S. Lecker

发表

The FOXO3a Transcription Factor Regulates Cardiac Myocyte Size Downstream of AKT Signaling*

A. Goldberg, I. Shiojima, M. Sandri, 2005, Journal of Biological Chemistry.

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

Marco Sandri, A. Goldberg, M. Sandri, 2004, Cell.

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.

A. Goldberg, W. Mitch, S. Lecker, 2006, Journal of the American Society of Nephrology : JASN.

Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide.

A. Goldberg, S. Lecker, M. Simons, 2000, The Journal of clinical investigation.

in Single Fiber Myosin Protein Content and Function Mechanisms Underlying Skeletal Muscle Weakness in Human Heart Failure: Alterations

D. Maughan, M. LeWinter, B. Palmer, 2015 .

Inhibition of ubiquitin-proteasome pathway–mediated IκBα degradation by a naturally occurring antibacterial peptide

A. Goldberg, Kaori Sato, S. Lecker, 2000 .

A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance

J. Rabinowitz, D. Forman, J. Baur, 2016, Nature Medicine.

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

A. Goldberg, R. Roy, V. Reggie Edgerton, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Calpain activity and muscle wasting in sepsis.

P. Hasselgren, Ira J. Smith, S. Lecker, 2008, American journal of physiology. Endocrinology and metabolism.

Slowing muscle atrophy: putting the brakes on protein breakdown

A. Goldberg, S. Lecker, Stewart H. Lecker, 2002, The Journal of physiology.

Diagnostic Use of Base Excess in Acid-Base Disorders.

S. Lecker, M. Zeidel, M. Hoenig, 2018, The New England journal of medicine.

Survey of muscle characteristics after statin-induced rhabdomyolysis

T. Wolfson, M. Orešič, R. Laaksonen, 2010 .

Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats.

A. Goldberg, W. Mitch, Y. Kwon, 1999, The Journal of clinical investigation.

S. Lecker, S. Karumanchi, A. Segal, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes.

P. Hasselgren, S. Lecker, E. Castillero, 2013, Metabolism: clinical and experimental.

Proteolysis by the ubiquitin-proteasome system and kidney disease.

W. Mitch, S. Lecker, 2011, Journal of the American Society of Nephrology : JASN.

The Glomerular Disease Study and Trial Consortium: A Grassroots Initiative to Foster Collaboration and Innovation

R. Rodby, H. Rennke, S. Lecker, 2018, Kidney international reports.

Statin‐induced muscle damage and atrogin‐1 induction is the result of a geranylgeranylation defect

V. Sukhatme, S. Lecker, J. Hanai, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Serum adiponectin in non-cachectic heart failure patients.

R. Arena, D. Forman, S. Lecker, 2013, International journal of cardiology.

RAAS-Blockade in COVID-19: The Ace of Spades?

S. Lecker, P. Kyriazis, Krishna Agarwal, 2021, Indian journal of nephrology.

Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications.

B. Rovin, G. McMahon, A. Vijayan, 2020, Clinical journal of the American Society of Nephrology : CJASN.

Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine

Zhaoyong Hu, S. Lecker, Pei-rang Cao, 2010, Diabetes.

Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle.

S. Wing, S. Lecker, I. Kettelhut, 2009, Endocrinology.

Patterns of gene expression in atrophying skeletal muscles: response to food deprivation

A. Goldberg, S. Lecker, Alfred L Goldberg, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.

Michiaki Yamashita, V. Sukhatme, S. Lecker, 2007, The Journal of clinical investigation.

Ubiquitin-protein ligases in muscle wasting.

S. Lecker, Pei-rang Cao, Stewart H Lecker, 2005, The international journal of biochemistry & cell biology.

TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k.

A. Goldberg, Yi-Ping Li, M. Reid, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

R. Arena, D. Forman, S. Lecker, 2012, Circulation. Heart failure.

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.

S. Lecker, M. Willis, L. Carrier, 2010, Cardiovascular research.

Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes

P. Hasselgren, S. Lecker, V. Petkova, 2008, Journal of cellular biochemistry.

Mechanisms Underlying Skeletal Muscle Weakness in Human Heart FailureCLINICAL PERSPECTIVE

D. Maughan, M. LeWinter, B. Palmer, 2009 .

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

A. Goldberg, V. Baracos, W. Mitch, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Interdialytic Creatinine Rise is a novel marker of volume overload and mortality risk in hemodialysis patients

Roger B. Davis, S. Lecker, Robert S. Brown, 2018, BMC Nephrology.

What's Old Is New Again: Harnessing the Power of Original Experiments to Learn Renal Physiology.

S. Lecker, M. Hoenig, Jeffrey H. William, 2022, Advances in chronic kidney disease.

Electrolyte-free water clearance: a key to the diagnosis of hypernatremia in resolving acute renal failure

S. Lecker, Gabor Bodonyi-Kovacs, 2008, Clinical and Experimental Nephrology.

Cobalt-catalyzed one-step assembly of B-ring aromatic steroids from acyclic precursors

S. Lecker, K. Vollhardt, N. Nguyen, 1986 .

The binding cascade of SecB to SecA to SecY E mediates preprotein targeting to the E. coli plasma membrane

F. Hartl, J. Hendrick, S. Lecker, 1990, Cell.

ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle

S. Lecker, W. Wickner, R. Lill, 1988, Cell.

ProOmpA contains secondary and tertiary structure prior to translocation and is shielded from aggregation by association with SecB protein.

A. Driessen, S. Lecker, W. Wickner, 1990, The EMBO journal.

Three pure chaperone proteins of Escherichia coli‐‐SecB, trigger factor and GroEL‐‐form soluble complexes with precursor proteins in vitro.

C. Georgopoulos, S. Lecker, W. Wickner, 1989, The EMBO journal.

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

A. Goldberg, M. Sandri, S. Lecker, 2007, Cell metabolism.

PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

Jiandie D. Lin, B. Spiegelman, A. Goldberg, 2006, Proceedings of the National Academy of Sciences.

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

A. Goldberg, S. Lecker, A. Navon, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks

S. Wing, S. Lecker, R. Jagoe, 2011, Critical reviews in clinical laboratory sciences.

Molecular basis for statin-induced muscle toxicity: implications and possibilities.

S. Lecker, C. Buettner, 2008, Pharmacogenomics.

Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress

M. Swanson, R. Moss, S. Lecker, 2012, Circulation.

Results Regional Expression of cMLCK Protein and Phosphorylation of MLC 2 v in Mouse and Human Hearts

M. Swanson, R. Moss, S. Lecker, 2012 .

Pattern Recognition versus Pathogenesis: Electrolytes in a Patient with Adrenal Insufficiency.

S. Lecker, M. Hoenig, 2022, Clinical journal of the American Society of Nephrology : CJASN.

Jade-1 inhibits Wnt signaling by ubiquitinating β-catenin and mediates Wnt pathway inhibition by pVHL

D. Seldin, S. Lecker, I. Dominguez, 2008, Nature Cell Biology.

Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states.

A. Goldberg, W. Mitch, S. Lecker, 1999, The Journal of nutrition.

Dynamic assessment of ventilatory efficiency during recovery from peak exercise to enhance cardiopulmonary exercise testing

R. Arena, D. Forman, S. Lecker, 2013, European journal of preventive cardiology.

More than meets the I(ris): Use of manual urine microscopy to complement automated findings in acute kidney injury

S. Lecker, M. Hoenig, J. D. Mena, 2022, Practical laboratory medicine.

The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle*

A. Goldberg, S. Lecker, A L Goldberg, 1998, The Journal of Biological Chemistry.

Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway

A. Varshavsky, Y. Kwon, I. Davydov, 2001, Molecular and Cellular Biology.

Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function

B. Schermer, T. Benzing, R. Brandes, 1999, Nature Medicine.

Given the science on malnutrition, how does the clinician respond? Practical lessons for and application to the dialysis patient.

S. Lecker, 2009, Clinical journal of the American Society of Nephrology : CJASN.

Analysis of skeletal muscle gene expression patterns and the impact of functional capacity in patients with systolic heart failure.

R. Arena, L. Cahalin, D. Forman, 2014, Journal of cardiac failure.

Adiposity facilitates increased strength capacity in heart failure patients with reduced ejection fraction.

R. Arena, D. Forman, S. Lecker, 2013, International journal of cardiology.

Ubiquitin‐protein ligases in muscle wasting: multiple parallel pathways?

S. Lecker, 2003, Current opinion in clinical nutrition and metabolic care.

Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia

V. Baracos, O. Bathe, L. Cervo, 2016, Oncogene.

Mechanisms Underlying Skeletal Muscle Weakness in Human Heart Failure: Alterations in Single Fiber Myosin Protein Content and Function

D. Maughan, M. LeWinter, B. Palmer, 2009, Circulation. Heart failure.

TNF‐α increases ubiquitin‐conjugating activity in skeletal muscle by up‐regulating UbcH2/E220k

A. Goldberg, Yi-Ping Li, M. Reid, 2003 .

Incidence and risk factors of venous thromboembolism in ANCA-associated vasculitis: a metaanalysis and metaregression

S. Lecker, C. Thongprayoon, W. Cheungpasitporn, 2021, Clinical Rheumatology.

Trials for the Treatment of Secondary Wasting and Cachexia Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States 1 , 2

A. Goldberg, W. Mitch, S. Lecker, 1999 .

Ca2+-free Calmodulin and Calmodulin Damaged byin Vitro Aging Are Selectively Degraded by 26 S Proteasomes without Ubiquitination*

A. Goldberg, S. Lecker, E. Tarcsa, 2000, The Journal of Biological Chemistry.

DECREMENTS IN BONE , CONNECTIVE TISSUE AND MUSCLE FUNCTION WITH PROLONGED SPACEFLIGHT : MECHANISMS AND COUNTERMEASURES

S. Lecker, R. Vanderby, A. Vailas, 2001 .

Acid Base Disorders in Cirrhosis.

S. Lecker, M. Hoenig, Eric J. Xu, 2023, Advances in kidney disease and health.

Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes

P. Hasselgren, S. Lecker, V. Petkova, 2008, Journal of cellular biochemistry.

Proteolysis by the ubiquitin-proteasome system and kidney disease.

W. Mitch, S. Lecker, 2011, Journal of the American Society of Nephrology : JASN.