B. Fang

J. Roth, I. Wistuba, S. Swisher, 2013, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo

Michael Peyton, John D. Minna, B. Nebiyou Bekele, 2010, PloS one.

Double-Stranded RNA-Dependent Protein Kinase-Dependent Apoptosis Induction by a Novel Small Compound

S. Swisher, Wei Guo, W. Hofstetter, 2009, Journal of Pharmacology and Experimental Therapeutics.

Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms.

P. Chiao, B. Fang, Lidong Zhang, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.

K. Aldape, Haitao Ji, D. Hawke, 2009, Molecular cell.

GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells

J. Roth, T. McDonnell, L. Ghibelli, 2004, Cancer Gene Therapy.

A packaging system for SV40 vectors without viral coding sequences.

M. Bouvet, B. Fang, L. Ji, 1997, Analytical biochemistry.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Steven B. Neuhauser, Yvonne A. Evrard, Michael W. Lloyd, 2019, Nature Genetics.

Eliminating Established Tumor in nu/nu Nude Mice by a Tumor Necrosis Factor-α-Related Apoptosis-Inducing Ligand–Armed Oncolytic Adenovirus

Wei Guo, B. Fang, Li Wang, 2006, Clinical Cancer Research.

Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.

Jeffrey S. Morris, I. Shureiqi, B. Fang, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Bax-induction gene therapy of pancreatic cancer.

J. Gu, Meng Yang, A. Moossa, 2002, The Journal of surgical research.

Redirecting adaptive immunity against foreign antigens to tumors for cancer therapy

S. Swisher, Wei Guo, B. Fang, 2007, Cancer biology & therapy.

An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53

J. Roth, S. Chada, B. Fang, 2002, Gene Therapy.

KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression

Li Wang, S. Swisher, W. Hofstetter, 2010, Cancer biology & therapy.

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Kellen L. Olszewski, L. Zhuang, B. Gan, 2021, Nature.

Synergistic Tumor Suppression by Coexpression of FHIT and p53 Coincides with FHIT-Mediated MDM2 Inactivation and p53 Stabilization in Human Non-Small Cell Lung Cancer Cells

J. Minna, J. Roth, E. Atkinson, 2004, Cancer Research.

Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization.

J. Roth, S. Swisher, R. Mehran, 2019, American journal of cancer research.

Influence and mechanism of lung cavitation development on antiangiogenic therapy.

B. Fang, Chuantao Zhang, H. Hou, 2019, Translational lung cancer research.

Induction of apoptosis and G2/M cell cycle arrest by DCC

J. Hsieh, B. Fang, Yong Q. Chen, 1999, Oncogene.

Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer.

J. Roth, X. Li, B. Fang, 2001, Cancer research.

Comprehensive Molecular Characterization of Young Chinese Patients with Lung Adenocarcinoma Identified a Distinctive Genetic Profile.

B. Liu, B. Fang, Y. Guan, 2018, The oncologist.

P1.05-028 Phenotypic and Functional Profiling of Tumor-Infiltrating Lymphocytes (TIL) in Early Stage Non-Small Cell Lung Cancer (NSCLC): Topic: Translational Research and Biomarkers

I. Wistuba, P. Sharma, J. Heymach, 2017 .

Prognostic Significance of RNA-Dependent Protein Kinase on Non–Small Cell Lung Cancer Patients

Stephen G Swisher, Koji Tsuta, Luisa Solis, 2010, Clinical Cancer Research.

Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance

S. Swisher, B. Fang, R. Shao, 2016, Oncotarget.

JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase

S. Swisher, W. Hofstetter, B. Fang, 2008, Cancer Gene Therapy.

Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences

G. Fuller, T. Tamiya, D. Dinh, 2002, Oncogene.

A Recombinant Adenovirus Expressing Wild-Type Bax Induces Apoptosis in Prostate Cancer Cells Independently of Their Bcl-2 Status and Androgen Sensitivity

J. Roth, T. McDonnell, B. Gjertsen, 2002, Cancer biology & therapy.

Advances in Brief Adenoviral Bak Overexpression Mediates Caspase-dependent Tumor Killing 1

K. Hunt, J. Roth, S. Swisher, 2000 .

Lack of p38 MAP Kinase Activation in TRAIL-Resistant Cells is Not Related to the Resistance to TRAIL-Mediated Cell Death

B. Fang, Yibin Wang, Lidong Zhang, 2004, Cancer biology & therapy.

Bcl-2-associated X protein is the main mediator of manumycin a-induced apoptosis in anaplastic thyroid cancer cells.

B. Fang, Jingxuan Pan, S. J. Yeung, 2005, The Journal of clinical endocrinology and metabolism.

Advances in Brief Antitumor Effect of Adenovirus-mediated Bax Gene Transfer on p 53-sensitive and p 53-resistant Cancer Lines 1

J. Gu, J. Roth, S. Swisher, 2000 .

Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53-resistant cancer lines.

J. Gu, J. Roth, S. Swisher, 2000, Cancer research.

Factors limiting adenovirus-mediated gene transfer into human lung and pancreatic cancer cell lines.

J. Roth, M. Xiong, P. Koch, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type p53 (Ad-p53)

F. Khuri, W. Hong, J. Roth, 2000, Cancer Gene Therapy.

Molecular therapy for peritoneal dissemination of xenotransplanted human MKN-45 gastric cancer cells with adenovirus mediated Bax gene transfer

J. Roth, T. Fujiwara, T. Fujiwara, 2004, Gut.

A rapid, sensitive, and nonradioactive method for assay of FHIT Ap3A hydrolase activity by fluorescence thin-layer chromatographic image analysis.

B. Fang, L. Ji, J. Roth, 1999, Analytical biochemistry.

Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway.

R. Bast, Yin-hua Yu, M. Andreeff, 2002, Cancer research.

Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide

C. Bucana, M. Bouvet, K. Hamada, 1998, Gene Therapy.

Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death.

J. Gu, S. Swisher, T. McDonnell, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Long-term tumor-free survival from treatment with the GFP–TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells

M. Xiong, K. Hunt, S. Curley, 2002, Oncogene.

Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities

J. Roth, S. Swisher, M. Andreeff, 2017, Oncotarget.

Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line.

Wei Guo, B. Fang, Z. Fan, 2005, Neoplasia.

A rapid and efficient method for purification of recombinant adenovirus with RGD-modified fibers

B. Fang, Li Wang, Shuhong Wu, 2008 .

A rapid and efficient method for purification of recombinant adenovirus with arginine-glycine-aspartic acid-modified fibers.

J. Roth, B. Fang, Li Wang, 2006, Analytical biochemistry.

Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter

B. Fang, Lidong Zhang, F. Teraishi, 2005, Cancer Gene Therapy.

Combination effect of oncolytic adenovirotherapy and TRAIL gene therapy in syngeneic murine breast cancer models

J. Roth, H. Jiang, B. Fang, 2006, Cancer Gene Therapy.

Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft

J. Gu, J. Roth, L. Stephens, 2002, Gene Therapy.

Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.

G. Mills, J. Gu, J. Roth, 2002, Gynecologic oncology.

Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells

Wei Guo, B. Fang, Lidong Zhang, 2005, Molecular Cancer Therapeutics.

KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations.

Jeffrey S. Morris, Jing Wang, J. Minna, 2020, American journal of cancer research.

Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia.

Ju-Seog Lee, M. Konopleva, M. Andreeff, 2015, Blood.

A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Steven B. Neuhauser, Yvonne A. Evrard, Jeffrey H. Chuang, 2022, bioRxiv.

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

Wei Guo, P. Chiao, B. Fang, 2005, Oncogene.

Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line

J. Gu, J. Roth, B. Fang, 2002, Gene Therapy.

Enhancing adenovirus‐mediated gene transfer in vitro and in vivo by addition of protamine and hydrocortisone

J. Gu, B. Fang, L. Ji, 2003, The journal of gene medicine.

Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma

Imran T. Mohiuddin, B. Fang, Xiaobo X. Cao, 2001, Cancer Gene Therapy.

Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines.

J. Roth, S. Swisher, T. McDonnell, 2001, The Journal of thoracic and cardiovascular surgery.

TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin

Jing Wang, J. Roth, V. Baladandayuthapani, 2016, Scientific Reports.

Therapy-Resistant Cancer Stem Cells Have Differing Sensitivity to Photon versus Proton Beam Radiation

Joe Y. Chang, R. Mohan, Steven H. Lin, 2013, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Evaluation of GAL4/TATA in Vivo

J. Roth, M. Bouvet, B. Fang, 1998, The Journal of Biological Chemistry.

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.

Kwok-Kin Wong, L. Nie, Chia-Hung Chen, 2018, Cancer cell.

Telomerase Promoter-Driven Cancer Cell Suicide

J. Gu, B. Fang, 2003, Cancer biology & therapy.

Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells.

P. Neuhaus, B. Fang, Lidong Zhang, 2005, World journal of gastroenterology.

Gene therapy in colon cancer cells with a fiber-modified adenovector expressing the TRAIL gene driven by the hTERT promoter.

P. Neuhaus, B. Fang, M. Bahra, 2004, Anticancer research.

Targeting different types of human meningioma and glioma cells using a novel adenoviral vector expressing GFP-TRAIL fusion protein from hTERT promoter

F. Murad, Dongho Kim, B. Fang, 2012 .

Reduced toxicity, attenuated immunogenicity and efficient mediation of human p53 gene expression in vivo by an adenovirus vector with deleted E1-E3 and inactivated E4 by GAL4-TATA promoter replacement

R. Price, J. Roth, M. Bouvet, 1999, Gene Therapy.

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells

J. Minna, J. Roth, S. Swisher, 2015, Oncotarget.

Oxidative stress in NSC-741909-induced apoptosis of cancer cells

Jinsong Liu, Peng Huang, B. Fang, 2010, Journal of Translational Medicine.

Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma.

Michael L. Wang, R. Advani, W. Jędrzejczak, 2013, The New England journal of medicine.

Harnessing plasma genotyping for precision therapy against lung cancer.

B. Fang, Xiang Yan, 2016, Journal of thoracic disease.

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Kellen L. Olszewski, M. J. You, L. Zhuang, 2020, Nature Cell Biology.

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Junjie Chen, Shu-Bing Qian, L. Zhuang, 2021, Nature Communications.

KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

Kellen L. Olszewski, B. Gan, B. Fang, 2021, iScience.

Adenovector-Mediated Cancer Gene Therapy

J. Roth, B. Fang, 2007 .

Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers

B. Fang, Lidong Zhang, 2005 .

The role of gene therapy in combined modality treatment strategies for cancer.

J. Roth, B. Fang, 2003, Current opinion in molecular therapeutics.

Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: correlation with insulin-like growth factors

W. Hong, J. Roth, J. Kurie, 1993 .

Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth.

J. Roth, Z. Gokaslan, A. Kyritsis, 1999, Cancer research.

Unbiased peptoid cell screen identifies a peptoid targeting newly appeared cell surface vimentin on tumor transformed early lung cancer cells.

J. Minna, B. Fang, Haowen Zhang, 2022, Bioorganic & medicinal chemistry.

Oncolytic virotherapy for cancer treatment: challenges and solutions

B. Fang, B Fang, J J Davis, 2005, The journal of gene medicine.

Cisplatin enhances apoptosis induced by a tumor-selective adenovirus expressing tumor necrosis factor-related apoptosis-inducing ligand.

D. Schrump, D. Nguyen, B. Fang, 2004, The Journal of thoracic and cardiovascular surgery.

Telomerase promoter-driven cancer gene therapy.

B. Fang, Jian Gu, 2003 .

Adenoviral Bak overexpression mediates caspase-dependent tumor killing.

K. Hunt, J. Roth, S. Swisher, 2000, Cancer research.

Structure-based classification predicts drug response in EGFR-mutant NSCLC

Jing Wang, C. Ren, M. Ha, 2021, Nature.

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment

Benjamin J. Raphael, Yvonne A. Evrard, Jeffrey H. Chuang, 2021, Nature Communications.

α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation

Haitao Ji, B. Fang, Zhimin Lu, 2011, Journal of Neuro-Oncology.

17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells

Xin Hu, Wei Zheng, B. Fang, 2019, Molecular Cancer Therapeutics.

RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer

J. Roth, I. Wistuba, S. Swisher, 2015, Oncotarget.

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

P. A. Futreal, Jing Wang, I. Wistuba, 2018, Nature Medicine.

Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance

W. Mao, B. Fang, D. Su, 2018, BMC Cancer.

Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy

J. Roth, S. Swisher, D. Gibbons, 2018, Oncoimmunology.

A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax

L Ji, J. Roth, S. Swisher, 2000, Gene Therapy.

IGFBP2/FAK Pathway Is Causally Associated with Dasatinib Resistance in Non–Small Cell Lung Cancer Cells

J. Minna, J. Roth, S. Swisher, 2013, Molecular Cancer Therapeutics.

Insulin-Like Growth Factor Binding Protein-2 Level Is Increased in Blood of Lung Cancer Patients and Associated with Poor Survival

Xifeng Wu, J. Roth, S. Swisher, 2013, PloS one.

IGFBP 2 / FAK pathway is causally associated with dasatinib resistance in non-small Cell Lung Cancer Cells

J. Minna, J. Roth, S. Swisher, 2013 .

RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.

B. Fang, 2015, Acta biochimica et biophysica Sinica.

PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis

L. Litovchick, Junjie Chen, Wenqi Wang, 2021, Molecular cell.

Tumor-specific apoptotic gene targeting overcomes radiation resistance in esophageal adenocarcinoma.

Joe Y. Chang, R. Komaki, B. Fang, 2006, International journal of radiation oncology, biology, physics.

Radiotherapy Sensitization by Tumor-Specific TRAIL Gene Targeting Improves Survival of Mice Bearing Human Non–Small Cell Lung Cancer

Joe Y. Chang, R. Komaki, B. Fang, 2005, Clinical Cancer Research.

Suppressing Orthotopic Pancreatic Tumor Growth with a Fiber-Modified Adenovector Expressing the TRAIL Gene from the Human Telomerase Reverse Transcriptase Promoter

B. Fang, Lidong Zhang, Shuhong Wu, 2004, Clinical Cancer Research.

Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression.

J. Minna, J. Roth, B. Fang, 1999, Cancer research.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Yvonne A. Evrard, Michael W. Lloyd, Jeffrey H. Chuang, 2021, Nature Genetics.

Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells.

Michael L. Wang, J. Minna, J. Roth, 2014, Journal of the National Cancer Institute.

Elevated NSD3 histone methylation activity drives squamous cell lung cancer

J. Minna, I. Wistuba, P. Mazur, 2021, Nature.

Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer

J. Minna, J. Roth, I. Wistuba, 2021, Nature.

Adenovirus-mediated wild-typep53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer

Michael Bouvet, Richard J. Bold, David J. McConkey, 1998, Annals of Surgical Oncology.

Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments].

J. Roth, R. Bold, D. McConkey, 1998, Annals of surgical oncology.

Oncogenes, Tumor Suppressor Genes and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy

B. Fang, Lidong Zhang, 2007 .

Bax-mediated Ca2+ Mobilization Promotes Cytochromec Release during Apoptosis*

J. Roth, S. Swisher, L. Nutt, 2002, The Journal of Biological Chemistry.

Bax and Bak Promote Apoptosis by Modulating Endoplasmic Reticular and Mitochondrial Ca2+ Stores*

J. Roth, S. Swisher, L. Nutt, 2002, The Journal of Biological Chemistry.

A Role for Mitochondrial Bak in Apoptotic Response to Anticancer Drugs*

A. Gambotto, Tae-Hyoung Kim, Xiao-Ming Yin, 2001, The Journal of Biological Chemistry.

Predictive biomarkers in precision medicine and drug development against lung cancer

S. Swisher, R. Mehran, B. Fang, 2015, Chinese journal of cancer.

TRAIL-β and TRAIL-γ: two novel splice variants of the human TNF-related apoptosis-inducing ligand (TRAIL) without apoptotic potential

C. Gerharz, B. Fang, C. Mahotka, 2003, British Journal of Cancer.

Inhibiting JNK Dephosphorylation and Induction of Apoptosis by Novel Anticancer Agent NSC-741909 in Cancer Cells*

Yiling Lu, Jinsong Liu, B. Fang, 2009, The Journal of Biological Chemistry.

P-Glycoprotein-Independent Apoptosis Induction by a Novel Synthetic Compound, MMPT [5-[(4-Methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone]

B. Fang, Lidong Zhang, Shuhong Wu, 2005, Journal of Pharmacology and Experimental Therapeutics.

Differential Expression of Viral Transcripts From Single-Cell RNA Sequencing of Moderate and Severe COVID-19 Patients and Its Implications for Case Severity

Zhongming Zhao, P. Jia, B. Fang, 2020, Frontiers in Microbiology.

Coxsackie-adenovirus receptor as a novel marker of stem cells in treatment-resistant non-small cell lung cancer.

Radhe Mohan, Joe Y. Chang, R. Mohan, 2012, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Tumor characteristics associated with engraftment of patient‐derived non–small cell lung cancer xenografts in immunocompromised mice

J. Roth, S. Swisher, J. Fujimoto, 2019, Cancer.

Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer.

K. Shaw, J. Roth, S. Swisher, 2015, Cancer letters.

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

Gong Yang, Jinsong Liu, B. Fang, 2003, Oncogene.

Adenovirus‐mediated small hairpin RNA targeting Bcl‐XL as therapy for colon cancer

B. Fang, Hongbo Zhu, Chao He, 2007, International journal of cancer.

Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers.

J. Gu, J. Roth, S. Kyo, 2000, Cancer research.

Aberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters

Jing Wang, Li Wang, J. Roth, 2012, PloS one.

Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells

P. Koch, B. Fang, J. Roth, 1998, Gene Therapy.

Enhancing TRAIL-induced apoptosis by Bcl-XL siRNA

Xiaobo Cao, Hongbo Zhu, B. Fang, 2005, Cancer biology & therapy.

A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo

J. Gu, J. Roth, B. Fang, 2002, Oncogene.

An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses

Jeffrey S. Morris, J. Roth, Steven H. Lin, 2019, Cancer immunology research.

Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer.

L. Ellis, Wenbiao Liu, C. Bucana, 1998, Cancer research.

Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis.

Jing Wang, J. Minna, J. Roth, 2018, Cancer research.

WNT5A-RHOA axis is a new vulnerability in small-cell lung cancer

Kwon-Sik Park, Kee-Beom Kim, B. Fang, 2022, bioRxiv.

Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer

J. Roth, S. Swisher, B. Fang, 2018, Journal of Translational Medicine.

Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells

B. Fang, B. Gastman, H. Rabinowich, 2004, Leukemia.

Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis

J. Gu, J. Roth, S. Swisher, 2004, Oncogene.

Non‐canonical cMet regulation by vimentin mediates Plk1 inhibitor–induced apoptosis

Jing Wang, X. Rao, B. Fang, 2019, EMBO molecular medicine.

Activation of c‐Jun NH2‐terminal kinase is required for gemcitabine's cytotoxic effect in human lung cancer H1299 cells

Wei Guo, A. Lin, B. Fang, 2005, FEBS letters.

3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib

Jing Wang, J. Roth, J. Riess, 2021, bioRxiv.

Resistance to Granzyme B-mediated Cytochrome c Release in Bak-deficient Cells

A. Gambotto, Xiao-Ming Yin, B. Fang, 2001, The Journal of experimental medicine.

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts

Jing Wang, J. Roth, F. Meric-Bernstam, 2021, Scientific Reports.

A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers

E. Dmitrovsky, Jing Wang, J. Kurie, 2020, Molecular Cancer Therapeutics.

Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo.

J. Minna, J. Roth, M. Lerman, 2002, Cancer research.

Generation of patient‐derived xenografts from fine needle aspirates or core needle biopsy

S. Swisher, C. Dinney, J. Gershenwald, 2017, Surgery.

Gene Therapy of Pancreatic Cancer With Green Fluorescent Protein and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Fusion Gene Expression Driven by a Human Telomerase Reverse Transcriptase Promoter

Michael Bouvet, Robert M. Hoffman, A. Moossa, 2003, Annals of Surgical Oncology.

Combination of TRAIL gene therapy and chemotherapy enhances antitumor and antimetastasis effects in chemosensitive and chemoresistant breast cancers.

M. Xiong, J. Gu, J. Roth, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Treatment of Radioresistant Stem-Like Esophageal Cancer Cells by an Apoptotic Gene-Armed, Telomerase-Specific Oncolytic Adenovirus

Joe Y. Chang, R. Komaki, B. Fang, 2008, Clinical Cancer Research.

Genetic Interactions of STAT3 and Anticancer Drug Development

B. Fang, 2014, Cancers.

KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer.

K. Coombes, J. Minna, J. Roth, 2013, Cancer research.

Synthetic Lethality in Anticancer Drug Discovery and Target Identification

B. Fang, Zhong-sheng Guo, 2012 .

Genetic interactions in translational research on cancer

B. Fang, 2011 .

Antitumor Activity of a Novel Oncrasin Analogue Is Mediated by JNK Activation and STAT3 Inhibition

B. Fang, Li Wang, M. Hollingshead, 2011, PloS one.

Effect of combining anti-epidermal growth factor receptor antibody C225 and radiation on DU145 prostate cancer.

Joe Y. Chang, L. Levy, P. Allen, 2008, Oncology reports.

Altered regulation of HIF-1α in naïve- and drug-resistant EGFR mutant NSCLC: implications for a VEGF-dependent phenotype.

Jing Wang, J. Minna, I. Wistuba, 2020, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Variants with a low allele frequency detected in genomic DNA affect the accuracy of mutation detection in cell‐free DNA by next‐generation sequencing

K. Shaw, J. Roth, S. Swisher, 2018, Cancer.

Concurrent use of aspirin with osimertinib is associated with improved survival in advanced EGFR-mutant non-small cell lung cancer.

J. Roth, S. Swisher, B. Fang, 2020, Lung cancer.

Auranofin Enhances Ibrutinib's Anticancer Activity in EGFR-Mutant Lung Adenocarcinoma

B. Fang, Li Wang, Shuhong Wu, 2018, Molecular Cancer Therapeutics.

Gene transfer: the challenge of regulated gene expression

B. Fang, Z. Guo, D. Bartlett, 2008 .

Induction of Apoptosis and Down-Regulation of Bcl-XL in Cancer Cells by a Novel Small Molecule, 2[ [3-(2,3-Dichlorophenoxy)propyl]amino]ethanol

J. Gu, B. Fang, Lidong Zhang, 2004, Cancer Research.

Targeted expression of green fluorescent protein/tumor necrosis factor-related apoptosis-inducing ligand fusion protein from human telomerase reverse transcriptase promoter elicits antitumor activity without toxic effects on primary human hepatocytes.

Steven A Curley, S. Curley, J. Gu, 2002, Cancer research.

Advances in Brief Tumor-specific Transgene Expression from the Human Telomerase Reverse Transcriptase Promoter Enables Targeting of the Therapeutic Effects of the Bax Gene to Cancers 1

J. Gu, J. Roth, S. Kyo, 2000 .

Telomerase-specific oncolytic adenovirus expressing TRAIL suppresses peritoneal dissemination of gastric cancer

W. Zhou, B. Fang, S. Dai, 2017, Gene Therapy.

Targeting apoptosis to cancer via hTERT promoter

B. Fang, 2006, Cancer Biology & Therapy.

hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

B. Fang, J. Gu, J. Gu, 2002, Gene Therapy.

Potentiation of oncolytic virotherapy with armed shRNA

B. Fang, W. Guo, 2009, Cancer biology & therapy.

Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380

K. Baggerly, J. Roth, S. Swisher, 2014, Oncotarget.

Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.

Jinsong Liu, B. Fang, Li Wang, 2011, Journal of medicinal chemistry.

Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.

B. Fang, Li Wang, Shuhong Wu, 2010, European journal of pharmacology.

Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells.

Wei Guo, B. Fang, F. Dong, 2005, Cancer research.

Tumor Suppressing Gene Therapy

J. Roth, B. Fang, 2003, Cancer biology & therapy.

Isolated limb perfusion: a novel delivery system for wild-type p53 and fiber-modified oncolytic adenoviruses to extremity sarcoma

R. Pollock, D. Lev, D. Yu, 2007, Gene Therapy.

The Role of PKR/eIF2α Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer

Ignacio I. Wistuba, Liping Yu, Yihong Zhou, 2011, PloS one.

The laboratory’s role in combating COVID-19

B. Fang, Q. Meng, 2020, Critical reviews in clinical laboratory sciences.

Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)

Jinsong Liu, B. Fang, Li Wang, 2009, Molecular Cancer Therapeutics.

Methylated APC and RASSF1A in multiple specimens contribute to the differential diagnosis of patients with undetermined solitary pulmonary nodules.

Fang Wang, B. Fang, Tong-fu Yu, 2015, Journal of thoracic disease.

Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations

Jing Wang, J. Roth, F. Meric-Bernstam, 2022, Scientific reports.

STAT3 mediates resistance to MEK inhibitor through microRNA miR-17.

J. Minna, J. Roth, L. Girard, 2011, Cancer research.

Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation

Wei Guo, B. Fang, F. Dong, 2005, Cancer biology & therapy.

Researchstress in NSC-741909-induced apoptosis of cancer cells

Jinsong Liu, Peng Huang, B. Fang, 2010 .

B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy

Michael L. Wang, Shouhao Zhou, Sabah Kadri, 2017, Clinical Cancer Research.

Anti-liver cancer activity of TNF-related apoptosis-inducing ligand gene and its bystander effects.

J. Xu, B. Fang, Xiao-tong Hu, 2004, World journal of gastroenterology.

Cell to cell contact required for bystander effect of the TNF-related apoptosis-inducing ligand (TRAIL) gene.

J. Gu, J. Roth, Jinsong Liu, 2003, International journal of oncology.

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Jing Wang, J. Roth, I. Wistuba, 2019, Oncogene.

Downregulation of IFNG in CD4+ T Cells in Lung Cancer through Hypermethylation: A Possible Mechanism of Tumor-Induced Immunosuppression

B. Fang, S. Pan, Quan Zhu, 2013, PloS one.

TRAIL Gene-Armed Oncolytic Poxvirus and Oxaliplatin Can Work Synergistically against Colorectal Cancer

Yong J. Lee, B. Fang, Z. Guo, 2010, Gene Therapy.

Anti-CD20 and B-Cell Receptor-Mediated Growth Inhibition and Apoptosis: A Preclinical Study of Ibrutinib and Rituximab Combination Therapy in Mantle Cell Lymphoma in Vitro and in Vivo

Michael L. Wang, B. Fang, Hui Zhang, 2014 .

Epstein Barr virus–positive B-cell lymphoma is highly vulnerable to MDM2 inhibitors in vivo

Michael L. Wang, Jing Wang, J. Roth, 2021, Blood advances.

Xenograftic tumor models in mice for cancer research , a technical review

B. Fang, John J. Davis, Dietmar A Jacob, 2004 .

Dominant negative RAS as an anticancer agent

B. Fang, W. Guo, 2006, Cancer biology & therapy.

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

P. A. Futreal, Jing Wang, I. Wistuba, 2018, Nature Medicine.

Repurposing auranofin to treat TP53-mutated or PTEN-deleted refractory B-cell lymphoma

Michael L. Wang, Shouhao Zhou, B. Fang, 2019, Blood Cancer Journal.

Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer

G. Mills, K. Hunt, M. Yi, 2013, Breast Cancer Research.

Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells.

Wei Guo, S. Shirasawa, T. Sasazuki, 2006, Cancer research.

Activation of Sterile 20-Like Kinase 1 in Proteasome Inhibitor Bortezomib – Induced Apoptosis in Oncogenic Kras-Transformed Cells

Wei Guo, S. Shirasawa, T. Sasazuki, 2006 .

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Christian M. Metallo, Kellen L. Olszewski, M. J. You, 2020, Nature Cell Biology.

Diminishing adenovirus gene expression and viral replication by promoter replacement

J. Roth, P. Koch, B. Fang, 1997, Journal of virology.

HER2 Confers Resistance to Foretinib Inhibition of MET-Amplified Esophageal Adenocarcinoma Cells.

T. Pandita, S. Swisher, W. Hofstetter, 2017, The Annals of thoracic surgery.

Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer

G. Mills, K. Hunt, M. Yi, 2013, Breast Cancer Research.

Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells

W. Hong, J. Roth, J. Kurie, 2000, Oncogene.

Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.

Jinsong Liu, B. Fang, Shuhong Wu, 2008, Cancer research.

Antitumor activity and downregulation of pro‐angiogenic molecules in human prostate cancer cells by a novel thiazolidione compound

S. Inoue, Wei Guo, B. Fang, 2006, The Prostate.

Treatment of patient tumor-derived colon cancer xenografts by a TRAIL gene-armed oncolytic adenovirus

W. Zhou, B. Fang, C. He, 2011, Cancer Gene Therapy.

Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance

B. Fang, D. Su, W. Mao, 2018, BMC Cancer.

Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells.

Edward S. Kim, J. Minna, J. Roth, 2012, Biochemical Pharmacology.

Characterization of acute biliary hyperplasia in Fisher 344 rats administered the indole-3-carbinol analog, NSC-743380.

John R. Hamre, Joel Morris, B. Fang, 2014, Toxicology and applied pharmacology.

RNAi-Induced synthetic lethality in cancer therapy

J. Roth, B. Fang, B. Dai, 2009, Cancer biology & therapy.

Evaluation of GAL4/TATA in Vivo INDUCTION OF TRANSGENE EXPRESSION BY ADENOVIRALLY MEDIATED GENE CODELIVERY*

J. Roth, M. Bouvet, B. Fang, 1998 .

The Tumor Suppressor Gene TUSC2 (FUS1) Sensitizes NSCLC to the AKT Inhibitor MK2206 in LKB1-dependent Manner

J. Minna, J. Roth, J. Meng, 2013, PloS one.

Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29.

B. Fang, Xiao-tong Hu, X. Xu, 2003, World journal of gastroenterology.

Augmenting transgene expression from carcinoembryonic antigen (CEA) promoter via a GAL4 gene regulatory system.

J. Gu, J. Roth, P. Koch, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

[Activity of the TNF-related apoptosis-inducing ligand gene expressed from the hTERT promoter on colon cancer cell line HT-29].

B. Fang, Chao He, Bin Chen, 2006, Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.

Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380.

J. Roth, S. Swisher, B. Fang, 2014, Bioorganic & medicinal chemistry.

Advances in Brief Adenovirus-mediated Delivery of Antisense Gene to Urokinase-type Plasminogen Activator Receptor Suppresses Glioma Invasion and Tumor Growth 1

J. Roth, Z. Gokaslan, A. Kyritsis, 1999 .

Molecular pathogenesis of lung cancer with translation to the clinic: M10-01

K. Coombes, S. Lam, J. Minna, 2007 .

Gene transfer: the challenge of regulated gene expression

B. Fang, Z. Guo, D. Bartlett, 2008 .

PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery

Yvonne A. Evrard, David M. Rocke, Jessica J. Andrews, 2022, NAR cancer.

WNT5A-RHOA signaling is a driver of tumorigenesis and represents a therapeutically actionable vulnerability in small cell lung cancer.

Kwon-Sik Park, Kee-Beom Kim, B. Fang, 2022, Cancer Research.

Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.

J. Roth, B. Fang, L. Ji, 2007, Biochemical and biophysical research communications.

Targeting Different Types of Human Meningioma and Glioma Cells Using a Novel Adenoviral Vector Expressing Gfp-trail Fusion Protein from Htert Promoter

F. Murad, B. Fang, I. McCutcheon, 2022 .

EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.

K. Aldape, Haitao Ji, D. Hawke, 2009, Molecular cell.

The Role of PKR / eIF 2 a Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer

Behrens, Ignacio I. Wistuba, Liping Yu, 2011 .

The Role of PKR/eIF2 alpha Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer

Behrens, J. Roth, I. Wistuba, 2011 .

B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy

Michael L. Wang, Shouhao Zhou, Sabah Kadri, 2017, Clinical Cancer Research.

Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.

B. Fang, Li Wang, Shuhong Wu, 2010, European journal of pharmacology.