B. Chandrasekar

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CXCL16 Signals via Gi, Phosphatidylinositol 3-Kinase, Akt, IκB Kinase, and Nuclear Factor-κB and Induces Cell-Cell Adhesion and Aortic Smooth Muscle Cell Proliferation*

B. Chandrasekar, Sailaja Bysani, S. Mummidi, 2004, Journal of Biological Chemistry.

Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.

B. Chandrasekar, Jacob Russell, Laurel A. Grisanti, 2021, Cellular signalling.

Interleukin‐18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K‐Akt‐dependent NF‐κB activation

A. J. Valente, In‐San Kim, B. Chandrasekar, 2008, Journal of cellular physiology.

Effects of n−3 and n−6 fatty acids on the activities and expression of hepatic antioxidant enzymes in autoimmune-prone NZB×NZW F1 mice

B. Chandrasekar, J. Venkatraman, J. D. Kim, 1994, Lipids.

Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death.

A. J. Valente, B. Chandrasekar, D. Stec, 2008, Free radical biology & medicine.

TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice

B. Chandrasekar, Z. Grunewald, Makenzie L. Woodford, 2020, Hypertension.

WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death.

A. J. Valente, P. Delafontaine, B. Venkatesan, 2010, Cellular signalling.

Multinutrient undernutrition dysregulates the resident macrophage proinflammatory cytokine network, nuclear factor‐κB activation, and nitric oxide production

B. Chandrasekar, P. Melby, G. Anstead, 2003, Journal of leukocyte biology.

Differential regulation of nitric oxide synthase isoforms in experimental acute Chagasic cardiomyopathy

D. Troyer, G. Freeman, B. Chandrasekar, 2000, Clinical and experimental immunology.

Cloning of Syrian Hamster (Mesocricetus auratus) Cytokine cDNAs and Analysis of Cytokine mRNA Expression in Experimental Visceral Leishmaniasis

G. Freeman, B. Chandrasekar, P. Melby, 1998, Infection and Immunity.

Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury

V. Demarco, B. Chandrasekar, Guanghong Jia, 2018, Cardiovascular Diabetology.

Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice

V. Demarco, B. Chandrasekar, M. Dona, 2022, bioRxiv.

The Hamster as a Model of Human Visceral Leishmaniasis: Progressive Disease and Impaired Generation of Nitric Oxide in the Face of a Prominent Th1-Like Cytokine Response1

B. Chandrasekar, P. Melby, W. Zhao, 2001, The Journal of Immunology.

The Role of RECK in Hepatobiliary Neoplasia Reveals Its Therapeutic Potential in NASH

B. Chandrasekar, R. Rector, Ryan J. Dashek, 2021, Frontiers in Endocrinology.

Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition.

V. Demarco, B. Chandrasekar, A. Belenchia, 2019, Cellular signalling.

IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.

A. J. Valente, M. Feldman, B. Chandrasekar, 2007, American journal of physiology. Heart and circulatory physiology.

Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy.

A. J. Valente, P. Delafontaine, B. Venkatesan, 2011, Journal of molecular and cellular cardiology.

IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-β, NF-κB, and AP-1 activation

A. J. Valente, M. Feldman, B. Chandrasekar, 2007 .

Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression*

A. J. Valente, N. Webster, B. Chandrasekar, 2008, Journal of Biological Chemistry.

Contractile depression and expression of proinflammatory cytokines and iNOS in viral myocarditis.

G. Freeman, B. Chandrasekar, M. Zabalgoitia, 1998, American journal of physiology. Heart and circulatory physiology.

Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

S. N. Murthy, A. J. Valente, P. Delafontaine, 2012, American journal of physiology. Heart and circulatory physiology.

Induction of nuclear factor κB but not κB-responsive cytokine expression during myocardial reperfusion injury after neutropenia

G. Freeman, B. Chandrasekar, J. T. Colston, 2000 .

Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy.

B. Chandrasekar, S. Prabhu, A. Bhatnagar, 2011, American journal of physiology. Heart and circulatory physiology.

Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase.

B. Chandrasekar, S. Prabhu, A. Bhatnagar, 2002, American journal of physiology. Heart and circulatory physiology.

Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction *

A. J. Valente, Z. Saifudeen, B. Chandrasekar, 2016, The Journal of Biological Chemistry.

Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts.

A. J. Valente, B. Chandrasekar, S. Mummidi, 2008, American journal of physiology. Heart and circulatory physiology.

Aldosterone impairs coronary adenosine-mediated vasodilation via reduced functional expression of Ca2+-activated K+ channels.

B. Chandrasekar, Scott M. Brown, S. Bender, 2019, American journal of physiology. Heart and circulatory physiology.

Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice

V. Demarco, J. Sowers, B. Chandrasekar, 2017, Cardiovascular Diabetology.

Reduced Nitric Oxide Synthase 2 (NOS2) Promoter Activity in the Syrian Hamster Renders the Animal Functionally Deficient in NOS2 Activity and Unable to Control an Intracellular Pathogen1

B. Chandrasekar, B. Travi, P. Melby, 2006, The Journal of Immunology.

TNF-α and H2O2 induce IL-18 and IL-18Rβ expression in cardiomyocytes via NF-κB activation

G. Freeman, B. Chandrasekar, J. T. Colston, 2003 .

The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

V. Demarco, B. Chandrasekar, M. Hayden, 2019, Cardiovascular Diabetology.

Periodontal disease in association with systemic levels of interleukin-18 and CXC ligand 16 in patients undergoing cardiac catheterization.

B. Mealey, B. Chandrasekar, R. A. Schallhorn, 2010, Journal of periodontology.

Interleukin-18 Suppresses Adiponectin Expression in 3T3-L1 Adipocytes via a Novel Signal Transduction Pathway Involving ERK1/2-dependent NFATc4 Phosphorylation*

A. J. Valente, B. Chandrasekar, S. Mummidi, 2008, Journal of Biological Chemistry.

Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin.

A. J. Valente, P. Delafontaine, B. Chandrasekar, 2013, Cellular signalling.

CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction.

A. J. Valente, B. Venkatesan, B. Chandrasekar, 2013, Cellular signalling.

Induction of nuclear factor κB and activation protein 1 in postischemic myocardium

G. Freeman, B. Chandrasekar, 1997, FEBS letters.

In vivo induction of proinflammatory cytokines in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans.

B. Chandrasekar, L. Kesavalu, J. Ebersole, 2002, Oral microbiology and immunology.

Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide‐dependent TRAF3IP2/JNK signaling

A. J. Valente, B. Chandrasekar, Ulrich Siebenlist, 2013, Free radical biology & medicine.

Activation of Intrinsic and Extrinsic Proapoptotic Signaling Pathways in Interleukin-18-mediated Human Cardiac Endothelial Cell Death*

R. Surabhi, M. Li‐Weber, L. Owen-Schaub, 2004, Journal of Biological Chemistry.

Chemokine-Cytokine Cross-talk

H. Sarau, B. Chandrasekar, N. Dulin, 2003, The Journal of Biological Chemistry.

Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy.

D. Troyer, G. Freeman, B. Chandrasekar, 1998, The American journal of pathology.

Inhibition of nuclear factor kappa B attenuates proinflammatory cytokine and inducible nitric-oxide synthase expression in postischemic myocardium.

G. Freeman, B. Chandrasekar, J. T. Colston, 1998, Biochimica et biophysica acta.

Induction of proinflammatory cytokine and antioxidant enzyme gene expression following brief myocardial ischaemia

G. Freeman, B. Chandrasekar, J. T. Colston, 1997, Clinical and experimental immunology.

OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators.

A. J. Valente, B. Chandrasekar, Ulrich Siebenlist, 2014, Free radical biology & medicine.

Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium.

P. Ping, B. Chandrasekar, G. Wang, 2003, Journal of molecular and cellular cardiology.

Infiltration Via Lipopolysaccharide-Induced CXC Chemokine B and Induces Neutrophil κ Ischemia-Reperfusion of Rat Myocardium Activates Nuclear Factor

G. Freeman, B. Chandrasekar, Jeffrey B. Smith, 2001 .

TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells.

A. J. Valente, J. Shelhamer, J. Maranchie, 2006, Biochemical and biophysical research communications.

Ultrasound-targeted antisense oligonucleotide attenuates ischemia/reperfusion-induced myocardial tumor necrosis factor-alpha.

G. Freeman, B. Chandrasekar, J. Erikson, 2003, Journal of molecular and cellular cardiology.

β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo.

A. J. Valente, P. Delafontaine, B. Chandrasekar, 2012, Journal of molecular and cellular cardiology.

Tumor necrosis factor receptor 2 signaling limits β-adrenergic receptor-mediated cardiac hypertrophy in vivo

B. Chandrasekar, S. Prabhu, T. Hamid, 2011, Basic Research in Cardiology.

β-Adrenergic stimulation induces interleukin-18 expression via β2-AR, PI3K, Akt, IKK, and NF-κB

B. Chandrasekar, Sailaja Bysani, S. Prabhu, 2004 .

Chronic beta-adrenergic stimulation induces myocardial proinflammatory cytokine expression.

B. Chandrasekar, S. Prabhu, D. Murray, 2000, Circulation.

Expression-Adrenergic Stimulation Induces Myocardial Proinflammatory Cytokine β Chronic

B. Chandrasekar, S. Prabhu, D. Murray, 2000 .

beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling.

G. Freeman, B. Chandrasekar, S. Prabhu, 2000, Circulation.

Cytokines , Nitric Oxide , and Remodeling-Adrenergic Blockade in Developing Heart Failure : Effects on Myocardial Inflammatory

G. Freeman, B. Chandrasekar, D. Murray, 2000 .

Differential binding and biological activities of epidermal growth factor and transforming growth factor alpha in a human pancreatic cancer cell line.

M. Korc, B. Chandrasekar, G. Shah, 1991, Cancer research.

Docosahexaenoic Acid-Enriched Fish Oil Attenuates Kidney Disease and Prolongs Median and Maximal Life Span of Autoimmune Lupus-Prone Mice

B. Chandrasekar, J. Barnes, Md. Mizanur Rahman, 2010, The Journal of Immunology.

Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes*

B. Chandrasekar, S. Mummidi, W. Claycomb, 2005, Journal of Biological Chemistry.

Targeting TRAF3IP2 by Genetic and Interventional Approaches Inhibits Ischemia/Reperfusion-induced Myocardial Injury and Adverse Remodeling*

A. J. Valente, V. Demarco, B. Chandrasekar, 2017, The Journal of Biological Chemistry.

TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation.

G. Freeman, B. Chandrasekar, J. T. Colston, 2003, Biochemical and biophysical research communications.

Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1.

A. J. Valente, P. Delafontaine, B. Chandrasekar, 2012, Cellular signalling.

Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.

A. J. Valente, B. Chandrasekar, S. Mummidi, 2015, Cellular signalling.

Calorie restriction decreases platelet‐derived growth factor (PDGF)‐A and thrombin receptor mRNA expression in autoimmune murine lupus nephritis

D. Troyer, B. Chandrasekar, J. Barnes, 1997, Clinical and experimental immunology.

Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet.

B. Chandrasekar, J. Kang, M. M. Rahman, 2006, Biochemical and biophysical research communications.

Alteration of Cholecystokinin-Mediated Phosphatidylinositol Hydrolysis in Pancreatic Acini From Insulin-Deficient Rats: Evidence for Defective G Protein Activation

M. Korc, B. Chandrasekar, Murray Korc, 1991, Diabetes.

A Novel Peroxide-induced Calcium Transient Regulates Interleukin-6 Expression in Cardiac-derived Fibroblasts*

G. Freeman, B. Chandrasekar, J. T. Colston, 2002, The Journal of Biological Chemistry.

Regulation of CCAAT/Enhancer binding protein, interleukin-6, interleukin-6 receptor, and gp130 expression during myocardial ischemia/reperfusion.

D. H. Mitchell, G. Freeman, B. Chandrasekar, 1999, Circulation.

Cellular signals underlying β-adrenergic receptor mediated salivary gland enlargement.

B. Chandrasekar, M. S. Katz, C. Yeh, 2012, Differentiation; research in biological diversity.

Induction of proinflammatory cytokine expression in experimental acute Chagasic cardiomyopathy.

D. Troyer, G. Freeman, B. Chandrasekar, 1996, Biochemical and biophysical research communications.

CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy.

A. J. Valente, B. Chandrasekar, R. Clark, 2012, Journal of molecular and cellular cardiology.

Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB.

B. Chandrasekar, Sailaja Bysani, S. Prabhu, 2004, Biochemical and biophysical research communications.

Sacubitril/valsartan inhibits obesity-associated diastolic dysfunction through suppression of ventricular-vascular stiffness

V. Demarco, B. Chandrasekar, S. Mummidi, 2021, Cardiovascular Diabetology.

EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling.

A. J. Valente, P. Delafontaine, B. Venkatesan, 2010, Journal of molecular and cellular cardiology.

Acetylsalicylic Acid Inhibits IL‐18‐Induced Cardiac Fibroblast Migration Through the Induction of RECK

A. J. Valente, P. Delafontaine, B. Chandrasekar, 2014, Journal of cellular physiology.

CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.

B. Chandrasekar, Sailaja Bysani, S. Mummidi, 2004, The Journal of biological chemistry.

TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE(-/-) mice.

P. Delafontaine, B. Chandrasekar, Y. Higashi, 2016, Atherosclerosis.

Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation.

A. J. Valente, P. Delafontaine, B. Venkatesan, 2010, American journal of physiology. Heart and circulatory physiology.

Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-κB/iNOS/NO-dependent cardiomyocyte contractile depression and death.

B. Chandrasekar, R. Izadpanah, S. Bender, 2020, Cellular signalling.

Cholecystokinin-induced phosphatidylinositol hydrolysis in rat pancreatic acinar cells: modulation by extracellular calcium and manganese.

M. Korc, B. Chandrasekar, S. Siwik, 1991, Endocrinology.

EMMPRIN activates multiple transcription factor pathways in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF- κ B and MKK7/JNK/AP-1 signaling

A. J. Valente, P. Delafontaine, B. Venkatesan, 2011 .

Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice.

D. Troyer, B. Chandrasekar, R. Good, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Contractile depression and expression of proinflammatory cytokines and iNOS in viral myocarditis.

G. Freeman, B. Chandrasekar, M. Zabalgoitia, 1998, The American journal of physiology.

Decreased pro-inflammatory cytokines and increased antioxidant enzyme gene expression by omega-3 lipids in murine lupus nephritis.

B. Chandrasekar, G. Fernandes, 1994, Biochemical and biophysical research communications.

Autoimmune Lupus-Prone Mice Median and Maximal Life Span of Attenuates Kidney Disease and Prolongs Docosahexaenoic Acid-Enriched Fish Oil

B. Chandrasekar, J. Barnes, M. M. Rahman, 2010 .

Docosahexaenoic acid‐enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus ‐prone mice

B. Chandrasekar, M. M. Rahman, G. Fernandes, 2007 .

Effects of energy intake on type 1 plasminogen activator inhibitor levels in glomeruli of lupus-prone B/W mice.

D. Troyer, B. Chandrasekar, D. Loskutoff, 1995, The American journal of pathology.

Basic fibroblast growth factor is a calcium-mobilizing secretagogue in rat pancreatic acini.

M. Korc, B. Chandrasekar, 1991, Biochemical and biophysical research communications.

TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation.

A. J. Valente, B. Chandrasekar, S. S. Sakamuri, 2013, Cellular signalling.

Targeting TRAF3IP2 inhibits angiogenesis in glioblastoma

R. Mostany, S. Braun, B. Chandrasekar, 2022, Frontiers in Oncology.

Intracellular Pathogen NOS2 Activity and Unable to Control an Renders the Animal Functionally Deficient in Promoter Activity in the Syrian Hamster Reduced Nitric Oxide Synthase 2 (NOS2)

B. Chandrasekar, B. Travi, Luis E. Perez, 2006 .

Intracellular Pathogen NOS 2 Activity and Unable to Control an Renders the Animal Functionally Deficient in Promoter Activity in the Syrian Hamster Reduced Nitric Oxide Synthase 2 ( NOS 2 )

B. Chandrasekar, B. Travi, P. Melby, 2006 .

Gema Frühbeck and Javier Salvador Is Leptin Involved in the Signaling Cascade After Myocardial Ischemia and Reperfusion ?

D. H. Mitchell, G. Freeman, B. Chandrasekar, 2000 .

Angiotensin II Type 2 Receptor Potentiates Skeletal Muscle Satellite Cell Differentiation via the GSK3β/β-catenin Pathway AT2R regulates GSK3β signaling in satellite cells

P. Delafontaine, B. Chandrasekar, T. Yoshida, 2022 .

Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK.

A. J. Valente, B. Chandrasekar, S. S. Sakamuri, 2013, Journal of molecular and cellular cardiology.

Activation of nuclear factor kappa B in human lymphoblastoid cells by low-dose ionizing radiation.

M. Meltz, B. Chandrasekar, N. Mohan, 1994, Radiation research.

TRAF3IP2 mediates TWEAK/TWEAKR-induced pro-fibrotic responses in cultured cardiac fibroblasts and the heart.

R. Mostany, Ashok Kumar, B. Chandrasekar, 2018, Journal of molecular and cellular cardiology.

Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice.

B. Chandrasekar, X. Luan, W. Zhao, 1995, Immunology letters.

Response Face of a Prominent Th 1-Like Cytokine Impaired Generation of Nitric Oxide in the Leishmaniasis : Progressive Disease and The Hamster as a Model of Human Visceral

B. Chandrasekar, P. Melby, W. Zhao, 2001 .

The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin‐II‐Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4

A. J. Valente, P. Delafontaine, B. Chandrasekar, 2016, Journal of cellular physiology.

The site of cutaneous infection influences the immunological response and clinical outcome of hamsters infected with Leishmania panamensis

B. Chandrasekar, B. Travi, P. Melby, 2003, Parasite immunology.

Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp

B. Chandrasekar, B. Travi, P. Melby, 2002, Infection and Immunity.

Unfolded protein response and angiogenesis in malignancies.

B. Chandrasekar, R. Izadpanah, E. Alt, 2022, Biochimica et biophysica acta. Reviews on cancer.

Tissue specific regulation of transforming growth factor beta by omega-3 lipid-rich krill oil in autoimmune murine lupus

D. Troyer, B. Chandrasekar, J. Venkatraman, 1996 .

Differential effects of ω-6 and ω-3 fatty acids on interleukin-2 production and mRNA expression by EL-4.IL-2 cells

S. Weintraub, B. Chandrasekar, J. Venkatraman, 1995 .

Angiotensin II Upregulates Protein Phosphatase 2C&agr; and Inhibits AMP-Activated Protein Kinase Signaling and Energy Balance Leading to Skeletal Muscle Wasting

W. Mitch, P. Delafontaine, B. Chandrasekar, 2011, Hypertension.

Effects of n-3 and n-6 fatty acids on the activities and expression of hepatic antioxidant enzymes in autoimmune-prone NZBxNZW F1 mice.

B. Chandrasekar, J. Venkatraman, G. Fernandes, 1994, Lipids.

Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice

B. Chandrasekar, Y. Higashi, P. Delafontaine, 2021, Arteriosclerosis, thrombosis, and vascular biology.

Activation of Nuclear Factor κB in Human Lymphoblastoid Cells by Low-Dose Ionizing Radiation

M. Meltz, B. Chandrasekar, N. Mohan, 1994 .

Interaction of endothelial cells with self-assembled monolayers for potential use in drug-eluting coronary stents.

M. Feldman, B. Chandrasekar, C. Agrawal, 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

Small multifunctional nanoclusters (nanoroses) for targeted cellular imaging and therapy.

Marc D Feldman, Konstantin Sokolov, Amit S. Paranjape, 2009, ACS nano.

RECK suppresses interleukin‐17/TRAF3IP2‐mediated MMP‐13 activation and human aortic smooth muscle cell migration and proliferation

R. Mostany, B. Chandrasekar, S. Mummidi, 2019, Journal of cellular physiology.

Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK suppression.

P. Delafontaine, B. Chandrasekar, S. Mummidi, 2019, Cellular signalling.

Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation

A. J. Valente, K. McDonald, B. Chandrasekar, 2016, Hypertension Research.

Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration.

A. J. Valente, H. Iba, P. Delafontaine, 2014, Cellular signalling.

BMP‐2 regulates cardiomyocyte contractility in a phosphatidylinositol 3 kinase‐dependent manner

B. Chandrasekar, S. Abboud, G. Ghosh Choudhury, 2003, FEBS letters.

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.

H. Friess, M. Korc, B. Chandrasekar, 1992, The Journal of clinical investigation.

SM22&agr; (Smooth Muscle Protein 22-&agr;) Promoter-Driven IGF1R (Insulin-Like Growth Factor 1 Receptor) Deficiency Promotes Atherosclerosis

P. Delafontaine, Shin-ichiro Takahashi, B. Chandrasekar, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Breast Tumor Microenvironment Can Transform Naive Mesenchymal Stem Cells into Tumor-Forming Cells in Nude Mice.

B. Chandrasekar, S. Srivastav, R. Izadpanah, 2019, Stem cells and development.

Expression of apoptosis-related proteins in experimental coxsackievirus myocarditis.

G. Freeman, B. Chandrasekar, J. T. Colston, 1998, Cardiovascular research.

Phosphatidylinositol 3-Kinase Regulates Bone Morphogenetic Protein-2 (BMP-2)-induced Myocyte Enhancer Factor 2A-dependent Transcription of BMP-2 Gene in Cardiomyocyte Precursor Cells*

L. Mahimainathan, G. G. Choudhury, B. Chandrasekar, 2003, Journal of Biological Chemistry.

Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury*

A. J. Valente, B. Chandrasekar, S. Prabhu, 2009, Journal of Biological Chemistry.

Induction of transcription of "immediate early genes" by low-dose ionizing radiation.

M. Meltz, B. Chandrasekar, N. Mohan, 1995, Radiation research.

Malnutrition Alters the Innate Immune Response and Increases Early Visceralization following Leishmania donovani Infection

B. Chandrasekar, P. Melby, G. Anstead, 2001, Infection and Immunity.

NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen.

W. Friedrichs, M. Hidalgo, G. Weiss, 2004, Annals of oncology : official journal of the European Society for Medical Oncology.

Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death.

A. J. Valente, P. D. del Nido, P. Delafontaine, 2014, Journal of molecular and cellular cardiology.

Interleukin‐18/WNT1‐inducible signaling pathway protein‐1 signaling mediates human saphenous vein smooth muscle cell proliferation

A. J. Valente, P. Delafontaine, B. Chandrasekar, 2011, Journal of cellular physiology.

Ischemia-Reperfusion of Rat Myocardium Activates Nuclear Factor-&kgr;B and Induces Neutrophil Infiltration Via Lipopolysaccharide-Induced CXC Chemokine

G. Freeman, B. Chandrasekar, Jeffrey B. Smith, 2001, Circulation.

Genotype effects on the antioxidant enzymes activity and mRNA expression in liver and kidney tissues of autoimmune-prone MRL/MpJ-lpr/lpr mice.

B. Chandrasekar, J. Venkatraman, G. Fernandes, 1994, Biochimica et biophysica acta.

Modulation of antioxidant enzymes and programmed cell death by n-3 fatty acids

D. Troyer, B. Chandrasekar, X. Luan, 2007, Lipids.

Visceral Leishmaniasis Cytokine mRNA Expression in Experimental auratus) Cytokine cDNAs and Analysis of Cloning of Syrian Hamster (Mesocricetus

G. Freeman, B. Chandrasekar, P. Melby, 2013 .

Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation.

A. J. Valente, G. Freeman, L. Mahimainathan, 2006, Biochemical and biophysical research communications.

Interleukin-17 Stimulates C-reactive Protein Expression in Hepatocytes and Smooth Muscle Cells via p38 MAPK and ERK1/2-dependent NF-κB and C/EBPβ Activation*

A. J. Valente, S. Bailey, A. Agrawal, 2007, Journal of Biological Chemistry.

The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion.

B. Chandrasekar, S. Mummidi, Y. Higashi, 2020, Cellular signalling.

Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway.

B. Chandrasekar, Sailaja Bysani, S. Mummidi, 2003, The Biochemical journal.

Promotion of lung tumor growth by interleukin-17.

B. Shan, G. Morris, B. Chandrasekar, 2014, American journal of physiology. Lung cellular and molecular physiology.

TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.

B. Chandrasekar, H. Kandikattu, S. López-Ongil, 2018, American journal of physiology. Heart and circulatory physiology.

Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration.

A. J. Valente, B. Venkatesan, B. Chandrasekar, 2009, American journal of physiology. Heart and circulatory physiology.

Dietary Omega-3 Lipids Delay the Onset and Progression of Autoimmune Lupus Nephritis by Inhibiting Transforming Growth Factor β mRNA and Protein Expression

D. Troyer, B. Chandrasekar, J. Venkatraman, 1995 .

The Pro-atherogenic Cytokine Interleukin-18 Induces CXCL16 Expression in Rat Aortic Smooth Muscle Cells via MyD88, Interleukin-1 Receptor-associated Kinase, Tumor Necrosis Factor Receptor-associated Factor 6, c-Src, Phosphatidylinositol 3-Kinase, Akt, c-Jun N-terminal Kinase, and Activator Protein-1

A. J. Valente, S. Bailey, G. Freeman, 2005, Journal of Biological Chemistry.

Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle.

P. Delafontaine, Thaysa Ghiarone, B. Chandrasekar, 2019, Journal of applied physiology.

Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor.

S. Bailey, G. Freeman, B. Chandrasekar, 2007, American journal of physiology. Heart and circulatory physiology.

Downregulation of CuZn-superoxide dismutase contributes to beta-adrenergic receptor-mediated oxidative stress in the heart.

Yan Gu, B. Chandrasekar, S. Prabhu, 2007, Cardiovascular research.

WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor-α (TNF-α)-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF-α-induced Cardiomyocyte Death*

A. J. Valente, B. Venkatesan, B. Chandrasekar, 2009, Journal of Biological Chemistry.

Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload.

G. Freeman, M. Feldman, C. Jenkinson, 2007, Biochemical and biophysical research communications.

Interleukin-18-induced Human Coronary Artery Smooth Muscle Cell Migration Is Dependent on NF-κB- and AP-1-mediated Matrix Metalloproteinase-9 Expression and Is Inhibited by Atorvastatin*

A. J. Valente, W. Greene, S. Bailey, 2006, Journal of Biological Chemistry.

Dipeptidyl Peptidase‐4 Inhibition With Saxagliptin Ameliorates Angiotensin II‐Induced Cardiac Diastolic Dysfunction in Male Mice

J. Sowers, B. Chandrasekar, G. Meininger, 2017, Endocrinology.

TRAF3IP2, a novel therapeutic target in glioblastoma multiforme

S. Braun, B. Chandrasekar, Andreas Pfnür, 2018, Oncotarget.

Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo.

A. J. Valente, B. Chandrasekar, S. Mummidi, 2016, Journal of molecular and cellular cardiology.

Quantification of myocardial fibrosis using noninvasive T2‐mapping magnetic resonance imaging: Preclinical models of aging and pressure overload

B. Chandrasekar, Lixin Ma, Ping Yu, 2021, NMR in biomedicine.

Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation

B. Chandrasekar, W. Fay, N. Goyal, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Overexpression of cardiotrophin-1 and gp130 during experimental acute Chagasic cardiomyopathy.

G. Freeman, B. Chandrasekar, D. Pennica, 1998, Immunology letters.

Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer

B. Chandrasekar, S. Srivastav, M. Burow, 2020, Scientific Reports.

Infection donovani Leishmania Visceralization following Response and Increases Early Malnutrition Alters the Innate Immune

B. Chandrasekar, P. Melby, G. Anstead, 2001 .

Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury.

G. Freeman, J. Nelson, B. Chandrasekar, 2001, American journal of physiology. Heart and circulatory physiology.

Effects of calorie restriction on transforming growth factor beta 1 and proinflammatory cytokines in murine Sjogren's syndrome.

D. Troyer, B. Chandrasekar, N. Talal, 1995, Clinical Immunology and Immunopathology.

Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK.

B. Chandrasekar, S. S. Sakamuri, Tadashi Yoshida, 2013, Journal of molecular and cellular cardiology.

β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo.

P. Delafontaine, B. Chandrasekar, S. Mummidi, 2012, Journal of molecular and cellular cardiology.

Targeting TRAF3IP2 by Genetic and Interventional Approaches Inhibits Ischemia/Reperfusion-induced Myocardial Injury and Adverse Remodeling*

B. Chandrasekar, S. Mummidi, H. Kandikattu, 2017, The Journal of Biological Chemistry.

IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-β, NF-κB, and AP-1 activation

M. Feldman, B. Chandrasekar, S. Mummidi, 2007 .

Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation.

P. Delafontaine, B. Chandrasekar, S. Mummidi, 2010, American journal of physiology. Heart and circulatory physiology.

ScholarWorks @ UTRGV ScholarWorks @ UTRGV

R. Mostany, B. Chandrasekar, S. Mummidi, 2022 .

Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration

B. Chandrasekar, Y. Higashi, Srinivas Mummidi, 2023, Mediators of inflammation.

Docosahexaenoic Acid-Enriched Fish Oil Attenuates Kidney Disease and Prolongs Median and Maximal Life Span of Autoimmune Lupus-Prone Mice

B. Chandrasekar, J. Barnes, Md. Mizanur Rahman, 2010, The Journal of Immunology.

Dietary omega-3 lipids delay the onset and progression of autoimmune lupus nephritis by inhibiting transforming growth factor beta mRNA and protein expression.

D. Troyer, B. Chandrasekar, J. Venkatraman, 1995, Journal of autoimmunity.

TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.

B. Chandrasekar, H. Kandikattu, S. López-Ongil, 2018, American Journal of Physiology. Heart and Circulatory Physiology.