Li‐Jiau Huang

Chi-Tang Ho, S. Kuo, Li‐Jiau Huang, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Inhibition of lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages by a synthetic carbazole, LCY-2-CHO.

S. Kuo, Li‐Jiau Huang, L. Tsao, 2002, Biochemical pharmacology.

Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons.

P. Gean, Yi-Chien Lin, Sheng-Chih Chen, 2009, Bioorganic & medicinal chemistry letters.

Investigation of the cellular mechanism of inhibition of formyl-methionyl-leucyl-phenylalanine-induced superoxide anion generation in rat neutrophils by 2-benzyloxybenzaldehyde.

S. Kuo, Li‐Jiau Huang, Ling-Chu Chang, 2003, Biochemical pharmacology.

Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives.

Chin‐Chung Wu, S. Kuo, Li‐Jiau Huang, 2008, Bioorganic & medicinal chemistry.

Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils

Hui-Yi Lin, S. Kuo, Li‐Jiau Huang, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils.

Li‐Jiau Huang, Chi-Sen Chang, Ling-Chu Chang, 2011, Biochemical pharmacology.

Inhibition of lipopolysaccharide-stimulated NO production by crotafuran B in RAW 264.7 macrophages involves the blockade of NF-κB activation through the increase in IκBα synthesis

S. Kuo, Li‐Jiau Huang, Meng-Wei Lin, 2006 .

2-Benzyloxybenzaldehyde inhibits formyl peptide-stimulated increase in intracellular Ca2+ in neutrophils mainly by blocking Ca2+ entry

S. Kuo, Li‐Jiau Huang, L. Tsao, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils.

S. Kuo, Li‐Jiau Huang, Jih P. Wang, 2004, Biochemical pharmacology.

Activation of phosphoinositide 3-kinase and Src family kinase is required for respiratory burst in rat neutrophils stimulated with artocarpol A.

Hui-Yi Lin, Li‐Jiau Huang, L. Tsao, 2006, Biochemical pharmacology.

The anti‐inflammatory carbazole, LCY‐2‐CHO, inhibits lipopolysaccharide‐induced inflammatory mediator expression through inhibition of the p38 mitogen‐activated protein kinase signaling pathway in macrophages

Wan-Wan Lin, Li‐Jiau Huang, F. Ho, 2004, British journal of pharmacology.

Structure–activity relationships of a peptidic antagonist of Id1 studied by biosensor method, circular dichroism spectroscopy, and bioassay

S. Kuo, Li‐Jiau Huang, F. Lung, 2011, Journal of peptide science : an official publication of the European Peptide Society.

Smh-3 induces G(2)/M arrest and apoptosis through calcium‑mediated endoplasmic reticulum stress and mitochondrial signaling in human hepatocellular carcinoma Hep3B cells.

Jai-Sing Yang, Shih-Ming Huang, S. Kuo, 2013, Oncology reports.

Distinct effects of N-ethylmaleimide on formyl peptide- and cyclopiazonic acid-induced Ca2+ signals through thiol modification in neutrophils.

S. Kuo, Li‐Jiau Huang, L. Tsao, 2005, Biochemical pharmacology.

Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.

Yi-Chien Lin, S. Kuo, Li‐Jiau Huang, 2013, Bioorganic & medicinal chemistry.

Effect of a potent cyclooxygenase inhibitor, 5‐ethyl‐4‐methoxy‐2‐phenylquinoline (KTC‐5), on human platelets

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, The Journal of pharmacy and pharmacology.

1-(3,4-dimethoxyphenyl)-3,5-dodecenedione (I6) induces G1 arrest and apoptosis in human promyelocytic leukemia HL-60 cells.

Jing-Gung Chung, S. Kuo, Li‐Jiau Huang, 2005, Leukemia research.

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Li‐Jiau Huang, Jih P. Wang, H. Tsai, 1984 .

Neuroprotective effect of N‐acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: Involvement of ERK and p38 phosphorylation

P. Gean, S. Kuo, Li‐Jiau Huang, 2006, Journal of neuroscience research.

The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells.

Jai-Sing Yang, Jing-Gung Chung, C. Liaw, 2012, Oncology reports.

Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils

Hui-Yi Lin, S. Kuo, Li‐Jiau Huang, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents.

Jai-Sing Yang, Hui-Yi Lin, S. Kuo, 2010, European journal of medicinal chemistry.

Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.

S. Kuo, Li‐Jiau Huang, T. Yamori, 2005, Bioorganic & medicinal chemistry.

Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents.

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2007, Bioorganic & medicinal chemistry.

Synthesis of N2-(substituted benzyl)-3-(4-methylphenyl)indazoles as novel anti-angiogenic agents.

S. Kuo, Li‐Jiau Huang, C. Teng, 2006, Bioorganic & medicinal chemistry.

Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.

Hui-Yi Lin, Chi-Hung Huang, S. Kuo, 2010, Journal of medicinal chemistry.

Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.

S. Kuo, Li‐Jiau Huang, Keduo Qian, 2009, Journal of medicinal chemistry.

Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells.

Yi-Chien Lin, S. Kuo, Li‐Jiau Huang, 2016, European journal of medicinal chemistry.

Synthesis of 2-alkoxy 1,4-naphthoquinone derivatives as antiplatelet, antiinflammatory, and antiallergic agents.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Chemical & pharmaceutical bulletin.

Synthesis and SAR studies of novel 6,7,8‐substituted 4‐substituted benzyloxyquinolin‐2(1H)‐one derivatives for anticancer activity

Hui-Yi Lin, Yi-Chien Lin, S. Kuo, 2015, British journal of pharmacology.

Synthesis and Cytotoxicity of 1,6,8,9‐Substituted α‐Carboline Derivatives

Yi-Chien Lin, S. Kuo, Li‐Jiau Huang, 2010, The Kaohsiung journal of medical sciences.

Studies of heterocyclic compounds. VIII. Synthesis, anti‐inflammatory and antiallergic activities of n‐alkyl‐2,3,4,9‐tetrahydrofuro[2,3‐b]quinoline‐3,4‐diones and related compounds

S. Kuo, Li‐Jiau Huang, Hong Cheng, 1991 .

Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-ones as potent antitumor agents.

Chi-Hung Huang, Shih-Ming Huang, S. Kuo, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.

Chi-Hung Huang, Shih-Ming Huang, S. Kuo, 2010, Journal of medicinal chemistry.

Synthesis and Cytotoxicity of 6‐Pyrrolidinyl‐2‐(2‐Substituted Phenyl)‐4‐Quinazolinones

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2007 .

Effect of Indole‐3‐Acetic Acid Analogs on the Differentiation of HL‐60 Cells

S. Kuo, Li‐Jiau Huang, C. Chen, 2008 .

Novel quinolone CHM‐1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line

T. Hsia, Kuang-Chi Lai, Jai-Sing Yang, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Investigation of amination in 4-chloro-2-phenylquinoline derivatives with amide solvents

S. Kuo, Li‐Jiau Huang, Jui-Ying Tsai, 2008 .

1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of medicinal chemistry.

Synthesis of 1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole Analogues as Novel Antiplatelet Agents.

Chin‐Chung Wu, S. Kuo, Li‐Jiau Huang, 2010 .

Proteomic approach to studying the cytotoxicity of YC‐1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice

Jai-Sing Yang, Jing-Gung Chung, S. Kuo, 2007, Proteomics.

Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice.

S. Kuo, Li‐Jiau Huang, T. Ho, 2007, Journal of agricultural and food chemistry.

Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula

C. Liaw, Y. Wu, F. Chang, 2014, Molecules.

Hypolipidemic activity of Taraxacum mongolicum associated with the activation of AMP-activated protein kinase in human HepG2 cells.

Chi-Tang Ho, S. Kuo, Li‐Jiau Huang, 2014, Food & function.

Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells.

Jen-kun Lin, S. Tsai, S. Kuo, 2008, Molecular nutrition & food research.

Acetogenin and prenylated flavonoids from Helminthostachys zeylanica with inhibitory activity on superoxide generation and elastase release by neutrophils.

C. Liaw, Shih-Hsiung Wu, Sheng-Chih Chen, 2010, Planta medica.

The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells.

Jai-Sing Yang, Yi-Chien Lin, S. Kuo, 2013, International journal of oncology.

In Vitro and In Silico Biological Studies of 4-Phenyl-2-quinolone (4-PQ) Derivatives as Anticancer Agents

S. Kuo, Li‐Jiau Huang, Hsu-Shan Huang, 2023, Molecules.

The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells

Jai-Sing Yang, Jing-Gung Chung, S. Kuo, 2009, Journal of Gastroenterology.

The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.

Jai-Sing Yang, Hui-Yi Lin, S. Tsai, 2011, International journal of oncology.

CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.

M. Hung, Jing-Gung Chung, Chi-Hung Huang, 2011, European journal of pharmacology.

Inhibition of Ras-Mediated Cell Proliferation by Benzyloxybenzaldehyde

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of Biomedical Science.

The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells.

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2014, International journal of oncology.

The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells.

Wan-Wan Lin, Li‐Jiau Huang, F. Ho, 2007, Biochemical pharmacology.

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1

Hui-Yi Lin, R. Chou, S. Kuo, 2015, Cancer Chemotherapy and Pharmacology.

Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead.

Jai-Sing Yang, Hui-Yi Lin, S. Kuo, 2013, Bioorganic & medicinal chemistry letters.

Mechanistic Studies on Regioselective Dephosphorylation of Phosphate Prodrugs during a Facile Synthesis of Antitumor Phosphorylated 2-Phenyl-6,7-methylenedioxy-1H-quinolin-4-one

Chi-Hung Huang, S. Kuo, Li‐Jiau Huang, 2013, Molecules.

2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells.

Jing-Gung Chung, S. Kuo, Li‐Jiau Huang, 2007, European journal of pharmacology.

4-Fluoro-N-butylphenylacetamide (H6) inhibits cell growth via cell-cycle arrest and apoptosis in human cervical cancer cells.

S. Kuo, Li‐Jiau Huang, K. Tsai, 2009, Bioorganic & medicinal chemistry.

Induction of apoptosis by HAC-Y6, a novel microtubule inhibitor, through activation of the death receptor 4 signaling pathway in human hepatocellular carcinoma cells.

Jin Chung, Chi-Hung Huang, S. Kuo, 2010, Oncology reports.

The signaling mechanisms mediating the inhibitory effect of TCH-1116 on formyl peptide-stimulated superoxide anion generation in neutrophils.

C. Tzeng, S. Kuo, Li‐Jiau Huang, 2012, European journal of pharmacology.

The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis.

P. Gean, S. Kuo, Li‐Jiau Huang, 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Synthesis and anticancer activity of 2,4-disubstituted furo[3,2-b]indole derivatives.

Hui-Yi Lin, Chi-Hung Huang, Yi-Chien Lin, 2013, European journal of medicinal chemistry.

A phenylacetate derivative, SCK6, inhibits cell proliferation via G1 cell cycle arrest and apoptosis.

S. Hsu, S. Kuo, Li‐Jiau Huang, 2003, European journal of pharmacology.

Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells.

Hui-Yi Lin, S. Kuo, Li‐Jiau Huang, 2018, Bioorganic & medicinal chemistry.

Biological evaluation of 9-[(6-chloropyridin-4-yl)methyl]-9H-carbazole-3-carbinol as an anticancer agent.

Li‐Jiau Huang, Chin-Huei Lin, K. Tsai, 2013, Oncology reports.

Solvent Effect of Dimethyl Sulfoxide on the Chemical Shifts of Phenyl Vinyl Ketones

Sheng-Chih Chen, S. Kuo, Li‐Jiau Huang, 2004 .

BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide

S. Kuo, Li‐Jiau Huang, Tzong-Der Way, 2015, International journal of molecular medicine.