chemistry.

Activation of a human Ste20‐like kinase by oxidant stress defines a novel stress response pathway.

J. Bonventre, J. Kyriakis, T. Force, 1996, The EMBO journal.

In the Beginning, There Was Protein Phosphorylation

J. Kyriakis, 2014, The Journal of Biological Chemistry.

Thinking Outside the Box about Ras*

J. Kyriakis, 2009, Journal of Biological Chemistry.

Raf meets Ras: completing the framework of a signal transduction pathway.

X. F. Zhang, J. Avruch, J. Kyriakis, 1994, Trends in biochemical sciences.

Inhibitors of Protein Kinase Signaling Pathways: Emerging Therapies for Cardiovascular Disease

Keisuke Kuida, Mark Namchuk, Keykavous Parang, 2004, Circulation.

The GCK II and III subfamilies of the STE20 group kinases.

J. Kyriakis, T. Force, J. Zalvide, 2007, Frontiers in bioscience : a journal and virtual library.

Signaling by the Germinal Center Kinase Family of Protein Kinases*

J. Kyriakis, J M Kyriakis, 1999, The Journal of Biological Chemistry.

Dissection of a Signaling Pathway by Which Pathogen-associated Molecular Patterns Recruit the JNK and p38 MAPKs and Trigger Cytokine Release*

J. Kyriakis, J. Zhong, 2007, Journal of Biological Chemistry.

Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.

R. Brent, J. Kyriakis, A. Zervos, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2

J. Kyriakis, T. Yuasa, D. N. Chadee, 2002, Molecular and Cellular Biology.

Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase ( SAPK ) / Jun

Shigeo Ohno, J. Kyriakis, J. Kehrl, 1998 .

Cdc42Hs, but Not Rac1, Inhibits Serum-stimulated Cell Cycle Progression at G1/S through a Mechanism Requiring p38/RK*

L. Zon, J. Kyriakis, A. Theodoras, 1997, The Journal of Biological Chemistry.

GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38

R. V. van Etten, J. Kyriakis, J. Kehrl, 2009, Proceedings of the National Academy of Sciences.

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

Hong Liu, H. Ichijo, J. Kyriakis, 2000, Molecular and Cellular Biology.

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

Dazhong Xu, David H Gutmann, Ali Andalibi, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The Pro-hypertrophic Basic Helix-Loop-Helix Protein p8 Is Degraded by the Ubiquitin/Proteasome System in a Protein Kinase B/Akt- and Glycogen Synthase Kinase-3-dependent Manner, whereas Endothelin Induction of p8 mRNA and Renal Mesangial Cell Hypertrophy Require NFAT4*

S. Goruppi, J. Kyriakis, 2004, Journal of Biological Chemistry.

Phosphatidylinositol 3′-Kinase-dependent Activation of Renal Mesangial Cell Ki-Ras and ERK by Advanced Glycation End Products*

J. Kyriakis, Dazhong Xu, 2003, Journal of Biological Chemistry.

Signaling pathways and late‐onset gene induction associated with renal mesangial cell hypertrophy

S. Goruppi, J. Bonventre, J. Kyriakis, 2002, The EMBO journal.

Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.

J. Woodgett, J. Avruch, A. Kraft, 1995, Oncogene.

The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion.

J. Woodgett, J. Avruch, J. Bonventre, 1994, The Journal of biological chemistry.

Deficiency of transcriptional regulator p8 induces autophagy and causes impaired cardiac function

S. Goruppi, D. Kong, J. Kyriakis, 2010, Autophagy.

c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK

T. Hiraki, I. Nishimoto, J. Kyriakis, 2001, The Journal of Neuroscience.

Germinal Center Kinases (GCKs)

J. Kyriakis, 2002 .

Extracellular Signal-Regulated Kinases (ERKs)

J. Kyriakis, 2002 .

Enzymatic characteristics of the c-Raf-1 protein kinase.

J. Avruch, J. Bonventre, J. Kyriakis, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The stress-activated protein kinases. A novel ERK subfamily responsive to cellular stress and inflammatory cytokines.

J. Woodgett, J. Avruch, J. Kyriakis, 1995, Annals of the New York Academy of Sciences.

MAP Kinases and the Regulation of Nuclear Receptors

J. Kyriakis, 2000, Science's STKE.

The stress activated protein kinase pathway.

J. Woodgett, J. Avruch, J. Kyriakis, 1996, Cancer surveys.

Gene 33/Mig-6, a Transcriptionally Inducible Adapter Protein That Binds GTP-Cdc42 and Activates SAPK/JNK*

J. Bonventre, J. Kyriakis, C. Cadilla, 2000, The Journal of Biological Chemistry.

Mitogen‐Activated Protein Kinases (MAPKs)

J. Kyriakis, 2002 .

Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.

J. Kyriakis, J M Kyriakis, 1999, Biochemical Society symposium.

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

J. Kyriakis, 2003, Journal of biology.

Faculty Opinions recommendation of SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

J. Kyriakis, 2010 .

Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.

J. Hartwig, T. Stossel, J. Avruch, 1997, The Journal of biological chemistry.

Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice

Jen Q. Pan, M. Aronovitz, J. Kyriakis, 2014, Diabetes.

Insulin, epidermal growth factor and fibroblast growth factor elicit distinct patterns of protein tyrosine phosphorylation in BC3H1 cells.

J. Avruch, J. Kyriakis, 1990, Biochimica et biophysica acta.

Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function

S. Goruppi, J. Iovanna, D. Kong, 2010, Molecular biology of the cell.

Thinking Outside the Box about Ras*

J. Kyriakis, 2009, Journal of Biological Chemistry.