Á. González-Rodríguez

发表

Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum‐deprived hepatocytes

M. Benito, Á. Valverde, Á. González-Rodríguez, 2007, Journal of cellular physiology.

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency

T. Quesada-López, F. Villarroya, W. Wahli, 2016, Diabetes.

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P. Rada, Á. Valverde, Á. González-Rodríguez, 2020, Cell Death & Disease.

Intrahepatic Expression of Fatty Acid Translocase CD36 Is Increased in Obstructive Sleep Apnea

R. Farré, I. Almendros, Á. González-Rodríguez, 2020, Frontiers in Medicine.

Hypoxia‐inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36

Á. González-Rodríguez, J. Aragonés, C. García-Monzón, 2020, Liver international : official journal of the International Association for the Study of the Liver.

Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

Á. Valverde, J. Argente, Á. González-Rodríguez, 2016, Disease Models & Mechanisms.

Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation

Victoria P. Le, J. Tarbell, A. Baker, 2022, bioRxiv.

Impairment of Transforming Growth Factor β Signaling in Caveolin-1-deficient Hepatocytes

Á. Valverde, Á. González-Rodríguez, L. Boscá, 2009, The Journal of Biological Chemistry.

Sterile Inflammation in Acetaminophen-induced Liver Injury Is Mediated by Cot/tpl2*

J. Velasco-Martín, Á. Valverde, J. Regadera, 2013, The Journal of Biological Chemistry.

Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy‐proven nonalcoholic fatty liver disease subjects

R. Andrade, Á. González-Rodríguez, F. Jorquera, 2021, Liver international : official journal of the International Association for the Study of the Liver.

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.

Á. Valverde, A. Ortiz, D. Brazil, 2015, Biochimica et biophysica acta.

Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection.

Á. Valverde, J. Muntané, Á. González-Rodríguez, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Eukaryotic Elongation Factor 2 Controls Tnf-alpha Translation in Lps-induced Hepatitis Recommended Citation Eukaryotic Elongation Factor 2 Controls Tnf-alpha Translation in Lps- Induced Hepatitis Eukaryotic Elongation Factor 2 Controls Tnf-α Translation in Lps-induced Hepatitis

Pilar Martín, Á. Valverde, Roger J. Davis, 2022 .

Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis.

Pilar Martín, Á. Valverde, Roger J. Davis, 2013, The Journal of clinical investigation.

Bacterial antigen translocation and age as BMI‐independent contributing factors on systemic inflammation in NAFLD patients

Á. González-Rodríguez, J. Ampuero, M. Romero-Gómez, 2020, Liver international : official journal of the International Association for the Study of the Liver.

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

Á. Valverde, J. Muntané, G. Fimia, 2014, Cell Death and Disease.

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.

Takao Iwawaki, Viviana Scaiewicz, R. Xavier, 2013, Journal of hepatology.

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.

P. Rada, Á. Valverde, Cristina Sánchez-González, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study

Á. González-Rodríguez, J. Ancochea, C. García-Monzón, 2022, Frontiers in Medicine.

Protein-tyrosine Phosphatase 1B (PTP1B) Deficiency Confers Resistance to Transforming Growth Factor-β (TGF-β)-induced Suppressor Effects in Hepatocytes*

Á. Valverde, Á. González-Rodríguez, I. Fabregat, 2012, The Journal of Biological Chemistry.

Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy

Á. Valverde, R. Simó, Á. González-Rodríguez, 2013, Molecular vision.

Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

Á. Valverde, Á. González-Rodríguez, D. Burks, 2009, Diabetes.

The L‐α‐Lysophosphatidylinositol/G Protein–Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis

M. Martínez-Chantar, Á. González-Rodríguez, C. Diéguez, 2020, Hepatology.

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

Oscar M. Bautista-Aguilera, F. López-Muñoz, K. Kieć‐Kononowicz, 2020, ACS chemical neuroscience.

A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice

M. Bednarek, Á. Valverde, Á. González-Rodríguez, 2017, Hepatology.

Research update for articles published in EJCI in 2014

W. März, T. Miazgowski, G. Niccoli, 2016, European journal of clinical investigation.

PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin‐like growth factor‐I

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2010, Journal of cellular physiology.

Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance

Á. Valverde, D. Francés, C. Carnovale, 2014, Diabetes.

Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics.

M. Moreno-Aliaga, J. Balsinde, P. Rada, 2022, Cell death and differentiation.

Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis

M. Moreno-Aliaga, P. Rada, Á. Valverde, 2017, Molecular metabolism.

IL‐6 cooperates with peroxisome proliferator‐activated receptor‐α‐ligands to induce liver fatty acid binding protein (LFABP) up‐regulation

Á. Valverde, Á. González-Rodríguez, F. Pavón, 2013, Liver international : official journal of the International Association for the Study of the Liver.

Bone morphogenetic protein 2 is a new molecular target linked to non-alcoholic fatty liver disease with potential value as non-invasive screening tool

Á. González-Rodríguez, J. Ampuero, M. Romero-Gómez, 2022, medRxiv.

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.

D. Serra, M. Schwaninger, M. Martínez-Chantar, 2021, Journal of hepatology.

Liver osteopontin is required to prevent the progression of age‐related nonalcoholic fatty liver disease

S. Gaztambide, M. Martínez-Chantar, Á. González-Rodríguez, 2020, Aging cell.

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

P. Rada, Á. Valverde, Á. González-Rodríguez, 2019, Disease Models & Mechanisms.

Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus.

Á. Valverde, Á. González-Rodríguez, V. Pardo, 2012, Phytochemistry.

S6K1 deficiency protects against apoptosis in hepatocytes

Á. Valverde, Á. González-Rodríguez, Javier Alba, 2009, Hepatology.

Normal Proliferation and Tumorigenesis but Impaired Pancreatic Function in Mice Lacking the Cell Cycle Regulator Sei1

Á. Valverde, M. Serrano, J. Flores, 2010, PloS one.

Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis

Á. Valverde, J. Segovia, Á. González-Rodríguez, 2016, Hepatology.

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

F. López-Muñoz, Á. González-Rodríguez, A. Lopez-Rodriguez, 2020, Antioxidants.

Friedelane-type triterpenoids as selective anti-inflammatory agents by regulation of differential signaling pathways in LPS-stimulated macrophages.

Á. Valverde, Á. González-Rodríguez, E. López-Collazo, 2016, Toxicology and applied pharmacology.

Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions

Á. Valverde, R. Simó, Á. González-Rodríguez, 2012, Journal of cellular physiology.

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2010, Cellular signalling.

Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity

M. Benito, S. Fernández, Á. González-Rodríguez, 2019, Disease Models & Mechanisms.

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

B. Christensen, Á. González-Rodríguez, F. Tremblay, 2020, Nature Communications.

Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity

P. Rada, Á. Valverde, A. Cuadrado, 2013, Cell Death and Disease.

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.

P. Rada, Á. Valverde, J. Muntané, 2017, Antioxidants & redox signaling.

SIRT 1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

P. Rada, Á. Valverde, J. Muntané, 2018 .

Essential role of protein tyrosine phosphatase 1B in obesity‐induced inflammation and peripheral insulin resistance during aging

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2012, Aging cell.

Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling

Á. Valverde, Á. González-Rodríguez, 2013 .

Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.

Á. Valverde, G. Frühbeck, J. Argente, 2012, Endocrinology.

Sleep apnea-COPD overlap syndrome is associated with larger left carotid atherosclerotic plaques

Á. González-Rodríguez, J. Ancochea, C. García-Monzón, 2023, Frontiers in Cardiovascular Medicine.

Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage Activation*

J. Balsinde, Á. Valverde, Á. González-Rodríguez, 2015, The Journal of Biological Chemistry.

New therapeutic targets for the treatment of insulin resistance based on the paracrine cross-talk between hepatocytes and Kupffer cells

Á. Valverde, Á. González-Rodríguez, P. Marqués, 2016 .

Hypoxia and Non-alcoholic Fatty Liver Disease

Á. González-Rodríguez, C. García-Monzón, Elvira del Pozo-Maroto, 2020, Frontiers in Medicine.

In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2014, Disease Models & Mechanisms.

Editorial: Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches

Á. González-Rodríguez, C. Gómez-Guerrero, J. Moreno, 2019, Front. Pharmacol..

Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.

Á. Valverde, Á. González-Rodríguez, L. Boscá, 2011, Journal of hepatology.

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge

Á. Valverde, Á. González-Rodríguez, L. Boscá, 2014, Cell Death and Disease.

Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis.

Á. González-Rodríguez, J. Castell, P. Petrov, 2018, The American journal of pathology.

Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice.

Á. Valverde, Á. González-Rodríguez, Margarita Fernández, 2011, The American journal of pathology.

Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

Á. Valverde, R. Simó, Á. González-Rodríguez, 2013, Diabetes.

Concerted regulation of non-alcoholic fatty liver disease progression by microRNAs in apolipoprotein E-deficient mice

Á. González-Rodríguez, Ó. Escribano, A. Gómez-Hernández, 2021, Disease models & mechanisms.

Defective liver glycogen autophagy related to hyperinsulinemia in intrauterine growth-restricted newborn wistar rats

Á. Valverde, Á. González-Rodríguez, E. Fernández-Millán, 2020, Scientific Reports.

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

M. Benito, Á. Valverde, Á. González-Rodríguez, 2007, Endocrinology.

PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.

M. Benito, Á. Valverde, G. Sesti, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Abbreviated title: Glucose uptake in PTP1B -/- neonatal hepatocytes

A. Sols, M. Benito, Á. Valverde, 2008 .

PTP 1 B deficiency increases glucose uptake in neonatal hepatocytes : involvement of IRA / GLUT 2 complexes

M. Benito, Á. Valverde, G. Sesti, 2008 .

Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.

P. Rada, Á. Valverde, A. Cuadrado, 2015, Molecular nutrition & food research.

Essential Role of Protein-tyrosine Phosphatase 1B in the Modulation of Insulin Signaling by Acetaminophen in Hepatocytes*

Á. Valverde, J. Muntané, Á. González-Rodríguez, 2014, The Journal of Biological Chemistry.

Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.

J. Gisbert, Á. Valverde, Á. González-Rodríguez, 2013, Toxicology and applied pharmacology.

RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases.

Á. Valverde, Á. González-Rodríguez, 2015, Current pharmaceutical design.

Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice

M. Benito, P. Chambon, S. Fernández, 2016, Disease Models & Mechanisms.

Insights on the disruption of glucose metabolism and hepatic insulin resistance induced by hepatitis C virus

Á. González-Rodríguez, C. García-Monzón, Elvira del Pozo-Maroto, 2022, Metabolism and Target Organ Damage.

Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function

Á. Valverde, C. Avendaño, Á. González-Rodríguez, 2012, Molecular medicine.

Increased let‐7d‐5p in non‐alcoholic fatty liver promotes insulin resistance and is a potential blood biomarker for diagnosis

A. Baker, Á. González-Rodríguez, Ó. Escribano, 2023, Liver international : official journal of the International Association for the Study of the Liver.

Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice.

Á. Valverde, Á. González-Rodríguez, D. Burks, 2013, Investigative ophthalmology & visual science.

Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function

Á. Valverde, C. Avendaño, Á. González-Rodríguez, 2012, Molecular medicine.

IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling

Á. Valverde, Á. González-Rodríguez, 2011, Archives of physiology and biochemistry.

p38γ/δ MAPKs control TNFα translation in acute hepatitis

Pilar Martín, Á. Valverde, Á. González-Rodríguez, 2012 .

Insulin Receptor Substrate 2 ( IRS 2 )-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1 B ( PTP 1 B ) Loss of Function

Á. Valverde, Á. González-Rodríguez, G. Camarero, 2012 .

Sterile Inflammation in Acetaminophen-induced Liver Injury Is Mediated by Cot/tpl2*

J. Velasco-Martín, Á. Valverde, J. Regadera, 2013, The Journal of Biological Chemistry.

In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2014, Disease Models & Mechanisms.

Mitochondrial respiratory chain activity is associated with severity, corticosteroid response and prognosis of alcoholic hepatitis

Á. González-Rodríguez, M. Heneghan, C. García-Monzón, 2023, Alimentary pharmacology & therapeutics.

Editorial: mitochondrial respiratory chain activity—a potential link with disease severity and treatment response in alcoholic hepatitis. Authors' reply

Á. González-Rodríguez, C. García-Monzón, C. Fernández-García, 2023, Alimentary pharmacology & therapeutics.

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

B. Christensen, Á. González-Rodríguez, J. Crespo, 2020, Nature Communications.