S. D’Mello

发表

The c‐Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK‐ERK and Akt‐independent mechanism

P. C. Chin, R. Ratan, Paul C. Chin, 2004, Journal of neurochemistry.

Inhibition of ATF‐3 expression by B‐Raf mediates the neuroprotective action of GW5074

S. D’Mello, Hsin-Mei Chen, Lulu Wang, 2008, Journal of neurochemistry.

P21‐activated kinase‐1 is necessary for depolarization‐mediated neuronal survival

S. D’Mello, Kyle Johnson, 2005, Journal of neuroscience research.

Histone deacetylases 1, 2 and 3 in nervous system development.

S. D’Mello, 2020, Current opinion in pharmacology.

Histone Deacetylase 3 Is Necessary for Proper Brain Development*

S. D’Mello, Jordan N Norwood, J. M. Franklin, 2014, The Journal of Biological Chemistry.

Insights into the regulation of neuronal viability by nucleophosmin/B23

S. D’Mello, J. Pfister, 2015, Experimental biology and medicine.

Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease

D. Rubinsztein, M. Beal, R. Ferrante, 2004, The Journal of Neuroscience.

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

Chi Ma, B. Morrison, S. D’Mello, 2008, PloS one.

Transducin-like Enhancer of Split-1 (TLE1) Combines with Forkhead Box Protein G1 (FoxG1) to Promote Neuronal Survival*

Sriram Narayanan, S. D’Mello, S. Stifani, 2012, The Journal of Biological Chemistry.

Isoform-Specific Toxicity of Mecp2 in Postmitotic Neurons: Suppression of Neurotoxicity by FoxG1

V. Narayanan, Varun Rawat, Chi Ma, 2012, The Journal of Neuroscience.

Induction of neuronal cell death by paraneoplastic Ma1 antigen

S. D’Mello, Huai-Lu Chen, 2010, Journal of neuroscience research.

Overdosing on iron: Elevated iron and degenerative brain disorders

S. D’Mello, Mark Kindy, 2020, Experimental biology and medicine.

HDAC4 inhibits cell‐cycle progression and protects neurons from cell death

E. Olson, R. Bassel-Duby, B. Morrison, 2008, Developmental neurobiology.

Histone deacetylases as targets for the treatment of human neurodegenerative diseases.

S. D’Mello, 2009, Drug news & perspectives.

Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival

S. D’Mello, Chad Smith, 2016, Molecular Neurobiology.

Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex

M. Kilgard, M. Atzori, S. Rose-John, 2015, Brain, Behavior, and Immunity.

The Flathead Mutation Causes CNS-Specific Developmental Abnormalities and Apoptosis

S. D’Mello, J. Loturco, M. Roberts, 2000, The Journal of Neuroscience.

Akt Is a Downstream Target of NF-κB*

P. C. Chin, Li Liu, S. D’Mello, 2002, The Journal of Biological Chemistry.

Akt is a downstream target of NF-kappa B.

P. C. Chin, Li Liu, S. D’Mello, 2002, The Journal of biological chemistry.

Structural and functional identification of regulatory regions and cis elements surrounding the nerve growth factor gene promoter.

S. D’Mello, G. Heinrich, 1991, Brain research. Molecular brain research.

Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3β

S. D’Mello, Farah H Bardai, Farah H. Bardai, 2011, The Journal of Neuroscience.

Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1

Chi Ma, S. D’Mello, J. Pfister, 2019, PloS one.

JAZ (Znf346), a SIRT1-interacting Protein, Protects Neurons by Stimulating p21 (WAF/CIP1) Protein Expression*

S. D’Mello, Sathi Mallick, 2014, The Journal of Biological Chemistry.

Neuroprotection by Histone Deacetylase-7 (HDAC7) Occurs by Inhibition of c-jun Expression through a Deacetylase-independent Mechanism*

Chi Ma, S. D’Mello, 2010, The Journal of Biological Chemistry.

The human nerve growth factor gene: structure of the promoter region and expression in L929 fibroblasts.

S. D’Mello, S. Martin, G. Heinrich, 1992, Brain research. Molecular brain research.

Polydactyly in Mice Lacking HDAC9/HDRP

B. Morrison, S. D’Mello, Brad E. Morrison, 2008, Experimental biology and medicine.

Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons.

S. D’Mello, P. Calissano, R. Anelli, 1994, Experimental cell research.

SGP2, ubiquitin, 14K lectin and RP8 mRNAs are not induced in neuronal apoptosis

S. D’Mello, C. Galli, 1993, Neuroreport.

Histone deacetylase‐related protein inhibits AES‐mediated neuronal cell death by direct interaction

S. D’Mello, Hsin-Mei Chen, Lulu Wang, 2008, Journal of neuroscience research.

A gene essential to brain growth and development maps to the distal arm of rat chromosome 12

S. D’Mello, J. Loturco, M. Sarkisian, 1998, Neuroscience Letters.

Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death* ♦

S. D’Mello, Lulu Wang, Marcus Zaayman, 2012, The Journal of Biological Chemistry.

Neuron‐selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: Essential role for aggregation in neurotoxicity

S. D’Mello, Lulu Wang, W. Goux, 2010, Journal of neuroscience research.

Phosphorylation of IκB-β Is Necessary for Neuronal Survival*

Li Liu, S. D’Mello, 2006, Journal of Biological Chemistry.

Differential regulation of the nerve growth factor and brain‐derived neurotrophic factor genes in L929 mouse fibroblasts

S. D’Mello, S. Martin, C. Jiang, 1992, Journal of neuroscience research.

Opposing effects of thapsigargin on the survival of developing cerebellar granule neurons in culture

S. D’Mello, Valerie Levick, Heather Coffey, 1995, Brain Research.

Multiple Signalling Pathways Interact in the Regulation of Nerve Growth Factor Production in L929 Fibroblasts

S. D’Mello, G. Heinrich, 1991, Journal of neurochemistry.

Induction of Nerve Growth Factor Gene Expression by 12‐O‐Tetradecanoyl Phorbol 13‐Acetate

S. D’Mello, G. Heinrich, 1990, Journal of neurochemistry.

Aberrant apoptosis in the neurological mutant Flathead is associated with defective cytokinesis of neural progenitor cells.

S. D’Mello, B. Mitchell, J. Stella, 2001, Brain research. Developmental brain research.

When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer’s and Huntington’s Disease

S. D’Mello, 2021, International journal of molecular sciences.

Identification of novel 1,4‐benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration

Shashidhar Kumar Akubathini, Haribabu Ankati, Lulu Wang, 2010, Journal of neuroscience research.

Inhibition of neuronal apoptosis by the cyclin‐dependent kinase inhibitor GW8510: Identification of 3′ substituted indolones as a scaffold for the development of neuroprotective drugs

P. C. Chin, Li Liu, B. Morrison, 2005, Journal of neurochemistry.

Synthesis of 3- Benzylidene, 5-Substituted 3-Benzylidene, 3- Hetarylmethylene and 5-Substituted Hetarylmethylene Derivatives of Indolin- 2-ones

S. D’Mello, E. Biehl, S. Kamila, 2009 .

A chemical compound commonly used to inhibit PKR, {8‐(imidazol‐4‐ylmethylene)‐6H‐azolidino[5,4‐g] benzothiazol‐7‐one}, protects neurons by inhibiting cyclin‐dependent kinase

S. D’Mello, Lulu Wang, Hsin‐Mei Chen, 2008, The European journal of neuroscience.

Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis.

P. C. Chin, S. D’Mello, 2005, Frontiers in bioscience : a journal and virtual library.

Isolation and nucleotide sequence of a cDNA clone encoding bovine adrenal tyrosine hydroxylase: Comparative analysis of tyrosine hydroxylase gene products

S. D’Mello, M. Stachowiak, Anthony E. Gioio, 1988, Journal of neuroscience research.

Inhibition of GSK3beta is a common event in neuroprotection by different survival factors.

P. C. Chin, S. D’Mello, N. Majdzadeh, 2005, Brain research. Molecular brain research.

Class IIA HDACs in the regulation of neurodegeneration.

B. Morrison, S. D’Mello, Brad E. Morrison, 2008, Frontiers in bioscience : a journal and virtual library.

Histone deacetylases: Focus on the nervous system

B. Morrison, S. D’Mello, Brad E. Morrison, 2007, Cellular and Molecular Life Sciences.

Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling

S. D’Mello, S. Soltoff, K. Borodezt, 1997, The Journal of Neuroscience.

c-Fos Protects Neurons Through a Noncanonical Mechanism Involving HDAC3 Interaction: Identification of a 21-Amino Acid Fragment with Neuroprotective Activity

Varun Rawat, S. D’Mello, M. Piechaczyk, 2015, Molecular Neurobiology.

Molecular regulation of neuronal apoptosis.

S. D’Mello, 1998, Current topics in developmental biology.

Epigenetics, Autism Spectrum, and Neurodevelopmental Disorders

V. Narayanan, S. D’Mello, S. Rangasamy, 2013, Neurotherapeutics.

Apoptosis in cerebellar granule neurons is associated with reduced interaction between CREB‐binding protein and NF‐κB

Li Liu, S. D’Mello, Elena Koulich, 2003, Journal of neurochemistry.

NF‐κB is involved in the survival of cerebellar granule neurons: association of IκBβ phosphorylation with cell survival

C. Giardina, S. D’Mello, Kyle Johnson, 2001 .

NF‐κB is involved in the survival of cerebellar granule neurons: association of Iκβ phosphorylation with cell survival

C. Giardina, S. D’Mello, Kyle Johnson, 2001, Journal of neurochemistry.

Characterization of Seizures in the Flathead Rat: A New Genetic Model of Epilepsy in Early Postnatal Development

S. D’Mello, J. Loturco, M. Sarkisian, 1999, Epilepsia.

Regulation of Central Nervous System Development by Class I Histone Deacetylases

S. D’Mello, 2020, Developmental Neuroscience.

Isolation and structural characterization of the bovine tyrosine hydroxylase gene

S. D’Mello, Anthony E. Gioio, B. Kaplan, 1989, Journal of neuroscience research.

Neuroprotection by Heat Shock Factor-1 (HSF1) and Trimerization-Deficient Mutant Identifies Novel Alterations in Gene Expression

Z. Xuan, S. D’Mello, Z. Qu, 2018, Scientific Reports.

Epigenetics, Autism Spectrum, and Neurodevelopmental Disorders

V. Narayanan, S. D’Mello, S. Rangasamy, 2013, Neurotherapeutics.

Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease

S. D’Mello, D. Kretzschmar, Tanzeen Yusuff, 2017, The Journal of Neuroscience.

Featured Article: Transcriptome profiling of expression changes during neuronal death by RNA-Seq

S. D’Mello, M. Kim, Dharmendra Sharma, 2015, Experimental biology and medicine.

HSF1 Protects Neurons through a Novel Trimerization- and HSP-Independent Mechanism

S. D’Mello, J. Pfister, Sathi Mallick, 2014, The Journal of Neuroscience.

Disassociation of Histone Deacetylase-3 from Normal Huntingtin Underlies Mutant Huntingtin Neurotoxicity

Varun Rawat, S. D’Mello, Lulu Wang, 2013, The Journal of Neuroscience.

FoxG1 Promotes the Survival of Postmitotic Neurons

S. D’Mello, S. G. Dastidar, P. Landrieu, 2011, The Journal of Neuroscience.

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

S. D’Mello, P. Calissano, T. Ciotti, 1993, Proceedings of the National Academy of Sciences of the United States of America.

MECP2 and the biology of MECP2 duplication syndrome

S. D’Mello, 2021, Journal of neurochemistry.

Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome

S. D’Mello, Lulu Wang, A. S. C. Louis Sam Titus, 2018, Molecular Neurobiology.

HISTONE DEACETYLASES AS TARGETS FOR THE TREATMENT OF HUMANE

S. D’Mello, 2009 .

Uptake of SARS-CoV-2 workplace testing programs, March 2020 to March 2021

S. D’Mello, J. Van Wyk, M. Liu, 2021, medRxiv.

Caspase‐3 is required for apoptosis‐associated DNA fragmentation but not for cell death in neurons deprived of potassium

P. Rakic, C. Kuan, R. Flavell, 2000, Journal of neuroscience research.

Complex neuroprotective and neurotoxic effects of histone deacetylases

S. D’Mello, E. Thomas, E. Thomas, 2018, Journal of neurochemistry.

Regulation of Neuronal Survival by Nucleophosmin 1 (NPM1) Is Dependent on Its Expression Level, Subcellular Localization, and Oligomerization Status*

S. D’Mello, J. Pfister, 2016, The Journal of Biological Chemistry.

The complete nuleotide sequence and structure of the gene encoding bovine phenylethanolamine N‐methyltransferase

D. Batter, S. D’Mello, Anthony E. Gioio, 1988, Journal of neuroscience research.

NF-kappaB stimulates Akt phosphorylation and gene expression by distinct signaling mechanisms.

S. D’Mello, F. Meng, 2003, Biochimica et biophysica acta.

The Stress-Induced Cytokine Interleukin-6 Decreases the Inhibition/Excitation Ratio in the Rat Temporal Cortex via Trans-Signaling

M. Atzori, S. Rose-John, R. Ramirez, 2012, Biological Psychiatry.

Synthesis of 2-Benzylidene and 2-Hetarylmethyl Derivatives of 2H-1,4-Benzoxazin-3-(4H)-ones as Neuroprotecting Agents

S. D’Mello, E. Biehl, S. K. Akubathini, 2010 .

Treating neurodegenerative conditions through the understanding of neuronal apoptosis.

P. C. Chin, S. D’Mello, 2005, Current drug targets. CNS and neurological disorders.

Conditional deletion of histone deacetylase‐4 in the central nervous system has no major effect on brain architecture or neuronal viability

S. D’Mello, Lulu Wang, Valerie J Price, 2013, Journal of neuroscience research.

Citron-Kinase, A Protein Essential to Cytokinesis in Neuronal Progenitors, Is Deleted in the FlatheadMutant Rat

F. Di Cunto, S. D’Mello, J. Loturco, 2002, The Journal of Neuroscience.

Neuroprotection by Histone Deacetylase-Related Protein

E. Olson, R. Bassel-Duby, B. Morrison, 2006, Molecular and Cellular Biology.

Histone deacetylase-3: Friend and foe of the brain

S. D’Mello, 2020, Experimental biology and medicine.

Proteomic analysis identifies NPTX1 and HIP1R as potential targets of histone deacetylase-3-mediated neurodegeneration

S. D’Mello, Z. Qu, 2018, Experimental biology and medicine.

Decreased expression of the metabotropic glutamate receptor‐4 gene is associated with neuronal apoptosis

S. D’Mello, K Borodezt, S R D'Mello, 1998, Journal of neuroscience research.

Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival

S. D’Mello, Chad Smith, 2016, Molecular Neurobiology.

c-Fos Protects Neurons Through a Noncanonical Mechanism Involving HDAC3 Interaction: Identification of a 21-Amino Acid Fragment with Neuroprotective Activity

Varun Rawat, S. D’Mello, M. Piechaczyk, 2016, Molecular Neurobiology.

The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

S. D’Mello, M. Kim, Dharmendra Sharma, 2019, BMC Neuroscience.

A DEVD‐Inhibited Caspase Other than CPP32 Is Involved in the Commitment of Cerebellar Granule Neurons to Apoptosis Induced by K+ Deprivation

J. Haycock, S. D’Mello, Melanie R. Roberts, 1998, Journal of neurochemistry.

Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways.

P. C. Chin, S. D’Mello, 2004, Brain research. Molecular brain research.

The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

S. D’Mello, M. Kim, Dharmendra Sharma, 2019, BMC Neuroscience.

Neuroprotection by Heat Shock Factor-1 (HSF1) and Trimerization-Deficient Mutant Identifies Novel Alterations in Gene Expression

Z. Xuan, S. D’Mello, Z. Qu, 2018, Scientific Reports.

Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons.

S. D’Mello, X. Zhang, X. Liu, 2001, Brain research. Molecular brain research.

NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta phosphorylation with cell survival. CORRECTION

C. Giardina, S. D’Mello, Kyle Johnson, 2001 .

Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome

S. D’Mello, Lulu Wang, A. S. C. Louis Sam Titus, 2018, Molecular Neurobiology.

Synthesis and Structure-Activity Relationship Studies of 3-Substituted Indolin-2-ones as Effective Neuroprotective Agents

S. D’Mello, Lulu Wang, E. Biehl, 2008, Experimental biology and medicine.