J. An

发表

Neuronal Apoptotic Signaling Pathways Probed and Intervened by Synthetically and Modularly Modified (SMM) Chemokines*

M. Kaul, S. Lipton, Won-Tak Choi, 2007, Journal of Biological Chemistry.

Structure-based virtual screening of chemical libraries for drug discovery.

J. An, Sutapa Ghosh, A. Nie, 2006, Current opinion in chemical biology.

Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists

J. An, Ziwei Huang, Maocai Yan, 2011, Experimental biology and medicine.

Virtual Screening, Biological Evaluation, and 3D-QSAR Studies of New HIV-1 Entry Inhibitors That Function via the CD4 Primary Receptor

Siyu Zhu, R. Schooley, J. An, 2018, Molecules.

Novel X-linked inhibitor of apoptosis protein inhibitors as probes of apoptosis in biology and medicine

J. Reed, K. Welsh, J. An, 2011, Experimental biology and medicine.

Structural and Biological Characterizations of Novel High-Affinity Fluorescent Probes with Overlapped and Distinctive Binding Regions on CXCR4

R. Schooley, J. An, Ziwei Huang, 2019, Molecules.

Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor

J. An, Ziwei Huang, A. Nie, 2007, Oncogene.

Synergistic inhibition of hepatitis C virus infection by a novel microtubule inhibitor in combination with daclatasvir

R. Schooley, Mohsin Khan, J. An, 2022, Biochemistry and biophysics reports.

Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction

J. An, Maocai Yan, Xiaofeng Han, 2016, PloS one.

NEW SYNTHESIS OF PYRVINIUM THAT INHIBITS THE β-CATENIN/TCF4 PATHWAY

N. Lin, J. An, Ziwei Huang, 2012 .

Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis.

Won-Tak Choi, J. An, Yan Xu, 2014, Current topics in medicinal chemistry.

Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors

R. Schooley, J. An, Ziwei Huang, 2019, Molecules.

Pharmacokinetics of a novel microtubule inhibitor mHA11 in rats.

Yinsong Zhu, J. An, Ziwei Huang, 2019, Chemico-biological interactions.

Development of a Novel Class of Tubulin Inhibitors with Promising Anticancer Activities

Xiaobin Han, J. An, Ziwei Huang, 2013, Molecular Cancer Research.

SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development.

D. Richman, J. Sodroski, James J Pesavento, 2006, Chemistry & biology.

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias

E. Estey, M. Konopleva, M. Andreeff, 2006, Molecular Cancer Therapeutics.

Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1α probed by a novel synthetically and modularly modified-chemokine analog

J. Sodroski, Won-Tak Choi, Santosh Kumar, 2011, Experimental biology and medicine.

A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys

A. Ciechanover, J. An, Ziwei Huang, 2020, Stem cell research & therapy.

Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry.

Bethany A. Reinecke, D. Selley, J. An, 2020, ACS medicinal chemistry letters.

Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists.

R. Schooley, J. An, Ziwei Huang, 2020, European journal of medicinal chemistry.

A synthetic bivalent ligand of CXCR4 inhibits HIV infection.

D. Richman, J. An, Ziwei Huang, 2013, Biochemical and biophysical research communications.

Critical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1α probed by novel N-methylated synthetically and modularly modified chemokine analogues.

Won-Tak Choi, C. Dong, J. An, 2012, Biochemistry.

Novel Bivalent and D-Peptide Ligands of CXCR4 Mobilize Hematopoietic Progenitor Cells to the Blood in C3H/HeJ Mice

E. Snyder, J. An, Ziwei Huang, 2018, Cell transplantation.

Discovery and Characterization of a Novel Cyclic Peptide That Effectively Inhibits Ephrin Binding to the EphA4 Receptor and Displays Anti-Angiogenesis Activity

J. An, Ziwei Huang, Xiaofeng Han, 2013, PloS one.

Development of a Novel Fluorescence Polarization–Based Assay for Studying the β-Catenin/Tcf4 Interaction

Xiaobin Han, J. An, Ziwei Huang, 2012, Journal of biomolecular screening.

Distinct Functional Sites for Human Immunodeficiency Virus Type 1 and Stromal Cell-Derived Factor 1α on CXCR4 Transmembrane Helical Domains

Won-Tak Choi, Dongxiang Liu, J. Sodroski, 2005, Journal of Virology.

Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.

John Calvin Reed, K. Welsh, J. An, 2009, Bioorganic & medicinal chemistry letters.

Oligomerization of BH4-truncated Bcl-x(L) in solution.

J. An, Ziwei Huang, R. Cao, 2007, Biochemical and biophysical research communications.

IV-1 gp120-CXCR4 recognition probed with synthetic nanomolar affinity D-peptides containing fragments of gp120 V3 loop.

R. Schooley, J. An, Ziwei Huang, 2022, European journal of medicinal chemistry.

LC–MS/MS assay for the determination of a novel D‐peptide antagonist of CXCR4 in rat plasma and its application to a preclinical pharmacokinetic study

Yinsong Zhu, J. An, Ziwei Huang, 2018, Journal of pharmaceutical and biomedical analysis.

Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor.

E. Pasquale, J. An, Ziwei Huang, 2013, ACS medicinal chemistry letters.

A synthetic bivalent peptide ligand of EphB4 with potent agonistic activity.

A. Ciechanover, J. An, Ziwei Huang, 2022, European journal of medicinal chemistry.

Convenient Synthesis of Toxoflavin that Targets β‐Catenin/Tcf4 Signaling Activities

J. An, Ziwei Huang, Wang Tian, 2014 .

Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities.

J. An, Ziwei Huang, Huijun Zhang, 2018, European journal of medicinal chemistry.

Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases

Won-Tak Choi, Won-Tak Choi, J. An, 2011, Experimental biology and medicine.

Discovery of small molecule inhibitors of the Wnt/β-catenin signaling pathway by targeting β-catenin/Tcf4 interactions

J. An, Maocai Yan, Guanqun Li, 2017, Experimental biology and medicine.

The chemical biology of apoptosis: Revisited after 17 years.

J. An, Ziwei Huang, Shu Yang, 2019, European journal of medicinal chemistry.

Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction.

N. Lin, Xiaobin Han, J. An, 2012, Biochemistry.

Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitors.

N. Lin, Xiaobin Han, J. An, 2012, Journal of medicinal chemistry.

Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration

R. Sidman, Yinsong Zhu, E. Snyder, 2020, Proceedings of the National Academy of Sciences.

A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonist.

A. Ciechanover, R. Schooley, J. An, 2022, European journal of medicinal chemistry.

Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).

Won-Tak Choi, Won-Tak Choi, J. An, 2012, Journal of medicinal chemistry.

A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities

A. Ciechanover, A. Warshel, K. Yuen, 2021, European Journal of Medicinal Chemistry.

Critical Upstream Signals of Cytochrome c Release Induced by a Novel Bcl-2 Inhibitor*

J. An, Ziwei Huang, Y. Chen, 2004, Journal of Biological Chemistry.

High affinity CXCR4 inhibitors generated by linking low affinity peptides.

R. Schooley, J. An, Ziwei Huang, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological characterization of novel PEG-linked dimeric modulators for CXCR4.

J. An, Ziwei Huang, Chaozai Zhang, 2016, Bioorganic & medicinal chemistry.

Crystal Structure and Structural Mechanism of a Novel Anti-Human Immunodeficiency Virus and d-Amino Acid-Containing Chemokine

Ying Li, Won-Tak Choi, Rong Cao, 2007, Journal of Virology.

Exploring the Stereochemistry of CXCR4-Peptide Recognition and Inhibiting HIV-1 Entry with d-Peptides Derived from Chemokines*

J. Sodroski, Xiaobin Han, James J Pesavento, 2002, The Journal of Biological Chemistry.

A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry.

J. Sodroski, Won-Tak Choi, C. Dong, 2012, Biochemistry.

Crystal structure of chemically synthesized vMIP‐II

Santosh Kumar, C. Dong, J. An, 2007, Proteins.

Novel aromatase inhibitors by structure-guided design.

Jessica Lo, Daniel Morton, Huw M. L. Davies, 2012, Journal of medicinal chemistry.

Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).

Won-Tak Choi, J. An, Ziwei Huang, 2011, Journal of medicinal chemistry.

Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4.

N. Lin, R. Noberini, E. Pasquale, 2013, Biochemical pharmacology.

Trends in application of advancing computational approaches in GPCR ligand discovery

J. An, Ziwei Huang, Siyu Zhu, 2021, Experimental biology and medicine.

Structural and Biological Characterizations of Novel High-Affinity Fluorescent Probes with Overlapped and Distinctive Binding Regions on CXCR4

R. Schooley, J. An, Ziwei Huang, 2019, Molecules.

Discoveries and developments of CXCR4-targeted HIV-1 entry inhibitors

J. An, Ziwei Huang, Chaozai Zhang, 2020, Experimental biology and medicine.

Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method

J. An, Ziwei Huang, Huijun Zhang, 2023, Viruses.

CXCR4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120

J. An, Ziwei Huang, Lina S. Huang, 2023, Viruses.

Unique Ligand Binding Sites on CXCR4 Probed by a Chemical Biology Approach: Implications for the Design of Selective Human Immunodeficiency Virus Type 1 Inhibitors

Won-Tak Choi, Dongxiang Liu, Navid Madani, 2005, Journal of Virology.

Basic and Translational Research of Chemokine Ligands and Receptors and Development of Novel Therapeutics

D. Richman, J. Sodroski, Won-Tak Choi, 2006 .

Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand.

J. Sodroski, Won-Tak Choi, Santosh Kumar, 2005, Journal of medicinal chemistry.