Takashi Ito

发表

Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes.

Y. Fujio, T. Mohri, Yasuhiro Yamamoto, 2008, Cardiovascular research.

Oxygen management in mechanically ventilated patients: A multicenter prospective observational study

M. Nishimura, M. Egi, N. Shime, 2018, Journal of critical care.

C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells.

S. Takao, N. Taniguchi, Takashi Ito, 2008, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

Takahiro Miyauchi, S. Yamada, Takashi Ito, 2013, PloS one.

Taurine-Conjugated Metabolites in Hearts.

Takashi Ito, S. Murakami, S. Schaffer, 2019, Advances in experimental medicine and biology.

Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment

S. Yamada, Takashi Ito, I. Maruyama, 2014, Laboratory Investigation.

Secondary prevention of stroke: Pleiotropic effects of optimal oral pharmacotherapy.

M. Hirohata, Takashi Ito, I. Maruyama, 2012, Experimental and therapeutic medicine.

Evaluation of taurine content on skeletal muscle of exercised rats using MALDI-TOF MS imaging analysis

Takashi Ito, T. Miyazaki, S. Murakami, 2020, The Journal of Physical Fitness and Sports Medicine.

Impact of taurine depletion on glucose control and insulin secretion in mice.

Hiromi Ito, Takashi Ito, S. Schaffer, 2015, Journal of pharmacological sciences.

The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II

Takashi Ito, J. Azuma, S. Schaffer, 2013, Amino Acids.

The potential usefulness of taurine on diabetes mellitus and its complications

Takashi Ito, J. Azuma, S. Schaffer, 2011, Amino Acids.

Effect of β-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content

Takashi Ito, J. Azuma, M. Mozaffari, 2010, Journal of Biomedical Science.

Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells.

Y. Fujio, Takashi Ito, J. Azuma, 2004, The Biochemical journal.

Roles of theWHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases

Takashi Ito, TsutomuKobayashi, andMasashi Shiomi, 2014 .

Impaired energy metabolism of the taurine-deficient heart

Takashi Ito, Kyoko Takahashi, C. J. Jong, 2015, Amino Acids.

Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review).

Takashi Ito, I. Maruyama, M. Morioka, 2012, Experimental and therapeutic medicine.

Beyond neurological disease: new targets for edaravone (Review).

Takashi Ito, K. Kikuchi, K. Kawahara, 2011, International journal of molecular medicine.

Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.

M. Shigemori, Takashi Ito, I. Maruyama, 2009, Biochemical and biophysical research communications.

The Free Radical Scavenger Edaravone Rescues Rats from Cerebral Infarction by Attenuating the Release of High-Mobility Group Box-1 in Neuronal Cells

M. Shigemori, Takashi Ito, I. Maruyama, 2009, Journal of Pharmacology and Experimental Therapeutics.

Potential diagnostic markers for disseminated intravascular coagulation of sepsis.

Takashi Ito, I. Maruyama, J. Thachil, 2016, Blood reviews.

Role of taurine in the pathologies of MELAS and MERRF

Takashi Ito, J. Azuma, C. J. Jong, 2012, Amino Acids.

Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy.

M. Ikawa, M. Okabe, Y. Fujio, 2008, Journal of molecular and cellular cardiology.

The Edible Brown Seaweed Sargassum horneri (Turner) C. Agardh Ameliorates High-Fat Diet-Induced Obesity, Diabetes, and Hepatic Steatosis in Mice

Takashi Ito, S. Murakami, N. Ma, 2021, Nutrients.

Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study.

Takashi Ito, T. Yasuda, Y. Kakihana, 2018, Advances in experimental medicine and biology.

Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice

Y. Fujio, Takashi Ito, Y. Uozumi, 2010, Journal of Biomedical Science.

Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression.

A. Ochiai, K. Nagai, G. Ishii, 2011, Cancer research.

DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC.

Takashi Ito, P. Liaw, J. Thachil, 2016, Blood reviews.

HMGB1 Promotes the Development of Pulmonary Arterial Hypertension in Rats

S. Yamada, Takashi Ito, I. Maruyama, 2014, PloS one.

Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells.

M. Shigemori, Takashi Ito, I. Maruyama, 2009, Biochemical and biophysical research communications.

Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis

Takashi Ito, I. Maruyama, M. Morioka, 2017, Oxidative medicine and cellular longevity.

Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow‐derived endothelial cells and myofibroblasts in cancer‐induced stroma

M. Miyazaki, Y. Aoyagi, A. Ochiai, 2005, International journal of cancer.

The quest for an animal model of diabetic nephropathy and the role of taurine deficiency.

Xiaobin Han, R. Chesney, Takashi Ito, 2015, Advances in experimental medicine and biology.

Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study

Takashi Ito, I. Maruyama, H. Hashiguchi, 2019, Thrombosis Journal.

Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis.

M. Yamakuchi, Takashi Ito, I. Maruyama, 2013, Biochemical and biophysical research communications.

1,5-Anhydro-D-fructose: A natural antibiotic that inhibits the growth of gram-positive bacteria and microbial biofilm formation to prevent nosocomial infection.

Takashi Ito, I. Maruyama, K. Kikuchi, 2011, Experimental and therapeutic medicine.

Nuclear survivin expression in stromal cells of phyllodes tumors and fibroadenomas of the breast.

K. Matsushita, Takashi Ito, A. Okimura, 2014, Anticancer research.

Uric acid enhances alteplase-mediated thrombolysis as an antioxidant

Takashi Ito, I. Maruyama, M. Morioka, 2018, Scientific Reports.

Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts.

T. Ushijima, M. Kojima, A. Ochiai, 2010, International journal of oncology.

Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse.

Takashi Ito, S. Murakami, Y. Nakanishi, 2018, Biological & pharmaceutical bulletin.

Role of Mitochondria and Endoplasmic Reticulum in Taurine-Deficiency-Mediated Apoptosis

Takashi Ito, Jang-Yen Wu, H. Prentice, 2017, Nutrients.

Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression.

K. Hirata, Takashi Ito, I. Miyamori, 2011, Biochemical and biophysical research communications.

Mechanisms Underlying Development of Taurine-Deficient Cardiomyopathy

Takashi Ito, J. Azuma, J. Kramer, 2020, Hearts.

Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions

Takashi Ito, I. Maruyama, T. Koide, 2012, Thrombosis and Haemostasis.

Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.

Takashi Ito, I. Maruyama, Y. Nawa, 2008, International journal of molecular medicine.

Role for Taurine in Development of Oxidative Metabolism After Birth.

Takashi Ito, Kyoko Takahashi, S. Schaffer, 2017, Advances in experimental medicine and biology.

Impaired Energy Production Contributes to Development of Failure in Taurine Deficient Heart.

Takashi Ito, C. J. Jong, S. Schaffer, 2017, Advances in experimental medicine and biology.

Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine.

I. Kawase, Y. Fujio, T. Mohri, 2007, Cytokine.

Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles.

Y. Fujio, T. Mohri, Y. Hoshino, 2006, The Biochemical journal.

Myogenic induction of taurine transporter prevents dexamethasone-induced muscle atrophy.

Y. Fujio, T. Mohri, Takashi Ito, 2006, Advances in experimental medicine and biology.

1,5-Anhydro-D-fructose Protects against Rotenone-Induced Neuronal Damage In Vitro through Mitochondrial Biogenesis

M. Yamakuchi, Takashi Ito, I. Maruyama, 2021, International journal of molecular sciences.

The ubiquitin–proteasome system and autophagy are defective in the taurine-deficient heart

Takashi Ito, C. J. Jong, S. Schaffer, 2015, Amino Acids.

Beneficial Role of Taurine Against Myocardial Apoptosis During Ischemic Injury

Takashi Ito, J. Azuma, S. Schaffer, 2010 .

Molecular mechanisms of cardioprotection by taurine on ischemia-induced apoptosis in cultured cardiomyocytes.

Y. Fujio, Takashi Ito, Y. Uozumi, 2006, Advances in experimental medicine and biology.

Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway.

Y. Fujio, Takashi Ito, Y. Uozumi, 2004, Biochemical and biophysical research communications.

Beneficial effect of taurine treatment against doxorubicin-induced cardiotoxicity in mice.

Y. Fujio, Takashi Ito, J. Azuma, 2009, Advances in experimental medicine and biology.

Taurine attenuates the development of hepatic steatosis through the inhibition of oxidative stress in a model of nonalcoholic fatty liver disease in vivo and in vitro

Takashi Ito, S. Murakami, T. Takenaga, 2018, Amino Acids.

Physiological and therapeutic roles of taurine in the heart

Takashi Ito, J. Azuma, C. J. Jong, 2012 .

Taurine Depletion Decreases GRP78 Expression and Downregulates Perk-Dependent Activation of the Unfolded Protein Response.

Takashi Ito, J. Azuma, C. J. Jong, 2015, Advances in experimental medicine and biology.

Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice

Takashi Ito, H. Ichinose, Y. Kakihana, 2021, Frontiers in Pharmacology.

Tissue Taurine Depletion Alters Metabolic Response to Exercise and Reduces Running Capacity in Mice

Takashi Ito, J. Azuma, S. Schaffer, 2014, Journal of amino acids.

In Vivo and In Vitro Study of N-Methyltaurine on Pharmacokinetics and Antimuscle Atrophic Effects in Mice

Takashi Ito, S. Murakami, S. Schaffer, 2020, ACS omega.

Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice.

Takashi Ito, S. Murakami, S. Schaffer, 2018, Biological & pharmaceutical bulletin.

Pathway Analysis of a Transcriptome and Metabolite Profile to Elucidate a Compensatory Mechanism for Taurine Deficiency in the Heart of Taurine Transporter Knockout Mice

Takashi Ito, S. Murakami, S. Schaffer, 2018, J.

Beta-Catenin and SMAD3 Are Associated with Skeletal Muscle Aging in the Taurine Transpoeter Knockout Mouse.

Takashi Ito, S. Schaffer, Shintaro Nakajima, 2017, Advances in experimental medicine and biology.

Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart

D. Shibata, Takashi Ito, K. Okazaki, 2017, Amino Acids.

Role of protein phosphorylation in excitation-contraction coupling in taurine deficient hearts.

Takashi Ito, J. Azuma, C. J. Jong, 2015, American journal of physiology. Heart and circulatory physiology.

Potential Anti-aging Role of Taurine via Proper Protein Folding: A Study from Taurine Transporter Knockout Mouse.

Takashi Ito, J. Azuma, S. Schaffer, 2015, Advances in experimental medicine and biology.

Does taurine prolong lifespan by improving heart function?

Takashi Ito, J. Azuma, C. J. Jong, 2015, Advances in experimental medicine and biology.

Taurine deficiency and MELAS are closely related syndromes.

Takashi Ito, J. Azuma, C. J. Jong, 2013, Advances in experimental medicine and biology.

Clinical significance of taurine

Takashi Ito, J. Azuma, S. Schaffer, 2013, Amino Acids.

Effect of taurine on protein kinase C isoforms: role in taurine's actions?

Takashi Ito, J. Azuma, S. Schaffer, 2009, Advances in experimental medicine and biology.

Regulation of Cytochrome P450 2E1 under Hypertonic Environment through TonEBP in Human Hepatocytes

S. Nonen, Y. Fujio, Takashi Ito, 2007, Molecular Pharmacology.

Involvement of transcriptional factor TonEBP in the regulation of the taurine transporter in the cardiomyocyte.

Y. Fujio, Takashi Ito, J. Azuma, 2009, Advances in experimental medicine and biology.

TauT gene expression is regulated by TonEBP and plays a role in cell survival.

Y. Fujio, Takashi Ito, Y. Uozumi, 2006, Advances in experimental medicine and biology.

Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals.

H. Yamazaki, Y. Fujio, Takashi Ito, 2007, Drug metabolism and pharmacokinetics.

Hemoperfusion with a high-mobility group box 1 adsorption column can prevent the occurrence of hepatic ischemia–reperfusion injury in rats*

Takashi Ito, I. Maruyama, Tsuneo Tanaka, 2010, Critical care medicine.

Increased Proportions of Peripheral Blood γδ T Cells in Patients with Pulmonary Tuberculosis

Takashi Ito, J. Funada, T. Kokubu, 1992 .

Thioredoxin Increases Exocytosis by Denitrosylating N-Ethylmaleimide-sensitive Factor

M. Yamakuchi, C. Lowenstein, Takashi Ito, 2011, The Journal of Biological Chemistry.

Breeding of a Rabbit Strain of Hyperlipidemia and Characteristic of These Strain

Takashi Ito, Yoshio Watanabe, T. Kondo, 1977 .

Fulminant myocarditis associated with severe fever with thrombocytopenia syndrome: a case report

Takashi Ito, T. Yasuda, Y. Kakihana, 2019, BMC Infectious Diseases.

Thrombomodulin in disseminated intravascular coagulation and other critical conditions—a multi-faceted anticoagulant protein with therapeutic potential

Takashi Ito, J. Thachil, T. Iba, 2019, Critical Care.

[Taurine is a possible anti-atherosclerotic agent].

Takashi Ito, J. Azuma, 2004, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Serum α 1-Antichimotrypsin Levels and Cardiovasucular Risk Factors in the Japanese Elderly Population:

Takashi Ito, K. Yagyu, K. Okamoto, 1998 .

Puerarin blocks the aging phenotype in human dermal fibroblasts

Takashi Ito, Yuki Kamiya, Shigeru Murakami, 2021, PloS one.

Puerarin blocks aging phenotype in cultured human dermal fibroblasts

Takashi Ito, S. Murakami, Yuki Kamiya, 2020, bioRxiv.

Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus.

Takashi Ito, I. Maruyama, K. Hatakeyama, 2012, Atherosclerosis.

Association Between HMGB1 and Thrombogenesis in a Hyperlipaemia-induced Microminipig Model of Atherosclerosis

Takashi Ito, I. Maruyama, A. Tanimoto, 2020, In Vivo.

HMGB1 release in co‐cultures of porcine endothelial and human T cells

S. Takao, Takashi Ito, I. Maruyama, 2007, Xenotransplantation.

Thrombus formation and innate immunity

Takashi Ito, I. Maruyama, 2012 .

MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells.

M. Torii, Takashi Ito, I. Maruyama, 2009, Biochemical and biophysical research communications.

Nucleophosmin may act as an alarmin: implications for severe sepsis

Takashi Ito, I. Maruyama, Y. Masuda, 2009, Journal of leukocyte biology.

Cytokine and inducible nitric oxide synthase gene expressions in peripheral blood mononuclear cells and related clinical characteristics in Theileria orientalis sergenti-infected calves.

Takashi Ito, Y. Yagi, H. Shiono, 2003, The Journal of veterinary medical science.

B Cell-Derived Vascular Endothelial Growth Factor A Promotes Lymphangiogenesis and High Endothelial Venule Expansion in Lymph Nodes

Takashi Ito, I. Maruyama, K. Arimura, 2010, The Journal of Immunology.

Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit

Takashi Ito, I. Maruyama, Y. Kakihana, 2020, Scientific Reports.

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

Takashi Ito, I. Maruyama, T. Nagasato, 2019, Front. Immunol..

Thrombomodulin exerts cytoprotective effect on low-dose UVB-irradiated HaCaT cells.

Takashi Ito, I. Maruyama, T. Kanekura, 2008, Biochemical and biophysical research communications.

Impaired energy metabolism of the taurine-deficient heart

Takashi Ito, Kyoko Takahashi, C. J. Jong, 2016, Amino Acids.

The ubiquitin–proteasome system and autophagy are defective in the taurine-deficient heart

Takashi Ito, C. J. Jong, S. Schaffer, 2015, Amino Acids.

Effect of taurine and potential interactions with caffeine on cardiovascular function

Takashi Ito, J. Azuma, Kyoko Takahashi, 2014, Amino Acids.

Effect of taurine on ischemia–reperfusion injury

Takashi Ito, J. Azuma, C. J. Jong, 2012, Amino Acids.

Hyaluronan protection of corneal endothelial cells against extracellular histones after phacoemulsification

Takashi Ito, I. Maruyama, T. Sakamoto, 2014, Journal of cataract and refractive surgery.

Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc.

Takashi Ito, I. Maruyama, Y. Nawa, 2009, International journal of molecular medicine.

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

Takashi Ito, I. Maruyama, N. Aikawa, 2020, Research and practice in thrombosis and haemostasis.

Sepsis-induced myocardial dysfunction: pathophysiology and management

Takashi Ito, T. Yasuda, Y. Kakihana, 2016, Journal of Intensive Care.

Japanese Apricot (Ume): A Novel Therapeutic Approach for the Treatment of Periodontitis

M. Torii, Takashi Ito, I. Maruyama, 2012 .

Preventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty rats

Takashi Ito, I. Maruyama, K. Kikuchi, 2013, Experimental and therapeutic medicine.

Hydroxyapatite formed on/in agarose gel induces activation of blood coagulation and platelets aggregation.

M. Matsusaki, M. Akashi, Takashi Ito, 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

Role of taurine in the pathologies of MELAS and MERRF

Takashi Ito, J. Azuma, C. J. Jong, 2012, Amino Acids.

MicroRNA-34a regulation of endothelial senescence.

M. Yamakuchi, Takashi Ito, S. Yagi, 2010, Biochemical and biophysical research communications.

MicroRNA-22 Regulates Hypoxia Signaling in Colon Cancer Cells

M. Yamakuchi, C. Lowenstein, Takashi Ito, 2011, PloS one.

Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice

Takashi Ito, I. Maruyama, Seiya Takada, 2021, Scientific Reports.

Coagulation activity and white thrombus formation in the microminipig.

Takashi Ito, I. Maruyama, A. Tanimoto, 2013, In vivo.

Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases

Takashi Ito, I. Maruyama, Y. Kakihana, 2016, Expert opinion on therapeutic targets.

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes

S. Yamada, Takashi Ito, I. Maruyama, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Attempt to Develop Rat Disseminated Intravascular Coagulation Model Using Yamakagashi (Rhabdophis tigrinus) Venom Injection

Takashi Ito, T. Hifumi, A. Yamamoto, 2021, Toxins.

N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes.

Junichi Azuma, Takashi Ito, Kyoko Takahashi, 2006, Journal of molecular and cellular cardiology.

Taurine suppresses liquid–liquid phase separation of lysozyme protein

Takashi Ito, S. Murakami, S. Schaffer, 2021, Amino Acids.

Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke

Takashi Ito, I. Maruyama, K. Kikuchi, 2013, International journal of molecular sciences.

High-Mobility Group Box 1: Missing Link Between Thrombosis and Inflammation?

Takashi Ito, I. Maruyama, K. Kawahara, 2008 .

Newly identifi ed message for rescue and repair from necrotic cell: Biology and clinical relevance of“endokine, HMGB1”

Takashi Ito, I. Maruyama, T. Hashiguchi, 2007 .

Tissue Depletion of Taurine Accelerates Skeletal Muscle Senescence and Leads to Early Death in Mice

Takashi Ito, J. Azuma, S. Schaffer, 2014, PloS one.

Minoxidil Attenuates Ischemia-Induced Apoptosis in Cultured Neonatal Rat Cardiomyocytes

Takashi Ito, J. Azuma, Kyoko Takahashi, 2004, Journal of cardiovascular pharmacology.

Cardiovascular risk factors are associated with augmented thrombogenicity in healthy individuals: analysis using the Total Thrombus-formation Analysis System

Takashi Ito, I. Maruyama, T. Hashiguchi, 2021, Thrombosis Journal.

PAMPs and DAMPs as triggers for DIC

Takashi Ito, Takashi Ito, 2014, Journal of Intensive Care.

Periodontal disease and type 2 diabetes mellitus: is the HMGB1-RAGE axis the missing link?

M. Torii, Takashi Ito, K. Kikuchi, 2012, Medical hypotheses.

Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation

Takashi Ito, I. Maruyama, Midori Kakuuchi, 2021, Critical Care.

Specific detection of high mobility group box 1 degradation product with a novel ELISA

S. Yamada, Takashi Ito, I. Maruyama, 2021, Molecular medicine.

Recombinant thrombomodulin does not promote bacterial propagation but alleviates oxidative stress in rats infected with methicillin-resistant Staphylococcus aureus

Takashi Ito, I. Maruyama, Y. Kakihana, 2020 .

Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study

S. Yamada, Takashi Ito, I. Maruyama, 2019, Thrombosis Journal.

Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3

S. Yamada, Takashi Ito, I. Maruyama, 2018, Journal of Intensive Care.

The use of hyaluronan in phacoemulsification protects human corneal endothelial cells from the noxious effect of extracellular histones.

Takashi Ito, I. Maruyama, T. Sakamoto, 2014 .

Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice.

K. Node, M. Bianchi, T. Minami, 2019, Circulation journal : official journal of the Japanese Circulation Society.

Loss of Endogenous HMGB 2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice

K. Node, M. Bianchi, T. Minami, 2019 .

Recombinant thrombomodulin alleviates oxidative stress without compromising host resistance to infection in rats infected with methicillin-resistant Staphylococcus aureus

Takashi Ito, I. Maruyama, Y. Kakihana, 2020, Scientific Reports.

The potential usefulness of taurine on diabetes mellitus and its complications

Takashi Ito, J. Azuma, S. Schaffer, 2011, Amino Acids.

Taurine attenuates the development of hepatic steatosis through the inhibition of oxidative stress in a model of nonalcoholic fatty liver disease in vivo and in vitro

Takashi Ito, S. Murakami, T. Takenaga, 2018, Amino Acids.

Knockout of the TauT Gene Predisposes C57BL/6 Mice to Streptozotocin-Induced Diabetic Nephropathy

Xiaobin Han, A. Patters, R. Chesney, 2015, PloS one.

Serum histone H3 levels and platelet counts are potential markers for coagulopathy with high risk of death in septic patients: a single-center observational study

S. Yamada, Takashi Ito, I. Maruyama, 2019, Journal of Intensive Care.

Degradation of NFAT5, a Transcriptional Regulator of Osmotic Stress-related Genes, Is a Critical Event for Doxorubicin-induced Cytotoxicity in Cardiac Myocytes*

Y. Fujio, Takashi Ito, J. Azuma, 2007, Journal of Biological Chemistry.

Brain-Derived Neurotrophic Factor Protects Against Cardiac Dysfunction After Myocardial Infarction via a Central Nervous System–Mediated Pathway

I. Komuro, T. Minamino, H. Katagiri, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Differential Regulation of Damage-Associated Molecular Pattern Release in a Mouse Model of Skeletal Muscle Ischemia/Reperfusion Injury

S. Yamada, Takashi Ito, I. Maruyama, 2021, Frontiers in Immunology.

HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development.

Takashi Ito, K. Kikuchi, K. Kawahara, 2011, Experimental and therapeutic medicine.

Influence of Nutritional Management and Rehabilitation on Physical Outcome in Japanese Intensive Care Unit Patients: A Multicenter Observational Study

M. Nishimura, M. Egi, Takashi Ito, 2018, Annals of Nutrition and Metabolism.

Clinical significance of taurine

Takashi Ito, J. Azuma, S. Schaffer, 2013, Amino Acids.

Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress.

Y. Fujio, Takashi Ito, J. Azuma, 2007, Biochemical and biophysical research communications.

Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction.

M. Shigemori, Takashi Ito, I. Maruyama, 2011, Experimental and therapeutic medicine.

Influence of recombinant human-soluble thrombomodulin on extracorporeal circuit clotting in septic patients undergoing blood purification: a propensity-matched cohort study

Takashi Ito, O. Nishida, T. Yatabe, 2021, Journal of Artificial Organs.

GABAA Receptors and Maternally Derived Taurine Regulate the Temporal Specification of Progenitors of Excitatory Glutamatergic Neurons in the Mouse Developing Cortex.

Takashi Ito, H. Matsuzaki, A. Fukuda, 2021, Cerebral cortex.

Mechanism of HMGB 1 release inhibition from RAW 264 . 7 cells by oleanolic acid in Prunus mume Sieb . et Zucc

Takashi Ito, I. Maruyama, Y. Nawa, 2009 .

Thrombomodulin maintains the systemic circulation in good condition

Takashi Ito, I. Maruyama, K. Kawahara, 2009 .

Uric acid enhances alteplase-mediated thrombolysis as an antioxidant

Takashi Ito, I. Maruyama, M. Morioka, 2018, Scientific Reports.

Beneficial Effects of the Free Radical Scavenger Edaravone (Radicut) in Neurologic Diseases

Takashi Ito, I. Maruyama, M. Morioka, 2011 .

Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care

S. Yamada, Takashi Ito, I. Maruyama, 2021, Frontiers in Cardiovascular Medicine.

A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia

Takashi Ito, I. Maruyama, T. Yasuda, 2020, Thrombosis Journal.

Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit

Takashi Ito, I. Maruyama, Y. Kakihana, 2020, Scientific Reports.

External Validation of the Two Newly Proposed Criteria for Assessing Coagulopathy in Sepsis

Takashi Ito, M. Hayakawa, K. Yamakawa, 2018, Thrombosis and Haemostasis.

An evaluation of circulating activated TAFI in septic DIC: a case series and review of the literature

Takashi Ito, I. Maruyama, Y. Kakihana, 2022, Thrombosis Journal.

Circulating Activated TAFI is a Prognostic Indicator in Septic DIC

Takashi Ito, I. Maruyama, Y. Kakihana, 2020 .

Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin

Takashi Ito, I. Maruyama, T. Yasuda, 2018, Thrombosis Journal.

N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes.

Y. Fujio, Takashi Ito, Tetsuro Nariai, 2004, Biochemical and biophysical research communications.

Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases

Takashi Ito, I. Maruyama, Y. Kakihana, 2016, Expert opinion on therapeutic targets.

Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy.

M. Ikawa, M. Okabe, Y. Fujio, 2008, Journal of molecular and cellular cardiology.

Circulating intranuclear proteins may play a role in development of disseminated intravascular coagulation in individuals with acute leukemia

S. Yamada, Takashi Ito, T. Ikezoe, 2019, International Journal of Hematology.

Effect of taurine on ischemia–reperfusion injury

Takashi Ito, J. Azuma, C. J. Jong, 2012, Amino Acids.

Cleavage of Host Cytokeratin-6 by Lysine-Specific Gingipain Induces Gingival Inflammation in Periodontitis Patients

Takashi Ito, I. Maruyama, K. Kikuchi, 2015, PloS one.

The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II

Takashi Ito, J. Azuma, S. Schaffer, 2013, Amino Acids.

C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells.

S. Takao, N. Taniguchi, Takashi Ito, 2008, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Potential diagnostic markers for disseminated intravascular coagulation of sepsis.

Takashi Ito, I. Maruyama, J. Thachil, 2016, Blood reviews.

Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells.

Y. Fujio, Takashi Ito, J. Azuma, 2004, The Biochemical journal.