M. Sajan

发表

FoxO1 Regulates Multiple Metabolic Pathways in the Liver

K. Heidenreich, D. Stolz, M. Montminy, 2006, Journal of Biological Chemistry.

muscles of old vs. adult rats phosphorylation in the soleus, but not epitrochlearis, Insulin resistance for glucose uptake and Akt2

Robert V Farese, Jun Ren, J. Treebak, 2015 .

Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats.

M. Sajan, R. Farese, G. Cartee, 2011, American journal of physiology. Endocrinology and metabolism.

Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats.

M. Sajan, R. Farese, G. Cartee, 2010, Journal of applied physiology.

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

M. Sajan, R. Farese, D. Cooper, 2021, MedComm.

Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status.

M. Sajan, R. Farese, 2010, American journal of physiology. Endocrinology and metabolism.

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.

M. Sajan, R. Farese, U. Varanasi, 2009, Journal of lipid research.

Exercise improves phosphatidylinositol‐3,4,5‐trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle

M. Sajan, R. Farese, J. Wojtaszewski, 2007, The Journal of physiology.

Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice.

M. Sajan, R. Farese, A. Miura, 2004, Molecular endocrinology.

Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome.

M. Sajan, R. Farese, Scott Lucidi, 2004, Metabolic syndrome and related disorders.

Cbl, IRS-1, and IRS-2 Mediate Effects of Rosiglitazone on PI3K, PKC-λ, and Glucose Transport in 3T3/L1 Adipocytes.

M. Sajan, R. Farese, G. Bandyopadhyay, 2002, Endocrinology.

Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.

M. Quon, M. Sajan, R. Farese, 1999, The Journal of biological chemistry.

Protein Kinase C-ζ and Phosphoinositide-dependent Protein Kinase-1 Are Required for Insulin-induced Activation of ERK in Rat Adipocytes*

M. Quon, T. Burke, M. Sajan, 1999, The Journal of Biological Chemistry.

Dependence of insulin-stimulated glucose transporter 4 translocation on 3-phosphoinositide-dependent protein kinase-1 and its target threonine-410 in the activation loop of protein kinase C-zeta.

M. Quon, L. Karnitz, M. Sajan, 1999, Molecular endocrinology.

Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes.

M. Sajan, R. Farese, G. Bandyopadhyay, 2000, Endocrinology.

In Vitro Inhibition of Mammalian Glutathione Transferases by Selected Nitrobenzenes

M. Sajan, G. Reddy, A. Kulkarni, 2000 .

Thiazolidinedione treatment enhances insulin effects on protein kinase C-zeta /lambda activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic rats.

M. Sajan, R. Farese, G. Bandyopadhyay, 2000, The Journal of biological chemistry.

Activation of the ERK Pathway and Atypical Protein Kinase C Isoforms in Exercise- and Aminoimidazole-4-carboxamide- 1-β-d-riboside (AICAR)-stimulated Glucose Transport*

Robert V Farese, M. Sajan, Hubert C. Chen, 2002, The Journal of Biological Chemistry.

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

E. Van Obberghen, M. Sajan, R. Farese, 2010, American journal of physiology. Endocrinology and metabolism.

Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects

M. Sajan, R. Farese, A. Miura, 2006, Diabetologia.

Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C.

A. Ryan, M. Sajan, R. Farese, 2011, Antioxidants & redox signaling.

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

Robert V Farese, C. Newgard, M. Sajan, 2007, American journal of physiology. Endocrinology and metabolism.

Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus

M. Sajan, R. Farese, Mackenzie C. Lee, 2014, Expert opinion on therapeutic targets.

PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes.

M. Quon, M. Sajan, R. Farese, 2002, The Journal of clinical endocrinology and metabolism.

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

W. Kaelin, Wenyi Wei, R. Freeman, 2005, Cancer cell.

Insulin-induced Activation of Atypical Protein Kinase C, but Not Protein Kinase B, Is Maintained in Diabetic (ob/ob and Goto-Kakazaki) Liver

M. Sajan, R. Farese, Hubert C. Chen, 2004, Journal of Biological Chemistry.

Atypical Protein Kinase C Hyperactivity in Insulin-Resistant and Insulin-Sensitive Forms of Alzheimer’s Disease: A Potential Therapeutic Target

M. Sajan, R. Farese, M. Kindy, 2020, Alzheimer’s Disease: Drug Discovery.

Knockout of PKC Enhances Insulin Signaling Through PI3K

M. Sajan, R. Farese, M. Plomann, 2002 .

Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.

Robert V Farese, M. Sajan, Hubert C. Chen, 2004, Diabetes.

Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis

G. Shulman, M. Sajan, R. Farese, 2013, Adipocyte.

Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus

M. Sajan, R. Farese, Mackenzie C. Lee, 2014, Journal of clinical medicine.

Requirements for Pseudosubstrate Arginine Residues during Autoinhibition and Phosphatidylinositol 3,4,5-(PO4)3-dependent Activation of Atypical PKC*

M. Sajan, R. Farese, R. Ivey, 2014, The Journal of Biological Chemistry.

Repletion of Atypical Protein Kinase C following RNA Interference-mediated Depletion Restores Insulin-stimulated Glucose Transport*

Pengfei Li, M. Sajan, R. Farese, 2006, Journal of Biological Chemistry.

Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans

M. Sajan, R. Farese, M. Standaert, 2006, Diabetologia.

Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects.

P. Vollenweider, M. Sajan, R. Farese, 2004, The Journal of clinical endocrinology and metabolism.

Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes.

M. Sajan, R. Farese, G. Bandyopadhyay, 2003, Endocrinology.

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.

M. Sajan, R. Farese, G. Bandyopadhyay, 2003, Diabetes.

Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.

M. Quon, I. Dikic, M. Sajan, 2002, The Biochemical journal.

Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota.

M. Sajan, R. Farese, B. Hansen, 2002, Diabetes.

Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.

M. Quon, I. Dikic, M. Sajan, 2001, The Journal of biological chemistry.

Rosiglitazone, Insulin Treatment, and Fasting Correct Defective Activation of Protein Kinase C-ζ/λ by Insulin in Vastus Lateralis Muscles and Adipocytes of Diabetic Rats.

M. Sajan, R. Farese, G. Bandyopadhyay, 2001, Endocrinology.

Glucose Activates Mitogen-activated Protein Kinase (Extracellular Signal-regulated Kinase) through Proline-rich Tyrosine Kinase-2 and the Glut1 Glucose Transporter*

M. Quon, C. Newgard, I. Dikic, 2000, The Journal of Biological Chemistry.

Downregulation of Adiponectin/AdipoR2 is Associated with Steatohepatitis in Obese Mice

M. Sajan, R. Farese, Min You, 2009, Journal of Gastrointestinal Surgery.

insulin-dependent GLUT4 translocation Muscle cells engage Rab8A and myosin Vb in

Robert V Farese, A. Klip, M. Sajan, 2010 .

Combined thiazolidinedione–metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle

M. Sajan, R. Farese, M. Standaert, 2008, Diabetologia.

Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses.

B. Wisse, M. Schwartz, M. Sajan, 2009, Endocrinology.

M. Sajan, R. Farese, R. Ivey, 2015, Metabolism: clinical and experimental.

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

M. Sajan, R. Farese, R. Ivey, 2015, Journal of Lipid Research.

PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.

G. Shulman, M. Sajan, R. Farese, 2014, Molecular endocrinology.

Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

M. Sajan, R. Farese, M. Standaert, 2014, Diabetes.

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.

C. Kahn, A. Fields, M. Sajan, 2012, Metabolism: clinical and experimental.

Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors

M. Sajan, R. Farese, 2012, Diabetologia.

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance

C. Kahn, C. Taniguchi, M. Sajan, 2009, Diabetologia.

Increased atypical PKC activity in endurance-trained human skeletal muscle.

M. Sajan, R. Farese, J. Wojtaszewski, 2003, Biochemical and biophysical research communications.

Lipoxygenase-Mediated N-Demethylation of Imipramine and Related Tricyclic Antidepressants in the Presence of Hydrogen Peroxide

M. Sajan, A. Kulkarni, Jian'an Hu, 1999 .

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42 and Phospho-Tau May Abet Alzheimer Development

M. Sajan, R. Farese, M. Leitges, 2016, Diabetes.

Activity of some respiratory enzymes and cytochrome contents in rat hepatic mitochondria following aflatoxin B1 administration.

M. Sajan, J. G. Satav, R. K. Bhattacharya, 1995, Toxicology letters.

Lipoxygenase-mediated glutathione oxidation and superoxide generation.

M. Sajan, A. Kulkarni, P. Roy, 1995, Journal of biochemical toxicology.

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity

M. Schwartz, M. Sajan, R. Farese, 2017, Diabetes.

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease

Robert V Farese, M. Sajan, B. Hansen, 2018, Neurobiology of Aging.

Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid.

M. Sajan, A. P. Kulkarni, 1999, Archives of biochemistry and biophysics.

A novel mechanism of glutathione conjugate formation by lipoxygenase: a study with ethacrynic acid.

M. Sajan, A. P. Kulkarni, 1997, Toxicology and applied pharmacology.

Linkage of atypical protein kinase C to Alzheimer disease

Robert V Farese, M. Sajan, 2020 .

Effect of aflatoxin B in vitro on rat liver mitochondrial respiratory functions.

M. Sajan, J. G. Satav, R. K. Bhattacharya, 1997, Indian journal of experimental biology.

A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma.

M. Sajan, R. Farese, D. Ostrov, 2011, The international journal of biochemistry & cell biology.

Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.

C. Kahn, Pixu Liu, Jean J. Zhao, 2010, Cell metabolism.

Cbl, IRS-1, and IRS-2 mediate effects of rosiglitazone on PI3K, PKC-lambda, and glucose transport in 3T3/L1 adipocytes.

M. Sajan, R. Farese, G. Bandyopadhyay, 2002, Endocrinology.

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

Sunmin Park, M. White, Shaodong Guo, 2009, Molecular and Cellular Biology.

Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.

Robert V Farese, A. Hevener, C. Newgard, 2007, Cell metabolism.

Atypical protein kinase C in insulin action and insulin resistance.

M. Sajan, R. Farese, M. Standaert, 2005, Biochemical Society transactions.

Atypical PKC controls β-secretase expression and thereby regulates production of Alzheimer plaque precursor Aβ in brain and insulin receptor degradation in liver.

Robert V Farese, M. Sajan, M. Leitges, 2020 .

Insulin-Sensitive Protein Kinases (Atypical Protein Kinase C and Protein Kinase B/Akt): Actions and Defects in Obesity and Type II Diabetes

M. Sajan, R. Farese, M. Standaert, 2005, Experimental biology and medicine.

Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

Harel Z Shouval, Robert V Farese, André Antonio Fenton, 2016, eLife.

Insulin signalling downstream of protein kinase B is potentiated by 5′AMP-activated protein kinase in rat hearts in vivo

M. Sajan, R. Farese, E. Obberghen, 2005, Diabetologia.

Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal‐regulated protein kinase in skeletal muscle

M. Sajan, R. Farese, E. Richter, 2004, The Journal of physiology.

Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites.

M. Sajan, R. Farese, M L Standaert, 2001, Biochemistry.

Protein Kinase C- (cid:1) Knockout in Embryonic Stem Cells and Adipocytes Impairs Insulin-Stimulated Glucose Transport

Atsushi Miura, M. Sajan, R. Farese, 2004 .

Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes

C. Kahn, G. Shulman, Hong Yang, 2007 .

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.

C. Kahn, G. Shulman, Hong Yang, 2007, The Journal of clinical investigation.

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.

C. Kahn, L. Cantley, C. Taniguchi, 2006, Cell metabolism.

Knockout of PKC alpha enhances insulin signaling through PI3K.

M. Sajan, R. Farese, M. Leitges, 2002, Molecular endocrinology.

Thiazolidinedione Treatment Enhances Insulin Effects on Protein Kinase C-ζ/λ Activation and Glucose Transport in Adipocytes of Nondiabetic and Goto-Kakizaki Type II Diabetic Rats*

Robert V Farese, M. Sajan, Robert V. Farese, 2000, The Journal of Biological Chemistry.

Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.

Robert V Farese, M. Sajan, F. Foufelle, 2018, Cellular signalling.

Atypical protein kinase C in cardiometabolic abnormalities

M. Sajan, R. Farese, 2012, Current opinion in lipidology.

Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression

M. Sajan, R. Farese, R. Ivey, 2013, Diabetologia.

Glucose Activates Protein Kinase C-ζ/λ through Proline-rich Tyrosine Kinase-2, Extracellular Signal-regulated Kinase, and Phospholipase D

Robert V Farese, M. Quon, M. Sajan, 2001, The Journal of Biological Chemistry.

Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.

C. Kahn, M. Sajan, R. Farese, 2004, Biochemistry.

Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.

M. Sajan, R. Farese, G. Bandyopadhyay, 2004, Biochemistry.

Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

Robert V Farese, H. Shouval, T. Sacktor, 2016, eLife.

FoxO1 Regulates Multiple Metabolic Pathways in the Liver

K. Heidenreich, D. Stolz, M. Montminy, 2006, Journal of Biological Chemistry.

Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status.

M. Sajan, R. Farese, 2010, American journal of physiology. Endocrinology and metabolism.

Cbl, IRS-1, and IRS-2 Mediate Effects of Rosiglitazone on PI3K, PKC-λ, and Glucose Transport in 3T3/L1 Adipocytes.

M. Sajan, R. Farese, G. Bandyopadhyay, 2002, Endocrinology.

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

M. Sajan, R. Farese, F. Foufelle, 2010, American journal of physiology. Endocrinology and metabolism.