Shaodong Guo

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FoxO1 Regulates Multiple Metabolic Pathways in the Liver

K. Heidenreich, D. Stolz, M. Montminy, 2006, Journal of Biological Chemistry.

Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms

Stephen Adam, Haiyun Pan, A. Mesecar, 2002, The Journal of Biological Chemistry.

Insulin Suppresses Transactivation by CAAT/Enhancer-binding Proteins β (C/EBPβ)

Peter F. Johnson, A. Ghosh, T. Unterman, 2001, The Journal of Biological Chemistry.

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*

P. Cohen, T. Unterman, G. Rena, 1999, The Journal of Biological Chemistry.

APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

Feng Dong, Steven N. Austad, Feng Liu, 2014, Cell reports.

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.

Shaodong Guo, K. Drosatos, Nina M. Pollak, 2016, Circulation research.

Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1.

Shaodong Guo, J. Qiu, Hua Yu, 2014, Journal of diabetes and its complications.

Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R

S. Samson, Shaodong Guo, Yuxiang Sun, 2017, Scientific Reports.

Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases

Shaodong Guo, Hongting Zheng, Jun Wu, 2018, Mediators of inflammation.

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

J. Mattick, Q. Kaas, Shaodong Guo, 2020, Proceedings of the National Academy of Sciences.

A Recurring Chemogenetic Switch for Chimeric Antigen Receptor T Cells

Shaodong Guo, W. Liu, Jianfeng Zhou, 2021, bioRxiv.

Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice

James J. Cai, G. Calin, Daniel Osório, 2022, Redox biology.

Estrogen Protects Cardiac Function and Energy Metabolism in Dilated Cardiomyopathy Induced by Loss of Cardiac IRS1 and IRS2

Shaodong Guo, Hui Yan, C. Allred, 2022, Circulation. Heart failure.

Cardiac Myocyte KLF 5 Regulates Ppara Expression and Cardiac Function

Shaodong Guo, K. Drosatos, Nina M. Pollak, 2015 .

Dipteran toxicity assays for determining the oral insecticidal activity of venoms and toxins

Shaodong Guo, G. King, V. Herzig, 2018, Toxicon : official journal of the International Society on Toxinology.

Mibefradil alleviates high glucose-induced cardiac hypertrophy by inhibiting PI3K/Akt/mTOR-mediated autophagy.

Zihui Xu, Shaodong Guo, Pei Li, 2020, Journal of cardiovascular pharmacology.

Obesity-induced RCAN1 Overexpression Leads to β-Cell Failure through Mitophagy Pathway Inhibition.

Guohua Yang, Kai Sun, F. Zhou, 2019, Antioxidants & redox signaling.

Activation of Foxo1 by Insulin Resistance Promotes Cardiac Dysfunction and &bgr;–Myosin Heavy Chain Gene Expression

Zihui Xu, Shaodong Guo, Kebin Zhang, 2015, Circulation. Heart failure.

Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin

Shaodong Guo, Yuxiang Sun, Hui-Chen Lu, 2021, World journal of diabetes.

GHS-R in brown fat potentiates differential thermogenic responses under metabolic and thermal stresses

Shaodong Guo, Yuxiang Sun, C. Wolfrum, 2021, PloS one.

Protective effects of ghrelin on fasting-induced muscle atrophy in aging mice.

Guoyao Wu, S. Safe, J. Lawler, 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus

Shaodong Guo, Yumin Yang, Caiping Wang, 2016, Scientific Reports.

Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity

Qifu Li, S. Glaser, G. Alpini, 2018, Hepatology.

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Yuehua Wu, D. Craik, I. Vetter, 2022, Nature communications.

Ex Vivo Smooth Muscle Pharmacological Effects of a Novel Bradykinin-Related Peptide, and Its Analogue, from Chinese Large Odorous Frog, Odorrana livida Skin Secretions

Shaodong Guo, C. Shaw, Tianbao Chen, 2016, Toxins.

Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1

Zheng Shen, Shaodong Guo, Yuxiang Sun, 2018, Diabetes.

It Takes Two: Dimerization Is Essential for the Broad-Spectrum Predatory and Defensive Activities of the Venom Peptide Mp1a from the Jack Jumper Ant Myrmecia pilosula

I. Vetter, Shaodong Guo, G. King, 2020, Biomedicines.

RTEF-1 Attenuates Blood Glucose Levels by Regulating Insulin-Like Growth Factor Binding Protein-1 in the Endothelium

Shaodong Guo, Jian Li, Angela F. Messmer-Blust, 2012 .

A structural and functional analogue of a Bowman–Birk-type protease inhibitor from Odorrana schmackeri

Shaodong Guo, C. Shaw, Tianbao Chen, 2017, Bioscience reports.

Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis

Q. Tong, Jing Xu, B. Zeng, 2019, EBioMedicine.

Nano‐curcumin safely prevents streptozotocin‐induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus

Shaodong Guo, R. Basu, Beiyan Zhou, 2017, British journal of pharmacology.

Activation of the canonical ER stress IRE1–XBP1 pathway by insulin regulates glucose and lipid metabolism

F. Wondisford, Shaodong Guo, M. Hussain, 2022, The Journal of biological chemistry.

β Cell GHS-R Regulates Insulin Secretion and Sensitivity

A. Gaharwar, Shaodong Guo, Yuxiang Sun, 2021, International journal of molecular sciences.

ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration

Shaodong Guo, Hui Jiang, Zhifang Xie, 2018, Cell Death & Disease.

Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis

Zheng Shen, Shaodong Guo, Yuxiang Sun, 2021, Diabetes.

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase B a and the Forkhead Transcription Factor

R. Walther, D. Alessi, T. Unterman, 2000 .

Genomic, Functional and Structural Analyses Reveal Mechanisms of Evolutionary Innovation within the Sea Anemone 8 Toxin Family

K. Dudley, D. Hurwood, R. Norton, 2022, bioRxiv.

Amino Acids in Autophagy: Regulation and Function.

Shaodong Guo, Guoyao Wu, J. Shen, 2021, Advances in experimental medicine and biology.

Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance

M. White, Zihui Xu, Shaodong Guo, 2013, Diabetes.

Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention.

Shaodong Guo, 2014, The Journal of endocrinology.

AKT-Independent Protection of Prostate Cancer Cells from Apoptosis Mediated through Complex Formation between the Androgen Receptor and FKHR

G. Jenster, Pengfei Li, W. Bai, 2003, Molecular and Cellular Biology.

Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

M. White, T. Boronina, P. Cole, 2017, Nature Communications.

Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.

Shaodong Guo, 2014, The Journal of endocrinology.

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence*

P. Cohen, T. Unterman, G. Rena, 1999, The Journal of Biological Chemistry.

Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38a MAPK During Insulin

R. Kumar, M. White, Zihui Xu, 2013 .

The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor

M. White, Shaodong Guo, Liqing Yu, 2022, The Journal of biological chemistry.

Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice.

R. DePinho, B. Gan, Shaodong Guo, 2012, Endocrinology.

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence*

A. Klippel, T. Unterman, Shaodong Guo, 1998, The Journal of Biological Chemistry.

Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation.

Shaodong Guo, Hua Yu, Kebin Zhang, 2014, Canadian journal of microbiology.

Insulin Resistance in Obesity

Shaodong Guo, Yajuan Qi, Xiaoqin Guo, 2015 .

DPP-4 Inhibitors Improve Diabetic Wound Healing via Direct and Indirect Promotion of Epithelial-Mesenchymal Transition and Reduction of Scarring

Shaodong Guo, Hongting Zheng, Gangyi Yang, 2017, Diabetes.

FoxO1 Deficiency Enhances Cell Proliferation and Survival Under Normoglycemia and Promotes Angiogenesis Under Hyperglycemia in the Placenta.

Shaodong Guo, Lanjing Zhang, Linglin Xie, 2023, Laboratory investigation; a journal of technical methods and pathology.

Activation of AMPK restricts coxsackievirus B3 replication by inhibiting lipid accumulation.

Shaodong Guo, F. Hu, Hua Yu, 2015, Journal of molecular and cellular cardiology.

Foxo1 integrates insulin signaling with mitochondrial function in the liver

P. Puigserver, R. DePinho, M. White, 2009, Nature Medicine.

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.

R. DePinho, Yedan Li, M. White, 2008, Cell metabolism.

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

F. Wondisford, S. Radovick, B. O’Rourke, 2019, Cell reports.

Vascular Endothelial Growth Factor Activates PI3K/Akt/Forkhead Signaling in Endothelial Cells

W. Aird, M. Abid, K. Spokes, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Carsten Endothelial Cells Vascular Endothelial Growth Factor Activates PI 3 K / Akt / Forkhead Signaling in

W. Aird, M. Abid, K. Spokes, 2004 .

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

Sunmin Park, M. White, Shaodong Guo, 2009, Molecular and Cellular Biology.

The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.

M. White, Shaodong Guo, Sarah L. Dunn, 2006, Molecular endocrinology.

Etiology of Metabolic Syndrome and Dietary Intervention

Shaodong Guo, K. Kubena, Hang Xu, 2018, International journal of molecular sciences.

Novel Mechanism of Blood Pressure Regulation By Forkhead Box Class O1–Mediated Transcriptional Control of Hepatic Angiotensinogen

Zihui Xu, Shaodong Guo, Kebin Zhang, 2014, Hypertension.

Identification of Calcium-modulating Cyclophilin Ligand (CAML) as Transducer of Angiotensin II-mediated Nuclear Factor of Activated T Cells (NFAT) Activation*

Shaodong Guo, V. Dzau, M. Lopez-Ilasaca, 2005, Journal of Biological Chemistry.

Phosphatase and Tensin Homolog Regulation of Islet Growth and Glucose Homeostasis*

J. Kushner, M. White, R. Parsons, 2005, Journal of Biological Chemistry.

Metformin Targets Foxo1 to Control Glucose Homeostasis

Shaodong Guo, Yuxiang Sun, Hongting Zheng, 2021, Biomolecules.

Ghrelin Signaling in Immunometabolism and Inflamm-Aging.

Shaodong Guo, Yuxiang Sun, S. Mertens-Talcott, 2018, Advances in experimental medicine and biology.

Gene- and Activation-specific Mechanisms for Insulin Inhibition of Basal and Glucocorticoid-induced Insulin-like Growth Factor Binding Protein-1 and Phosphoenolpyruvate Carboxykinase Transcription

T. Unterman, Shaodong Guo, D. Yeagley, 2001, The Journal of Biological Chemistry.

Insulin receptor substrate signaling controls cardiac energy metabolism and heart failure.

Shaodong Guo, Cathy A. Guo, 2017, The Journal of endocrinology.

Molecular Basis of Insulin Resistance: The Role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications.

Shaodong Guo, 2013, Drug discovery today. Disease mechanisms.

Ginsenoside Rg2 inhibits adipogenesis in 3T3-L1 preadipocytes and suppresses obesity in high-fat-diet-induced obese mice through the AMPK pathway.

Shaodong Guo, Sanabil Yaqoob, Mingzhu Zheng, 2019, Food & function.

Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R

S. Samson, Shaodong Guo, Yuxiang Sun, 2017, Scientific Reports.

A Nucleoprotein Complex containing CCAAT/Enhancer-binding Protein β Interacts with an Insulin Response Sequence in the Insulin-like Growth Factor-binding Protein-1 Gene and Contributes to Insulin-regulated Gene Expression*

Pixu Liu, A. Ghosh, T. Unterman, 2001, The Journal of Biological Chemistry.

Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1.

Shaodong Guo, Yuxiang Sun, Chaodong Wu, 2019, The Journal of endocrinology.

Forkhead Transcription Factors Inhibit Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia*[boxs]

W. Aird, C. Ferran, M. Abid, 2005, Journal of Biological Chemistry.

Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis

F. Wondisford, Zihui Xu, Yunmei Chen, 2018, Diabetes.

Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice.

D. Threadgill, M. White, Zihui Xu, 2019, Endocrinology.

Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis

Shaodong Guo, Yuxiang Sun, De-Pei Li, 2017, International journal of molecular sciences.

Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets

B. Graham, S. Samson, Shaodong Guo, 2022, Biomolecules.

Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice

Zheng Shen, Shaodong Guo, Quan Pan, 2023, Diabetologia.

Epigallocatechin Gallate Inhibits Hepatic Glucose Production in Primary Hepatocytes via Downregulating PKA Signaling Pathways and Transcriptional Factor FoxO1.

Yunmei Chen, Huimin Liu, Shaodong Guo, 2019, Journal of agricultural and food chemistry.

Transcription factor Foxo1 mediates TGF-β1-induced apoptosis in hepatocytes.

Yunmei Chen, Shaodong Guo, Sijun Yang, 2023, The American journal of pathology.

Structural and functional analysis of the related transcriptional enhancer factor-1 and NF-κB interaction.

Shaodong Guo, Jian Li, Hongsheng Liu, 2014, American journal of physiology. Heart and circulatory physiology.

Genomic, Functional and Structural Analyses Reveal Mechanisms of Evolutionary Innovation within the Sea Anemone 8 Toxin Family

K. Dudley, D. Hurwood, R. Norton, 2022, bioRxiv.

Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs.

D. Rokyta, Shaodong Guo, G. King, 2019, ACS pharmacology & translational science.

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity.

R. Walther, D. Alessi, T. Unterman, 2000, The Journal of biological chemistry.

A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice.

Shaodong Guo, Yuxiang Sun, C. Allred, 2019, Journal of visualized experiments : JoVE.

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.

P. Cohen, T. Unterman, G. Rena, 2001, The Biochemical journal.

Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH.

Qifu Li, Qingsheng Li, Xiaoqiu Xiao, 2019, The Journal of endocrinology.

Insulin receptor substrate signaling controls cardiac energy metabolism and heart failure.

Shaodong Guo, Cathy A. Guo, 2017, The Journal of endocrinology.

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

R. Walther, D. Alessi, T. Unterman, 2000, The Journal of Biological Chemistry.

Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1.

Shaodong Guo, J. Qiu, Hua Yu, 2014, Journal of diabetes and its complications.

Identification of Calcium-modulating Cyclophilin Ligand (CAML) as Transducer of Angiotensin II-mediated Nuclear Factor of Activated T Cells (NFAT) Activation*

Shaodong Guo, V. Dzau, M. Lopez-Ilasaca, 2005, Journal of Biological Chemistry.

FoxO1 Regulates Multiple Metabolic Pathways in the Liver

K. Heidenreich, D. Stolz, M. Montminy, 2006, Journal of Biological Chemistry.

Suppression of FOXO1 attenuates inflamm‐aging and improves liver function during aging

James J. Cai, Shaodong Guo, Wesley A Brashear, 2023, Aging cell.

Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice.

R. DePinho, B. Gan, Shaodong Guo, 2012, Endocrinology.

Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammation and TGF-β1-mediated HSC Activation

Shaodong Guo, Yajuan Qi, Mingchen Gao, 2023, Cellular and molecular gastroenterology and hepatology.

Activation of Foxo1 by Insulin Resistance Promotes Cardiac Dysfunction and &bgr;–Myosin Heavy Chain Gene Expression

Zihui Xu, Shaodong Guo, Kebin Zhang, 2015, Circulation. Heart failure.

RTEF-1 Attenuates Blood Glucose Levels by Regulating Insulin-Like Growth Factor Binding Protein-1 in the Endothelium

Shaodong Guo, Jian Li, Angela F. Messmer-Blust, 2012, Circulation research.

Sample preparation for the metabolomics investigation of poly-gamma-glutamate-producing Bacillus licheniformis by GC-MS.

Shaodong Guo, Jian Ji, Shouwen Chen, 2013, Journal of microbiological methods.

Reciprocal regulation of hepatic TGF-β1 and Foxo1 controls gluconeogenesis and energy expenditure.

S. Safe, Yunmei Chen, Zheng Shen, 2023, Diabetes.