Toshifumi Takahashi

发表

Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin.

Kazuhiro Takahashi, J. Hayakawa, M. Ohmichi, 2004, Endocrinology.

Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies

H. Igarashi, Toshifumi Takahashi, S. Nagase, 2015, Reproductive medicine and biology.

Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines

S. Kyo, M. Inoue, M. Ohmichi, 2004, Oncogene.

Fasudil inhibits vascular endothelial growth factor–induced angiogenesis in vitro and in vivo

Kazuhiro Takahashi, T. Ohta, J. Kawagoe, 2007, Molecular Cancer Therapeutics.

Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia: A Prospective Pilot Study of Seven Cases

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2010, Gynecologic and Obstetric Investigation.

Raloxifene Inhibits Estrogen-induced Up-regulation of Telomerase Activity in a Human Breast Cancer Cell Line*

Kazuhiro Takahashi, S. Kyo, M. Inoue, 2003, Journal of Biological Chemistry.

Pioglitazone counteracts the tumor necrosis factor-α inhibition of follicle-stimulating hormone-induced follicular development and estradiol production in an in vitro mouse preantral follicle culture system

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2013, Journal of Ovarian Research.

Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausal women

Kazuhiro Takahashi, T. Ohta, H. Kurachi, 2010, Menopause.

Raloxifene Increases Proliferation and Up-regulates Telomerase Activity in Human Umbilical Vein Endothelial Cells*

Kazuhiro Takahashi, M. Ohmichi, T. Ohta, 2006, Journal of Biological Chemistry.

Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cells.

Kazuhiro Takahashi, M. Ohmichi, T. Ohta, 2005, Endocrinology.

Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells

Kazuhiro Takahashi, M. Ohmichi, T. Ohta, 2012, Cancer biology & therapy.

Non-sex cord-stromal ovarian tumors frequently produce and secrete estrogen in postmenopausal women: impact on bone metabolism and abnormal endometrial histology.

Kazuhiro Takahashi, T. Ohta, H. Kurachi, 2013, The Journal of clinical endocrinology and metabolism.

Aged Mouse Oocytes Fail to Readjust Intracellular Adenosine Triphosphates at Fertilization1

Kazuhiro Takahashi, H. Igarashi, H. Kurachi, 2005, Biology of reproduction.

Oxidative Stress in the Visceral Fat Is Elevated in Postmenopausal Women with Gynecologic Cancer.

Kazuhiro Takahashi, T. Ohta, H. Kurachi, 2018, Journal of women's health.

Peroxisome Proliferator-Activated Receptor-&ggr; Agonists Prevent Tumor Necrosis Factor-&agr;-Mediated Inhibition of FSH-Induced Follicle Development and Estradiol Production in a Preantral Follicle Culture System

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2014 .

Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate.

Kazuhiro Takahashi, T. Ohta, H. Igarashi, 2010, Endocrinology.

Clomiphene citrate down-regulates estrogen receptor-α through the ubiquitin-proteasome pathway in a human endometrial cancer cell line

H. Igarashi, Toshifumi Takahashi, S. Nagase, 2016, Molecular and Cellular Endocrinology.

Roles of Prostaglandins During Oocyte Maturation: Lessons from Knockout Mice

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2010 .

Cyclooxygenase-2-derived Prostaglandin E2 Directs Oocyte Maturation by Differentially Influencing Multiple Signaling Pathways*

J. Morrow, S. Dey, Haibin Wang, 2006, Journal of Biological Chemistry.

The Wilms' Tumor Gene WT1 − 17AA/− KTS Splice Variant Increases Tumorigenic Activity Through Up-Regulation of Vascular Endothelial Growth Factor in an In Vivo Ovarian Cancer Model

Kazuhiro Takahashi, T. Ohta, H. Kurachi, 2014, Translational oncology.

Evaluation of preventive methods for the symptomatic pulmonary thromboembolism by postoperative anticoagulant therapy in venous thromboembolism high risk patients with gynecologic malignancy

H. Kurachi, Toshifumi Takahashi, Manabu Seino, 2012 .

The Activity of Trabectedin As a Single Agent or in Combination with Everolimus for Clear Cell Carcinoma of the Ovary

Kazuhiro Takahashi, M. Hayashi, S. Mabuchi, 2011, Clinical Cancer Research.

Cancer Therapy: Preclinical The Activity of Trabectedin As a Single Agent or in Combination with Everolimus for Clear Cell Carcinoma of the Ovary

Kazuhiro Takahashi, M. Hayashi, S. Mabuchi, 2011 .

Bezafibrate Restores the Inhibition of FSH-Induced Follicular Development and Steroidogenesis by Tumor Necrosis Factor-Alpha Through Peroxisome Proliferator-Activated Receptor-Gamma Pathway in an In Vitro Mouse Preantral Follicle Culture1

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2011, Biology of reproduction.

Both estrogen and raloxifene protect against beta-amyloid-induced neurotoxicity in estrogen receptor alpha-transfected PC12 cells by activation of telomerase activity via Akt cascade.

Kazuhiro Takahashi, M. Ohmichi, T. Ohta, 2004, The Journal of endocrinology.

Effects of Different Trehalose Concentrations in a Warming Medium on Embryo Survival and Clinical Outcomes in Vitrified Human Embryos

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2013, Gynecologic and Obstetric Investigation.

Combination Treatment With Trabectedin and Irinotecan or Topotecan Has Synergistic Effects Against Ovarian Clear Cell Carcinoma Cells

Kazuhiro Takahashi, S. Mabuchi, Toshifumi Takahashi, 2014, International Journal of Gynecologic Cancer.

Lowering intracellular and extracellular calcium contents prevents cytotoxic effects of ethylene glycol‐based vitrification solution in unfertilized mouse oocytes

Kazuhiro Takahashi, H. Igarashi, M. Doshida, 2004, Molecular reproduction and development.

Prognostic factors for patients undergoing vitrified-warmed human embryo transfer cycles: a retrospective cohort study

H. Igarashi, Toshifumi Takahashi, S. Nagase, 2017, Human fertility.

Application of Vitrification to Human Embryo Freezing

Toshifumi Takahashi, T. Kaneko, H. Saito, 2000, Gynecologic and Obstetric Investigation.

Molecular mechanism of poor embryo development in postovulatory aged oocytes: Mini review

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2013, The journal of obstetrics and gynaecology research.

Impact of oxidative stress in aged mouse oocytes on calcium oscillations at fertilization

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2003, Molecular reproduction and development.

Eight-hydroxy-2'-deoxyguanosine in granulosa cells is correlated with the quality of oocytes and embryos in an in vitro fertilization-embryo transfer program.

H. Kurachi, Toshifumi Takahashi, T. Kaneko, 2002, Fertility and sterility.

Effects of aging on inositol 1,4,5‐triphosphate‐induced Ca2+ release in unfertilized mouse oocytes

Toshifumi Takahashi, E. Takahashi, T. Takahashi, 2000, Molecular reproduction and development.

Cellular and molecular mechanisms of various types of oocyte aging

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2011, Reproductive medicine and biology.

miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.

E. Lengyel, Y. Tomita, S. Mabuchi, 2013, The American journal of pathology.

High levels of Wilms' tumor 1 (WT1) expression were associated with aggressive clinical features in ovarian cancer.

Kazuhiro Takahashi, H. Kurachi, Toshifumi Takahashi, 2014, Anticancer research.

Poor Embryo Development in Mouse Oocytes Aged In Vitro Is Associated with Impaired Calcium Homeostasis1

J. Kawagoe, H. Igarashi, H. Kurachi, 2009, Biology of reproduction.

Development of a new clinically applicable device for embryo evaluation which measures embryo oxygen consumption.

N. Yaegashi, H. Igarashi, Toshifumi Takahashi, 2016, Human reproduction.

A Case Report of Preoperative Diagnosis and Laparoscopic Resection of a Non-communicating Rudimentary Uterine Horn Pregnancy

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2008 .

Spontaneous Perforation of Pyometra: A Report of Seven Cases and Review of the Literature

H. Kurachi, Toshifumi Takahashi, M. Ikeda, 2013, Gynecologic and Obstetric Investigation.

Activation of estrogen receptor α by estradiol and cisplatin induces platinum-resistance in ovarian cancer cells

Kazuhiro Takahashi, T. Ohta, H. Kurachi, 2017, Cancer biology & therapy.

Both estrogen and raloxifene protect against β-amyloid-induced neurotoxicity in estrogen receptor α-transfected PC12 cells by activation of telomerase activity via Akt cascade

Kazuhiro Takahashi, M. Ohmichi, T. Ohta, 2004 .

Fatty acid amide hydrolase deficiency limits early pregnancy events.

H. Zhang, L. Marnett, B. Cravatt, 2006, The Journal of clinical investigation.

The Akt and ERK activation by platinum-based chemotherapy in ovarian cancer is associated with favorable patient outcome.

T. Ohta, T. Motoyama, H. Kurachi, 2009, Anticancer research.

Medroxyprogesterone acetate attenuates estrogen-induced nitric oxide production in human umbilical vein endothelial cells.

Kazuhiro Takahashi, M. Ohmichi, J. Kawagoe, 2004, Biochemical and biophysical research communications.

Fasudil-induced hypoxia-inducible factor-1α degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells

Kazuhiro Takahashi, T. Ohta, J. Kawagoe, 2008, Molecular Cancer Therapeutics.

Predictive factors for oocyte retrieval failure in controlled ovarian hyperstimulation protocols: a retrospective observational cohort study

H. Igarashi, Toshifumi Takahashi, S. Nagase, 2015, Reproductive Biology and Endocrinology.

Growth factors change nuclear distribution of estrogen receptor-alpha via mitogen-activated protein kinase or phosphatidylinositol 3-kinase cascade in a human breast cancer cell line.

Kazuhiro Takahashi, M. Ohmichi, T. Ohta, 2005, Endocrinology.

Effects of Controlled Ovarian Hyperstimulation on Oocyte Quality in Terms of the Incidence of Apoptotic Granulosa Cells

Toshifumi Takahashi, T. Kaneko, H. Saito, 2000, Journal of Assisted Reproduction and Genetics.

Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells

Kazuhiro Takahashi, T. Ohta, H. Kurachi, 2012, Cancer biology & therapy.

Brachial-to-ankle pulse wave velocity as an independent prognostic factor for ovulatory response to clomiphene citrate in women with polycystic ovary syndrome

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2014, Journal of Ovarian Research.

The incidence of apoptotic bodies in membrana granulosa can predict prognosis of ova from patients participating in in vitro fertilization programs.

Toshifumi Takahashi, K. Nakahara, T. Saito, 1997, Fertility and sterility.

Poor embryo development in post-ovulatory in vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation.

O. Nakajima, H. Igarashi, Toshifumi Takahashi, 2016, Human Reproduction.

Fasudil-induced hypoxia-inducible factor-1α degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells

Kazuhiro Takahashi, T. Ohta, J. Kawagoe, 2008, Molecular Cancer Therapeutics.

Oxidative Stress in the Visceral Fat Is Elevated in Postmenopausal Women with Gynecologic Cancer.

Kazuhiro Takahashi, T. Ohta, H. Kurachi, 2017, Journal of women's health.

Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells.

Kazuhiro Takahashi, M. Ohmichi, J. Kawagoe, 2003, The Journal of endocrinology.

The Activity of Trabectedin As a Single Agent or in Combination with Everolimus for Clear Cell Carcinoma of the Ovary

Kazuhiro Takahashi, M. Hayashi, S. Mabuchi, 2011, Clinical Cancer Research.

Molecular mechanism of poor embryo development in postovulatory aged oocytes: Mini review

H. Igarashi, H. Kurachi, Toshifumi Takahashi, 2013, The journal of obstetrics and gynaecology research.

TUMORIGENESIS AND NEOPLASTIC PROGRESSION miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin a 5 Expression

S. Mabuchi, Toshifumi Takahashi, Kae Hashimoto, 2022 .