E. Deenick

发表

Protein Kinase B , c-Rel , θ Differentially by Protein Kinase C T Cell Survival Is Regulated + and CD 8 + CD 4

Russell G. Jones, J. Woodgett, S. Gerondakis, 2007 .

CD4+ and CD8+ T Cell Survival Is Regulated Differentially by Protein Kinase Cθ, c-Rel, and Protein Kinase B1

Russell G. Jones, J. Woodgett, S. Gerondakis, 2007, The Journal of Immunology.

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Sami Al-Hajjar, J. Casanova, S. Choo, 2010, The Journal of experimental medicine.

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

J. Casanova, S. Choo, Joanne M. Smart, 2012, Blood.

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

J. Casanova, S. Choo, Joanne M. Smart, 2013, The Journal of experimental medicine.

Regulation of T follicular helper cell formation and function by antigen presenting cells.

S. Tangye, E. Deenick, R. Brink, 2011, Current opinion in immunology.

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

S. Tangye, J. Cyster, B. Whittle, 2009, Nature Immunology.

NK Cells Regulate CD8+ T Cell Mediated Autoimmunity

T. Mak, T. Holderried, A. Pandyra, 2020, Frontiers in Cellular and Infection Microbiology.

Phosphatidylinositol 3-kinase signaling and immune regulation: insights into disease pathogenesis and clinical implications

S. Tangye, E. Deenick, T. Nguyen, 2021, Expert review of clinical immunology.

Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD—the Goldilocks’ Effect

S. Tangye, G. Uzel, E. Deenick, 2019, Journal of Clinical Immunology.

Monitoring T Cell Proliferation

P. Hodgkin, E. Deenick, E. Hawkins, 2005 .

This information is current as Responses Mechanism for Enhanced Secondary Immune Naive and Memory Human B Cells as a Intrinsic Differences in the Proliferation of

S. Tangye, P. Hodgkin, E. Deenick, 2002 .

c‐Rel but not NF‐κB1 is important for T regulatory cell development

T. Mak, M. Pellegrini, P. Ohashi, 2010, European journal of immunology.

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

D. Chaussabel, J. Casanova, P. Li, 2018, Science Immunology.

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

S. Tangye, P. Schwartzberg, E. Deenick, 2010, Immunity.

STAT3 mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8 + T cell memory formation and function

S. Choo, Joanne M. Smart, C. Picard, 2013 .

The role of SAP and SLAM family molecules in the humoral immune response

E. Deenick, Cindy S. Ma, 2011, Annals of the New York Academy of Sciences.

Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice

M. Jordana, T. Mak, A. Wakeham, 2006, Molecular and Cellular Biology.

Survival Precursor Frequencies , Cell Cycle Time , and Calculus Revealing IL-2 Regulation of Stochastic Model of T Cell Proliferation : A

E. Deenick, Amanda V. Gett, A. Gett, 2003 .

Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency

S. Tangye, O. Sanal, I. Tezcan, 2021, Journal of Clinical Immunology.

Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency

S. O’Donoghue, M. Hodson, E. Deenick, 2022, bioRxiv.

For whom the B cells toll

E. Deenick, A. Kane, 2022, Immunology and cell biology.

Autoimmunity: IL‐21: a new player in Th17‐cell differentiation

S. Tangye, E. Deenick, 2007, Immunology and cell biology.

Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells.

L. Notarangelo, S. Choo, Joanne M. Smart, 2019, The Journal of allergy and clinical immunology.

Activating mutations in PIK3CD and murine CD4 + T cells

L. Notarangelo, S. Choo, Joanne M. Smart, 2019 .

Autoimmunity: IL‐21: a new player in Th17‐cell differentiation

S. Tangye, E. Deenick, 2008 .

Decision criteria for resolving isotype switching conflicts by B cells

P. Hodgkin, E. Deenick, J. Hasbold, 2005, European journal of immunology.

c‐Rel phenocopies PKCθ but not Bcl‐10 in regulating CD8+ T‐cell activation versus tolerance

T. Mak, J. Ruland, S. Gerondakis, 2010, European journal of immunology.

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

S. Choo, S. Tangye, T. Phan, 2011, PLoS biology.

T cell–B cell interactions in primary immunodeficiencies

S. Tangye, E. Deenick, U. Palendira, 2012, Annals of the New York Academy of Sciences.

Human Th9 cells: inflammatory cytokines modulate IL‐9 production through the induction of IL‐21

S. Tangye, E. Deenick, Cindy S. Ma, 2010, Immunology and cell biology.

Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

L. Notarangelo, S. Choo, Joanne M. Smart, 2019, The Journal of experimental medicine.

Everolimus-Induced Remission of Classic Kaposi’s Sarcoma Secondary to Cryptic Splicing Mediated CTLA4 Haploinsufficiency

S. Tangye, B. Gloss, T. Phan, 2020, Journal of Clinical Immunology.

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Matthew E. Ritchie, Timothy Baldwin, I. Konstantinov, 2019, Science Immunology.

Immunology: Helpful T cells are sticky

S. Tangye, E. Deenick, 2008, Nature.

Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

S. Tangye, J. Cyster, B. Whittle, 2010, Nature Immunology.

Quantitative analysis of lymphocyte differentiation and proliferation in vitro using carboxyfluorescein diacetate succinimidyl ester

P. Hodgkin, E. Deenick, J. Hasbold, 1999, Immunology and cell biology.

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19

José Alquicira-Hernández, T. Phan, A. Kelleher, 2022, Clinical Immunology.

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

J. Casanova, A. Sette, S. Tangye, 2018, Science Immunology.

Human T follicular helper (Tfh) cells and disease

E. Deenick, Cindy S. Ma, 2014, Immunology and cell biology.

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies.

J. Casanova, J. Ziegler, Joanne M. Smart, 2015, The Journal of allergy and clinical immunology.

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

J. B. Oliveira, J. Hughes, J. McElwee, 2014, Science.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

J. B. Oliveira, S. Pittaluga, S. Holland, 2013, Nature Immunology.

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

J. Casanova, A. Sette, L. Notarangelo, 2015, Science.

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL‐12

S. Tangye, E. Deenick, D. Avery, 2009, Immunology and cell biology.

The role of dysregulated PI3Kdelta signaling in human autoimmunity *

E. Deenick, Julia Bier, 2022, Immunological reviews.

Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD—the Goldilocks’ Effect

S. Tangye, G. Uzel, E. Deenick, 2019, Journal of Clinical Immunology.

Germline-activating mutations in PIK3CD compromise B cell development and function

W. Shi, S. Choo, S. Holland, 2018, The Journal of experimental medicine.

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

J. Casanova, J. Ziegler, Joanne M. Smart, 2013, Blood.

Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation.

P. Hodgkin, E. Deenick, J. Hasbold, 1999, Journal of immunology.

Molecular and cellular mechanisms underlying defective antibody responses

E. Deenick, A. Kane, Julia Bier, 2020, Immunology and cell biology.

Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19

José Alquicira-Hernández, T. Phan, A. Kelleher, 2022, bioRxiv.

The origins, function, and regulation of T follicular helper cells

S. Tangye, M. Batten, E. Deenick, 2012, The Journal of experimental medicine.

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity

S. Choo, S. Holland, S. Tangye, 2019, The Journal of allergy and clinical immunology.

Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency

J. Casanova, C. Picard, S. Tangye, 2017, The Journal of clinical investigation.

Intrinsic Differences in the Proliferation of Naive and Memory Human B Cells as a Mechanism for Enhanced Secondary Immune Responses1

Elissa K. Deenick, Philip D. Hodgkin, Stuart G. Tangye, 2003, The Journal of Immunology.

Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival1

Elissa K. Deenick, Philip D. Hodgkin, P. Hodgkin, 2003, The Journal of Immunology.

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects.

L. Notarangelo, S. Tangye, T. Phan, 2019, The Journal of allergy and clinical immunology.

Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

E. Deenick, Cindy S. Ma, A. Kane, 2018, Front. Immunol..

STAT3 is a central regulator of lymphocyte differentiation and function.

S. Tangye, G. Uzel, M. Cook, 2014, Current opinion in immunology.

Ar Ticle B Cell–intrinsic Signaling through Il-21 Receptor and Stat3 Is Required for Establishing Long-lived Antibody Responses in Humans Engagement of Cytokine Receptors by Specific Ligands Activate Janus Kinase–signal Transducer and Activator of Transcription (stat) Signaling Pathways. the Exact R

Sami Al-Hajjar, J. Casanova, S. Choo, 2022 .

Disruption of an anti-mycobacterial circuit between dendritic and Th cells in human SPPL2a deficiency

J. Casanova, M. Nussenzweig, A. Sette, 2018, Nature Immunology.

Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies

S. Tangye, E. Deenick, Cindy S. Ma, 2017, The Journal of Immunology.

Insights from Primary Immunodeficiencies Lymphocyte Development and Function : Cytokine-Mediated Regulation of Human

S. Tangye, E. Deenick, Cindy S. Ma, 2017 .

CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells

C. Goodnow, E. Deenick, K. Horikawa, 2023, Frontiers in Immunology.

TCR affinity and negative regulation limit autoimmunity

D. Moskophidis, L. Nguyen, J. Boulter, 2004, Nature Medicine.

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets

J. Casanova, J. Ziegler, A. Bousfiha, 2016, The Journal of experimental medicine.

T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.

Imogen Moran, Tri Giang Phan, Warren Kaplan, 2015, Immunity.

The good, the bad and the ugly — TFH cells in human health and disease

S. Tangye, E. Deenick, R. Brink, 2013, Nature Reviews Immunology.

The regulation and role of T follicular helper cells in immunity

E. Deenick, Cindy S. Ma, Elissa K. Deenick, 2011, Immunology.

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

J. Casanova, Joanne M. Smart, C. Picard, 2015, The Journal of experimental medicine.

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells

J. Sprent, T. Phan, C. King, 2017, Nature Communications.

PKCθ Signals Activation versus Tolerance In Vivo

Russell G. Jones, D. Littman, P. Ohashi, 2004, The Journal of experimental medicine.

P90: LANADELUMAB EFFICACY AND SAFETY REGARDLESS OF BASELINE ATTACK RATE IN PATIENTS WITH PREVIOUS LONG‐TERM PROPHYLAXIS OF HEREDITARY ANGIOEDEMA: A POST HOC SUBANALYSIS OF HELP OLE

Louise, A. Kelleher, E. Deenick, 2022 .

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

David R. Croucher, David E. James, D. Croucher, 2023, The Journal of experimental medicine.

The sound of silence: modulating anergy in T lymphocytes.

P. Ohashi, S. Saibil, E. Deenick, 2007, Current opinion in immunology.

STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis.

Timothy J. Peters, W. Al-Herz, S. Tangye, 2022, Journal of Allergy and Clinical Immunology.

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

J. Casanova, M. Nussenzweig, A. Sette, 2018, Nature Immunology.

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.

J. Casanova, S. Choo, Joanne M. Smart, 2013, The Journal of allergy and clinical immunology.

Monogenic mutations differentially impact the quantity and quality of T follicular helper cells in human primary immunodeficiencies

Polina, Wong, Seyed, 2016 .

Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse

David R. Croucher, D. Croucher, T. Phan, 2023, Science advances.

Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome.

S. Tangye, E. Deenick, Simon J. Pelham, 2016, The Journal of allergy and clinical immunology.

B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.

S. Tangye, E. Deenick, R. Brink, 2016, The Journal of allergy and clinical immunology.

a Stochastic Framework for Describing Division Linked and Independent, Revealing Switching to IgG3, IgG2b, and IgA Is

Elissa K. Deenick, Jhagvaral Hasbold, Philip D. Hodgkin, 2013 .

Differentiation a Stochastic Framework for Describing Division Linked and Independent , Revealing Switching to IgG 3 , IgG 2 b , and IgA Is

E. Deenick, J. Hasbold, 1999 .

Inborn errors of human B cell development, differentiation, and function

S. Tangye, E. Deenick, Cindy S. Ma, 2023, The Journal of experimental medicine.

The circulating life of a memory T-follicular helper cell

E. Deenick, Cindy S. Ma, 2017, Clinical & translational immunology.

Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency

S. Tangye, M. Cowley, T. Phan, 2018, Journal of Clinical Immunology.

The TORC that Gets the GC Cycling.

S. Tangye, E. Deenick, 2017, Immunity.

Disruption of an anti-mycobacterial circuit between dendritic and Th cells in human SPPL2a deficiency

Caroline, Tomi, A. Sette, 2018 .

Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency

S. Tangye, M. Cowley, T. Phan, 2018, Journal of Clinical Immunology.