M. Czech

Jessica L. Cohen, Karen Gallagher-Dorval, M. Czech, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Activation of cell surface glucose transporters measured by photoaffinity labeling of insulin-sensitive 3T3-L1 adipocytes.

M. Czech, S. Harrison, A. Pessino, 1992, The Journal of biological chemistry.

Signaling Mechanisms That Regulate Glucose Transport*

M. Czech, S. Corvera, 1999, The Journal of Biological Chemistry.

PYK2 as a Mediator of Endothelin-1/Gα11Signaling to GLUT4 Glucose Transporters*

A. Bose, J. Leszyk, M. Czech, 2001, The Journal of Biological Chemistry.

Signal transduction: Lipid rafts and insulin action

M. Czech, 2000, Nature.

Interaction of Insulin Receptor Substrate-1 with the ς3A Subunit of the Adaptor Protein Complex-3 in Cultured Adipocytes*

M. Czech, R. Heller-Harrison, M. Morin, 1998, The Journal of Biological Chemistry.

Insulin Regulation of Membrane-associated Insulin Receptor Substrate 1 (*)

M. Czech, R. Heller-Harrison, M. Morin, 1995, The Journal of Biological Chemistry.

Intracellular trafficking of the GLUT4 glucose transporter

M. Czech, S. Corvera, 1996 .

Fat targets for insulin signaling.

M. Czech, 2002, Molecular cell.

Insulin stimulates a novel Mn2+-dependent cytosolic serine kinase in rat adipocytes.

M. Czech, K. Yu, N. Khalaf, 1987, The Journal of biological chemistry.

Sensitivity of the adipocyte D-glucose transport system to membrane fluidity in reconstituted vesicles.

M. Czech, D. Melchior, 1979, The Journal of biological chemistry.

Molecular biology of the insulin receptor

Robert E. Lewis, M. Czech, 1988 .

Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C.

M. Czech, D. Perregaux, R. Lewis, 1990, Biochemistry.

Multifunctional glycoprotein receptors for insulin and the insulin-like growth factors.

M. Czech, S. Corvera, R. Lewis, 1989, Ciba Foundation symposium.

Association of cytosolic Rab4 with GDI isoforms in insulin-sensitive 3T3-L1 adipocytes.

M. Czech, A. Shisheva, 1997, Biochemistry.

Tensions rise and blood flows over dysfunctional fat.

M. Czech, S. Corvera, 2011, Circulation.

The actions of insulin-like growth factors I and II on cultured Sertoli cells.

J. Massagué, M. Czech, P. Hall, 1984, Endocrinology.

Insulin stimulates a membrane-bound serine kinase that may be phosphorylated on tyrosine.

M. Czech, K. Yu, N. Khalaf, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Role of the Raf/Mitogen-activated Protein Kinase Pathway in p21ras Desensitization*

A. Cherniack, M. McMahon, M. Czech, 1996, The Journal of Biological Chemistry.

Macrophages dispose of catecholamines in adipose tissue

M. Czech, 2017, Nature Medicine.

Insulin Action on Membrane Components: The Glucose Transporter and the Type II Insulinlike Growth Factor Receptor

M. Czech, Y. Oka, Yoshitomo Oka, 1985 .

Insulin receptor kinase and its mode of signaling membrane components.

R. Davis, M. Czech, S. Corvera, 1985, Diabetes/metabolism reviews.

Affinity Labelling Techniques for Low-Abundance Membrane Components: Peptide Hormone Receptors and the D-Glucose Transporter

J. Massagué, M. Czech, J. Pessin, 1984 .

Partial purification of the D-glucose transport system in rat adipocyte plasma membranes.

M. Czech, M. Shanahan, M. F. Shanahan, 1977, The Journal of biological chemistry.

Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor

M. Czech, C. Carter-Su, P. Pilch, 1980 .

Purification and reconstitution of the adipocyte plasma membrane D-glucose transport system.

M. Czech, M. Shanahan, 1977, The Journal of biological chemistry.

Evidence for electron transfer reactions involved in the Cu2+ -dependent thiol activation of fat cell glucose utilization.

M. Czech, J. Lawrence, W. Lynn, 1974, The Journal of biological chemistry.

Retention of insulin-stimulated D-glucose transport activity by adipocyte plasma membranes following extraction of extrinsic proteins.

M. Czech, M. Shanahan, D. Pillion, 1978, Journal of supramolecular structure.

Evidence for the involvement of sulfhydryl oxidation in the regulation of fat cell hexose transport by insulin.

M. Czech, J. Lawrence, W. Lynn, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Antibodies against intrinsic adipocyte plasma membrane proteins activate D-glucose transport independent of interaction with insulin binding sites.

M. Czech, D. Pillion, 1978, The Journal of biological chemistry.

Differential effects of sulfhydryl reagents on activation and deactivation of the fat cell hexose transport system.

M. Czech, 1976, The Journal of biological chemistry.

Reconstituted D-glucose transport from the adipocyte plasma membrane. Chromatographic resolution of transport activity from membrane glycoproteins using immobilized concanavalin A.

M. Czech, C. Carter-Su, D. Pillion, 1980, Biochemistry.

Activation of hexose transport by concanavalin A in isolated brown fat cells. Effects of cell surface modification with neuraminidase and trypsin on lectin and insulin action.

M. Czech, J. Lawrence, W. Lynn, 1974, The Journal of biological chemistry.

Biological properties of antibodies against rat adipocyte intrinsic membrane proteins. Dependence on multivalency for insulin-like activity.

M. Czech, J. Grantham, D. Pillion, 1979, The Journal of biological chemistry.

Biochemical Studies of RT6 Alloantigens in BB/Wor and Normal Rats: Evidence for Intact Unexpressed RT6a Structural Gene in Diabetes-Prone BB Rats

M. Czech, D. Greiner, J. Mordes, 1990, Diabetes.

Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation.

J. Axelrod, M. Czech, P. Pilch, 1981, The Journal of biological chemistry.

The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium

Y. Ip, Lan Xu, M. Czech, 2019, Journal of cellular physiology.

Suppressed intrinsic catalytic activity of GLUT1 glucose transporters in insulin-sensitive 3T3-L1 adipocytes.

M. Czech, J. Buxton, S. Harrison, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

R. Davis, M. Czech, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate

M. Czech, J. Virbasius, G. Zhou, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and properties of GRP1, an ADP-ribosylation factor (ARF)-guanine nucleotide exchange protein regulated by phosphatidylinositol 3,4,5-trisphosphate.

M. Czech, J. Klarlund, 2001, Methods in enzymology.

Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate*

L. Cantley, L. Rameh, J. Holik, 1998, The Journal of Biological Chemistry.

src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase.

I. Pastan, M. Czech, K. Yu, 1985, The Journal of biological chemistry.

Characterization of (3H)cytochalasin B binding to the fat cell plasma membrane.

M. Czech, 1976, The Journal of biological chemistry.

The Cellular Function of Stearoyl-CoA Desaturase-2 in Development and Differentiation

J. Ntambi, M. Czech, Jennifer L. Cantley, 2013 .

4-23-2008 A Rictor-Myo 1 c complex participates in dynamic cortical actin events in 3 T 3-L 1 adipocytes

J. Avruch, G. Hagan, M. Czech, 2017 .

A Rictor-Myo 1 c Complex Participates in Dynamic Cortical Actin Events in 3 T 3L 1 Adipocytes ‡

J. Avruch, G. Hagan, M. Czech, 2017 .

A Rictor-Myo1c Complex Participates in Dynamic Cortical Actin Events in 3T3-L1 Adipocytes

J. Avruch, G. Hagan, M. Czech, 2008, Molecular and Cellular Biology.

Pericentriolar targeting of GDP-dissociation inhibitor isoform 2.

M. Czech, S. Doxsey, A. Shisheva, 1995, European journal of cell biology.

Multiple Redox Forms of the Insulin Receptor in Native Liver Membranes

J. Massagué, M. Czech, 1980, Diabetes.

Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice

Lawrence M. Lifshitz, Xianlin Han, R. Friedline, 2022, The Journal of biological chemistry.

Direct modulation of insulin-like growth factor-II receptor affinity by insulin action in adipocytes and H-35 hepatoma cells

J. Massagué, M. Czech, J. Pessin, 1982 .

The adipocyte supersystem of insulin and cAMP signaling.

M. Czech, A. Guilherme, Hui Wang, 2022, Trends in cell biology.

Evidence that erythroid-type glucose transporter intrinsic activity is modulated by cadmium treatment of mouse 3T3-L1 cells.

M. Czech, J. Buxton, S. Harrison, 1991, The Journal of biological chemistry.

Obesity Notches up fatty liver

M. Czech, 2013, Nature Medicine.

Production by plasma membranes of a chemical mediator of insulin action.

M. Czech, J. Seals, 1982, Federation proceedings.

The Rat T-Cell Surface Protein RT6 Is Associated With src Family Tyrosine Kinases and Generates an Activation Signal

M. Czech, J. Klarlund, D. Greiner, 1996, Diabetes.

Phosphorylation of Tyrosyl Residues 350/354 of the β-Adrenergic Receptor Is Obligatory for Counterregulatory Effects of Insulin (*)

M. Czech, C. Malbon, K. Baltensperger, 1995, The Journal of Biological Chemistry.

Insulin-like growth factor I and insulin rapidly increase casein kinase II activity in BALB/c 3T3 fibroblasts.

M. Czech, J. Klarlund, 1988, The Journal of biological chemistry.

Phox homology domains specifically bind phosphatidylinositol phosphates.

M. Czech, A. Zhang, J. Virbasius, 2001, Biochemistry.

Effects of General Receptor for Phosphoinositides 1 on Insulin and Insulin-Like Growth Factor I-Induced Cytoskeletal Rearrangement, Glucose Transporter-4 Translocation, and Deoxyribonucleic Acid Synthesis* * This work was supported by Grants J 01287-Med and J 1584-Med from the Erwin Schrödinger Sti

P. Vollenweider, J. Olefsky, M. Czech, 1998, Endocrinology.

Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells

M. Czech, B. Conway, D. Hartley, 1995, Molecular and cellular biology.

CHAPTER 4 – Mechanisms of Biological Signaling by the Insulin Receptor

J. Massagué, M. Czech, J. Seals, 1984 .

Cyclic AMP-dependent protein kinase inhibits the activity of myogenic helix-loop-helix proteins

E. Olson, M. Czech, R. Heller-Harrison, 1992, Molecular and cellular biology.

Evidence that functional erythrocyte-type glucose transporters are oligomers.

D. Hebert, M. Czech, J. Buxton, 1991, The Journal of biological chemistry.

Signaling Complexes of the FERM Domain-containing Protein GRSP1 Bound to ARF Exchange Factor GRP1*

J. Holik, A. Chawla, M. Czech, 2001, The Journal of Biological Chemistry.

Insulin action on activity and cell surface disposition of human HepG2 glucose transporters expressed in Chinese hamster ovary cells.

M. Czech, J. Buxton, S. Harrison, 1990, The Journal of biological chemistry.

Enhanced casein kinase II activity in COS-1 cells upon overexpression of either its catalytic or noncatalytic subunit.

M. Czech, R. Heller-Harrison, 1991, The Journal of biological chemistry.

Role of Protein Kinase C in Signal Attenuation following T Cell Receptor Engagement*

M. Czech, B. Fernández, H. Meisner, 1999, The Journal of Biological Chemistry.

Insulin action.

M. Czech, 1981, The American journal of medicine.

Phosphatidylinositol-3-Phosphate

M. Czech, J. Virbasius, 2004 .

ARNT misbehavin' in diabetic beta cells

M. Czech, 2006, Nature Medicine.

Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor.

A. Ross, M. Czech, K. Baltensperger, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The Insulinlike Growth Factor Receptors

M. Czech, Y. Oka, C. Mottola, 1986 .

The role of tyrosine phosphorylation in the regulation of insulin and insulin-like growth factor-I receptor kinase activities.

M. Czech, K. Yu, 1986, Advances in experimental medicine and biology.

Regulation of insulin receptor kinase by multisite phosphorylation.

M. Czech, J. Pessin, K. Yu, 1985, Biochimie.

Amiloride directly inhibits growth factor receptor tyrosine kinase activity.

R. Davis, M. Czech, 1985, The Journal of biological chemistry.

Tyrosine phosphorylation of insulin receptor beta subunit activates the receptor tyrosine kinase in intact H-35 hepatoma cells.

M. Czech, K. Yu, 1986, The Journal of biological chemistry.

beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.

M. Czech, Y. Oka, J. Pessin, 1983, The Journal of biological chemistry.

Role of disulfides in the subunit structure of the insulin receptor. Reduction of class I disulfides does not impair transmembrane signalling.

J. Massagué, M. Czech, 1982, The Journal of biological chemistry.

Purification of the adipocyte insulin receptor by immunoaffinity chromatography.

M. Czech, P. Pilch, J. Heinrich, 1980, The Journal of biological chemistry.

Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.

R. Davis, M. Czech, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Endothelial protein kinase MAP 4 K 4 promotes vascular inflammation and atherosclerosis Citation

L. Buckbinder, M. Czech, R. Flach, 2015 .

STRUCTURAL FEATURES OF THE INSULIN EFFECTOR SYSTEM: RELATION TO HEXOSE TRANSPORT ACTIVATION

J. Massagué, M. Czech, C. Carter-Su, 1980, Annals of the New York Academy of Sciences.

The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes.

R. Whitehead, M. Czech, S. Corvera, 1986, The Journal of biological chemistry.

Biosynthesis and processing of the type II insulin-like growth factor receptor in H-35 hepatoma cells.

M. Czech, R. Macdonald, 1985, The Journal of biological chemistry.

The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells.

M. Czech, C. Mottola, 1984, The Journal of biological chemistry.

Regulatory control of the epidermal growth factor receptor tyrosine kinase.

R. Davis, M. Czech, 1987, Haematology and blood transfusion.

Reconstitution of D-glucose transport activity from cytoplasmic membranes. Evidence against recruitment of cytoplasmic membrane transporters into the plasma membrane as the sole action of insulin.

M. Czech, C. Carter-Su, 1980, The Journal of biological chemistry.

Extracellular release as the major degradative pathway of the insulin-like growth factor II/mannose 6-phosphate receptor.

M. Czech, K. B. Clairmont, 1991, The Journal of biological chemistry.

Direct demonstration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process.

M. Czech, Y. Oka, L. Rozek, 1985, The Journal of biological chemistry.

The plasma membrane of isolated fat cells. I. Identification of trypsin-sensitive membrane peptides by sodium dodecyl sulfate polyacrylamide gel electrophoresis.

M. Czech, W. Lynn, 1973, The Journal of biological chemistry.

Mechanisms That Regulate Membrane Growth Factor Receptors

M. Czech, Y. Oka, J. Pessin, 1985 .

Characterization of a pyruvate dehydrogenase activator released by adipocyte plasma membranes in response to insulin.

M. Czech, J. Seals, 1981, The Journal of biological chemistry.

Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells. IGF-II receptors isolated from insulin-treated cells exhibit enhanced in vitro phosphorylation by casein kinase II.

A. Depaoli-Roach, P. Roach, M. Czech, 1988, The Journal of biological chemistry.

Structural requirements for diacylglycerols to mimic tumor-promoting phobol diester action on the epidermal growth factor receptor.

R. Davis, M. Czech, R. Bell, 1985, The Journal of biological chemistry.

Cytochalasin B-sensitive 2-deoxy-D-glucose transport in adipose cell ghosts.

M. Czech, D. Lynn, W. Lynn, 1973, The Journal of biological chemistry.

Chromatographic resolution of insulin receptor from insulin-sensitive D-glucose transporter of adipocyte plasma membranes.

M. Czech, C. Carter-Su, P. Pilch, 1981, Biochemistry.

A highly phosphorylated subpopulation of insulin-like growth factor II/mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction.

M. Czech, S. Corvera, K. B. Clairmont, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Purification and amino-terminal sequence of an insulin-like growth factor-binding protein secreted by rat liver BRL-3A cells.

M. Czech, R. Macdonald, J. Mole, 1986, The Journal of biological chemistry.

Mechanism of insulin action on membrane protein recycling: a selective decrease in the phosphorylation state of insulin-like growth factor II receptors in the cell surface membrane.

M. Czech, S. Corvera, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Purification of the type II insulin-like growth factor receptor from rat placenta.

M. Czech, C. Oppenheimer, 1983, The Journal of biological chemistry.

Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues.

J. Massagué, M. Czech, B. Guillette, 1981, The Journal of biological chemistry.

Regulation of transferrin receptor expression at the cell surface by insulin‐like growth factors, epidermal growth factor and platelet‐derived growth factor.

R. Davis, M. Czech, 1986, The EMBO journal.

Activation of protein kinases by insulin and non-hydrolyzable GTP analogs in permeabilized 3T3-L1 adipocytes.

M. Czech, J. Klarlund, L. Kozma, 1993, The Journal of biological chemistry.

Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.

R. Davis, M. Czech, G. Johnson, 1986, The Journal of biological chemistry.

Identiﬁcation of Map4k4 as a Novel Suppressor of Skeletal Muscle Differentiation

A. Chawla, M. Czech, Mengxi Wang, 2013 .

Parallel Decreases in the Expression of Receptors for Insulin and Insulin-like Growth Factor I in a Mutant Human Fibroblast Line

J. Massagué, J. Olefsky, M. Czech, 1983, Diabetes.

Cellular signaling by the insulin receptor.

M. Czech, K. Yu, J. Seals, 1984, Diabetes care.

Membrane receptors and cellular regulation

C. Kahn, M. Czech, 1984 .

PIP2 and PIP3 Complex Roles at the Cell Surface

M. Czech, M P Czech, 2000, Cell.

M. Czech, M. Peters, K. Yu, 1986, The Journal of biological chemistry.

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

J. Massagué, M. Czech, J Massagué, 1982, The Journal of biological chemistry.

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus

M. Czech, A. Guilherme, Felipe Henriques, 2019, Nature Reviews Endocrinology.

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

M. Czech, A. Guilherme, V. Puri, 2008, Nature Reviews Molecular Cell Biology.

Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.

D. Lambright, M. Czech, A. Guilherme, 2007, Molecular cell.

The nature and regulation of the insulin receptor: structure and function.

M. Czech, 1985, Annual review of physiology.

Studies on the topography of the fat cell plasma membrane.

M. Czech, W. Lynn, 1973, Biochemistry.

sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.

R. Davis, M. Czech, R. Bell, 1985, The Journal of biological chemistry.

MicroRNAs as therapeutic targets.

M. Czech, 2006, The New England journal of medicine.

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

Q. Boese, Qiong L. Zhou, M. Czech, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Chicken and Xenopus mannose 6-phosphate receptors fail to bind insulin-like growth factor II.

M. Czech, K. B. Clairmont, 1989, The Journal of biological chemistry.

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction.

M. Czech, S. Corvera, 1998, Trends in cell biology.

Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.

A. Cherniack, E. Kiskinis, M. Czech, 2005, The Journal of clinical investigation.

C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.

M. Mann, F. Gnad, L. Brill, 2011, Cell metabolism.

Insulin Receptor Tyrosine Kinase

M. Sleeman, M. Czech, Barbara Van Renterghem, 2011 .

EHD2 and the Novel EH Domain Binding Protein EHBP1 Couple Endocytosis to the Actin Cytoskeleton*

A. Bose, J. Holik, J. Leszyk, 2004, Journal of Biological Chemistry.

RNAi-based therapeutic strategies for metabolic disease

M. Czech, M. Aouadi, G. Tesz, 2011, Nature Reviews Endocrinology.

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

M. Czech, Mengxi Wang, M. Aouadi, 2009, Nature.

Mitochondrial Biogenesis and Remodeling during Adipogenesis and in Response to the Insulin Sensitizer Rosiglitazone

J. Leszyk, M. Czech, S. Corvera, 2003, Molecular and Cellular Biology.

Map4k4 Negatively Regulates Peroxisome Proliferator-activated Receptor (PPAR) γ Protein Translation by Suppressing the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Cultured Adipocytes*

Kalyani V. P. Guntur, A. Chawla, M. Czech, 2009, The Journal of Biological Chemistry.

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.

Kalyani V. P. Guntur, M. Czech, A. Guilherme, 2016, The Journal of clinical investigation.

Tumor Necrosis Factor-α Induces Caspase-mediated Cleavage of Peroxisome Proliferator-activated Receptor γ in Adipocytes*

Kalyani V. P. Guntur, M. Czech, A. Guilherme, 2009, The Journal of Biological Chemistry.

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

J. Holik, A. Chawla, M. Czech, 1997, Science.

The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.

Y. Ip, Lan Xu, S. Kaneko, 2014, Developmental cell.

Insulin signalling mechanisms for triacylglycerol storage

M. Czech, M. Aouadi, D. J. Pedersen, 2013, Diabetologia.

Coronin2A mediates actin-dependent de-repression of inflammatory response genes

C. Glass, M. Rosenfeld, W. Huang, 2011, Nature.

Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling[S]

Kalyani V. P. Guntur, M. Czech, A. Guilherme, 2013, Journal of Lipid Research.

Liver X Receptor α Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype

Alexander V. Medvedev, Yuan Zhang, Naresh Kumar, 2008, Molecular and Cellular Biology.

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

M. Lazar, J. Leszyk, M. Czech, 2004, The Journal of clinical investigation.

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia*

Marina T. DiStefano, M. Czech, Jason K. Kim, 2016, The Journal of Biological Chemistry.

Insulin's expanding control of forkheads

M. Czech, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The GLUT4 glucose transporter.

M. Czech, Shaohui Huang, 2007, Cell metabolism.

Mouse p170 Is a Novel Phosphatidylinositol 3-Kinase Containing a C2 Domain*

M. Czech, A. Guilherme, J. Virbasius, 1996, The Journal of Biological Chemistry.

Micromanaging insulin secretion

C. Mello, M. Czech, 2004, Nature Medicine.

A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation

M. Czech, H. Tissenbaum, G. Tesz, 2009, Cell.

Role of EHD1 and EHBP1 in Perinuclear Sorting and Insulin-regulated GLUT4 Recycling in 3T3-L1 Adipocytes*

M. Czech, A. Guilherme, Neil A Soriano, 2004, Journal of Biological Chemistry.

Serum form of the rat insulin-like growth factor II/mannose 6-phosphate receptor is truncated in the carboxyl-terminal domain.

M. Czech, K. B. Clairmont, R. Macdonald, 1989, The Journal of biological chemistry.

Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues

Jong Hun Kim, M. Czech, Jason K. Kim, 2015, Molecular and Cellular Biology.

PTEN, but Not SHIP2, Suppresses Insulin Signaling through the Phosphatidylinositol 3-Kinase/Akt Pathway in 3T3-L1 Adipocytes*

M. Czech, A. Guilherme, Xiaoqing Tang, 2005, Journal of Biological Chemistry.

Disassembly of Son-of-sevenless Proteins from Grb2 during p21 Desensitization by Insulin (*)

A. Cherniack, M. Czech, J. Klarlund, 1995, The Journal of Biological Chemistry.

Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle

T. Südhof, M. Czech, A. Shisheva, 1994, Molecular and cellular biology.

CRISPR-enhanced human adipocyte “browning” as cell therapy for metabolic disease

Lawrence M. Lifshitz, Tomás C. Rodríguez, R. Friedline, 2020, bioRxiv.

Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II.

M. Czech, H. Meisner, M. P. Czech, 1991, Current opinion in cell biology.

Perinuclear Localization and Insulin Responsiveness of GLUT4 Requires Cytoskeletal Integrity in 3T3-L1 Adipocytes*

J. Leszyk, M. Czech, M. Emoto, 2000, The Journal of Biological Chemistry.

Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.

R. Davis, M. Czech, 1984, The Journal of biological chemistry.

Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling.

J. Massagué, R. Bradshaw, M. Czech, 1981, The Journal of biological chemistry.

Divergent Mechanisms for Homologous Desensitization of p21ras by Insulin and Growth Factors (*)

A. Cherniack, M. Czech, J. Klarlund, 1995, The Journal of Biological Chemistry.

CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance.

R. Friedline, M. Czech, Mengxi Wang, 2013, American journal of physiology. Endocrinology and metabolism.

CD 40 Deficiency in Mice Exacerbates Obesity-induced Adipose 2 Tissue Inflammation , Hepatic Steatosis and Insulin Resistance

R. Friedline, M. Czech, Mengxi Wang, 2013 .

A single receptor binds both insulin-like growth factor II and mannose-6-phosphate.

A. Ullrich, L. Coussens, S. Pfeffer, 1988, Science.

Basic Mechanisms and Clinical Associations Epicardial and Perivascular Adipose Tissues and Their Influence on Cardiovascular Disease

M. Czech, T. Fitzgibbons, 2014 .

De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics

O. Ilkayeva, C. Newgard, M. Czech, 2023, Nature Communications.

Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor.

J. Massagué, M. Czech, G. Todaro, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Lipid droplets: FSP27 knockout enhances their sizzle.

M. Czech, V. Puri, 2008, The Journal of clinical investigation.

Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance

M. Czech, T. Fitzgibbons, 2016, Journal of Molecular Medicine.

Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.

Jessica L. Cohen, M. Czech, Shinya U. Amano, 2014, Cell metabolism.

Analysis of insulin signalling by RNAi-based gene silencing.

J. Holik, M. Czech, S. Semiz, 2004, Biochemical Society transactions.

Phospholipid environment alters hormone-sensitivity of the purified insulin receptor kinase.

M. Czech, R. Lewis, 1987, The Biochemical journal.

Cold-Induced Thermogenesis Increases Acetylation on the Brown Fat Proteome and Metabolome

D. Guertin, R. T. Lawrence, M. Czech, 2018, bioRxiv.

What causes the insulin resistance underlying obesity?

M. Czech, S. Corvera, O. Hardy, 2012, Current opinion in endocrinology, diabetes, and obesity.

Identification of the lipid droplet targeting domain of the Cidea protein[S]

A. Chawla, M. Czech, V. Puri, 2010, Journal of Lipid Research.

Distinct Polyphosphoinositide Binding Selectivities for Pleckstrin Homology Domains of GRP1-like Proteins Based on DiglycineVersus Triglycine Motifs*

J. Holik, A. Chawla, M. Czech, 2000, The Journal of Biological Chemistry.

Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity.

Karen Gallagher-Dorval, M. Czech, R. Perugini, 2011, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

L. Buckbinder, M. Czech, M. Aouadi, 2015, Nature Communications.

RNAi-based gene silencing in primary mouse and human adipose tissues Published, JLR Papers in Press, November 8, 2006.

G. Hagan, M. Czech, R. Perugini, 2007, Journal of Lipid Research.

Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes.

M. Czech, P. Pilch, M P Czech, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.

M. Czech, R. Heller-Harrison, H. Meisner, 1989, Biochemistry.

Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells1

M. Czech, D. Greiner, J. Mordes, 2004, The Journal of Immunology.

Interrelationships among receptor structures for insulin and peptide growth factors.

J. Massagué, M. Czech, C. Oppenheimer, 1983, Federation proceedings.

The β-Adrenergic Receptor Is a Substrate for the Insulin Receptor Tyrosine Kinase (*)

H Paul, M. Czech, C. Malbon, 1996, The Journal of Biological Chemistry.

Resistance to diet induced obesity in the apolipoprotein E deficient mouse is associated with an attenuated transcriptional response in visceral fat

M. Czech, Jason K. Kim, T. Fitzgibbons, 2018, bioRxiv.

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

E. Olson, M. Czech, R. Heller-Harrison, 1992, Cell.

Identification of WNK1 as a Substrate of Akt/Protein Kinase B and a Negative Regulator of Insulin-stimulated Mitogenesis in 3T3-L1 Cells*

J. Holik, Qiong L. Zhou, J. Leszyk, 2005, Journal of Biological Chemistry.

Affinity labeling of a nerve growth factor receptor component on rat pheochromocytoma (PC12) cells.

J. Massagué, M. Czech, G. Johnson, 1982, Biochimica et biophysica acta.

Molecular cloning of the human casein kinase II alpha subunit.

M. Czech, J. Buxton, R. Heller-Harrison, 1989, Biochemistry.

Phosphatidylinositol-4,5-Bisphosphate-Rich Plasma Membrane Patches Organize Active Zones of Endocytosis and Ruffling in Cultured Adipocytes

Lawrence M. Lifshitz, M. Czech, K. Fogarty, 2004, Molecular and Cellular Biology.

Cidea is associated with lipid droplets and insulin sensitivity in humans

A. Chawla, M. Czech, R. Perugini, 2008, Proceedings of the National Academy of Sciences.

A 115 kDa Tyrosine Phosphorylated Protein Associates with Grb‐2 in Activated Jurkat Cells a

M. Czech, H. Meisner, 1995, Annals of the New York Academy of Sciences.

Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase.

M. Czech, R. Macdonald, G. Wu, 1990, The Journal of biological chemistry.

Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains

D. Lambright, M. Czech, T. Cronin, 2004, The EMBO journal.

Gα11 Signaling through ARF6 Regulates F-Actin Mobilization and GLUT4 Glucose Transporter Translocation to the Plasma Membrane

A. Cherniack, J. G. Park, A. Bose, 2001, Molecular and Cellular Biology.

Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism

W. Hsueh, M. Czech, Joey Liu, 2019, The Journal of Immunology.

Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans

M. Schulze, H. Grallert, N. Stefan, 2012, PloS one.

Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development

U. Banerjee, A. Chawla, M. Czech, 1997, Molecular and cellular biology.

A Novel Pleckstrin Homology Domain-containing Protein Enhances Insulin-stimulated Akt Phosphorylation and GLUT4 Translocation in Adipocytes

D. Lambright, J. Holik, Qiong L. Zhou, 2010, The Journal of Biological Chemistry.

M. Czech, M. Aouadi, J. Straubhaar, 2011, American journal of physiology. Heart and circulatory physiology.

P. Vollenweider, J. Olefsky, M. Czech, 1998, Endocrinology.

Epicardial and Perivascular Adipose Tissues and Their Influence on Cardiovascular Disease: Basic Mechanisms and Clinical Associations

M. Czech, T. Fitzgibbons, 2014, Journal of the American Heart Association.

Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA.

Jessica L. Cohen, M. Czech, Shinya U. Amano, 2016, Molecular pharmaceutics.

Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains.

S. Lietzke, D. Lambright, A. Chawla, 2000, Molecular cell.

Hexose transport in isolated brown fat cells. A model system for investigating insulin action on membrane transport.

M. Czech, J. Lawrence, W. Lynn, 1974, The Journal of biological chemistry.

Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia

J. Seidman, S. Aranki, S. Body, 2017, Cardiovascular Diabetology.

RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27

M. Czech, A. Guilherme, V. Puri, 2007, Acta physiologica.

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC

S. O’Rahilly, V. Saudek, P. Murgatroyd, 2009, EMBO molecular medicine.

Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat

M. Czech, T. Fitzgibbons, Sarah M. Nicoloro, 2019, JCI insight.

Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice

Lawrence M. Lifshitz, Xianlin Han, R. Friedline, 2022, bioRxiv.

Macrophage ROBOcalls rattle adipose nerves

M. Czech, 2021, Nature Metabolism.

Dicer is required for the formation of white but not brown adipose tissue

M. Czech, A. Imbalzano, V. Puri, 2011, Journal of cellular physiology.

The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand.

M. Czech, Y. Oka, 1986, The Journal of biological chemistry.

Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes.

M. Czech, A. Shisheva, J. Buxton, 1994, The Journal of biological chemistry.

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program

O. Ilkayeva, C. Newgard, M. Czech, 2023, Cell reports.

Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter.

M. Czech, J. Buxton, S. Harrison, 1990, The Journal of biological chemistry.

Stimulation of epidermal growth factor receptor threonine 654 phosphorylation by platelet-derived growth factor in protein kinase C-deficient human fibroblasts.

R. Davis, M. Czech, 1987, The Journal of biological chemistry.

The Protein-tyrosine Kinase Fer Associates with Signaling Complexes Containing Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase*

A. Cherniack, M. Czech, M. Iwanishi, 2000, The Journal of Biological Chemistry.

Stearoyl-CoA Desaturase 2 Is Required for Peroxisome Proliferator-activated Receptor γ Expression and Adipogenesis in Cultured 3T3-L1 Cells*

M. Czech, J. Straubhaar, Sarah M. Nicoloro, 2008, Journal of Biological Chemistry.

NETs and traps delay wound healing in diabetes

M. Czech, R. Flach, 2015, Trends in Endocrinology & Metabolism.

ACTIVATION OF MULTIPLE SERINE KINASES

Robert E. Lewis, M. Czech, A. Bradford, 1988 .

Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice

A. Khvorova, M. Czech, Jason K. Kim, 2023, bioRxiv.

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

Lawrence M. Lifshitz, A. Khvorova, M. Czech, 2023, bioRxiv.

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance☆

Marina T. DiStefano, M. Wabitsch, M. Czech, 2016, Molecular metabolism.

Crystal Structure of the C2 Domain of Class II Phosphatidylinositide 3-Kinase C2α*

H. Bellamy, Lijun Liu, K. Miki, 2005, Journal of Biological Chemistry.

Adipocyte Insulin-Mediated Glucose Transport: The Role of Myosin 1c, and a Method for in vivo Investigation: A Dissertation

G. Hagan, M. Czech, Yong-Xu Wang, 2008 .

Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues

M. Czech, Jason K. Kim, J. Virbasius, 2015, Molecular and Cellular Biology.

Photoaffinity labeling of the stereospecific D-glucose transport system with cytochalasin B.

K. Isselbacher, M. Czech, J. Pessin, 1984, Federation proceedings.

The relationship of microvesicles to the plasmalemma of rat adipocytes.

M. Czech, Y. Oka, J. Pessin, 1983, European journal of cell biology.

Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis.

A. Ullrich, C. Bréchot, M. Czech, 1988, Cancer research.

Insulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface.

M. Czech, Y. Oka, C. Mottola, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Primary role of decreased fatty acid synthesis in insulin resistance of large rat adipocytes.

M. Czech, D. Richardson, M. Czech, 1978, The American journal of physiology.

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion

Marina T. DiStefano, A. Chawla, M. Czech, 2016 .

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.

M. Czech, D. Greiner, J. Mordes, 2009, Cellular immunology.

Control of Adipocyte Thermogenesis and Lipogenesis through Control of Adipocyte Thermogenesis and Lipogenesis through beta3-Adrenergic and Thyroid Hormone Signal Integration beta3-Adrenergic and Thyroid Hormone Signal Integration

M. Czech, A. Guilherme, Sarah M. Nicoloro, 2022 .

Purification of a novel insulin-stimulated protein kinase from rat liver.

M. Czech, A. Bradford, J. Klarlund, 1990, The Journal of biological chemistry.

plasma membrane plasma membrane patches organize active zones of endocytosis and ruffling in patches organize active zones of endocytosis and ruffling in cultured adipocytes cultured adipocytes

M. Czech, R. Tuft, Varsha Patki-Kamath, 2022 .

Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming

Lawrence M. Lifshitz, R. Friedline, S. Wolfe, 2023, Molecular metabolism.

Phosphatidylinositol-4,5-bisphosphate-rich Plasma Membrane Patches Organize Active Zones of Endocytosis and Ruffling in Cultured Adipocytes Repository Citation

Lawrence M. Lifshitz, M. Czech, K. Fogarty, 2022 .

Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.

Jessica L. Cohen, M. Czech, Shinya U. Amano, 2014, Cell metabolism.

Paradoxical Effect of Mitochondrial Respiratory Chain Impairment on Insulin Signaling and Glucose Transport in Adipose Cells*

M. Czech, S. Corvera, Xiarong Shi, 2008, Journal of Biological Chemistry.

A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal [published erratum appears in J Cell Biol 1994 Sep;126(6):1625]

A. Chawla, M. Czech, J. Buxton, 1994, The Journal of cell biology.

M. Czech, M. Aouadi, J. Straubhaar, 2011, American journal of physiology. Heart and circulatory physiology.

Endothelial protein kinase MAP4K4 promotes vascular Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis inflammation and atherosclerosis Let us know how access to this document benefits you.

S. Bhattacharya, L. Buckbinder, M. Czech, 2022 .

Depot-Specific Differences and Insufficient Subcutaneous Adipose Tissue Angiogenesis in Human Obesity

M. Czech, R. Perugini, S. Corvera, 2011, Circulation.

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes

M. Czech, Yuefei Shen, G. Godlewski, 2017, Diabetes.

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

J. Varga, M. Czech, P. Scherer, 2014, Nature Communications.

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

M. Czech, Mengxi Wang, M. Aouadi, 2009, Nature.

MAP4K4 impairs energy metabolism in endothelial cells and MAP4K4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity promotes insulin resistance in obesity Let us know how access to this document benefits you.

Marina T. DiStefano, M. Czech, R. Flach, 2022 .

C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.

M. Mann, L. Brill, S. Tatulian, 2011, Cell metabolism.

CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

Lawrence M. Lifshitz, S. Wolfe, E. Sontheimer, 2021, Nature Communications.

BLUNTED MUSCLE RESPONSIVENESS TO INSULIN IN THE NEONATAL RAT.: 842

W. Oh, M. Czech, J. Susa, 1980 .

Voices: Insulin and beyond.

F. Ashcroft, J. Holst, R. Bergman, 2021, Cell metabolism.

Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes[S]

A. Chawla, M. Czech, A. Greenberg, 2011, Journal of Lipid Research.

Identification of Map4k4 as a Novel Suppressor of Skeletal Muscle Differentiation Repository Citation Identification of Map4k4 as a Novel Suppressor of Skeletal Muscle Differentiation Rights and Permissions Differentiation Suppressor of Skeletal Muscle Identification of Map4k4 as a Novel

A. Chawla, M. Czech, R. Flach, 2022 .

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

Lawrence M. Lifshitz, A. Khvorova, M. Czech, 2024, eLife.