F. Han

发表

Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia

K. Fukunaga, N. Shioda, S. Moriguchi, 2007, Neuroscience.

Constitutively active calcineurin mediates delayed neuronal death through Fas‐ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia

K. Fukunaga, N. Shioda, S. Moriguchi, 2007, Journal of neurochemistry.

Functional Genomic Analyses Identify Pathways Dysregulated in Animal Model of Autism

K. Fukunaga, Huan Wang, Haibo Wang, 2016, CNS neuroscience & therapeutics.

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.

Yuqiang Ding, Z. Qin, Jun-chao Wu, 2019, Free radical biology & medicine.

Regulation of the ischemia‐induced autophagy–lysosome processes by nitrosative stress in endothelial cells

K. Fukunaga, Z. Qin, F. Han, 2011, Journal of pineal research.

Melatonin: the Weapon Against Oxidative Stress and Nitrosative Stress in Neurovascular Diseases

F. Han, Ji-yun Huang, Rong-rong Tao, 2012 .

Vascular endothelial σ1-receptor stimulation with SA4503 rescues aortic relaxation via Akt/eNOS signaling in ovariectomized rats with aortic banding.

K. Fukunaga, F. Han, H. Tagashira, 2013, Circulation journal : official journal of the Japanese Circulation Society.

Endogenous Polysialic Acid Based Micelles for Calmodulin Antagonist Delivery against Vascular Dementia.

K. Fukunaga, F. Han, Yongzhong Du, 2016, ACS applied materials & interfaces.

The γ‐Secretase Blocker DAPT Reduces the Permeability of the Blood–Brain Barrier by Decreasing the Ubiquitination and Degradation of Occludin During Permanent Brain Ischemia

K. Fukunaga, Y. Lou, F. Han, 2013, CNS neuroscience & therapeutics.

The vanadium (IV) compound rescues septo-hippocampal cholinergic neurons from neurodegeneration in olfactory bulbectomized mice

Z. Qin, N. Shioda, S. Moriguchi, 2008, Neuroscience.

Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

F. Han, Mei-hua Liao, Ying-Mei Lu, 2019, Scientific Reports.

Nitration of TRPM2 as a Molecular Switch Induces Autophagy During Brain Pericyte Injury.

Yan Wu, F. Han, Jianhong Luo, 2017, Antioxidants & redox signaling.

BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination

Chen Li, K. Fukunaga, Takuya Sasaki, 2022, Signal Transduction and Targeted Therapy.

Atg5 deficit exaggerates the lysosome formation and cathepsin B activation in mice brain after lipid nanoparticles injection.

K. Fukunaga, Huan Wang, F. Han, 2014, Nanomedicine : nanotechnology, biology, and medicine.

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

K. Fukunaga, F. Han, Sen Long, 2022, Signal Transduction and Targeted Therapy.

Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo.

K. Fukunaga, Huan Wang, Y. Lou, 2014, Antioxidants & redox signaling.

Inhibition of nitric oxide production and protein tyrosine nitration contribute to neuroprotection by a novel calmodulin antagonist, DY-9760e, in the rat microsphere embolism.

K. Fukunaga, S. Moriguchi, J. Kasahara, 2005, Biological & pharmaceutical bulletin.

DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart.

K. Fukunaga, N. Shioda, S. Moriguchi, 2006, Cardiovascular drug reviews.

Phenylephrine-Induced Cardiomyocyte Injury Is Triggered by Superoxide Generation through Uncoupled Endothelial Nitric-Oxide Synthase and Ameliorated by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a Novel Calmodulin Antagonist

K. Fukunaga, Z. Qin, N. Shioda, 2009, Molecular Pharmacology.

Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled eNOS and ameliorated by DY9836, a novel calmodulin antagonist

K. Fukunaga, Z. Qin, N. Shioda, 2008 .

Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism

K. Fukunaga, Z. Qin, N. Shioda, 2008, Neuroscience Letters.

Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin

K. Fukunaga, Y. Lou, F. Han, 2013, Journal of pineal research.

Melatonin ameliorates ischemic‐like injury‐evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells

K. Fukunaga, Y. Lou, F. Han, 2011, Journal of pineal research.

The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells.

Y. Lou, F. Han, Ji-yun Huang, 2010, Toxicology and applied pharmacology.

Inhibition of Dystrophin Breakdown and Endothelial Nitric-Oxide Synthase Uncoupling Accounts for Cytoprotection by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e) in Left Ventricular Hypertrophied Mice

K. Fukunaga, H. Hasegawa, H. Kanai, 2010, Journal of Pharmacology and Experimental Therapeutics.

DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.

K. Fukunaga, Z. Qin, N. Shioda, 2009, Cardiovascular therapeutics.

Melatonin ameliorates hypoglycemic stress‐induced brain endothelial tight junction injury by inhibiting protein nitration of TP53‐induced glycolysis and apoptosis regulator

K. Fukunaga, Z. Qin, F. Han, 2017, Journal of pineal research.

Targeted therapy of brain ischaemia using Fas ligand antibody conjugated PEG-lipid nanoparticles.

K. Fukunaga, F. Han, Yongzhong Du, 2014, Biomaterials.

Targeting nitrosative stress for neurovascular protection: new implications in brain diseases.

K. Fukunaga, F. Han, Rong-rong Tao, 2012, Current Drug Targets.

Microsphere embolism‐induced endothelial nitric oxide synthase expression mediates disruption of the blood–brain barrier in rat brain

K. Fukunaga, F. Han, Y. Shirasaki, 2006, Journal of neurochemistry.

Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice

K. Fukunaga, Yui Yamamoto, N. Shioda, 2009, Brain Research.

Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model

K. Fukunaga, Takuya Sasaki, N. Shioda, 2006, Brain Research.

Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin-dependent vascular remodeling.

K. Fukunaga, F. Han, Ying-Mei Lu, 2021, The Journal of clinical investigation.

Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism

Z. Qin, F. Han, Jinghua Gu, 2015, Neurochemistry International.

Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury

Guanghui Wang, Z. Qin, F. Han, 2015, Neuroscience Bulletin.

[Brain embolism-induced injury of vascular endothelial cells and a novel vasoprotective drug].

K. Fukunaga, F. Han, 2007, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Combination of NAD+ and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress

K. Fukunaga, Z. Qin, Jun-chao Wu, 2017, Molecular Neurobiology.

Combined NADPH and the NOX inhibitor apocynin provides greater anti‐inflammatory and neuroprotective effects in a mouse model of stroke

Z. Qin, F. Han, Jian Wang, 2017, Free radical biology & medicine.

3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydro-chloride 3.5 Hydrate (DY-9760e) Is Neuroprotective in Rat Microsphere Embolism: Role of the Cross-Talk between Calpain and Caspase-3 through Calpastatin

K. Fukunaga, F. Han, Y. Shirasaki, 2006, Journal of Pharmacology and Experimental Therapeutics.

1 H-indazole Dihydro-chloride 3 . 5 Hydrate ( DY-9760 e ) Is Neuroprotective in Rat Microsphere Embolism : Role of the Cross-Talk between Calpain and Caspase-3 through Calpastatin

K. Fukunaga, F. Han, Y. Shirasaki, 2006 .

Beta-amyloid accumulation in neurovascular units following brain embolism.

K. Fukunaga, F. Han, 2009, Journal of pharmacological sciences.

Accumulation of beta-amyloid in the brain microvessels accompanies increased hyperphosphorylated tau proteins following microsphere embolism in aged rats

Z. Qin, N. Shioda, F. Han, 2008, Neuroscience.

Down‐regulation of Bcl‐2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum

K. Fukunaga, Z. Qin, Jun-chao Wu, 2009, Journal of neuroscience research.

Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice

K. Fukunaga, Yui Yamamoto, N. Shioda, 2009, Journal of neurochemistry.

CaM kinase II and protein kinase C activations mediate enhancement of long‐term potentiation by nefiracetam in the rat hippocampal CA1 region

K. Fukunaga, N. Shioda, S. Moriguchi, 2008, Journal of neurochemistry.

P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy

Huan Wang, F. Han, W. Shi, 2015, Cell Research.

Stimulation of Sigma-1 Receptor Ameliorates Depressive-like Behaviors in CaMKIV Null Mice

K. Fukunaga, S. Moriguchi, F. Han, 2014, Molecular Neurobiology.

Overexpression of PEP-19 suppresses angiotensin II-induced cardiomyocyte hypertrophy.

F. Han, Ping Wang, Ying-Mei Lu, 2014, Journal of pharmacological sciences.

The effect of lipid nanoparticle PEGylation on neuroinflammatory response in mouse brain.

Feng Han, Jun Liu, Muhammad Masood Ahmed, 2013, Biomaterials.

p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum

K. Fukunaga, Z. Qin, Jun-chao Wu, 2009, Autophagy.

Endothelial peroxynitrite causes disturbance of neuronal oscillations by targeting caspase-1 in the arcuate nucleus

K. Fukunaga, F. Han, Ying-Mei Lu, 2021, Redox Biology.

Valproic Acid Influences MTNR1A Intracellular Trafficking and Signaling in a β-Arrestin 2-Dependent Manner

K. Fukunaga, F. Han, Ji-yun Huang, 2016, Molecular Neurobiology.

Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism

K. Fukunaga, S. Moriguchi, F. Han, 2014, Journal of pineal research.

Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury

Guanghui Wang, Z. Qin, F. Han, 2015, Neuroscience Bulletin.

Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4

K. Fukunaga, F. Han, W. Shi, 2019, Neuron.

Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function

K. Fukunaga, F. Han, Ji-yun Huang, 2018, Cerebral cortex.

Enhancement of ATP production ameliorates motor and cognitive impairments in a mouse model of MPTP−induced Parkinson's disease

K. Fukunaga, F. Han, Y. Yabuki, 2019, Neurochemistry International.

Myt1l induced direct reprogramming of pericytes into cholinergic neurons

K. Fukunaga, F. Han, Chao Tan, 2018, CNS neuroscience & therapeutics.

Calpain-Dependent ErbB4 Cleavage Is Involved in Brain Ischemia-Induced Neuronal Death

F. Han, Gang Wu, Ji-yun Huang, 2015, Molecular Neurobiology.

Chlorpromazine confers neuroprotection against brain ischemia by activating BKCa channel.

F. Han, Mao-qiang Xue, Li Zhou, 2014, European journal of pharmacology.

Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes.

K. Fukunaga, Z. Qin, N. Shioda, 2007, Biochemical pharmacology.

P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand

K. Fukunaga, F. Han, Ji-yun Huang, 2012, Journal of Neuroinflammation.

Galantamine enhancement of long‐term potentiation is mediated by calcium/calmodulin‐dependent protein kinase II and protein kinase C activation

K. Fukunaga, N. Shioda, S. Moriguchi, 2009, Hippocampus.

The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus

K. Fukunaga, F. Han, Ji-yun Huang, 2013, CNS neuroscience & therapeutics.

Decreased calcium/calmodulin‐dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long‐term potentiation in the olfactory bulbectomized mice

K. Fukunaga, S. Moriguchi, F. Han, 2006, Journal of neurochemistry.

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation

Feng Han, Akira Nakajima, K. Fukunaga, 2009, Brain Research.

Reduced Nicotinamide Adenine Dinucleotide Phosphate, a Pentose Phosphate Pathway Product, Might Be a Novel Drug Candidate for Ischemic Stroke

Z. Qin, Jun-chao Wu, F. Han, 2016, Stroke.

Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia

N. Shioda, F. Han, K. Fukunaga, 2008, Neuroscience.

[Donepezil-induced neuroprotection of acetylcholinergic neurons in olfactory bulbectomized mice].

K. Fukunaga, Yui Yamamoto, N. Shioda, 2010, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression

K. Fukunaga, H. Hasegawa, H. Kanai, 2016, PloS one.

Stimulation of σ1-receptor restores abnormal mitochondrial Ca²⁺ mobilization and ATP production following cardiac hypertrophy.

K. Fukunaga, H. Hasegawa, H. Kanai, 2013, Biochimica et biophysica acta.

Stimulation of Sigma-1 Receptor Ameliorates Depressive-like Behaviors in CaMKIV Null Mice

K. Fukunaga, S. Moriguchi, F. Han, 2015, Molecular Neurobiology.

Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes.

K. Fukunaga, Yui Yamamoto, N. Shioda, 2010, Biochimica et biophysica acta.

Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels.

K. Fukunaga, N. Shioda, F. Han, 2019, Journal of pharmacological sciences.

Novel cognitive enhancer ST101 enhances acetylcholine release in mouse dorsal hippocampus through T-type voltage-gated calcium channel stimulation.

K. Fukunaga, Yui Yamamoto, N. Shioda, 2013, Journal of pharmacological sciences.

Role of Akt and ERK signaling in the neurogenesis following brain ischemia.

K. Fukunaga, N. Shioda, F. Han, 2009, International review of neurobiology.

[Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders].

K. Fukunaga, N. Shioda, F. Han, 2008, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice

K. Fukunaga, Yui Yamamoto, N. Shioda, 2010, Journal of Pharmacology and Experimental Therapeutics.

Abstract 93: In Vivo Two-photon Fluorescence Microscopy Reveals Disturbed Cerebral Capillary Blood Flow and Increased Susceptibility to Ischemic Insults in Diabetic Mice

Feng Han, Huan Wang, Zhong Chen, 2013, Hypertension.

CaMKIIδB Mediates Aberrant NCX1 Expression and the Imbalance of NCX1/SERCA in Transverse Aortic Constriction-Induced Failing Heart

K. Fukunaga, N. Shioda, F. Han, 2011, PloS one.

[Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior].

K. Fukunaga, Yui Yamamoto, N. Shioda, 2011, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Ca2+/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy

K. Fukunaga, Y. Oomura, N. Shioda, 2011, Molecular and Cellular Neuroscience.

Effects of Galantamine on the fEPSPs and Phosphorylation of CaMKII , PKC a , and DARPP-32 in the Hippocampal CA 1 Regions

K. Fukunaga, N. Shioda, S. Moriguchi, 2009 .

Combination of NAD+ and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress

K. Fukunaga, Z. Qin, Jun-chao Wu, 2018, Molecular Neurobiology.

Expression profiling of Ca(2+)/calmodulin-dependent signaling molecules in the rat dorsal and ventral hippocampus after acute lead exposure.

K. Fukunaga, F. Han, Ji-yun Huang, 2012, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Cerebral microvascular dysfunction and neurodegeneration in dementia

F. Han, 2019, Stroke and Vascular Neurology.

Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice

F. Han, Ying-Mei Lu, Guojun Jiang, 2017, CNS neuroscience & therapeutics.

Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons

K. Fukunaga, H. Fan, F. Han, 2019, Molecular Psychiatry.

Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) Treatment Rescues Olfactory Bulbectomy-Induced Memory Impairment by Activating Ca2+/Calmodulin Kinase II and Protein Kinase C in Mouse Hippocampus

K. Fukunaga, Yui Yamamoto, N. Shioda, 2008, Journal of Pharmacology and Experimental Therapeutics.

pyridine-3 , 2-indan ]-2 ( 3 H )-one ( ZSET 1446 / ST 101 ) Treatment Rescues Olfactory Bulbectomy-Induced Memory Impairment by Activating Ca 2 / Calmodulin Kinase II and Protein Kinase C in Mouse Hippocampus

K. Fukunaga, Yui Yamamoto, N. Shioda, 2008 .

Effects of Low Doses of Ketamine on Pyramidal Neurons in Rat Prefrontal Cortex

F. Han, W. Shi, Guofang Shen, 2018, Neuroscience.

Calpain-Dependent ErbB4 Cleavage Is Involved in Brain Ischemia-Induced Neuronal Death

F. Han, Gang Wu, Ji-yun Huang, 2016, Molecular Neurobiology.

Peroxiredoxin 1 participates in ischemia‐triggered endothelial polarization

K. Fukunaga, Huan Wang, F. Han, 2014, CNS neuroscience & therapeutics.

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation

K. Fukunaga, Yui Yamamoto, N. Shioda, 2009, Brain Research.

Valproic Acid Influences MTNR1A Intracellular Trafficking and Signaling in a β-Arrestin 2-Dependent Manner

K. Fukunaga, F. Han, Ji-yun Huang, 2015, Molecular Neurobiology.

Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes.

K. Fukunaga, Yui Yamamoto, N. Shioda, 2010, Biochimica et biophysica acta.

The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus

K. Fukunaga, F. Han, Ji-yun Huang, 2013, CNS neuroscience & therapeutics.

Down‐regulation of Bcl‐2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum

K. Fukunaga, Jun-chao Wu, F. Han, 2009, Journal of neuroscience research.

The glymphatic system delivery enhances the transduction efficiency of AAV1 to brain endothelial cells in adult mice

F. Han, T. Cui, Ying-Mei Lu, 2019, Journal of Neuroscience Methods.