Ziwei Huang

发表

Neuronal Apoptotic Signaling Pathways Probed and Intervened by Synthetically and Modularly Modified (SMM) Chemokines*

M. Kaul, S. Lipton, Won-Tak Choi, 2007, Journal of Biological Chemistry.

Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists

J. An, Ziwei Huang, Maocai Yan, 2011, Experimental biology and medicine.

Virtual Screening, Biological Evaluation, and 3D-QSAR Studies of New HIV-1 Entry Inhibitors That Function via the CD4 Primary Receptor

Siyu Zhu, R. Schooley, J. An, 2018, Molecules.

Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins.

Ziwei Huang, Bin Yang, Dongxiang Liu, 2004, Bioorganic & medicinal chemistry letters.

The chemical biology of apoptosis. Exploring protein-protein interactions and the life and death of cells with small molecules.

Ziwei Huang, Ziwei Huang, 2002, Chemistry & biology.

Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.

Jeffrey W. Smith, A. Godzik, A. Strongin, 2006, The Biochemical journal.

Novel X-linked inhibitor of apoptosis protein inhibitors as probes of apoptosis in biology and medicine

J. Reed, K. Welsh, J. An, 2011, Experimental biology and medicine.

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia.

M. Konopleva, Z. Estrov, D. Harris, 2002, Blood.

Structural and Biological Characterizations of Novel High-Affinity Fluorescent Probes with Overlapped and Distinctive Binding Regions on CXCR4

R. Schooley, J. An, Ziwei Huang, 2019, Molecules.

Synergistic inhibition of hepatitis C virus infection by a novel microtubule inhibitor in combination with daclatasvir

R. Schooley, Mohsin Khan, J. An, 2022, Biochemistry and biophysics reports.

Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis.

Jun Wang, Ziwei Huang, O. Meucci, 2004, AIDS research and human retroviruses.

NEW SYNTHESIS OF PYRVINIUM THAT INHIBITS THE β-CATENIN/TCF4 PATHWAY

N. Lin, J. An, Ziwei Huang, 2012 .

XIAP mediates NOD signaling via interaction with RIP2

J. B. Garrison, John Calvin Reed, K. Welsh, 2009, Proceedings of the National Academy of Sciences.

Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors

R. Schooley, J. An, Ziwei Huang, 2019, Molecules.

Molecular understanding of postharvest flower opening and senescence

Ziwei Huang, Junping Gao, N. Ma, 2021, Molecular Horticulture.

Pharmacokinetics of a novel microtubule inhibitor mHA11 in rats.

Yinsong Zhu, J. An, Ziwei Huang, 2019, Chemico-biological interactions.

Development of a Novel Class of Tubulin Inhibitors with Promising Anticancer Activities

Xiaobin Han, J. An, Ziwei Huang, 2013, Molecular Cancer Research.

SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development.

D. Richman, J. Sodroski, James J Pesavento, 2006, Chemistry & biology.

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias

E. Estey, M. Konopleva, M. Andreeff, 2006, Molecular Cancer Therapeutics.

Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1α probed by a novel synthetically and modularly modified-chemokine analog

J. Sodroski, Won-Tak Choi, Santosh Kumar, 2011, Experimental biology and medicine.

Reactions of salicylaldehydes with alkyl cyanoacetates on the surface of solid catalysts: syntheses of 4H-chromene derivatives

J. Aramini, Ziwei Huang, M. Germann, 2000 .

A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys

A. Ciechanover, J. An, Ziwei Huang, 2020, Stem cell research & therapy.

Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists.

R. Schooley, J. An, Ziwei Huang, 2020, European journal of medicinal chemistry.

A Novel CXCR4-Selective High-Affinity Fluorescent Probe and Its Application in Competitive Binding Assays

Ziwei Huang, Xiaohong Yang, Mei Gao, 2014, Biochemistry.

A synthetic bivalent ligand of CXCR4 inhibits HIV infection.

D. Richman, J. An, Ziwei Huang, 2013, Biochemical and biophysical research communications.

Critical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1α probed by novel N-methylated synthetically and modularly modified chemokine analogues.

Won-Tak Choi, C. Dong, J. An, 2012, Biochemistry.

Novel Bivalent and D-Peptide Ligands of CXCR4 Mobilize Hematopoietic Progenitor Cells to the Blood in C3H/HeJ Mice

E. Snyder, J. An, Ziwei Huang, 2018, Cell transplantation.

Discovery and Characterization of a Novel Cyclic Peptide That Effectively Inhibits Ephrin Binding to the EphA4 Receptor and Displays Anti-Angiogenesis Activity

J. An, Ziwei Huang, Xiaofeng Han, 2013, PloS one.

Cyanidin-3-O-glucoside extracted from the Chinese bayberry (Myrica rubra Sieb. et Zucc.) alleviates antibiotic-associated diarrhea by regulating gut microbiota and down-regulating inflammatory factors in NF-κB pathway

Meiyu Qu, Ziwei Huang, Chongde Sun, 2022, Frontiers in Nutrition.

Development of a Novel Fluorescence Polarization–Based Assay for Studying the β-Catenin/Tcf4 Interaction

Xiaobin Han, J. An, Ziwei Huang, 2012, Journal of biomolecular screening.

Bcl-2 family proteins as targets for anticancer drug design

Ziwei Huang, Ziwei Huang, 2000, Oncogene.

ARTS and Siah collaborate in a pathway for XIAP degradation.

J. B. Garrison, John Calvin Reed, K. Welsh, 2011, Molecular cell.

Distinct Functional Sites for Human Immunodeficiency Virus Type 1 and Stromal Cell-Derived Factor 1α on CXCR4 Transmembrane Helical Domains

Won-Tak Choi, Dongxiang Liu, J. Sodroski, 2005, Journal of Virology.

Control of apoptosis by using small molecule regulators of Bcl-2 family proteins

E. Alnemri, C. Croce, Ziwei Huang, 2002 .

Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.

John Calvin Reed, K. Welsh, J. An, 2009, Bioorganic & medicinal chemistry letters.

US 6 , 613 , 742 B 1 1 CHEMOKINE-DERVED SYNTHETIC PEPTIDES CROSS

Ziwei Huang, Jiansong Luo, Zhaowen Luo, 2017 .

Oligomerization of BH4-truncated Bcl-x(L) in solution.

J. An, Ziwei Huang, R. Cao, 2007, Biochemical and biophysical research communications.

Structure-activity relationship analysis of peptides targeting the EphA2 receptor.

E. Pasquale, Ziwei Huang, Xuejun Zhu, 2010, Biochemistry.

IV-1 gp120-CXCR4 recognition probed with synthetic nanomolar affinity D-peptides containing fragments of gp120 V3 loop.

R. Schooley, J. An, Ziwei Huang, 2022, European journal of medicinal chemistry.

LC–MS/MS assay for the determination of a novel D‐peptide antagonist of CXCR4 in rat plasma and its application to a preclinical pharmacokinetic study

Yinsong Zhu, J. An, Ziwei Huang, 2018, Journal of pharmaceutical and biomedical analysis.

Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor.

E. Pasquale, J. An, Ziwei Huang, 2013, ACS medicinal chemistry letters.

A synthetic bivalent peptide ligand of EphB4 with potent agonistic activity.

A. Ciechanover, J. An, Ziwei Huang, 2022, European journal of medicinal chemistry.

Convenient Synthesis of Toxoflavin that Targets β‐Catenin/Tcf4 Signaling Activities

J. An, Ziwei Huang, Wang Tian, 2014 .

Reactions of Salicylaldehydes with Alkyl Cyanoacetates on the Surface of Solid Catalysts: Syntheses of 4H‐Chromene Derivatives.

J. Aramini, Ziwei Huang, M. Germann, 2000 .

Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities.

J. An, Ziwei Huang, Huijun Zhang, 2018, European journal of medicinal chemistry.

Structural and Functional Characterization of Human CXCR4 as a Chemokine Receptor and HIV-1 Co-receptor by Mutagenesis and Molecular Modeling Studies*

Zhaowen Luo, James W. Hall, R. Pomerantz, 2001, The Journal of Biological Chemistry.

NMR structures of anti-HIV D-peptides derived from the N-terminus of viral chemokine vMIP-II.

Santosh Kumar, Ziwei Huang, Dongxiang Liu, 2005, Biochemical and biophysical research communications.

The chemical biology of apoptosis: Revisited after 17 years.

J. An, Ziwei Huang, Shu Yang, 2019, European journal of medicinal chemistry.

A Conserved Mechanism for Control of Human and Mouse Embryonic Stem Cell Pluripotency and Differentiation by Shp2 Tyrosine Phosphatase

T. Mustelin, Ziwei Huang, L. Tautz, 2009, PloS one.

Synthetic peptide sequence from the C‐terminus of the insulin‐like growth factor‐I receptor that induces apoptosis and inhibition of tumor growth

S. Srinivasula, E. Alnemri, K. Reiss, 1999, Journal of cellular physiology.

TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma

Jun Ma, Ziwei Huang, Yupei Chen, 2023, Science advances.

Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction.

N. Lin, Xiaobin Han, J. An, 2012, Biochemistry.

Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway*

S. Srinivasula, E. Alnemri, T. Fernandes-Alnemri, 2000, The Journal of Biological Chemistry.

Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells.

H. Yamaguchi, K. Bhalla, Ziwei Huang, 2002, Cancer research.

Breast Cancer Cells through Induction of Bax Conformational Change in Human Epothilone B Analogue ( BMS-247550 )-mediated Cytotoxicity

K. Bhalla, Ziwei Huang, Hong-Gang Wang, 2002 .

Analogue ( BMS-247550 )-mediated Cytotoxicity through Induction of Bax Conformational Change in Human Breast Cancer Cells 1

H. Yamaguchi, K. Bhalla, Ziwei Huang, 2002 .

Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitors.

N. Lin, Xiaobin Han, J. An, 2012, Journal of medicinal chemistry.

Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration

R. Sidman, Yinsong Zhu, E. Snyder, 2020, Proceedings of the National Academy of Sciences.

A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonist.

A. Ciechanover, R. Schooley, J. An, 2022, European journal of medicinal chemistry.

EC3, a Novel Heterodimeric Disintegrin from Echis carinatus Venom, Inhibits α4 and α5 Integrins in an RGD-independent Manner*

M. Raida, J. Calvete, Ziwei Huang, 1999, The Journal of Biological Chemistry.

Generation of Constitutively Active Recombinant Caspases-3 and -6 by Rearrangement of Their Subunits*

S. Srinivasula, E. Alnemri, T. Fernandes-Alnemri, 1998, The Journal of Biological Chemistry.

Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).

Won-Tak Choi, Won-Tak Choi, J. An, 2012, Journal of medicinal chemistry.

A natural motif approach to protein design: a synthetic leucine zipper peptide mimics the biological function of the platelet factor 4 protein

Ziwei Huang, M. Kowalska, S. Niewiarowski, 1997, FEBS letters.

A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities

A. Ciechanover, A. Warshel, K. Yuen, 2021, European Journal of Medicinal Chemistry.

Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inﬂammasome in MPTP-induced Parkinson disease in mice

Xizeng Feng, Ziwei Huang, Dashuai Zhu, 2020, Behavioural Brain Research.

Critical Upstream Signals of Cytochrome c Release Induced by a Novel Bcl-2 Inhibitor*

J. An, Ziwei Huang, Y. Chen, 2004, Journal of Biological Chemistry.

TGF-β1 and TIMP-4 regulate atrial fibrosis in atrial fibrillation secondary to rheumatic heart disease

Ziwei Huang, Yunmei Zhang, Yu Sun, 2015, Molecular and Cellular Biochemistry.

Identification of a novel human CD8 surface region involved in MHC class I binding

Jimin Gao, Ziwei Huang, R. Korngold, 2002 .

High affinity CXCR4 inhibitors generated by linking low affinity peptides.

R. Schooley, J. An, Ziwei Huang, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological characterization of novel PEG-linked dimeric modulators for CXCR4.

J. An, Ziwei Huang, Chaozai Zhang, 2016, Bioorganic & medicinal chemistry.

Crystal Structure and Structural Mechanism of a Novel Anti-Human Immunodeficiency Virus and d-Amino Acid-Containing Chemokine

Ying Li, Won-Tak Choi, Rong Cao, 2007, Journal of Virology.

Exploring the Stereochemistry of CXCR4-Peptide Recognition and Inhibiting HIV-1 Entry with d-Peptides Derived from Chemokines*

J. Sodroski, Xiaobin Han, James J Pesavento, 2002, The Journal of Biological Chemistry.

Molecular modeling and site‐directed mutagenesis of CCR5 reveal residues critical for chemokine binding and signal transduction

James W. Hall, Xiaobin Han, Ziwei Huang, 2000, European journal of immunology.

A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry.

J. Sodroski, Won-Tak Choi, C. Dong, 2012, Biochemistry.

Crystal structure of chemically synthesized vMIP‐II

Santosh Kumar, C. Dong, J. An, 2007, Proteins.

Differential Regulation of Bax and Bak by Anti-apoptotic Bcl-2 Family Proteins Bcl-B and Mcl-1*

John Calvin Reed, Ziwei Huang, D. Zhai, 2008, Journal of Biological Chemistry.

Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).

Won-Tak Choi, J. An, Ziwei Huang, 2011, Journal of medicinal chemistry.

Effects of Broussonetia papyrifera (L.) L'Hér. ex Vent. fruits water extract on hippocampal neurogenesis in the treatment of APP/PS1 transgenic mice

Ziwei Huang, Yu-hui Yan, Lan Sun, 2022, Frontiers in Pharmacology.

Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4.

N. Lin, R. Noberini, E. Pasquale, 2013, Biochemical pharmacology.

PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity

N. Prigozhina, R. Noberini, E. Pasquale, 2011, PloS one.

Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model

Ziwei Huang, Ran Wang, Xiaoyan Xie, 2017, Cellular Physiology and Biochemistry.

Trends in application of advancing computational approaches in GPCR ligand discovery

J. An, Ziwei Huang, Siyu Zhu, 2021, Experimental biology and medicine.

An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis.

Ziwei Huang, R. Korngold, S. Choksi, 2002, Journal of autoimmunity.

Effect of a cyclic heptapeptide based on the human CD4 domain 1 CC′ loop region on murine experimental allergic encephalomyelitis: inhibition of both primary and secondary responses

Ziwei Huang, R. Korngold, S. Choksi, 2001, Journal of Neuroimmunology.

Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of SARS-CoV-2 Main Protease and 20S Proteasome.

A. Warshel, Ziwei Huang, A. Saha, 2022, Journal of the American Chemical Society.

Structural and Biological Characterizations of Novel High-Affinity Fluorescent Probes with Overlapped and Distinctive Binding Regions on CXCR4

R. Schooley, J. An, Ziwei Huang, 2019, Molecules.

Discoveries and developments of CXCR4-targeted HIV-1 entry inhibitors

J. An, Ziwei Huang, Chaozai Zhang, 2020, Experimental biology and medicine.

Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method

J. An, Ziwei Huang, Huijun Zhang, 2023, Viruses.

Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.

J. Mikolajczyk, G. Salvesen, Ziwei Huang, 2007, The Biochemical journal.

Identification of the CD8 DE Loop as a Surface Functional Epitope

Ziwei Huang, R. Korngold, Z Huang, 1998, The Journal of Biological Chemistry.

CXCR4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120

J. An, Ziwei Huang, Lina S. Huang, 2023, Viruses.

Bioactive Peptide Design Based on Protein Surface Epitopes

Ute Koch, Jimin Gao, J. Aramini, 1997, The Journal of Biological Chemistry.

A cyclic heptapeptide mimics CD4 domain 1 CC’ loop and inhibits CD4 biological function

J. Aramini, Jimin Gao, T. Satoh, 2002 .

Retrorectal mucinous adenocarcinoma arising from a tailgut cyst: A case report and review of literature

Ziwei Huang, Yi-xiong Zheng, Yansong Wang, 2022, World journal of gastrointestinal surgery.

Unique Ligand Binding Sites on CXCR4 Probed by a Chemical Biology Approach: Implications for the Design of Selective Human Immunodeficiency Virus Type 1 Inhibitors

Won-Tak Choi, Dongxiang Liu, Navid Madani, 2005, Journal of Virology.

Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells.

E. Alnemri, C. Croce, Ziwei Huang, 2000, Cancer research.

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.

S. Srinivasula, E. Alnemri, C. Croce, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Detection of Lung Cancer from Pathological Images Using CNN Model

Ziwei Huang, Mengshi Chen, Siming Huang, 2021, 2021 IEEE International Conference on Computer Science, Electronic Information Engineering and Intelligent Control Technology (CEI).

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia.

M. Konopleva, Z. Estrov, D. Harris, 2002, Blood.

A chemical strategy to promote helical peptide-protein interactions involved in apoptosis.

Ziwei Huang, R. Cao, Bin Yang, 2005, Bioorganic & medicinal chemistry letters.

Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor

J. An, Ziwei Huang, A. Nie, 2007, Oncogene.

Basic and Translational Research of Chemokine Ligands and Receptors and Development of Novel Therapeutics

D. Richman, J. Sodroski, Won-Tak Choi, 2006 .

Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand.

J. Sodroski, Won-Tak Choi, Santosh Kumar, 2005, Journal of medicinal chemistry.

The role of positively charged residues in CXCR4 recognition probed with synthetic peptides.

James W. Hall, J. Hall, Ziwei Huang, 1999, Biochemical and Biophysical Research Communications - BBRC.

ARTS and Siah collaborate in a pathway for XIAP degradation.

J. B. Garrison, John Calvin Reed, K. Welsh, 2011, Molecular cell.

A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics.

T. Satoh, Ziwei Huang, R. Korngold, 1997, Proceedings of the National Academy of Sciences of the United States of America.