N. Weigel

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Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity.

J. Richards, M. Rudd, I. Gonzalez-Robayna, 2007, Journal of molecular endocrinology.

Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression.

Anna Frolov, M. Ittmann, Carolyn L. Smith, 2005, Cancer research.

Metabolomic profiling identifies biochemical pathways associated with castration-resistant prostate cancer.

A. Chinnaiyan, A. Shojaie, G. Michailidis, 2014, Journal of proteome research.

Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells

S. Hilsenbeck, S. Fuqua, S. Andò, 2010, Breast Cancer Research and Treatment.

Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK.

Michael J. Bolt, D. Edwards, N. Weigel, 2016, Molecular endocrinology.

Vector-averaged gravity-induced changes in cell signaling and vitamin D receptor activity in MG-63 cells are reversed by a 1,25-(OH)2D3 analog, EB1089.

N. Weigel, R. Narayanan, C. Smith, 2002, Bone.

Activation of the Human Androgen Receptor through a Protein Kinase A Signaling Pathway*

L. Nazareth, N. Weigel, 1996, The Journal of Biological Chemistry.

Repressors of Androgen and Progesterone Receptor Action*

N. Weigel, W. Bingman, G. Ayala, 2003, Journal of Biological Chemistry.

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.

L. Neckers, J. Trepel, J. Gestwicki, 2018, Cancer research.

Steroid receptor phosphorylation: a key modulator of multiple receptor functions.

N. Moore, N. Weigel, N. L. Moore, 2007, Molecular endocrinology.

Use of the probasin promoter ARR2PB to express Bax in androgen receptor-positive prostate cancer cells.

R. Matusik, X. Li, N. Weigel, 2001, Journal of the National Cancer Institute.

1,25-dihydroxyvitamin D3 and 9-cis-retinoic acid act synergistically to inhibit the growth of LNCaP prostate cells and cause accumulation of cells in G1.

N. Weigel, J. Pike, S. Blutt, 1997, Endocrinology.

1 , 25-Dihydroxyvitamin D 3 and 9-cis-Retinoic Acid Act Synergistically to Inhibit the Growth of LNCaP Prostate Cells and Cause Accumulation of Cells in G 1 *

N. Weigel, J. Pike, S. Blutt, 1997 .

Regulation of Bcl-2 expression by dihydrotestosterone in hormone sensitive LNCaP-FGC prostate cancer cells.

T. McDonnell, C. Logothetis, E. Bruckheimer, 2003, The Journal of urology.

Dual Roles for the Phosphatase PPM1D in Regulating Progesterone Receptor Function*

L. Donehower, D. Proia, N. Weigel, 2006, Journal of Biological Chemistry.

Cyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cells

D. Edwards, N. Moore, N. Weigel, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

Chapter 127 – Estrogen and Progesterone Action

Carolyn L. Smith, N. Weigel, 2016 .

A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo.

D. Edwards, N. Weigel, F. DeMayo, 2014, Molecular endocrinology.

Vitamin D and Prostate Cancer

N. Weigel, S. Blutt, 1999, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Vitamin D and Prostate Cancer

N. Weigel, S. Blutt, 1999, Journal of andrology.

Cyclin-Dependent Kinase Activity Is Required for Progesterone Receptor Function: Novel Role for Cyclin A/Cdk2 as a Progesterone Receptor Coactivator

D. Edwards, N. Weigel, R. Narayanan, 2005, Molecular and Cellular Biology.

Vitamin D and Prostate Cancer

N. Weigel, L. Stewart, 2004 .

1α,25‐dihydroxyvitamin D3 induced growth inhibition of PC‐3 prostate cancer cells requires an active transforming growth factor beta signaling pathway

N. Weigel, Shalini Murthy, 2004, The Prostate.

1α,25‐dihydroxyvitamin D3 inhibits C4‐2 prostate cancer cell growth via a retinoblastoma protein (Rb)‐independent G1 arrest

N. Weigel, Jung-Sun Kim, M. Washington, 2011, The Prostate.

A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk.

D. Edwards, N. Weigel, D. Kieback, 2004, The Journal of clinical endocrinology and metabolism.

Novel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium

N. Weigel, S. Blutt, M. Boehm, 2001, The Prostate.

Role of insulin‐like growth factor binding proteins in 1α,25‐dihydroxyvitamin D3‐induced growth inhibition of human prostate cancer cells

N. Weigel, L. Stewart, 2005, The Prostate.

Studies on the structure and function of the chicken progesterone receptor.

W. Grody, B. O’Malley, N. Weigel, 1981, Recent progress in hormone research.

Purification and Characterization of Chicken Progesterone Receptor

N. Weigel, 1990 .

Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400.

D. Edwards, N. Weigel, S. Wardell, 2010, Molecular endocrinology.

Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites.

B. O’Malley, N. Weigel, O. Conneely, 1993, Biochemistry.

Phosphorylation of the chicken progesterone receptor.

G. Greene, N. Weigel, W. Bingman, 1987, Journal of steroid biochemistry.

The Functional Consequences of Cross-talk between the Vitamin D Receptor and ERK Signaling Pathways Are Cell-specific*

M. Falzon, N. Weigel, V. Sepulveda, 2004, Journal of Biological Chemistry.

Structural analysis of chicken oviduct progesterone receptor using monoclonal antibodies to the subunit B protein.

D. Edwards, W. McGuire, B. O’Malley, 1984, Biochemistry.

Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase

Gratien G. Prefontaine, N. Weigel, R. Haché, 1997, The Journal of Biological Chemistry.

Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

D. Edwards, B. O’Malley, M. Tsai, 1992, The Journal of biological chemistry.

Phosphorylation: a fundamental regulator of steroid receptor action

N. Weigel, L. Treviño, 2013, Trends in Endocrinology & Metabolism.

3C. 3-Ketosteroid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

D. Edwards, Sean M. Hartig, J. Cidlowski, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Steroid receptor phosphorylation: Assigning function to site‐specific phosphorylation

N. Weigel, R. Ward, 2009, BioFactors.

Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody.

D. Edwards, N. Weigel, L. Sherman, 2000, Molecular endocrinology.

Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor.

D. Edwards, N. Weigel, Y. Zhang, 1995, Molecular endocrinology.

Two Types of Anti-progestins Have Distinct Effects on Site-specific Phosphorylation of Human Progesterone Receptor (*)

D. Edwards, N. Weigel, Yixian Zhang, 1996, The Journal of Biological Chemistry.

A Genetic Mutation in the Progesterone Receptor (PROGINS) leads to an increased risk of non-familial breast and ovarian cancer causing inadequate control of estrogen receptor driven proliferation

N. Weigel, D. Kieback, I. Agoulnik, 1998 .

Inhibition of Proliferation and Induction of Apoptosis by 25-Hydroxyvitamin D3-3β-(2)-Bromoacetate, a Nontoxic and Vitamin D Receptor-Alkylating Analog of 25-Hydroxyvitamin D3 in Prostate Cancer Cells

M. Holick, P. Dhawan, R. Mehta, 2004, Clinical Cancer Research.

c-Jun N-Terminal Kinase Contributes to Aberrant Retinoid Signaling in Lung Cancer Cells by Phosphorylating and Inducing Proteasomal Degradation of Retinoic Acid Receptor (cid:2)

R. Price, D. Cody, J. Kurie, 2005 .

A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1)

D. Edwards, L. Nazareth, D. Lamb, 1999, Molecular endocrinology.

Multiple signaling pathways activate the chicken progesterone receptor.

N. Weigel, Y. Zhang, V. Allgood, 1994, Molecular endocrinology.

Hormonal regulation and identification of chicken progesterone receptor phosphorylation sites.

B. O’Malley, N. Weigel, L. Denner, 1990, The Journal of biological chemistry.

Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells.

N. Weigel, W. C. Krause, Ayesha A. Shafi, 2014, The international journal of biochemistry & cell biology.

The structure and function of the progesterone receptor

W. Grody, B. O’Malley, N. Weigel, 1981 .

Analysis of receptor phosphorylation.

N. Weigel, B. Rowan, R. Narayanan, 2003, Methods in enzymology.

Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting.

M. Gleave, A. Zoubeidi, R. Matusik, 2018, European urology.

Species, interindividual, and tissue specificity in endocrine signaling.

J. Russo, G. Lucier, N. Weigel, 1999, Environmental health perspectives.

Androgen receptor signaling and vitamin D receptor action in prostate cancer cells

N. Weigel, I. Agoulnik, Shalini Murthy, 2005, The Prostate.

[71] Enzyme I from Salmonella typhimurium

E. Waygood, N. Weigel, M. Kukuruzinska, 1982 .

Prostate cancer cell type-specific involvement of the VDR and RXR in regulation of the human PTHrP gene via a negative VDRE

M. Falzon, N. Weigel, V. Sepulveda, 2006, Steroids.

Effects of hormone and cellular modulators of protein phosphorylation on transcriptional activity, DNA binding, and phosphorylation of human progesterone receptors.

D. Edwards, N. Weigel, C. Beck, 1992, Molecular endocrinology.

The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

D. Edwards, S. Nordeen, N. Weigel, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Erratum: A c619y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1) (Molecular Endocrinology (1999) 13 (2065-2075))

D. Edwards, L. Nazareth, D. Lamb, 2000 .

1 a , 25-DihydroxyvitaminD 3 Inhibits C 4-2 Prostate

N. Weigel, Jung-Sun Kim, Jung‐Sun Kim, 2010 .

Identification of Phosphorylation Sites Unique to the B Form of Human Progesterone Receptor

D. Edwards, N. Weigel, Y. Zhang, 1994 .

Mechanistic differences in the activation of estrogen receptor-alpha (ER alpha)- and ER beta-dependent gene expression by cAMP signaling pathway(s).

Carolyn L. Smith, N. Weigel, B. Rowan, 2003, The Journal of biological chemistry.

Vitamin D and Prostate Cancer

N. Weigel, L. Stewart, 2004, Experimental biology and medicine.

Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients

C. Guillemette, R. Mehra, L. Lacombe, 2022, Cells.

Stable expression of full length human androgen receptor in PC‐3 prostate cancer cells enhances sensitivity to retinoic acid but not to 1α,25‐dihydroxyvitamin D3

N. Weigel, M. Marcelli, Shalini Murthy, 2003, The Prostate.

[72] HPr from Salmonella typhimurium

A. Nakazawa, N. Weigel, 1982 .

Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.

D. Edwards, T. Yip, T. Hutchens, 1997, Molecular endocrinology.

Stoichiometry and Site-specific Phosphorylation of Human Progesterone Receptor in Native Target Cells and in the Baculovirus Expression System*

D. Edwards, N. Weigel, M. Altmann, 1996, The Journal of Biological Chemistry.

Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody.

D. Edwards, P. Prendergast, N. Weigel, 1992, Molecular endocrinology.

Hormone-induced changes in the in vitro DNA-binding activity of the chicken progesterone receptor.

M. Carson, B. O’Malley, N. Weigel, 1989, Molecular endocrinology.

Parathyroid Hormone-Related Protein Regulates Cell Survival Pathways via Integrin α6β4-Mediated Activation of Phosphatidylinositol 3-Kinase/Akt Signaling

Ramanjaneya V. R. Mula, M. Falzon, N. Weigel, 2009, Molecular Cancer Research.

PTHrP contributes to the anti-proliferative and integrin α6β4-regulating effects of 1,25-dihydroxyvitamin D3

Xiaoli Shen, Ramanjaneya V. R. Mula, M. Falzon, 2007, Steroids.

Hormone-dependent regulation of chicken progesterone receptor deoxyribonucleic acid binding and phosphorylation.

B. O’Malley, N. Weigel, L. Denner, 1989, Endocrinology.

Vitamin D receptor agonists induce prostatic acid phosphatase to reduce cell growth and HER-2 signaling in LNCaP-derived human prostate cancer cells

N. Weigel, Ming-Fong Lin, L. Stewart, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089).

Carolyn L. Smith, N. Weigel, D. Gaddy, 2004, Bone.

Analysis of chicken progesterone receptor function and phosphorylation using an adenovirus-mediated procedure for high-efficiency DNA transfer.

B. O’Malley, N. Weigel, Y. Zhang, 1997, Biochemistry.

p53 Is required for 1,25-dihydroxyvitamin D3-induced G0 arrest but is not required for G1 accumulation or apoptosis of LNCaP prostate cancer cells.

N. Weigel, E. Ryu, Michael B. Cohen, 2003, Endocrinology.

c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha.

R. Price, D. Cody, J. Kurie, 2005, Molecular and cellular biology.

Synergism between steroid response and promoter elements during cell-free transcription.

B. O’Malley, M. Tsai, S. Tsai, 1991, Journal of Biological Chemistry.

Androgen receptors in hormone-dependent and castration-resistant prostate cancer.

N. Weigel, Ayesha A. Shafi, Nancy L Weigel, 2013, Pharmacology & therapeutics.

Coactivator selective regulation of androgen receptor activity

N. Weigel, I. Agoulnik, 2009, Steroids.

Molecular analysis of the androgen receptor in ten prostate cancer specimens obtained before and after androgen ablation.

D. Lamb, N. Weigel, M. Marcelli, 2003, Journal of andrology.

Androgen Signaling in Prostatic Neoplasia and Hyperplasia

D. Lamb, N. Weigel, M. Marcelli, 2003 .

Steroid Receptors in Prostate Cancer Development and Progression

D. Lamb, N. Weigel, M. Marcelli, 2000 .

7alpha-Iodo and 7alpha-fluoro steroids as androgen receptor-mediated imaging agents.

L. Nazareth, D. Labaree, N. Weigel, 1999, Journal of medicinal chemistry.

Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities

C. Coarfa, N. Weigel, W. Bingman, 2021, Scientific Reports.

International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors

Donald P. McDonnell, V. Giguère, J. Cidlowski, 2006, Pharmacological Reviews.

A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity.

G. Buchanan, W. Tilley, Jonathan M. Harris, 2002, Molecular endocrinology.

Androgen receptors and their biology.

D. Lamb, N. Weigel, M. Marcelli, 2001, Vitamins and hormones.

Androgen receptor mutations in prostate cancer.

J. Eastham, M. Ittmann, D. Lamb, 2000, Cancer research.

Androgen Receptor Mutations in Prostate Cancer 1

J. Eastham, M. Ittmann, D. Lamb, 2000 .

Regulation of progesterone receptor-mediated transcription by phosphorylation.

B. O’Malley, N. Weigel, L. Denner, 1990, Science.

Sugar transport by the bacterial phosphotransferase system. Phosphoryl transfer reactions catalyzed by enzyme I of Salmonella typhimurium.

S. Roseman, A. Nakazawa, E. Waygood, 1982, The Journal of biological chemistry.

Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression

D. Proia, N. Weigel, J. Acquaviva, 2012, International journal of oncology.

High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae

B. O’Malley, Z. Nawaz, N. Weigel, 1991, The Journal of Steroid Biochemistry and Molecular Biology.

Calcitriol-Induced Apoptosis in LNCaP Cells Is Blocked By Overexpression of Bcl-21.

T. McDonnell, N. Weigel, S. Blutt, 2000, Endocrinology.

T. McDonnell, N. Weigel, S. Blutt, 1999 .

Phosphorylation of Ser211 in the Chicken Progesterone Receptor Modulates its Transcriptional Activity*

N. Weigel, W. Bai, 1996, The Journal of Biological Chemistry.

Phosphorylation and steroid hormone action.

N. Weigel, W. Bai, 1995, Vitamins and hormones.

Phosphorylation of hen progesterone receptor by cAMP dependent protein kinase.

B. O’Malley, N. Weigel, J. Tash, 1981, Biochemical and biophysical research communications.

Dimerization of the chicken progesterone receptor in vitro can occur in the absence of hormone and DNA.

B. O’Malley, N. Weigel, W. Schrader, 1990, Molecular endocrinology.

Differential expression of uterine progesterone receptor forms A and B during the menstrual cycle

N. Weigel, A. Poindexter, R. Wiehle, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

Molecular mechanism of action of a steroid hormone receptor.

B. O’Malley, M. Tsai, S. Tsai, 1991, Recent progress in hormone research.

An alternative ligand-independent pathway for activation of steroid receptors.

B. O’Malley, Carolyn L. Smith, N. Weigel, 1995, Recent progress in hormone research.

Identification of a transferable two-amino-acid motif (GT) present in the C-terminal tail of the human lutropin receptor that redirects internalized G protein-coupled receptors from a degradation to a recycling pathway.

C. Galet, N. Weigel, M. Ascoli, 2003, Molecular endocrinology.

Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.

G. Hammer, B. Darimont, N. Weigel, 1999, Molecular cell.

Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.

P. Brown, J. Kurie, N. Moore, 2006, The Biochemical journal.

c-Jun N-Terminal Kinase Contributes to Aberrant Retinoid Signaling in Lung Cancer Cells by Phosphorylating and Inducing Proteasomal Degradation of Retinoic Acid Receptor α

R. Price, D. Cody, J. Kurie, 2005, Molecular and Cellular Biology.

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

B. O’Malley, M. Tsai, S. Tsai, 1988, Cell.

The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex

B. O’Malley, L. Klein-Hitpass, S. Tsai, 1990, Cell.

Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.

Leif E. Peterson, M. Ittmann, N. Weigel, 2011, Cancer research.

Tumor and Stem Cell Biology Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP 4 B in Prostate Cancer

Leif E. Peterson, M. Ittmann, N. Weigel, 2011 .

Coregulators and the Regulation of Androgen Receptor Action in Prostate Cancer

N. Weigel, I. Agoulnik, 2009 .

Androgen receptor coactivators and prostate cancer.

N. Weigel, I. Agoulnik, 2008, Advances in experimental medicine and biology.

Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer.

M. Ittmann, Carolyn L. Smith, N. Weigel, 2006, Cancer research.

Inositol Polyphosphate 4-phosphatase Type II Regulation of Androgen Receptor Activity

Leif E. Peterson, K. Rajapakshe, C. Coarfa, 2018, Oncogene.

Steroid Receptor Crosstalk With Cellular Signaling Pathways

N. Weigel, S. Mani, A. Acevedo-Rodriguez, 2003 .

Mechanisms of Steroid Receptor and Growth Factor Cross Talk

N. Weigel, R. Narayanan, 2002 .

Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG

Jeffery A. Dodge, C. Coarfa, N. Weigel, 2017, Oncotarget.

The prostate cancer TMPRSS2:ERG fusion synergizes with the vitamin D receptor (VDR) to induce CYP24A1 expression-limiting VDR signaling.

M. Ittmann, Jianghuai Wang, N. Weigel, 2014, Endocrinology.

1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion.

N. Weigel, M. Washington, 2010, Endocrinology.

1Alpha,25-dihydroxyvitamin D3 reduces c-Myc expression, inhibiting proliferation and causing G1 accumulation in C4-2 prostate cancer cells.

N. Weigel, J. Rohan, 2009, Endocrinology.

1,25(OH)2D3 reduces c-Myc expression, inhibiting proliferation and causing G1 accumulation in C4-2 prostate cancer cells.

N. Weigel, J. Rohan, 2009 .

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex

S. Hilsenbeck, Sean M. Hartig, K. Rajapakshe, 2014, Proceedings of the National Academy of Sciences.

Isoform specific activities of androgen receptor and its splice variants in prostate cancer cells.

C. Coarfa, N. Weigel, N. Putluri, 2020, Endocrinology.

Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells

C. Coarfa, N. Weigel, Jianrong Dong, 2021, Scientific Reports.

Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells.

N. Weigel, I. Agoulnik, Manjula Nakka, 2013, The international journal of biochemistry & cell biology.

Ligand-independent activation of steroid hormone receptors

N. Weigel, Yixian Zhang, 1998, Journal of Molecular Medicine.

AR collaborates with ERα in aromatase inhibitor-resistant breast cancer

S. Fuqua, P. Brown, I. Barone, 2014, Breast Cancer Research and Treatment.

Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression

Leif E. Peterson, K. Rajapakshe, M. Ittmann, 2016, Clinical Cancer Research.

Steroid hormone receptors and their regulation by phosphorylation.

N. Weigel, 1996, The Biochemical journal.

Identification of the DNA-Binding Domain of the Chicken Progesterone Receptor A Subunit

B. O’Malley, N. Weigel, W. Schrader, 1983 .

High-yield high-performance liquid chromatographic analysis of steroid hormone receptors on glass columns.

B. O’Malley, N. Weigel, L. Denner, 1987, Analytical biochemistry.

Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells

C. Coarfa, N. Weigel, A. Sreekumar, 2015, Oncotarget.

Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity

N. Moore, N. Weigel, R. Narayanan, 2007, Steroids.

Phosphorylation of Steroid Receptor Coactivator-1

B. O’Malley, N. Weigel, B. Rowan, 2000, The Journal of Biological Chemistry.

Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase.

X. Liu, Wei Li, Qianben Wang, 2008, Molecular endocrinology.

Monoclonal antibody to the hen oviduct progesterone receptor produced following in vitro immunization.

B. O’Malley, M. Tsai, S. Tsai, 1984, Journal of steroid biochemistry.

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone.

N. Weigel, M. Marcelli, M. Mancini, 1999, Human molecular genetics.

Mechanistic Differences in the Activation of Estrogen Receptor-α (ERα)- and ERβ-dependent Gene Expression by cAMP Signaling Pathway(s)*

Carolyn L. Smith, N. Weigel, B. Rowan, 2003, The Journal of Biological Chemistry.

Human Progesterone Receptor Displays Cell Cycle-Dependent Changes in Transcriptional Activity

D. Edwards, N. Weigel, R. Narayanan, 2005, Molecular and Cellular Biology.

Transcriptional Activation of the Chicken Progesterone Receptor

W. Bai, N. Weigel, Suma Tulles, 1994 .

Roles of Androgen Receptor Coregulators and Cell Signaling in the Regulation of Androgen-Responsive Genes

N. Weigel, I. Agoulnik, 2013 .

Quantifying effects of ligands on androgen receptor nuclear translocation, intranuclear dynamics, and solubility

Adam T. Szafran, J. Price, N. Weigel, 2006, Journal of cellular biochemistry.

Kinases and protein phosphorylation as regulators of steroid hormone action

N. Moore, N. Weigel, N. L. Moore, 2007, Nuclear receptor signaling.

8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein

N. Weigel, B. Rowan, Bert W. O’Malley, 2000, Molecular and Cellular Biology.

Interactions between vitamin D and androgen receptor signaling in prostate cancer cells.

N. Weigel, 2007, Nutrition reviews.

The Nuclear Corepressors NCoR and SMRT Are Key Regulators of Both Ligand- and 8-Bromo-Cyclic AMP-Dependent Transcriptional Activity of the Human Progesterone Receptor

N. Weigel, T. Knotts, D. McDonnell, 1998, Molecular and Cellular Biology.

Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract.

N. Weigel, M. Marcelli, M. Mancini, 2000, Human molecular genetics.

1,25-dihydroxyvitamin D3 modulates phosphorylation of serine 205 in the human vitamin D receptor: site-directed mutagenesis of this residue promotes alternative phosphorylation.

R. Cook, N. Weigel, J. Pike, 1994, Biochemistry.

EB1089 inhibits the parathyroid hormone–related protein–enhanced bone metastasis and xenograft growth of human prostate cancer cells

Xiaoli Shen, M. Falzon, N. Weigel, 2009, Molecular Cancer Therapeutics.

Phosphorylation and progesterone receptor function

D. Edwards, N. Weigel, A. Poletti, 1995, The Journal of Steroid Biochemistry and Molecular Biology.

Identification of a hormone-dependent phosphorylation site adjacent to the DNA-binding domain of the chicken progesterone receptor.

N. Weigel, A. Poletti, 1993, Molecular endocrinology.

Steroid Receptor Regulation by Phosphorylation and Cell Signaling Pathways

N. Weigel, 2000 .

Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays.

B. O’Malley, N. Weigel, T. Carter, 1992, Molecular endocrinology.

Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae).

B. O’Malley, N. Weigel, P. Mak, 1989, The Journal of biological chemistry.

Modulators of cellular protein phosphorylation alter thetrans-activation function of human progesterone receptor and the biological activity of progesterone antagonists

D. Edwards, S. Nordeen, N. Weigel, 2004, Breast Cancer Research and Treatment.

Differential Phosphorylation of Chicken Progesterone Receptor in Hormone-dependent and Ligand-independent Activation*

B. O’Malley, N. Weigel, B. Rowan, 1997, The Journal of Biological Chemistry.

Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer

Ali Shojaie, Katrin Panzitt, Fabio Stossi, 2016, Nature Communications.

A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae.

B. O’Malley, N. Weigel, O. Conneely, 1992, Gene.

ReviewVitamin D and Prostate Cancer

N. Weigel, T. C. Polek, 2002 .

Sugar transport by the bacterial phosphotransferase system. Primary structure and active site of a general phosphocarrier protein (HPr) from Salmonella typhimurium.

S. Roseman, N. Weigel, D. Powers, 1982, The Journal of biological chemistry.

Progesterone receptor and the mechanism of action of progesterone antagonists

D. Edwards, A. DeMarzo, N. Weigel, 1995, The Journal of Steroid Biochemistry and Molecular Biology.

Cyclins, cyclin dependent kinases, and regulation of steroid receptor action

N. Moore, N. Weigel, N. L. Moore, 2007, Molecular and Cellular Endocrinology.

Identification of a Phosphorylation Site in the Hinge Region of the Human Progesterone Receptor and Additional Amino-terminal Phosphorylation Sites*

D. Edwards, R. Cook, N. Weigel, 2001, The Journal of Biological Chemistry.

Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus.

N. Moore, N. Weigel, N. L. Moore, 2011, The international journal of biochemistry & cell biology.

Activation of Progesterone and Androgen Receptors by Signal Transduction Pathways

L. Nazareth, N. Weigel, M. Keightley, 1998 .

Regulation of in vitro transcription by progesterone receptor. Characterization and kinetic studies.

B. O’Malley, M. Tsai, S. Tsai, 1990, The Journal of biological chemistry.

Phosphorylation of Ser530 facilitates hormone-dependent transcriptional activation of the chicken progesterone receptor.

N. Weigel, W. Bai, S. Tullos, 1994, Molecular Endocrinology.

The steroid-dependent regulatory element in the ovalbumin gene does not function as a typical steroid response element.

N. Weigel, D. E. Frank, M. M. Sanders, 1990, The Journal of biological chemistry.

Androgen receptor action in hormone‐dependent and recurrent prostate cancer

N. Weigel, I. Agoulnik, Nancy L. Weigel, 2006, Journal of cellular biochemistry.

Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression

N. Weigel, Ayesha A. Shafi, M. Cox, 2013, Steroids.

Antibodies to chicken progesterone receptor peptide 523-536 recognize a site exposed in receptor-deoxyribonucleic acid complexes but not in receptor-heat shock protein-90 complexes.

B. O’Malley, N. Weigel, W. Schrader, 1989, Endocrinology.

3C. 3-Ketosteroid receptors in GtoPdb v.2023.1 3C. 3-Ketosteroid receptors in GtoPdb v.2023.1

D. Edwards, Sean M. Hartig, J. Cidlowski, 2023 .

Cross-talk between Androgen Receptors and Cell Signaling Pathways in Prostate Cancer

N. Weigel, W. Krause, 2012 .

PTHrP contributes to the anti-proliferative and integrin alpha6beta4-regulating effects of 1,25-dihydroxyvitamin D(3).

Xiaoli Shen, Ramanjaneya V. R. Mula, M. Falzon, 2007, Steroids.

Amino acid sequence of a chicken heat shock protein derived from the complementary DNA nucleotide sequence.

M. Kulomaa, B. O’Malley, C. March, 1986, Biochemistry.

Molecular biology of the vitamin D hormone.

B. Komm, J. Shine, M. Haussler, 1988, Recent progress in hormone research.

Calcitriol-Induced Apoptosis in LNCaP Cells Is Blocked By Overexpression of Bcl-21.

T. McDonnell, N. Weigel, S. Blutt, 2000, Endocrinology.

Direct G Protein Modulation of Cav2 Calcium Channels

B. Spiegelman, S. Kliewer, G. Eichele, 2006, Pharmacological Reviews.

Molecular cloning of a cDNA for the chicken progesterone receptor B antigen.

D. Edwards, W. McGuire, M. Kulomaa, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.

D. Edwards, T. Yip, T. Hutchens, 1997, Molecular endocrinology.

Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription.

R. Schwartz, F. Booth, N. Weigel, 2003, Biochemistry.

Sugar transport. 3. Purification and properties of a phosphocarrier protein (HPr) of the phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli.

S. Roseman, N. Weigel, W. Kundig, 1971, The Journal of biological chemistry.

EB1089 inhibits the parathyroid hormone–related protein–enhanced bone metastasis and xenograft growth of human prostate cancer cells

Xiaoli Shen, M. Falzon, N. Weigel, 2009, Molecular Cancer Therapeutics.

A calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice.

M. Kattan, N. Weigel, S. Blutt, 2000, Cancer research.

Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2.

N. Weigel, S. Blutt, Tyler McDonnell, 2000, Endocrinology.

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.

L. Neckers, J. Trepel, J. Gestwicki, 2018, Cancer research.

Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.

Leif E. Peterson, M. Ittmann, N. Weigel, 2011, Cancer research.

A standards-based, peer-reviewed teaching award to enhance a medical school's teaching environment and inform the promotions process.

B. Richards, N. Weigel, C. Teal, 2012, Academic medicine : journal of the Association of American Medical Colleges.

Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting.

M. Gleave, A. Zoubeidi, R. Matusik, 2018, European urology.

Sugar transport by the bacterial phosphotransferase system. Isolation and characterization of enzyme I from Salmonella typhimurium.

S. Roseman, A. Nakazawa, E. Waygood, 1982, The Journal of biological chemistry.

Sugar transport by the bacterial phosphotransferase system. Isolation and characterization of a phosphocarrier protein HPr from wild type and mutants of Salmonella typhimurium.

S. Roseman, A. Nakazawa, N. Weigel, 1982, The Journal of biological chemistry.

Vitamin D and prostate cancer.

N. Weigel, T. C. Polek, 2002, Journal of andrology.