W. V. van Blitterswijk

发表

Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects.

M. Verheij, W. V. van Blitterswijk, 2008, Current pharmaceutical design.

Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy.

J. Schellens, M. Verheij, W. V. van Blitterswijk, 2007, Cancer treatment reviews.

Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport*

R. Dwek, W. V. van Blitterswijk, F. Platt, 2004, Journal of Biological Chemistry.

Protein Kinase Cζ Is a Negative Regulator of Protein Kinase B Activity*

W. V. van Blitterswijk, A. Verkleij, P. V. B. E. en Henegouwen, 1999, The Journal of Biological Chemistry.

Effect of dietary lipids on plasma lipoproteins and fluidity of lymphoid cell membranes in normal and leukemic mice.

W. V. van Blitterswijk, J. Damen, J. de Widt, 1988, Biochimica et biophysica acta.

Alterations in biosynthesis and homeostasis of cholesterol and in lipoprotein patterns in mice bearing a transplanted lymphoid tumor.

W. V. van Blitterswijk, J. Damen, J. de Widt, 1985, Biochimica et biophysica acta.

Accumulation of HDL-like lipoproteins in the plasma low-density fractions of tumor-bearing mice.

W. V. van Blitterswijk, J. Damen, T. Hengeveld, 1985, Biochimica et biophysica acta.

Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: Biochemical rationale and case report

J. C. van de Nes, W. V. van Blitterswijk, P. Wuisman, 2003, BMC complementary and alternative medicine.

Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones.

W. V. van Blitterswijk, J. D. de Vries, H. Spits, 1984, Journal of immunological methods.

The Retinoblastoma Family Proteins Bind to and Activate Diacylglycerol Kinaseζ*

M. Topham, N. Divecha, W. V. van Blitterswijk, 2006, Journal of Biological Chemistry.

Protein kinase C activation by acidic proteins including 14-3-3.

W. V. van Blitterswijk, W. J. Blitterswijk, P. van der Hoeven, 2000, The Biochemical journal.

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis.

H. Bartelink, A. Haimovitz-Friedman, S. Zerp, 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.

S. Zerp, M. Verheij, David R. Jones, 2011, The Biochemical journal.

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin.

K. Jalink, W. V. van Blitterswijk, W. Moolenaar, 1992, The Biochemical journal.

Metabolic conversion of the biologically active phospholipid, lysophosphatidic acid, in fibroblasts.

W. V. van Blitterswijk, W. Moolenaar, J. de Widt, 1992, Biochimica et biophysica acta.

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin.

W. V. van Blitterswijk, W. Moolenaar, J. de Widt, 1992, The Biochemical journal.

Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis.

G. A. van der Marel, K. Jalink, W. V. van Blitterswijk, 1995, The Biochemical journal.

Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency.

M. Verheij, W. V. van Blitterswijk, A. H. van der Luit, 2009, The Biochemical journal.

Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts

J. Schellens, A. Begg, M. Verheij, 2006, Clinical Cancer Research.

Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts.

S. Zerp, M. Verheij, W. V. van Blitterswijk, 2007, The Biochemical journal.

Phospholipid metabolism in bradykinin-stimulated human fibroblasts. II. Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C.

W. V. van Blitterswijk, J. de Widt, H. Hilkmann, 1991, The Journal of biological chemistry.

Diacylglycerol Kinase θ Binds to and Is Negatively Regulated by Active RhoA*

W. V. van Blitterswijk, O. Kranenburg, W. Moolenaar, 1999, The Journal of Biological Chemistry.

Is there a role for diacylglycerol kinase-zeta in cell cycle regulation?

N. Divecha, W. V. van Blitterswijk, A. Los, 2008, Advances in enzyme regulation.

Radiation-induced apoptosis--the ceramide-SAPK signaling pathway and clinical aspects.

H. Bartelink, M. Verheij, W. V. van Blitterswijk, 1998, Acta oncologica.

New physiological functions for drug-transporting P-glycoproteins?

P. Borst, W. V. van Blitterswijk, J. Borst, 1998, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

The role of ceramide in apoptosis

W. V. van Blitterswijk, J. Borst, E. de Vries, 2000 .

N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx

S. Zerp, M. Verheij, W. V. van Blitterswijk, 2004, British Journal of Cancer.

Differences in membrane lipid composition and fluidity of transplanted GRSL lymphoma cells, depending on their site of growth in the mouse.

W. V. van Blitterswijk, T. Hengeveld, H. Hilkmann, 1984, Biochimica et biophysica acta.

SAP-Mediated Inhibition of Diacylglycerol Kinase α Regulates TCR-Induced Diacylglycerol Signaling

K. Nichols, X. Zhong, W. V. van Blitterswijk, 2011, The Journal of Immunology.

Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase.

W. V. van Blitterswijk, G. Baldanzi, A. Graziani, 2005, Blood.

Diacylglycerol kinase in receptor-stimulated cells converts its substrate in a topologically restricted manner.

W. V. van Blitterswijk, J. de Widt, H. Hilkmann, 1994, The Journal of biological chemistry.

A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

E. Solary, M. Verheij, W. V. van Blitterswijk, 2007, Molecular Cancer Therapeutics.

Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein.

M. Topham, N. Divecha, W. V. van Blitterswijk, 2007, Biochimica et biophysica acta.

Quantitative contributions of cholesterol and the individual classes of phospholipids and their degree of fatty acyl (un)saturation to membrane fluidity measured by fluorescence polarization.

W. V. van Blitterswijk, B. W. van der Meer, H. Hilkmann, 1987, Biochemistry.

Lysophosphatidic acid: a novel phospholipid with hormone- and growth factor-like activities.

K. Jalink, W. V. van Blitterswijk, W. Moolenaar, 1992, Cold Spring Harbor symposia on quantitative biology.

1-O-hexadecyl-2-Q-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophils.

W. V. van Blitterswijk, I. Kramer, D. Roos, 1989, The Journal of biological chemistry.

Sphingomyelin Hydrolysis to Ceramide during the Execution Phase of Apoptosis Results from Phospholipid Scrambling and Alters Cell-Surface Morphology

W. V. van Blitterswijk, J. Borst, P. Sims, 2000, The Journal of cell biology.

Immunologic, virologic, and genetic aspects of mammary tumor virus-induced cell-surface antigens: presence of these antigens and the Thy 1.2 antigen on murine mammary gland and tumor cells.

R. Nusse, W. V. van Blitterswijk, J. Calafat, 1975, Journal of the National Cancer Institute.

Ceramide: second messenger or modulator of membrane structure and dynamics?

M. Verheij, W. V. van Blitterswijk, J. Borst, 2003, The Biochemical journal.

Alkyl-lysophospholipid Accumulates in Lipid Rafts and Induces Apoptosis via Raft-dependent Endocytosis and Inhibition of Phosphatidylcholine Synthesis*

M. Verheij, W. V. van Blitterswijk, A. H. van der Luit, 2002, The Journal of Biological Chemistry.

Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis.

W. V. van Blitterswijk, J. Borst, A. Tepper, 2001, Biochemical and biophysical research communications.

Glucosylceramide Synthase Does Not Attenuate the Ceramide Pool Accumulating during Apoptosis Induced by CD95 or Anti-cancer Regimens*

W. V. van Blitterswijk, J. Borst, A. Tepper, 2000, The Journal of Biological Chemistry.

Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.

M. Verheij, W. V. van Blitterswijk, S. Vink, 2007, Biochemical pharmacology.

Involvement of Phosphatidylcholine-specific Phospholipase C in Platelet-derived Growth Factor-induced Activation of the Mitogen-activated Protein Kinase Pathway in Rat-1 Fibroblasts*

W. V. van Blitterswijk, J. de Widt, H. Hilkmann, 1997, The Journal of Biological Chemistry.

Alterations in plasma lipoproteins and heparin-releasable lipase activities in mice bearing the GRSL ascites tumor.

W. V. van Blitterswijk, J. Damen, J. van Ramshorst, 1984, Biochimica et biophysica acta.

Ceramide mass analysis by normal-phase high-performance liquid chromatography.

W. V. van Blitterswijk, A. Tepper, 2000, Methods in enzymology.

Isolation of plasma membranes from rat and mouse livers and hepatomas.

W. V. van Blitterswijk, C. J. Bos, P. Emmelot, 1974, Methods in enzymology.

Lipid structural order parameters (reciprocal of fluidity) in biomembranes derived from steady-state fluorescence polarization measurements.

W. V. van Blitterswijk, B. W. van der Meer, R. P. van Hoeven, 1981, Biochimica et biophysica acta.

Differences in lipid fluidity among isolated plasma membranes of normal and leukemic lympocytes and membranes exfoliated from their cell surface.

W. V. van Blitterswijk, P. Emmelot, W. J. Blitterswijk, 1977, Biochimica et biophysica acta.

Changes in membrane lipid composition of human erythrocytes after dietary supplementation of (n-3) polyunsaturated fatty acids. Maintenance of membrane fluidity.

W. V. van Blitterswijk, C. Popp‐Snijders, J. Schouten, 1986, Biochimica et biophysica acta.

Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro.

W. V. van Blitterswijk, F. Bussolino, G. Baldanzi, 2004, Oncogene.

Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-zeta.

W. V. van Blitterswijk, W. Moolenaar, W. J. Blitterswijk, 1997, The Biochemical journal.

Quantitation of virus-induced (MLr) and normal (Thy.1.2) cell surface antigens in isolated plasma membranes and the extracellular ascites fluid of mouse leukemia cells.

R. Nusse, W. V. van Blitterswijk, P. Emmelot, 1975, Cancer research.

Comparative lipid analysis of purified plasma membranes and shed extracellular membrane vesicles from normal murine thymocytes and leukemic GRSL cells.

W. V. van Blitterswijk, P. Emmelot, J. Krol, 1982, Biochimica et biophysica acta.

Studies on plasma membranes: XIX. Isolation and characterization of a plasma membrane fraction from calf thymocytes

W. V. van Blitterswijk, P. Emmelot, W. J. Blitterswijk, 1973 .

Effect on glutaraldehyde fixation on lectin-mediated agglutination of mouse leukaemia cells.

W. V. van Blitterswijk, P. Emmelot, E. Walborg, 1976, Journal of cell science.

Catalytic hydrogenation of fatty acyl chains in plasma membranes; effect on membrane lipid fluidity and expression of cell surface antigens.

W. V. van Blitterswijk, H. Hilkmann, S. Benkö, 1987, Biochimica et biophysica acta.

Properties and functions of diacylglycerol kinases.

W. V. van Blitterswijk, B. Houssa, Wim J van Blitterswijk, 2000, Cellular signalling.

Diacylglycerol kinases in signal transduction.

W. V. van Blitterswijk, B. Houssa, 1999, Chemistry and physics of lipids.

Antiinvasive effect of racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine on MO4 mouse fibrosarcoma cells in vitro.

M. Mareel, G. Storme, W. V. van Blitterswijk, 1985, Cancer research.

Changes in concanavalin A-mediated agglutination of hormone-dependent mouse mammary tumour cells during serial transplantation.

W. V. van Blitterswijk, M. A. van der Valk, M. Sluyser, 1980, British Journal of Cancer.

Fluorescence polarization measurements on normal and tumour cells and their corresponding plasma membranes.

W. V. van Blitterswijk, P. Emmelot, R. P. van Hoeven, 1979, Biochimica et biophysica acta.

Anticancer mechanisms and clinical application of alkylphospholipids.

M. Verheij, W. V. van Blitterswijk, 2013, Biochimica et biophysica acta.

Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase–Akt/PKB survival pathway

H. Bartelink, S. Zerp, M. Verheij, 2003, Anti-cancer drugs.

CD95 (Fas/APO-1) Induces Ceramide Formation and Apoptosis in the Absence of a Functional Acid Sphingomyelinase*

W. V. van Blitterswijk, J. Borst, E. de Vries, 1998, The Journal of Biological Chemistry.

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis.

W. V. van Blitterswijk, J. Borst, E. de Vries, 1999, The Journal of clinical investigation.

Src‐mediated activation of α‐diacylglycerol kinase is required for hepatocyte growth factor‐induced cell motility

P. Comoglio, W. V. van Blitterswijk, E. Giraudo, 2000, The EMBO journal.

Submicromolar doses of alkyl‐lysophospholipids induce rapid internalization, but not activation, of epidermal growth factor receptor and concomitant MAPK/ERK activation in A431 cells

S. Zerp, M. Verheij, W. V. van Blitterswijk, 2002, International journal of cancer.

Distribution and antibody-induced redistribution of a mammary tumor virus-induced and a normal antigen on the surface of mouse leukemia cells.

R. Nusse, W. V. van Blitterswijk, P. Emmelot, 1975, Journal of the National Cancer Institute.

Rigid plasma‐membrane‐derived vesicles, enriched in tumour‐associated surface antigens (MLr), occurring in the ascites fluid of a murine leukaemia (GRSL)

W. V. van Blitterswijk, P. Emmelot, W. J. Blitterswijk, 1979, International journal of cancer.

Chronic Disease Among the Indigenous Population of Central Australia

W. V. van Blitterswijk, P. J. van der Sluis, P. Emmelot, 2006, Preventing chronic disease.

Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine.

M. Verheij, W. V. van Blitterswijk, A. H. van der Luit, 2003, The Biochemical journal.

The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

K. Wirtz, B. Roelofsen, P. Borst, 1994, FEBS letters.

Cloning of a Novel Human Diacylglycerol Kinase (DGKθ) Containing Three Cysteine-rich Domains, a Proline-rich Region, and a Pleckstrin Homology Domain with an Overlapping Ras-associating Domain*

T. Takenawa, K. Goto, W. V. van Blitterswijk, 1997, The Journal of Biological Chemistry.

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

C. Marshall, W. V. van Blitterswijk, L. R. Howe, 1993, The Journal of biological chemistry.

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.

H. Bartelink, Dajun Yang, S. Zerp, 2009, Radiation oncology.

Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.

H. Bartelink, S. Zerp, M. Verheij, 1999, Cancer research.

Coformulated N-Octanoyl-glucosylceramide Improves Cellular Delivery and Cytotoxicity of Liposomal Doxorubicin

Gert Storm, S. Zerp, M. Verheij, 2005, Journal of Pharmacology and Experimental Therapeutics.

Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids.

C. Limatola, W. V. van Blitterswijk, W. Moolenaar, 1994, The Biochemical journal.

Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance

S. Marrink, J. Jonkers, M. Verheij, 2013, Scientific Reports.

Improving Intracellular Doxorubicin Delivery Through Nanoliposomes Equipped with Selective Tumor Cell Membrane Permeabilizing Short-Chain Sphingolipids

W. V. van Cappellen, A. Eggermont, M. Verheij, 2013, Pharmaceutical Research.

Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.

S. Zerp, M. Verheij, W. V. van Blitterswijk, 2001, International journal of radiation oncology, biology, physics.

Translocation of Diacylglycerol Kinase θ from Cytosol to Plasma Membrane in Response to Activation of G Protein-coupled Receptors and Protein Kinase C*

N. Divecha, W. V. van Blitterswijk, Nullin Divecha, 2005, Journal of Biological Chemistry.

Diacylglycerol kinase theta is translocated and phosphoinositide 3-kinase-dependently activated by noradrenaline but not angiotensin II in intact small arteries.

W. V. van Blitterswijk, J. Ohanian, V. Ohanian, 2001, The Biochemical journal.

Phospholipid metabolism in bradykinin-stimulated human fibroblasts. I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C.

W. V. van Blitterswijk, J. de Widt, H. Hilkmann, 1991, The Journal of biological chemistry.

Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.

H. Ploegh, W. V. van Blitterswijk, D. Schaap, 1993, The Biochemical journal.

Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.

N. Divecha, W. V. van Blitterswijk, J. de Widt, 2012, The international journal of biochemistry & cell biology.

Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.

W. V. van Blitterswijk, G. Baldanzi, N. Filigheddu, 2007, Molecular biology of the cell.

Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1.

W. V. van Blitterswijk, H. Hilkmann, M. V. van Dijk, 1997, The Biochemical journal.

Steady-state fluorescence polarization data in membranes. Resolution into physical parameters by an extended Perrin equation for restricted rotation of fluorophores.

W. V. van Blitterswijk, B. W. van der Meer, R. P. van Hoeven, 1986, Biochimica et biophysica acta.

Membrane organization determines barrier properties of endothelial cells and short-chain sphingolipid-facilitated doxorubicin influx.

M. Verheij, G. Koning, W. V. van Blitterswijk, 2014, Biochimica et biophysica acta.

On the lipid fluidity of malignant lymphoid cell membranes.

W. V. van Blitterswijk, P. Emmelot, R. P. van Hoeven, 1981, Cancer research.

Structure-activity relationship of diacylglycerol kinase theta.

N. Divecha, W. V. van Blitterswijk, A. Los, 2004, Biochimica et Biophysica Acta.

Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents

H. Bartelink, D. de Jong, S. Zerp, 2008, Anti-cancer drugs.

Common Regulation of Apoptosis Signaling Induced by CD95 and the DNA-damaging Stimuli Etoposide and γ-Radiation Downstream from Caspase-8 Activation*

W. V. van Blitterswijk, J. Borst, E. de Vries, 1999, The Journal of Biological Chemistry.

Sphingomyelin Hydrolysis to Ceramide during the Execution Phase of Apoptosis Results from Phospholipid Scrambling and Alters Cell-Surface Morphology

W. V. van Blitterswijk, J. Borst, P. Sims, 2000, The Journal of cell biology.

Glucosylceramide Synthase Does Not Attenuate the Ceramide Pool Accumulating during Apoptosis Induced by CD95 or Anti-cancer Regimens*

W. V. van Blitterswijk, J. Borst, A. Tepper, 2000, The Journal of Biological Chemistry.

CD95 (Fas/APO-1) Induces Ceramide Formation and Apoptosis in the Absence of a Functional Acid Sphingomyelinase*

W. V. van Blitterswijk, J. Borst, E. de Vries, 1998, The Journal of Biological Chemistry.

CD95/Fas-induced Ceramide Formation Proceeds with Slow Kinetics and Is Not Blocked by Caspase-3/CPP32 Inhibition*

W. V. van Blitterswijk, J. Borst, E. de Vries, 1997, The Journal of Biological Chemistry.

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

H. Bartelink, Dajun Yang, S. Zerp, 2009, Radiation oncology.

Consensus sequences for ATP-binding sites in protein kinases do not apply to diacylglycerol kinases.

W. V. van Blitterswijk, D. Schaap, J. van der Wal, 1994, The Biochemical journal.

Bmc Complementary and Alternative Medicine Glucosamine and Chondroitin Sulfate Supplementation to Treat Symptomatic Disc Degeneration: Biochemical Rationale and Case Report

W. V. van Blitterswijk, P. Wuisman, Jos Cm Van De Nes, 2003 .