S. Kuo

Chi-Tang Ho, S. Kuo, Li‐Jiau Huang, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Inhibition of lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages by a synthetic carbazole, LCY-2-CHO.

S. Kuo, Li‐Jiau Huang, L. Tsao, 2002, Biochemical pharmacology.

Dietary Uptake of Wedelia chinensis Extract Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

S. Kuo, Shu Lin, N. Yang, 2013, PloS one.

Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons.

P. Gean, Yi-Chien Lin, Sheng-Chih Chen, 2009, Bioorganic & medicinal chemistry letters.

Investigation of the cellular mechanism of inhibition of formyl-methionyl-leucyl-phenylalanine-induced superoxide anion generation in rat neutrophils by 2-benzyloxybenzaldehyde.

S. Kuo, Li‐Jiau Huang, Ling-Chu Chang, 2003, Biochemical pharmacology.

Mechanism of Action of p‐Chlorobiphenyl on the Inhibition of Platelet Aggregation

S. Kuo, C. Teng, F. Ko, 1996, The Journal of pharmacy and pharmacology.

Antiproliferative effects of A02011‐1, an adenylyl cyclase activator, in cultured vascular smooth muscle cells of rat

S. Kuo, Sheu‐Meei Yu, Z. Cheng, 1995, British journal of pharmacology.

Electrophysiological characteristics of antiarrhythmic potential of acrophyllidine, a furoquinoline alkaloid isolated from Acronychia halophylla

S. Kuo, G. Chang, Mei-Hwan Wu, 2000 .

Investigation of the inhibition by acetylshikonin of the respiratory burst in rat neutrophils

S. Kuo, L. Tsao, Jih P. Wang, 1997, British journal of pharmacology.

Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives.

Chin‐Chung Wu, S. Kuo, Li‐Jiau Huang, 2008, Bioorganic & medicinal chemistry.

YC-1 [3-(5 (cid:1) -Hydroxymethyl-2 (cid:1) -furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G 0 -G 1 in Human Hepatocellular Carcinoma Cells

S. Kuo, C. Teng, S. Pan, 2005 .

The role of PAR4 in thrombin-induced thromboxane production in human platelets

Chin‐Chung Wu, S. Kuo, C. Teng, 2003, Thrombosis and Haemostasis.

Selective Inhibition of Protease-activated Receptor 4-dependent Platelet Activation by YD-3

Chin‐Chung Wu, S. Kuo, C. Teng, 2002, Thrombosis and Haemostasis.

YD‐3, a novel inhibitor of protease‐induced platelet activation

Chin‐Chung Wu, S. Kuo, C. Teng, 2000, British journal of pharmacology.

Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils

Hui-Yi Lin, S. Kuo, Li‐Jiau Huang, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models

S. Kuo, C. Teng, S. Pan, 2005, Thrombosis and Haemostasis.

Inhibition of lipopolysaccharide-stimulated NO production by crotafuran B in RAW 264.7 macrophages involves the blockade of NF-κB activation through the increase in IκBα synthesis

S. Kuo, Li‐Jiau Huang, Meng-Wei Lin, 2006 .

Aggravated DNA damage as a basis for enhanced glioma cell killing by MJ-66 in combination with minocycline.

P. Gean, S. Kuo, Wei-Ting Liu, 2014, American journal of cancer research.

The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM)

Yan Peng, Jai-Sing Yang, F. Tsai, 2018, BioMedicine.

YC-1 potentiates the antiplatelet effect of hydrogen peroxide via sensitization of soluble guanylate cyclase.

S. Kuo, C. Teng, C. Wu, 1999, European journal of pharmacology.

2-Benzyloxybenzaldehyde inhibits formyl peptide-stimulated increase in intracellular Ca2+ in neutrophils mainly by blocking Ca2+ entry

S. Kuo, Li‐Jiau Huang, L. Tsao, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils.

S. Kuo, Li‐Jiau Huang, Jih P. Wang, 2004, Biochemical pharmacology.

Exploitation of a rod-shaped, acid-labile curcumin-loaded polymeric nanogel system in the treatment of systemic inflammation.

Guan-Jhong Huang, S. Kuo, Yi-Ting Chiang, 2021, Materials science & engineering. C, Materials for biological applications.

Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents

Jai-Sing Yang, Y. Wu, S. Kuo, 2014, Journal of medicinal chemistry.

AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells.

Jai-Sing Yang, Jing-Gung Chung, S. Tsai, 2012, International journal of oncology.

Electrophysiological basis for the antiarrhythmic action and positive inotropy of HA‐7, a furoquinoline alkaloid derivative, in rat heart

S. Kuo, G. Chang, M. Su, 1997, British journal of pharmacology.

Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells.

S. Kuo, Chih-Hsin Tang, Chih-Ho Lai, 2012, European journal of medicinal chemistry.

Mechanical and electrophysiological studies on the positive inotropic effect of 2‐phenyl‐4‐oxo‐hydroquinoline in rat cardiac tissues

S. Kuo, G. Chang, M. Su, 1993, British Journal of Pharmacology.

Inhibition of plasma extravasation by abruquinone A, a natural isoflavanquinone isolated from Abrus precatorius.

S. Kuo, J. Kuo, L. C. Chang, 1995, European journal of pharmacology.

YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Inhibits Neointima Formation in Balloon-Injured Rat Carotid through Suppression of Expressions and Activities of Matrix Metalloproteinases 2 and 9

S. Kuo, C. Teng, S. Pan, 2006, Journal of Pharmacology and Experimental Therapeutics.

YC-1 Inhibits Neointima Formation in Balloon-Injured Rat Carotid Through Suppression of Expressions and Activities of MMP-2 and MMP-9

S. Kuo, C. Teng, S. Pan, 2005 .

YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells.

S. Kuo, C. Teng, S. Pan, 2004, Cardiovascular research.

2-Phenylnaphthyridin-4-one Derivative LYF-11 Inhibits Interleukin-6-mediated Epithelial-to-Mesenchymal Transition via the Inhibition of JAK2/STAT3 Signaling Pathway in MCF-7 Cells.

Shou‐Tung Chen, Chi-Tang Ho, S. Kuo, 2018, Anticancer research.

Structure–activity relationships of a peptidic antagonist of Id1 studied by biosensor method, circular dichroism spectroscopy, and bioassay

S. Kuo, Li‐Jiau Huang, F. Lung, 2011, Journal of peptide science : an official publication of the European Peptide Society.

Smh-3 induces G(2)/M arrest and apoptosis through calcium‑mediated endoplasmic reticulum stress and mitochondrial signaling in human hepatocellular carcinoma Hep3B cells.

Jai-Sing Yang, Shih-Ming Huang, S. Kuo, 2013, Oncology reports.

Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin.

S. Kuo, L. C. Chang, J. P. Wang, 1995, European journal of pharmacology.

AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells.

Jai-Sing Yang, S. Tsai, S. Kuo, 2013, International journal of oncology.

Distinct effects of N-ethylmaleimide on formyl peptide- and cyclopiazonic acid-induced Ca2+ signals through thiol modification in neutrophils.

S. Kuo, Li‐Jiau Huang, L. Tsao, 2005, Biochemical pharmacology.

Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta

S. Kuo, S. Yu, Sheu‐Meei Yu, 1995, British journal of pharmacology.

Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.

Yi-Chien Lin, S. Kuo, Li‐Jiau Huang, 2013, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 6 , 7 , 2 ′ , 3 ′ , 4 ′-Substituted-1 , 2 , 3 , 4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents

S. Kuo, Yi Xia, K. Lee, 1998 .

YC‐1 inhibited human platelet aggregation through NO‐independent activation of soluble guanylate cyclase

S. Kuo, C. Teng, F. Ko, 1995, British journal of pharmacology.

Vasorelaxation of Rat Thoracic Aorta Caused by Two Ca2+‐Channel Blockers, HA‐22 and HA‐23

S. Kuo, C. Teng, L. Huang, 1992, The Journal of pharmacy and pharmacology.

Inhibition of superoxide anion generation by YC-1 in rat neutrophils through cyclic GMP-dependent and -independent mechanisms.

S. Kuo, Ling-Chu Chang, Jih P. Wang, 2002, Biochemical pharmacology.

MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex

P. Gean, S. Kuo, Wei-Ting Liu, 2014, Neuropharmacology.

Effect of a potent cyclooxygenase inhibitor, 5‐ethyl‐4‐methoxy‐2‐phenylquinoline (KTC‐5), on human platelets

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, The Journal of pharmacy and pharmacology.

1-(3,4-dimethoxyphenyl)-3,5-dodecenedione (I6) induces G1 arrest and apoptosis in human promyelocytic leukemia HL-60 cells.

Jing-Gung Chung, S. Kuo, Li‐Jiau Huang, 2005, Leukemia research.

A benzodiazepines derived compound, 4-(3-chlorophenyl)-1,3-dihydronaphtho [2,3-b][1,4]diazepin-2-one (ND700C), inhibits fMLP-induced superoxide anion release by activating protein phosphatase 2A in human neutrophils.

C. Tseng, S. Kuo, Y. Day, 2008, Biochemical pharmacology.

High-performance liquid chromatography determination of methionine adenosyltransferase activity using catechol-O-methyltransferase-coupled fluorometric detection.

Sheng-Chih Chen, S. Kuo, Sheng-Hung Wang, 2003, Analytical biochemistry.

Bp5250 inhibits vascular endothelial growth factor-induced angiogenesis and HIF-1α expression on endothelial cells

S. Kuo, C. Chung, Kuan-Ting Lin, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Neuroprotective effect of N‐acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: Involvement of ERK and p38 phosphorylation

P. Gean, S. Kuo, Li‐Jiau Huang, 2006, Journal of neuroscience research.

The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells.

Jai-Sing Yang, Jing-Gung Chung, C. Liaw, 2012, Oncology reports.

Inhibition of platelet function by A02131-1, a novel inhibitor of cGMP-specific phosphodiesterase, in vitro and in vivo.

S. Kuo, J. Ou, S. Tsai, 1996, Blood.

MTH-3 sensitizes oral cancer cells to cisplatin via regulating TFEB.

Jai-Sing Yang, S. Tsai, S. Kuo, 2022, The Journal of pharmacy and pharmacology.

Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.

A. Tropsha, A. Brossi, S. Kuo, 2000, Journal of medicinal chemistry.

In Silico and In Vitro studies of taiwan chingguan yihau (NRICM101) on TNF-α/IL-1β-induced human lung cells

Jai-Sing Yang, S. Tsai, S. Kuo, 2022, BioMedicine.

Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils

Hui-Yi Lin, S. Kuo, Li‐Jiau Huang, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents.

Jai-Sing Yang, Hui-Yi Lin, S. Kuo, 2010, European journal of medicinal chemistry.

HA-29: an inhibitor of thromboxane A2 formation with antagonism of thromboxane A2/prostaglandin endoperoxide receptor in rabbit platelets.

C. H. Lin, S. Kuo, C. Teng, 1992, Thrombosis research.

Dehydrative Ring‐Opening of gem ‐Difluorocyclopropyl Carbinols to Allylic Trifluoromethyl and Difluorohalomethyl Derivatives Promated by Titanium Tetrahalide

S. Kuo, Min-Tsang Hsieh, Manickavasakam Ramasamy, 2020 .

Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.

S. Kuo, Li‐Jiau Huang, T. Yamori, 2005, Bioorganic & medicinal chemistry.

Cardiac glycosides from Antiaris toxicaria with potent cardiotonic activity.

S. Kuo, Han-Dong Sun, K. Lee, 2010, Journal of natural products.

Studies on heterocyclic compounds. 6. Synthesis and analgesic and antiinflammatory activities of 3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives.

S. Kuo, L. Huang, H. Nakamura, 1984, Journal of medicinal chemistry.

Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents.

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2007, Bioorganic & medicinal chemistry.

6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, Li‐Jiau Huang, M. Hour, 2000, Journal of medicinal chemistry.

Synthesis of N2-(substituted benzyl)-3-(4-methylphenyl)indazoles as novel anti-angiogenic agents.

S. Kuo, Li‐Jiau Huang, C. Teng, 2006, Bioorganic & medicinal chemistry.

Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents.

Chin‐Chung Wu, S. Kuo, Li‐Jiau Huang, 2001, Journal of medicinal chemistry.

STUDIES ON HETEROCYCLIC COMPOUNDS. 6. SYNTHESIS AND ANALGESIC AND ANTIINFLAMMATORY ACTIVITIES OF 3,4‐DIMETHYLPYRANO(2,3‐C)PYRAZOL‐6‐ONE DERIVATIVES

S. Kuo, Hideo Nakamura, L. Huang, 1984 .

Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.

Hui-Yi Lin, Chi-Hung Huang, S. Kuo, 2010, Journal of medicinal chemistry.

Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.

S. Kuo, Li‐Jiau Huang, Keduo Qian, 2009, Journal of medicinal chemistry.

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.

S. Kuo, M. Hour, Yi Xia, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and antiplatelet activities of N-arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives.

S. Kuo, C. Teng, M. Hour, 1992, Chemical & pharmaceutical bulletin.

Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, A. Mauger, K. Lee, 1999, Journal of medicinal chemistry.

Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.

S. Kuo, C. Teng, M. Hour, 2001, Bioorganic & medicinal chemistry letters.

Studies on heterocyclic compounds. IX. Synthesis and antiallergic activity of furo[2,3-b] [1,8]naphthyridine-3,4(2H,9H)-diones and 4H-furo[2,3-d]pyrido [1,2-alpha]-pyrimidine-3,4(2H)-diones.

S. Kuo, S. Tsai, C. H. Wu, 1988, Chemical & pharmaceutical bulletin.

Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells.

Yi-Chien Lin, S. Kuo, Li‐Jiau Huang, 2016, European journal of medicinal chemistry.

Synthesis of 2-alkoxy 1,4-naphthoquinone derivatives as antiplatelet, antiinflammatory, and antiallergic agents.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Chemical & pharmaceutical bulletin.

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds.

S. Kuo, C. Teng, K. Lee, 1998, Bioorganic & medicinal chemistry.

Synthesis and antiplatelet, antiinflammatory and antiallergic activities of 2,3-disubstituted 1,4-naphthoquinones.

S. Kuo, C. Teng, K. Lee, 1996, Chemical & pharmaceutical bulletin.

Synthesis and SAR studies of novel 6,7,8‐substituted 4‐substituted benzyloxyquinolin‐2(1H)‐one derivatives for anticancer activity

Hui-Yi Lin, Yi-Chien Lin, S. Kuo, 2015, British journal of pharmacology.

Solvent- and Transition Metal Catalyst-Dependent Regioselectivity in the [3+2] Cyclocondensation of Trifluoromethyl-α,β-ynones with Hydrazines: Switchable Access to 3- and 5-Trifluoromethylpyrazoles

S. Kuo, Min-Tsang Hsieh, Hui-Chang Lin, 2015 .

Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.

S. Kuo, C. Teng, M. Hour, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and Cytotoxicity of 1,6,8,9‐Substituted α‐Carboline Derivatives

Yi-Chien Lin, S. Kuo, Li‐Jiau Huang, 2010, The Kaohsiung journal of medical sciences.

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.

K. Paull, S. Kuo, H. Lee, 1993, Journal of medicinal chemistry.

HMJ-53A accelerates slow inactivation gating of voltage-gated K+ channels in mouse neuroblastoma N2A cells

S. Kuo, M. Hour, Y. Leung, 2008, Neuropharmacology.

Synthesis and antiallergic activities of 2-alkyl-3,4-dimethylfuro[2,3-c] pyrazole-5-carboxamides and related compounds.

S. Kuo, J. P. Wang, L. Huang, 1994, Chemical & pharmaceutical bulletin.

Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.

S. Kuo, A. Mauger, K. Lee, 1997, Journal of medicinal chemistry.

Synthesis and antiplatelet activity of phenyl quinolones.

S. Kuo, C. Teng, K. Lee, 1998, Bioorganic & medicinal chemistry.

Studies of heterocyclic compounds. VIII. Synthesis, anti‐inflammatory and antiallergic activities of n‐alkyl‐2,3,4,9‐tetrahydrofuro[2,3‐b]quinoline‐3,4‐diones and related compounds

S. Kuo, Li‐Jiau Huang, Hong Cheng, 1991 .

Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, D. Lednicer, K. Lee, 1994, Journal of medicinal chemistry.

YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activating JNK pathway

S. Kuo, C. Teng, S. Pan, 2007 .

YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells

S. Kuo, C. Teng, S. Pan, 2005, Molecular Cancer Therapeutics.

YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Inhibits Endothelial Cell Functions Induced by Angiogenic Factors in Vitro and Angiogenesis in Vivo Models

S. Kuo, C. Teng, S. Pan, 2005, Journal of Pharmacology and Experimental Therapeutics.

YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice.

S. Kuo, C. Teng, F. Ko, 1997, European journal of pharmacology.

YC-1, a novel activator of platelet guanylate cyclase.

S. Kuo, C. Teng, F. Ko, 1994, Blood.

2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells.

Jai-Sing Yang, F. Tsai, S. Kuo, 2017, Oncology reports.

Quinazoline analog HMJ-30 inhibits angiogenesis: involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling.

Jai-Sing Yang, S. Kuo, M. Hour, 2014, Oncology reports.

Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-ones as potent antitumor agents.

Chi-Hung Huang, Shih-Ming Huang, S. Kuo, 2013, Bioorganic & medicinal chemistry letters.

The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells.

Jai-Sing Yang, Jing-Gung Chung, S. Kuo, 2011, European journal of medicinal chemistry.

Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.

Chi-Hung Huang, Shih-Ming Huang, S. Kuo, 2010, Journal of medicinal chemistry.

Synthesis and Cytotoxicity of 6‐Pyrrolidinyl‐2‐(2‐Substituted Phenyl)‐4‐Quinazolinones

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2007 .

Palladium(II) acetate mediated oxidative cyclization of ω-unsaturated α-cyano ketones for facile construction of methylenecyclohexane ring system.

S. Kuo, Kak‐Shan Shia, Min-Tsang Hsieh, 2012, Organic & biomolecular chemistry.

Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.

Harukuni Tokuda, Sheng-Chu Kuo, S. Kuo, 2005, Bioorganic & medicinal chemistry.

Effect of Indole‐3‐Acetic Acid Analogs on the Differentiation of HL‐60 Cells

S. Kuo, Li‐Jiau Huang, C. Chen, 2008 .

Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones

S. Kuo, Min-Tsang Hsieh, Hui-Chang Lin, 2019, Synlett.

Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria.

S. Kuo, Han-Dong Sun, K. Lee, 2014, Bioorganic & medicinal chemistry.

CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway.

Chi-Tang Ho, S. Kuo, Tzong-Der Way, 2016, Chemico-biological interactions.

CHM-1, a New Vascular Targeting Agent, Induces Apoptosis of Human Umbilical Vein Endothelial Cells via p53-mediated Death Receptor 5 Up-regulation*

Hui-Lung Sun, S. Kuo, C. Teng, 2009, The Journal of Biological Chemistry.

Novel quinolone CHM‐1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line

T. Hsia, Kuang-Chi Lai, Jai-Sing Yang, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives.

S. Kuo, Li‐Jiau Huang, C. Teng, 1997, Bioorganic & medicinal chemistry.

Investigation of amination in 4-chloro-2-phenylquinoline derivatives with amide solvents

S. Kuo, Li‐Jiau Huang, Jui-Ying Tsai, 2008 .

1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of medicinal chemistry.

Novel Pyrazole Derivatives Effectively Inhibit Osteoclastogenesis, a Potential Target for Treating Osteoporosis.

W. Fu, Rong-Sen Yang, S. Kuo, 2015, Journal of medicinal chemistry.

Synthesis of 1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole Analogues as Novel Antiplatelet Agents.

Chin‐Chung Wu, S. Kuo, Li‐Jiau Huang, 2010 .

Proteomic approach to studying the cytotoxicity of YC‐1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice

Jai-Sing Yang, Jing-Gung Chung, S. Kuo, 2007, Proteomics.

Mechanistic Study of Tetrahydrofuran- acetogenins In Triggering Endoplasmic Reticulum Stress Response-apotoposis in Human Nasopharyngeal Carcinoma

Jai-Sing Yang, S. Kuo, Shih-Hao Wang, 2016, Scientific Reports.

Asperjinone, a nor-neolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from thermophilic Aspergillus terreus.

C. Liaw, Shih-Hsiung Wu, S. Kuo, 2012, Journal of natural products.

Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst by cirsimaritin involves inhibition of phospholipase D signaling in rat neutrophils

Sheng-Chih Chen, S. Kuo, Ling-Chu Chang, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius.

L. H. Chen, S. Kuo, C. Teng, 1995, Planta medica.

Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation

Shing-Hwa Liu, S. Kuo, C. Chiu, 2020, Molecules.

Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice.

S. Kuo, Li‐Jiau Huang, T. Ho, 2007, Journal of agricultural and food chemistry.

Yuwen02f1 suppresses LPS-induced endotoxemia and adjuvant-induced arthritis primarily through blockade of ROS formation, NFkB and MAPK activation.

S. Kuo, Chien-Hsin Chang, Chun-Chieh Hsu, 2013, Biochemical pharmacology.

Clerodane diterpenes from Polyalthia longifolia var. pendula protect SK-N-MC human neuroblastoma cells from β-amyloid insult

C. Liaw, Y. Wu, S. Kuo, 2014 .

Constituents and bioactive principles of Polygonum chinensis.

S. Kuo, Jih P. Wang, P. Chao, 1998, Phytochemistry.

Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma.

S. Kuo, C. Teng, F. Ko, 1995, Biochimica et biophysica acta.

Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula

C. Liaw, Y. Wu, F. Chang, 2014, Molecules.

Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives

Jai-Sing Yang, Hui-Yi Lin, S. Kuo, 2020, Molecules.

Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng.

Sheng-Chih Chen, S. Kuo, C. Teng, 1989, Biochimica et biophysica acta.

Hypolipidemic activity of Taraxacum mongolicum associated with the activation of AMP-activated protein kinase in human HepG2 cells.

Chi-Tang Ho, S. Kuo, Li‐Jiau Huang, 2014, Food & function.

Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells.

Jen-kun Lin, S. Tsai, S. Kuo, 2008, Molecular nutrition & food research.

Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity.

S. Kuo, Yu-Chi Hou, S. Tsai, 2009, Planta medica.

Inhibition of platelet aggregation by shikonin derivatives isolated from Arnebia euchroma.

S. Kuo, C. Teng, F. Ko, 1993, Planta Medica.

Determination of nalidixic acid by fluorometry with sodium borohydride and hydrogen peroxide.

Sheng-Chih Chen, S. Kuo, J. Lien, 2002, Journal of AOAC International.

The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells.

Jai-Sing Yang, Yi-Chien Lin, S. Kuo, 2013, International journal of oncology.

Lewis acid‐mediated defluorinative [3+2] cycloaddition/aromatization cascade of 2,2‐difluoroethanol systems with nitriles

S. Kuo, K. Lee, Min-Tsang Hsieh, 2018 .

In Vitro and In Silico Biological Studies of 4-Phenyl-2-quinolone (4-PQ) Derivatives as Anticancer Agents

S. Kuo, Li‐Jiau Huang, Hsu-Shan Huang, 2023, Molecules.

Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, A. Mauger, K. Lee, 1997, Journal of medicinal chemistry.

A Novel pH-Tunable Secondary Conformation Containing Mixed Micellar System in Anticancer Treatment

Guan-Jhong Huang, S. Kuo, Xiaojie Lin, 2020, Cancers.

Baicalin AKT serine / threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T 24 cells

Jai-Sing Yang, S. Tsai, S. Kuo, 2013 .

The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells

Jai-Sing Yang, Jing-Gung Chung, S. Kuo, 2009, Journal of Gastroenterology.

Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines

Wei-Ting Chang, Sheng-Chu Kuo, S. Kuo, 2011, Journal of Biomedical Science.

The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.

Jai-Sing Yang, Hui-Yi Lin, S. Tsai, 2011, International journal of oncology.

The Indazole Derivative YD-3 Specifically Inhibits Thrombin-Induced Angiogenesis In Vitro and In Vivo

S. Kuo, C. Teng, S. Pan, 2010, Shock.

CSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway

S. Kuo, Tzong-Der Way, Tai‐Lung Cha, 2016, Journal of Biomedical Science.

The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3‐kinase pathway in maintaining thrombin‐induced platelet aggregation

Chin‐Chung Wu, S. Kuo, C. Teng, 2010, British journal of pharmacology.

CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.

M. Hung, Jing-Gung Chung, Chi-Hung Huang, 2011, European journal of pharmacology.

Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study

Jai-Sing Yang, F. Tsai, S. Kuo, 2017, International journal of oncology.

4-Fluoro-N-butylphenylacetamide: a synthetic phenylacetate derivative that upregulates Bcl-X(S), activates caspase cascade and induces apoptosis in human squamous lung cancer CH27 cells.

S. Hsu, S. Kuo, Chung-Hsien Liu, 2002, Cancer letters.

Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG

C. Liaw, S. Kuo, Shiaw-Min Hwang, 2013, Evidence-based complementary and alternative medicine : eCAM.

Inhibitory effects of ethanolic extracts of Boussingaultia gracilis on the spasmogen-induced contractions of the rat isolated gastric fundus.

S. Kuo, W. C. Lin, S. C. Wu, 1997, Journal of ethnopharmacology.

Autophagy and its link to type II diabetes mellitus

Ying-Ju Lin, Yuan-Man Hsu, Fuu-Jen Tsai, 2017, BioMedicine.

Inhibition of Ras-Mediated Cell Proliferation by Benzyloxybenzaldehyde

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of Biomedical Science.

The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells.

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2014, International journal of oncology.

Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2.

Jai-Sing Yang, S. Kuo, M. Tu, 2012, Oncology reports.

YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia

F. Lee, S. Kuo, C. Teng, 2007, Oncogene.

Chemical constituents and anticancer activity of yellow camellias against MDA-MB-231 human breast cancer cells.

Hui-Yi Lin, Chi-Tang Ho, S. Kuo, 2013, Journal of agricultural and food chemistry.

CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.

S. Kuo, C. Teng, S. Pan, 2007, Cancer letters.

Synthesis and cytotoxicity of acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones.

S. Kuo, A. Mauger, A. McPhail, 1998, Bioorganic & medicinal chemistry letters.

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1

Hui-Yi Lin, R. Chou, S. Kuo, 2015, Cancer Chemotherapy and Pharmacology.

Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead.

Jai-Sing Yang, Hui-Yi Lin, S. Kuo, 2013, Bioorganic & medicinal chemistry letters.

Mechanistic Studies on Regioselective Dephosphorylation of Phosphate Prodrugs during a Facile Synthesis of Antitumor Phosphorylated 2-Phenyl-6,7-methylenedioxy-1H-quinolin-4-one

Chi-Hung Huang, S. Kuo, Li‐Jiau Huang, 2013, Molecules.

The quinolone derivative CHM-1 inhibits murine WEHI-3 leukemia in BALB/c mice in vivo

Jai-Sing Yang, Jing-Gung Chung, S. Kuo, 2010, Leukemia & lymphoma.

2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells.

Jing-Gung Chung, S. Kuo, Li‐Jiau Huang, 2007, European journal of pharmacology.

Suppressive effect of 2-phenyl-4-quinolone (YT 1) on hind-paw edema and cutaneous vascular plasma extravasation in mice

S. Kuo, Jih P. Wang, S. Raung, 1994, Naunyn-Schmiedeberg's Archives of Pharmacology.

HPLC DETERMINATION OF 2-PHENYL-4-QUINOLONE IN RABBIT SERUM

S. Kuo, Tai-Hung Huang, S. Tsai, 2001 .

Synthesis and cytotoxicity of methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione derivatives.

S. Kuo, A. Mauger, K. Lee, 1999, Bioorganic & medicinal chemistry.

Multiple Cellular Electrophysiological Effects of a Novel Antiarrhythmic Furoquinoline Derivative HA-7 [N-Benzyl-7-methoxy-2,3,4,9-tetrahydrofuro[2,3-b]quinoline-3,4-dione] in Guinea Pig Cardiac Preparations

S. Kuo, G. Chang, M. Su, 2006, Journal of Pharmacology and Experimental Therapeutics.

Analysis of COVID-19 prevention and treatment in Taiwan

Jai-Sing Yang, S. Tsai, S. Kuo, 2021, BioMedicine.

Investigation of anti-leukemia molecular mechanism of ITR-284, a carboxamide analog, in leukemia cells and its effects in WEHI-3 leukemia mice.

Jai-Sing Yang, Jing-Gung Chung, S. Kuo, 2010, Biochemical pharmacology.

Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells.

Li-Fen Huang, Chi-Tang Ho, S. Kuo, 2013, Journal of agricultural and food chemistry.

Novel quinazoline HMJ‐30 induces U‐2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up‐regulation of ATM/p53 signaling pathway

Jai-Sing Yang, Jing-Gung Chung, S. Kuo, 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

4-Fluoro-N-butylphenylacetamide (H6) inhibits cell growth via cell-cycle arrest and apoptosis in human cervical cancer cells.

S. Kuo, Li‐Jiau Huang, K. Tsai, 2009, Bioorganic & medicinal chemistry.

Next-generation sequencing analysis reveals that MTH-3, a novel curcuminoid derivative, suppresses the invasion of MDA-MB-231 triple-negative breast adenocarcinoma cells

Jai-Sing Yang, F. Tsai, S. Kuo, 2021, Oncology reports.

Antiangiogenic mechanisms of PJ-8, a novel inhibitor of vascular endothelial growth factor receptor signaling.

S. Kuo, J. Lien, Shiu‐Wen Huang, 2012, Carcinogenesis.

Induction of apoptosis by HAC-Y6, a novel microtubule inhibitor, through activation of the death receptor 4 signaling pathway in human hepatocellular carcinoma cells.

Jin Chung, Chi-Hung Huang, S. Kuo, 2010, Oncology reports.

A novel compound, NP-184, inhibits the vascular endothelial growth factor induced angiogenesis.

S. Kuo, C. Chung, Kuan-Ting Lin, 2010, European journal of pharmacology.

Inhibitory Effects of an Orally Active Thromboxane A2 Receptor Antagonist, nstpbp5185, on Atherosclerosis in ApoE-Deficient Mice

S. Kuo, J. Lien, Shiu‐Wen Huang, 2018, Thrombosis and Haemostasis.

The signaling mechanisms mediating the inhibitory effect of TCH-1116 on formyl peptide-stimulated superoxide anion generation in neutrophils.

C. Tzeng, S. Kuo, Li‐Jiau Huang, 2012, European journal of pharmacology.

The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis.

P. Gean, S. Kuo, Li‐Jiau Huang, 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.

Jai-Sing Yang, Jing-Gung Chung, S. Tsai, 2011, International journal of oncology.

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.

Pan‐Chyr Yang, S. Kuo, Jen-Yi Lee, 2015, Bioorganic & medicinal chemistry.

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo.

Hui-Yi Lin, S. Kuo, Chang-Hai Tsai, 2017, European journal of medicinal chemistry.

ITR‑284 modulates cell differentiation in human chronic myelogenous leukemia K562 cells.

Jai-Sing Yang, F. Tsai, S. Tsai, 2017, Oncology reports.

Synthesis and anticancer activity of 2,4-disubstituted furo[3,2-b]indole derivatives.

Hui-Yi Lin, Chi-Hung Huang, Yi-Chien Lin, 2013, European journal of medicinal chemistry.

Synthesis and anti-platelet, anti-inflammatory and anti-allergic activities of methoxyisoflavanquinone and related compounds.

S. Kuo, C. Teng, S. C. Chen, 2000, Chemical & pharmaceutical bulletin.

Approaches towards fighting the COVID-19 pandemic (Review)

Jai-Sing Yang, F. Tsai, S. Tsai, 2020, International journal of molecular medicine.

EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.

M. Hung, W. Xia, J. Hsu, 2014, Developmental cell.

A New Sapogenin from Boussingaultia gracilis.

S. Kuo, P. Chao, T. Lin, 1988, Journal of natural products.

Structure‐Activity Relationships of Anthraquinones in the Decrease of Intestinal Motility

S. Kuo, Juei-Tang Cheng, D. Kuo, 2000, The Journal of pharmacy and pharmacology.

Enhancement of learning behaviour by a potent nitric oxide‐guanylate cyclase activator YC‐1

W. Fu, S. Kuo, C. Teng, 2005, The European journal of neuroscience.

A phenylacetate derivative, SCK6, inhibits cell proliferation via G1 cell cycle arrest and apoptosis.

S. Hsu, S. Kuo, Li‐Jiau Huang, 2003, European journal of pharmacology.

Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells.

Hui-Yi Lin, S. Kuo, Li‐Jiau Huang, 2018, Bioorganic & medicinal chemistry.

Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.

W. Fu, S. Kuo, C. Teng, 2003, Molecular pharmacology.

Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.

S. Kuo, A. Mauger, K. Lee, 1994, Journal of medicinal chemistry.

Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication

J. Jan, S. Kuo, N. Yang, 2011, Journal of Traditional and Complementary Medicine.

Recent Studies and Progression of Yin Chen Hao (茵陳蒿 Yīn Chén Hāo), a Long-term Used Traditional Chinese Medicine

S. Kuo, Hsin-Yi Hung, 2013, Journal of traditional and complementary medicine.

Solvent Effect of Dimethyl Sulfoxide on the Chemical Shifts of Phenyl Vinyl Ketones

Sheng-Chih Chen, S. Kuo, Li‐Jiau Huang, 2004 .

Studies on Heterocyclic Compounds, VII. Synthesis of Isomaculosidine

S. Kuo, Tsung-Ping Lin, B. Shieh, 1987 .

BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide

S. Kuo, Li‐Jiau Huang, Tzong-Der Way, 2015, International journal of molecular medicine.

YC‐1 inhibits proliferation of breast cancer cells by down‐regulating EZH2 expression via activation of c‐Cbl and ERK

Hui-Yi Lin, R. Chou, S. Kuo, 2014, British journal of pharmacology.

Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo.

S. Kuo, T. L. Lin, J. F. Wu, 1997, The Biochemical journal.

2-(3-Methoxyphenyl)-6, 7-methylenedioxoquinolin-4-one, a novel synthetic compound, inhibited migration and invasion in TSGH8301 human bladder cancer cells

Kuang-Chi Lai, Jai-Sing Yang, Chao‐Lin Kuo, 2011, Human & experimental toxicology.

Neoflavonoids from Dalbergia odorifera

S. Kuo, Yuan-Shiun Chang, Shiuh-Chuan Chan, 1997 .

Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma

Wei Cheng, M. Hung, Hui-Yi Lin, 2023, The Journal of biological chemistry.

CSC‐3436 inhibits TWIST‐induced epithelial–mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma

C. Chen, Chi-Tang Ho, S. Kuo, 2018, Journal of cellular physiology.

AMPK‐dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF‐κB pathway

Jai-Sing Yang, S. Tsai, M. Tsai, 2016, Environmental toxicology.

DEVELOPMENT OF DIFFERENTIATION HELPER INDUCERS FOR THE DIFFERENTIATION THERAPY OF CANCER

S. Kuo, M. Liau, L. Huang, 1998 .

6-Pentadecylsalicylic acid: an antithrombin component isolated from the stem of Rhus semialata var. roxburghii.

T. Chou, S. Kuo, C. Teng, 1991, Planta medica.

α-Carboline derivative TJY-16 inhibits tumor growth by inducing G2/M cell cycle arrest in glioma cells

P. Gean, S. Kuo, Li‐Jiau Huang, 2016, Journal of Biomedical Science.

Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.

Jing-Gung Chung, S. Kuo, Li‐Jiau Huang, 2008, Biochemical pharmacology.

The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells.

Kuang-Chi Lai, Jai-Sing Yang, S. Kuo, 2013, Molecular medicine reports.

Cell differentiation enhancement by hydrophilic derivatives of 4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-diones in HL-60 leukemia cells.

S. Kuo, Li‐Jiau Huang, K. Lee, 2007, Bioorganic & medicinal chemistry letters.

Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity.

C. Liaw, S. Kuo, Hui-Kang Liu, 2023, Journal of natural products.

The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells.

Chi-Tang Ho, S. Kuo, Tzong-Der Way, 2014, Food & function.

TERPENOIDS FROM OCIMUM BASILICUM

S. Kuo, P. Chao, P. Wu, 1999 .

GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation.

S. Kuo, Li‐Jiau Huang, L. Tsao, 2006, European journal of pharmacology.

Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils.

S. Kuo, J. P. Wang, 1997, Biochemical pharmacology.

Inhibition by abruquinone A of phosphoinositide-specific phospholipase C activation in rat neutrophils.

S. Kuo, J. P. Wang, M. Hsu, 1997, European journal of pharmacology.

A Novel Morphinandienone Alkaloid from Fissistigma oldhamii.

S. Kuo, J. B. Wu, N. Chiu, 1993, Planta medica.

FISSOLDHIMINE, A NOVEL SKELETON ALKALOID FROM FISSISTIGMA OLDHAMII

S. Kuo, U. Sankawa, Y. Ebizuka, 1994 .

Fissoldhimine, a Novel Skeleton Alkaloid from Fissistigma oldhamii.

S. Kuo, U. Sankawa, Y. Ebizuka, 1995 .

Synthesis and cytotoxic activity of certain 2,3,4,9-tetrahydrofuro [2,3-b] quinolin-3,4-dione and ethyl 2-(substituted aniline) -4-oxo-4,5-dihydrofuran-3-carboxylate derivatives in murine leukemia WEHI-3 cells.

Jing-Gung Chung, S. Kuo, An-Cheng Huang, 2007, In vivo.

A novel synthetic 2-(3-methoxyphenyl)-6,7-methylenedioxoquinolin-4-one arrests the G2/M phase arrest via Cdc25c and induces apoptosis through caspase- and mitochondria-dependent pathways in TSGH8301 human bladder cancer cells.

Kuang-Chi Lai, Jai-Sing Yang, Jing-Gung Chung, 2011, International journal of oncology.

Benzyloxybenzaldehyde analogues as novel adenylyl cyclase activators.

Y. Lin, S. Kuo, J. Wang, 2001, Bioorganic & medicinal chemistry letters.

Synthesis of (2E)-3-{2-[(substituted benzyl)oxy]phenyl}acrylaldehydes as novel anti-inflammatory agents.

S. Kuo, Li‐Jiau Huang, Jih P. Wang, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and anticancer activity of benzyloxybenzaldehyde derivatives against HL-60 cells.

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2005, Bioorganic & medicinal chemistry.

Synthesis of (2E)-3-{2-[(Substituted benzyl)oxy]phenyl}acrylaldehydes as Novel Antiinflammatory Agents.

S. Kuo, Li‐Jiau Huang, Jih P. Wang, 2006 .

Inhibition of Ras-mediated cell proliferation by benzyloxybenzaldehyde.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of biomedical science.

Ibuprofen affects arylamine N‐acetyltransferase activity in Helicobacter pylori from peptic ulcer patients

S. Kuo, J. Chung, Shih H. Chang, 1998, Journal of applied toxicology : JAT.

The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury

S. Kuo, C. Teng, S. Pan, 2004, Thrombosis and Haemostasis.

Antiproliferative constituents from Gynura divaricata subsp. formosana

Sheng-Chih Chen, S. Kuo, C. Chen, 2003 .

Synthesis of fluazolate via the application of regioselective [3+2] cyclocondensation and nucleophilic substitution-cyclization strategies

S. Kuo, Hui-Chang Lin, Min‐Tsang Hsieh, 2016 .

Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.

S. Kuo, J. Guh, Z. Cheng, 1995, The Biochemical journal.

Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.

S. Kuo, J. Guh, Z. Cheng, 1995, Biochemical Journal.

AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells.

Jai-Sing Yang, Jing-Gung Chung, S. Tsai, 2012, International journal of oncology.

Bp5250 inhibits vascular endothelial growth factor-induced angiogenesis and HIF-1α expression on endothelial cells

S. Kuo, C. Chung, Kuan-Ting Lin, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pculin02H, a curcumin derivative, inhibits proliferation and clinical drug resistance of HER2-overexpressing cancer cells.

Chi-Tang Ho, S. Kuo, Tzong-Der Way, 2015, Chemico-biological interactions.

The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells.

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2014, International journal of oncology.

2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells.

S. Kuo, Li‐Jiau Huang, K. Lee, 2009, Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis.

(BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells

S. Kuo, Li‐Jiau Huang, K. Lee, 2009 .

Synthesis of 1-substituted 3-pyridinylmethylidenylindolin-2-ones and 1-substituted 3-quinolinylmethylidenylindolin-2-ones as the enhancers of ATRA-induced differentiation in HL-60 cells.

S. Kuo, Li‐Jiau Huang, Chrong-Shiong Hwang, 2008, Bioorganic & medicinal chemistry.

Synthesis and cytotoxicity of 2-acetyl-4,8-dihydrobenzodithiophene-4, 8-dione derivatives.

S. Kuo, A. Mauger, K. Lee, 1998, Journal of medicinal chemistry.

Ethyl 2- [N-m-chlorobenzyl- (2'-methyl)] anilino-4-oxo-4,5-dihydrofuran-3-carboxylate (JOT01006) induces apoptosis in human cervical cancer HeLa cells.

Jing-Gung Chung, S. Kuo, Li‐Jiau Huang, 2007, Anticancer research.