P. Arkhammar

发表

Identification of Akt Pathway Inhibitors Using Redistribution Screening on the FLIPR and the IN Cell 3000 Analyzer

S. Møller, B. K. Lundholt, V. Linde, 2005, Journal of biomolecular screening.

Excitation wave propagation as a possible mechanism for signal transmission in pancreatic islets of Langerhans.

A. Scott, O. Aslanidi, P. Arkhammar, 2001, Biophysical journal.

Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.

P. Rorsman, P. Berggren, P. Arkhammar, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function.

P. Arkhammar, N. Welsh, N. Makeeva, 2008, Biochemical pharmacology.

Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.

P. Rorsman, P. Berggren, P. Arkhammar, 1987, The Journal of biological chemistry.

40K glycoPEGylated, recombinant FVIIa: 3‐month, double‐blind, randomized trial of safety, pharmacokinetics and preliminary efficacy in hemophilia patients with inhibitors

P. Giangrande, R. Ljung, P. Arkhammar, 2013, Journal of thrombosis and haemostasis : JTH.

Functional identification and monitoring of individual α and β cells in cultured mouse islets of Langerhans

P. Arkhammar, O. Thastrup, B. R. Terry, 2004, Acta Diabetologica.

Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.

P. Rorsman, P. Berggren, P. Arkhammar, 1993, The Journal of clinical investigation.

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

J. Sturis, M. Donath, K. Maedler, 2004, Diabetes.

Characterization of the inositol 1,4,5-trisphosphate-induced Ca2+ release in pancreatic beta-cells.

P. Berggren, P. Arkhammar, A. Hallberg, 1987, The Biochemical journal.

Dihydroxyacetone-induced Oscillations in Cytoplasmic Free Ca2+ and the ATP/ADP Ratio in Pancreatic β-Cells at Substimulatory Glucose*

P. Berggren, P. Arkhammar, K. Tornheim, 2003, Journal of Biological Chemistry.

Establishment and Application of in Vitro Membrane Potential Assays in Cell Lines with Endogenous or Recombinant Expression of ATP-Sensitive Potassium Channels (Kir6.2/SUR1) Using a Fluorescent Probe Kit

P. Arkhammar, P. Wahl, J. Hansen, 2004, Journal of biomolecular screening.

Safety update on the use of recombinant activated factor VII in approved indications.

E. Neufeld, P. Arkhammar, C. Négrier, 2015, Blood reviews.

Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic β-cells

P. Rorsman, P. Berggren, P. Arkhammar, 1986, Bioscience reports.

Glucose-stimulated efflux of fura-2 in pancreatic beta-cells is prevented by probenecid.

P. Berggren, P. Arkhammar, T. Nilsson, 1989, Biochemical and biophysical research communications.

Stimulation of insulin release by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in the clonal cell line RINm5F despite a lowering of the free cytoplasmic Ca2+ concentration.

P. Berggren, P. Arkhammar, T. Nilsson, 1986, Biochimica et biophysica acta.

Depolarization-independent net uptake of calcium into clonal insulin-releasing cells exposed to glucose

P. Rorsman, A. Gazdar, P. Arkhammar, 1983, Bioscience reports.

Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration.

P. Berggren, P. Arkhammar, B. Ahrén, 1986, Biochemical and biophysical research communications.

Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture.

P. Rorsman, P. Berggren, P. Arkhammar, 1988, British Journal of Cancer.

Recombinant activated factor VII in the treatment of bleeds and for the prevention of surgery-related bleeding in congenital haemophilia with inhibitors.

P. Giangrande, E. Santagostino, M. Ozelo, 2015, Blood reviews.

Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.

P. Rorsman, P. Berggren, P. Arkhammar, 1989, The Journal of biological chemistry.

Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.

P. Rorsman, P. Berggren, P. Arkhammar, 1990, The Biochemical journal.

Dual effect of glucose on cytoplasmic free Ca2+ concentration and insulin release reflects the beta-cell being deprived of fuel.

P. Berggren, P. Arkhammar, T. Nilsson, 1988, Biochemical and biophysical research communications.

Pancreatic islets cultured on extracellular matrix: An excellent preparation for microfluorometry

P. Arkhammar, O. Thastrup, B. R. Terry, 1998 .

Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells

P. Rorsman, M. Köhler, P. Berggren, 1991, FEBS letters.

Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels.

P. Arkhammar, P. Wahl, M. Antoine, 2005, Bioorganic & medicinal chemistry.

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels.

P. Arkhammar, P. Wahl, F. Nielsen, 2004, Bioorganic & medicinal chemistry letters.

The potential correlation between patient-reported symptoms and the use of additional haemostatic medication for joint bleeding in haemophilia patients with inhibitors: a post hoc exploratory analysis of recombinant activated factor VII data from the ADEPT2 trial

P. Arkhammar, J. Mahlangu, S. Rangarajan, 2016, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

The use of recombinant activated factor VII in patients with acquired haemophilia.

P. Arkhammar, K. Amano, A. Tiede, 2015, Blood reviews.

Activation of protein kinase C assists insulin producing cells in recovery from raised cytoplasmic Ca2+ by stimulating Ca2+ efflux.

P. Berggren, P. Arkhammar, T. Nilsson, 1989, Biochemical and biophysical research communications.

Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells.

P. Arkhammar, P. Wahl, J. Hansen, 2001, Bioorganic & medicinal chemistry letters.

Extracellular Ca2+ induces a rapid increase in cytoplasmic free Ca2+ in pancreatic beta-cells.

P. Berggren, P. Arkhammar, T. Nilsson, 1987, Biochemical and biophysical research communications.

Dissociation between changes in cytoplasmic free Ca2+ concentration and insulin secretion as evidenced from measurements in mouse single pancreatic islets.

P. Berggren, P. Arkhammar, S. Efendić, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Protein kinase C modulates the insulin secretory process by maintaining a proper function of the beta-cell voltage-activated Ca2+ channels.

M. Köhler, P. Berggren, P. Arkhammar, 1994, The Journal of biological chemistry.

Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic beta-cells.

P. Berggren, P. Arkhammar, N. Welsh, 1989, The Biochemical journal.

A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release

P. Arkhammar, B. Pirotte, M. Antoine, 2000, Diabetologia.

Human interleukin 1 beta stimulates islet insulin release by a mechanism not dependent on changes in phospholipase C and protein kinase C activities or Ca2+ handling.

P. Berggren, P. Arkhammar, N. Welsh, 1989, Acta endocrinologica.

Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.

P. Rorsman, P. Berggren, P. Arkhammar, 1988, The Journal of biological chemistry.

Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis.

C. Heldin, C. Betsholtz, P. Berggren, 1990, Proceedings of the National Academy of Sciences of the United States of America.

New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.

A. F. Jensen, P. Arkhammar, P. Wahl, 2006, Journal of medicinal chemistry.

6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.

P. Arkhammar, P. Wahl, P. Mackay, 2002, Journal of medicinal chemistry.

Simultaneous visualization of the translocation of protein kinase Calpha-green fluorescent protein hybrids and intracellular calcium concentrations.

K. Almholt, P. Arkhammar, O. Thastrup, 1999, The Biochemical journal.

Regulation of cytoplasmic free Ca2+ in insulin-secreting cells.

M. Köhler, P. Berggren, P. Arkhammar, 1993, Advances in experimental medicine and biology.

Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cells.

G. Patterson, D. Piston, P. Arkhammar, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic beta-cells.

P. Berggren, P. Arkhammar, N. Welsh, 1989, The Biochemical journal.

Glucose‐stimulated efflux of indo‐1 from pancreatic β‐cells is reduced by probenecid

P. Berggren, P. Arkhammar, T. Nilsson, 1990, FEBS letters.

SYNTHESIS OF THIENO-1,2,4-THIADIAZINE 1,1-DIOXIDES VIA INTRAMOLECULAR COPPER PROMOTED CONDENSATION OF o-HALOTHIENYLSULFONYL GUANIDINES, AMIDINES OR ISOTHIOUREAS

P. Arkhammar, F. Nielsen, J. Hansen, 2003 .

Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells

Olof Larsson, Patrik Rorsman, Per-Olof Berggren, 1991, Nature.

Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells

P. Smith, P. Rorsman, P. Berggren, 1990, The Journal of general physiology.

Glucose-induced changes in cytoplasmic free Ca2+ concentration and the significance for the regulation of insulin release. Measurements with fura-2 in suspensions and single aggregates of mouse pancreatic beta-cells.

P. Berggren, P. Arkhammar, T. Nilsson, 1989, Cell calcium.

Voltage-activated Na+ currents and their suppression by phorbol ester in clonal insulin-producing RINm5F cells.

P. Berggren, P. Arkhammar, P. Rorsman, 1986, The American journal of physiology.

Glucose Decreases Na+,K+-ATPase Activity in Pancreatic β-Cells

O. Larsson, P. Berggren, P. Arkhammar, 1999, The Journal of Biological Chemistry.

Extracellular ATP mobilizes intracellular Ca2+ in T51B rat liver epithelial cells: a study involving single cell measurements.

P. Berggren, P. Arkhammar, A. Boynton, 1989, Experimental cell research.

Glucose-induced increase in cytoplasmic pH in pancreatic beta-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C.

P. Rorsman, P. Berggren, P. Arkhammar, 1991, The Journal of biological chemistry.

Polyamines in pancreatic islets of obese-hyperglycemic (ob/ob) mice of different ages.

P. Berggren, P. Arkhammar, Å. Sjöholm, 2001, American journal of physiology. Cell physiology.

Glucose decreases Na+,K+-ATPase activity in pancreatic beta-cells. An effect mediated via Ca2+-independent phospholipase A2 and protein kinase C-dependent phosphorylation of the alpha-subunit.

O. Larsson, P. Berggren, P. Arkhammar, 1999, Journal of Biological Chemistry.

Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders.

P. Arkhammar, P. Wahl, J. Hansen, 2004, Current medicinal chemistry.

Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.

P. Arkhammar, P. Wahl, M. Antoine, 2004, Journal of medicinal chemistry.

Oscillations in cytoplasmic free calcium concentration in human pancreatic islets from subjects with normal and impaired glucose tolerance

M. Köhler, P. Berggren, P. Arkhammar, 1994, Diabetologia.

Direct determination of selenium in solid biological materials by graphite furnace atomic absorption spectrometry

P. Berggren, P. Arkhammar, E. Lundberg, 1988 .

Functional identification and monitoring of individual alpha and beta cells in cultured mouse islets of Langerhans.

P. Arkhammar, O. Thastrup, B. R. Terry, 2004, Acta diabetologica.

Stimulation of pancreatic islet beta-cell replication by oncogenes.

D. Steiner, P. Berggren, P. Arkhammar, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms of action of entero-insular hormones and neural input on the insulin secretory process.

P. Rorsman, P. Berggren, P. Arkhammar, 1990, Biochemical Society transactions.