J. Caldwell

发表

Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

P. Workman, M. Walton, M. Garrett, 2010, Molecular Cancer Therapeutics.

Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library

J. Caldwell, F. Raynaud, S. Eccles, 2016, Chemistry.

Design and synthesis of 2(1H)-pyrazinones as inhibitors of protein kinases

J. Caldwell, I. Collins, N. Veillard, 2012 .

Chemistry of Fluorinated Purines

J. Caldwell, I. Collins, Alan M. Jones, 2014 .

Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases.

C. E. Allen, R. V. van Montfort, J. Caldwell, 2013, Bioorganic & medicinal chemistry.

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding

R. Bayliss, J. Caldwell, I. Collins, 2015, Oncotarget.

SimPLIT: Simplified Sample Preparation for Large-Scale Isobaric Tagging Proteomics

J. Choudhary, J. Caldwell, Laura Chan Wah Hak, 2022, Journal of proteome research.

The Synthetic Chemistry and Applications of Fluorinated Purines

J. Caldwell, Ian, Paul C. M. Winship, 2021 .

Synthesis of a Ribose‐Incorporating Medium Ring Scaffold via a Challenging Ring‐Closing Metathesis Reaction

R. V. van Montfort, N. Cronin, J. Caldwell, 2016, European journal of organic chemistry.

Synthesis of 4-(cyclic dialkylamino)-7-azaindoles by microwave heating of 4-halo-7-azaindoles and cyclic secondary amines

J. Caldwell, I. Collins, K. Cheung, 2007 .

Synthesis of 4‐(Cyclic dialkylamino)‐7‐azaindoles by Microwave Heating of 4‐Halo‐7‐azaindoles and Cyclic Secondary Amines.

J. Caldwell, I. Collins, K. Cheung, 2007 .

Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)†

G. Aherne, M. Garrett, L. Hunter, 2010, Journal of medicinal chemistry.

Bicyclic 5-6 Systems: Purines

J. Caldwell, I. Collins, 2008 .

CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.

L. Pearl, M. Walton, A. Oliver, 2011, Cancer research.

Sulfone-mediated total synthesis of (+/-)-lepadiformine.

J. Caldwell, D. Craig, 2007, Angewandte Chemie.

Chromium-mediated β-lactone synthesis using ultrasonication

J. Caldwell, W. Kerr, N. Heron, 1999 .

Novel Use of a Selenoalkyne Within Untraditionally Mild Dötz Benzannulation Processes; Total Synthesis of a Calceolaria andina L. Natural Hydroxylated Naphthoquinone

J. Caldwell, W. Kerr, R. Colman, 2001 .

Functionalised β-lactones from chromium alkyl(alkoxy)carbene complexes

J. Caldwell, W. Kerr, S. Mckendry, 1999 .

Application of a 5-endo-trig cyclisation in the total synthesis of (+)-preussin

J. Caldwell, D. Craig, S. East, 2007 .

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis.

E. Sahai, C. Marshall, M. Garrett, 2015, Cancer research.

Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2.

L. Pearl, A. Oliver, K. Boxall, 2011, Journal of medicinal chemistry.

Is a Potent and Selective Inhibitor of CHK 2 that Potentiates the Cytotoxicity of PARP Inhibitors

L. Pearl, M. Walton, A. Oliver, 2011 .

Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease

M. Walton, R. Bayliss, L. Pickard, 2019, Journal of medicinal chemistry.

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

P. Workman, P. Clarke, J. Caldwell, 2017, Journal of medicinal chemistry.

Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2.

C. E. Allen, L. Pearl, A. Oliver, 2010, Bioorganic & medicinal chemistry.

Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.

Ian Collins, Paul Workman, Michelle D Garrett, 2008, Journal of medicinal chemistry.

Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway

J. Caldwell, I. Collins, R. Chopra, 2017, The Biochemical journal.

A Sulfone-mediated Synthesis of (+)-Preussin

J. Caldwell, D. Craig, S. East, 2001 .

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.

Ian Collins, Paul Workman, Edward McDonald, 2006, Bioorganic & medicinal chemistry.

A Sulfone‐Mediated Synthesis of (+)‐Preussin.

J. Caldwell, D. Craig, S. East, 2002 .

iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells

T. Westbrook, R. V. van Montfort, Y. Le Bihan, 2023, iScience.

322 Novel isoquinoline-5-sulfonamides as biochemical and cellular inhibitors of PKB/AKt

P. Workman, M. Garrett, L. Hunter, 2004 .

Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.

Benjamin R Bellenie, R. V. van Montfort, A. Mirza, 2023, Journal of medicinal chemistry.

Fragment growing to retain or alter the selectivity of anchored kinase hinge-binding fragments

Ian Collins, C. E. Allen, J. Caldwell, 2014 .

The structure-activity relationship of inhibitors of serotonin uptake and receptor binding

Corwin Hansch, Jonathan Caldwell, C. Hansch, 1991, J. Comput. Aided Mol. Des..