Toshimitsu Komatsu

发表

Calorie restriction minimizes activation of insulin signaling in response to glucose: Potential involvement of the growth hormone-insulin-like growth factor 1 axis

T. Nagayasu, Y. Higami, H. Hayashi, 2008, Experimental Gerontology.

Acute stress response modified by modest inhibition of growth hormone axis: A potential machinery of the anti-aging effect of calorie restriction

H. Hayashi, Toshimitsu Komatsu, T. Chiba, 2011, Mechanisms of Ageing and Development.

Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8

D. Ingram, R. Cabo, Y. Higami, 2008, Experimental Gerontology.

Calorie restriction initiated at a young age activates the Akt/PKCζ/λ-Glut4 pathway in rat white adipose tissue in an insulin-independent manner

Y. Higami, H. Hayashi, H. Yamaza, 2008, AGE.

Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle

Y. Higami, H. Hayashi, H. Yamaza, 2006, Experimental Gerontology.

Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction

H. Chung, Toshimitsu Komatsu, T. Chiba, 2011, Geriatrics & gerontology international.

Y. Higami, H. Hayashi, H. Yamaza, 2009, Molecular and Cellular Endocrinology.

Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.

Y. Higami, H. Yamaza, Toshimitsu Komatsu, 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

A transgenic dwarf rat model as a tool for the study of calorie restriction and aging

Y. Higami, H. Yamaza, Toshimitsu Komatsu, 2004, Experimental Gerontology.

Identification of Fasting‐induced Genes in the Rat Hypothalamus

S. Fujita, Y. Higami, H. Yamaza, 2007, Annals of the New York Academy of Sciences.

The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis

H. Hayashi, Toshimitsu Komatsu, Seongjoon Park, 2021, Biomedicines.

Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction

H. Hayashi, Toshimitsu Komatsu, Seongjoon Park, 2015, AGE.

Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice

Toshimitsu Komatsu, Seongjoon Park, T. Chiba, 2019, Geriatrics & gerontology international.

Hepatic gene expression profile of lipid metabolism in rats: Impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression.

Y. Higami, H. Yamaza, Toshimitsu Komatsu, 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

Lifespan extension by reduction of the growth hormone‐insulin‐like growth factor‐1 axis: relation to caloric restriction

Y. Higami, H. Yamaza, Toshimitsu Komatsu, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling

H. Hayashi, H. Yamaza, Toshimitsu Komatsu, 2009, Experimental Gerontology.

NPY antagonism reduces adiposity and attenuates age‐related imbalance of adipose tissue metabolism

Toshimitsu Komatsu, Seongjoon Park, T. Chiba, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Neuropeptide Y resists excess loss of fat by lipolysis in calorie‐restricted mice: a trait potential for the life‐extending effect of calorie restriction

Katsuya Tanaka, H. Hayashi, Toshimitsu Komatsu, 2017, Aging cell.

Neuropeptide Y inhibits hepatocarcinogenesis in overnutrition in mice

H. Hayashi, Toshimitsu Komatsu, Seongjoon Park, 2019 .

A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction

H. Yamaza, Toshimitsu Komatsu, T. Chiba, 2009 .

Effect of leptin on hypothalamic gene expression in calorie-restricted rats.

Y. Higami, H. Yamaza, Toshimitsu Komatsu, 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

Effects of caloric restriction on gene expression in the arcuate nucleus

Y. Higami, Toshimitsu Komatsu, T. Chiba, 2003, Neurobiology of Aging.

The life-extending effect of dietary restriction requires Foxo3 in mice

H. Hayashi, H. Yamaza, Toshimitsu Komatsu, 2015, Aging cell.

Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model.

Y. Higami, H. Yamaza, Toshimitsu Komatsu, 2002, The American journal of pathology.

FoxO1 is involved in the antineoplastic effect of calorie restriction

T. Furuyama, H. Hayashi, H. Yamaza, 2010, Aging cell.

Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.

Paul Martin, Katsuya Tanaka, Toshimitsu Komatsu, 2014, The American journal of pathology.

Reduced FOXO 1 accelerates skin wound healing and attenuates scarring

Paul Martin, Katsuya Tanaka, Toshimitsu Komatsu, 2019 .

Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: Implications for longevity

S. Fujita, Y. Higami, H. Hayashi, 2009, Neurobiology of Aging.

Targeting miR‐223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds

Yutaka Suzuki, Y. Okada, Paul Martin, 2018, EMBO molecular medicine.

Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

H. Hayashi, H. Yamaza, Toshimitsu Komatsu, 2019, Nutrients.

Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: Relationship with caloric restriction

S. Fujita, Y. Higami, H. Hayashi, 2008, Experimental Gerontology.

Down-regulation of hepatic AMP-activated protein kinase and up-regulation of CREB coactivator CRTC2 for gluconeogenesis under calorie-restricted conditions at a young age

H. Hayashi, H. Yamaza, Toshimitsu Komatsu, 2011 .

NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.

H. Hayashi, Toshimitsu Komatsu, Seongjoon Park, 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

Modulation of oxidative phosphorylation machinery signifies a prime mode of anti-ageing mechanism of calorie restriction in male rat liver mitochondria

Y. Higami, Toshimitsu Komatsu, I. Shimokawa, 2010, Biogerontology.

A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction

Daeui Park, H. Chung, H. Hayashi, 2014, Scientific Reports.

Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect

T. Nagayasu, H. Hayashi, H. Yamaza, 2015, Experimental Gerontology.

Development of Calorie Restriction Mimetics as Therapeutics for Obesity, Diabetes, Inflammatory and Neurodegenerative Diseases

H. Hayashi, Toshimitsu Komatsu, T. Chiba, 2010, Current genomics.

Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation

Y. Higami, H. Yamaza, Toshimitsu Komatsu, 2005, Mechanisms of Ageing and Development.

Longevity genes: insights from calorie restriction and genetic longevity models.

H. Yamaza, Toshimitsu Komatsu, T. Chiba, 2008, Molecules and cells.

Molecular Medicine Role of miR-223 in S . aureus clearance

Yutaka Suzuki, Y. Okada, Paul Martin, 2019 .

MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton.

Paul Martin, Katsuya Tanaka, H. Hayashi, 2017, The Journal of investigative dermatology.

Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver

Y. Higami, H. Hayashi, H. Yamaza, 2007, Experimental Gerontology.

Nutrient‐dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster

S. Zou, Toshimitsu Komatsu, T. Alberico, 2012, Aging cell.