S. Yamazaki

M. Isobe, S. Yamazaki, J. Suzuki, 1997, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation

D. Tenen, A. Iwama, H. Nakauchi, 2003, The Journal of experimental medicine.

Development of an All-in-One Inducible Lentiviral Vector for Gene Specific Analysis of Reprogramming

H. Nakauchi, Toshihiro Kobayashi, S. Yamazaki, 2012, PloS one.

Antisense Cdk2 kinase oligodeoxynucleotide inhibits ICAM-1 expression in murine cardiac allograft arteriopathy.

M. Aoki, T. Ogihara, Y. Kaneda, 1998, Transplantation proceedings.

TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury

T. Abe, H. Kiyonari, S. Yamazaki, 2010, The Journal of experimental medicine.

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

H. Nakauchi, A. Yoshimura, M. Ueno, 2018, Cell stem cell.

Hemat opoietic Homeostasis against Diet-Induced Systemic Stress Graphical Abstract Highlights

H. Nakauchi, A. Yoshimura, M. Ueno, 2018 .

Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1/LFA-1 adhesion.

M. Isobe, S. Yamazaki, M. Sekiguchi, 1997, Circulation.

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.

A. Iwama, T. Minamino, Y. Kubota, 2018, Experimental hematology.

Sensitive diagnosis of cardiac allograft rejection by detection of cytokine transcription in situ.

M. Isobe, S. Yamazaki, J. Suzuki, 1998, Cardiovascular research.

Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients

H. Nakauchi, E. Ito, S. Yuasa, 2014, Leukemia.

Effect of anti-intercellular adhesion molecule-1 and anti-leukocyte function associated antigen-1 monoclonal antibodies on rat-to-mouse cardiac xenograft rejection.

S. Kawasaki, M. Makuuchi, M. Isobe, 1997, Surgery.

E2F decoy suppresses E-selectin expression in murine cardiac allograft arteriopathy.

Y. Kaneda, M. Isobe, S. Yamazaki, 1999, Transplantation proceedings.

Identification and characterization of in vitro expanded hematopoietic stem cells

B. Göttgens, Mairi S. Shepherd, D. Kent, 2022, EMBO reports.

Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo

A. Wilkinson, H. Nakauchi, Yukio Nakamura, 2021, Stem cell research.

Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse model.

H. Nakauchi, S. Yamazaki, Y. Nakauchi, 2015, Experimental hematology.

Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation

H. Nakauchi, Toshihiro Kobayashi, S. Yamazaki, 2018, Stem cell reports.

Inducible nitric oxide-mediated myocardial apoptosis contributes to graft failure during acute cardiac allograft rejection in mice.

M. Isobe, S. Yamazaki, A. Izawa, 2000, Japanese heart journal.

Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity

A. Wilkinson, H. Nakauchi, S. Yamazaki, 2018, Experimental hematology.

Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes

Y. Furukawa, S. Imoto, A. Yoshimura, 2022, Nature.

Interleukin-12 supports in vitro self-renewal of long-term hematopoietic stem cells

Shanshan Zhang, S. Yamazaki, Xiaofang Wang, 2018, Blood science.

Immunosuppression to cardiac allografts and soluble antigens by anti-vascular cellular adhesion molecule-1 and anti-very late antigen-4 monoclonal antibodies.

Y. Yazaki, M. Isobe, S. Yamazaki, 1994, Journal of immunology.

The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells

A. Iwama, H. Nakauchi, S. Yamazaki, 2014, Stem cell reports.

Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1/LFA-1 and VCAM-1/VLA-4.

M. Isobe, S. Yamazaki, M. Sekiguchi, 1999, Transplant immunology.

Ex vivo mouse hematopoietic stem cell expansion using polyvinyl alcohol

A. Wilkinson, H. Nakauchi, S. Yamazaki, 2019 .

Bmi1 Confers Resistance to Oxidative Stress on Hematopoietic Stem Cells

A. Iwama, H. Nakauchi, S. Yamazaki, 2012, PloS one.

Ultrastructural and immunohistochemical analysis of biopsy-proven chronic active mycocarditis with numerous clusters of lymphocytes

M. Isobe, S. Yamazaki, M. Sekiguchi, 1998, Virchows Archiv.

Bone marrow Schwann cells induce hematopoietic stem cell hibernation

H. Nakauchi, S. Yamazaki, 2014, International Journal of Hematology.

Stage‐Specific Roles for Cxcr4 Signaling in Murine Hematopoietic Stem/Progenitor Cells in the Process of Bone Marrow Repopulation

H. Nakauchi, M. Nojima, S. Yamazaki, 2014, Stem cells.

Hair follicle stem cells provide a functional niche for melanocyte stem cells.

H. Nakauchi, J. R. McMillan, N. Binh, 2011, Cell stem cell.

A melanocyte–melanoma precursor niche in sweat glands of volar skin

H. Nakauchi, T. Saida, S. Yamazaki, 2014, Pigment cell & melanoma research.

Generation of Mouse Functional Oocytes in Rat by Xeno-Ectopic Transplantation of Primordial Germ Cells1

H. Nakauchi, Toshihiro Kobayashi, S. Yamazaki, 2014, Biology of reproduction.

DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes.

A. Miyawaki, A. Iwama, S. Yamazaki, 2021, Blood advances.

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

A. Iwama, A. Kaneda, S. Yamazaki, 2020, The Journal of experimental medicine.

Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development

A. Iwama, H. Nakauchi, D. Vestweber, 2005, The Journal of experimental medicine.

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

A. Wilkinson, H. Nakauchi, S. Yamazaki, 2016, Science.

Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain.

M. Masu, A. Iwama, H. Nakauchi, 2006, Blood.

Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells

H. Nakauchi, Mamoru Ito, S. Yamazaki, 2013, Stem cell reports.

Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation.

H. Nakauchi, S. Yamazaki, M. Okabe, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Generation of Germline-Competent Rat Induced Pluripotent Stem Cells

H. Nakauchi, Toshihiro Kobayashi, S. Yamazaki, 2011, PloS one.

HHEX promotes myeloid transformation in cooperation with mutant ASXL1.

K. Nakai, Yosuke Tanaka, T. Shibata, 2020, Blood.

Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice.

S. Ogawa, H. Nakauchi, Y. Shiozawa, 2018, Blood.

Generation of Recombination Activating Gene-1-Deficient Neonatal Piglets: A Model of T and B Cell Deficient Severe Combined Immune Deficiency

H. Nakauchi, S. Yamazaki, Tetsuya Ito, 2014, PloS one.

TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

A. Iwama, H. Nakauchi, S. Yamazaki, 2009, Blood.

Cytokine Signaling, Lipid Raft Clustering, and HSC Hibernation

A. Iwama, H. Nakauchi, S. Yamazaki, 2007, Annals of the New York Academy of Sciences.

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

A. Iwama, H. Nakauchi, S. Yamazaki, 2006, The EMBO journal.

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.

Hiroshi Kimura, Fumio Arai, Tetsuhiro Chiba, 2016, Blood.

Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method

A. Wilkinson, H. Nakauchi, S. Yamazaki, 2017, Scientific Reports.

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

H. Nakauchi, John J Miles, S. Burrows, 2015, Stem cell reports.

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

Yosuke Tanaka, M. Oyama, H. Mano, 2018, Nature Communications.

Adult mouse hematopoietic stem cells: purification and single-cell assays

H. Nakauchi, J. Seita, S. Yamazaki, 2006, Nature Protocols.

Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.

A. Iwama, H. Nakauchi, S. Yamazaki, 2010, Cell stem cell.

Identification of immature podocyte specific antigen using retrovirus-mediated gene transfer and cell sorting

H. Nakauchi, S. Yamazaki, M. Osawa, 2005, Clinical and Experimental Nephrology.

Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma

A. Iwama, S. Yamazaki, Jian Jin, 2019, Cancer science.

A Single Cell Cloning Platform for Gene Edited Functional Murine Hematopoietic Stem Cells

C. Coban, D. Kent, A. Wilkinson, 2022, bioRxiv.

Pre‐Transplantation Blockade of TNF‐α‐Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells

H. Nakauchi, M. Nojima, S. Yamazaki, 2017, Stem cells.

Long-term ex vivo expansion of mouse hematopoietic stem cells

A. Wilkinson, H. Nakauchi, S. Yamazaki, 2020, Nature Protocols.

Reactive oxygen species in hematopoietic stem cells affect culture outcomes under inflammatory conditions

H. Nakauchi, S. Yamazaki, M. Otsu, 2015 .

Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing.

H. Masai, S. Yamazaki, Motoshi Hayano, 2013, Trends in genetics : TIG.

Rif1 regulates the replication timing domains on the human genome

Hisao Masai, Yutaka Kanoh, Y. Nishito, 2012, The EMBO journal.

Transcription factor 21 expression in injured podocytes of glomerular diseases

S. Yamazaki, K. Yamagata, S. Seshan, 2020, Scientific Reports.

The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages.

E. Latz, S. Yamazaki, H. Tsukamoto, 2020, International immunology.

Hoxb5 marks long-term haematopoietic stem cells revealing a homogenous perivascular niche

Irving L. Weissman, Hiromitsu Nakauchi, I. Weissman, 2016, Nature.

Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies

M. Oshimura, H. Nakauchi, T. Toki, 2014, Scientific Reports.

Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).

Lewis L Lanier, L. Lanier, S. Yamazaki, 2004, International immunology.

Mechanism of Cancer Cell Death Induced by Depletion of an Essential Replication Regulator

A. Miyawaki, Asako Sakaue-Sawano, N. Kakusho, 2012, PloS one.

In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma

A. Wilkinson, H. Nakauchi, Motomi Osato, 2017, Stem cell reports.

Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells

A. Wilkinson, A. Iwama, S. Yamazaki, 2021, Nature Communications.

Long-term ex vivo hematopoietic stem cell expansion affords nonconditioned transplantation

Adam C. Wilkinson, Kyle M. Loh, Kazuhiro Sudo, 2019, Nature.

A highly efficient reporter system for identifying and characterizing in vitro expanded hematopoietic stem cells

B. Göttgens, Mairi S. Shepherd, D. Kent, 2021, bioRxiv.

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

H. Nakauchi, J. Seita, K. Takatsu, 2007, Proceedings of the National Academy of Sciences.

Title Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells

H. Nakauchi, Mamoru Ito, S. Yamazaki, 2019 .

Hematopoietic progenitor cells specifically induce a unique immune response in dental pulp under conditions of systemic inflammation

S. Yamazaki, K. Hoshi, A. Hikita, 2022, Heliyon.

Loss of full-length DNA replication regulator Rif1 in two-cell embryos is associated with zygotic transcriptional activation

Y. Nishito, H. Masai, S. Yamazaki, 2021, The Journal of biological chemistry.

Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

Hideaki Nakajima, Fumi Shibata, S. Yamazaki, 2008, Blood.

Rif1, a Conserved Chromatin Factor Regulating DNA Replication, DNA Repair, and Transcription

H. Masai, S. Yamazaki, N. Yoshizawa-Sugata, 2016 .

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

K. Sakimura, H. Masai, S. Yamazaki, 2016, Nature Communications.

Clock gene Bmal1 is dispensable for intrinsic properties of murine hematopoietic stem cells

H. Nakauchi, S. Shimba, S. Yamazaki, 2014, Journal of Negative Results in BioMedicine.

Long-term ex vivo hematopoietic stem cell expansion affords nonconditioned transplantation

A. Wilkinson, H. Nakauchi, Yukio Nakamura, 2019, Nature.

Acceptance of primary skin graft after treatment with anti-intercellular adhesion molecule-1 and anti-leukocyte function-associated antigen-1 monoclonal antibodies in mice.

M. Isobe, S. Yamazaki, M. Sekiguchi, 1996, Transplantation.

TGF-β as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Commentary

A. Iwama, H. Nakauchi, S. Karlsson, 2009 .

Insights into signaling and function of hematopoietic stem cells at the single-cell level

H. Nakauchi, S. Yamazaki, 2009, Current opinion in hematology.

Chemically defined cytokine-free expansion of human haematopoietic stem cells

D. Kent, A. Wilkinson, A. Iwama, 2023, Nature.

Hemolytic Anemia with Fragmented Red Blood Cells Following Vascular Access Grafting for Hemodialysis in a Patient with Chronic Kidney Disease

S. Yamazaki, M. Nishimura, T. Hashimoto, 2014 .

Activated HoxB4-induced Hematopoietic Stem Cells from Murine Pluripotent Stem Cells via Long-Term Programming.

S. Yamazaki, A. Tojo, J. Bhadury, 2020, Experimental hematology.

Assessment of tolerance induction to cardiac allograft by anti-ICAM-1 and anti-LFA-1 monoclonal antibodies.

M. Isobe, S. Yamazaki, J. Suzuki, 1997, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

Yosuke Tanaka, M. Oyama, H. Mano, 2018, Nature Communications.

Efficacy of the novel tubulin polymerization inhibitor PTC‐028 for myelodysplastic syndrome

A. Miyawaki, Y. Furukawa, A. Iwama, 2020, Cancer science.

Acute pericarditis before engraftment in hematopoietic stem cell transplantation

S. Yamazaki, M. Kurokawa, A. Tsukamoto, 2016, Bone Marrow Transplantation.

Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

H. Nakauchi, S. Kakinuma, K. Takatsu, 2020 .

Running title : Generation of oocyte from xenogenic PGC

H. Nakauchi, Toshihiro Kobayashi, S. Yamazaki, 2014 .

Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion

C. Coban, D. Kent, A. Wilkinson, 2023, Cell stem cell.