H. Joost

发表

Cellular models for the analysis of signaling by protein kinase B and the forkhead transcription factor FKHR (Foxo1a)

W. Scherbaum, S. Bornstein, A. Barthel, 2004, Regulatory Peptides.

DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression.

A. Barthel, D. Schmoll, Hans-Martin Orth, 2003, Biochemical and biophysical research communications.

Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.

R A Roth, R. Walther, A. Barthel, 2001, Biochemical and biophysical research communications.

Association of impaired phosphatidylinositol 3-kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of fibroblasts from a patient with severe insulin resistance and clinical features of Werner syndrome.

A. Niendorf, H. Joost, H. Häring, 2000, The Journal of clinical endocrinology and metabolism.

GOAT links dietary lipids with the endocrine control of energy balance

P. Pfluger, M. Tschöp, A. Schürmann, 2009, Nature Medicine.

Personalised nutrition: status and perspectives

Christine M. Williams, M. Gibney, J. Mathers, 2007, British Journal of Nutrition.

Assessing improvement in disease prediction using net reclassification improvement: impact of risk cut-offs and number of risk categories

M. Schulze, E. Steyerberg, H. Boeing, 2012, European Journal of Epidemiology.

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach

A. Peters, M. Schulze, T. Pischon, 2013, Diabetes.

Erratum: Does gut hormone PVY3-36 decrease food intake in rodents? (Nature (2004) 430 (165) DOI:10.1038/nature03019)

D. Allison, R. Seeley, M. Tschöp, 2004 .

A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice

H. Joost, H. Al-Hasani, S. Wuschke, 2007, International Journal of Obesity.

Cloning of a Novel Family of Mammalian GTP-binding Proteins (RagA, RagBs, RagB1) with Remote Similarity to the Ras-related GTPases *

A. Schürmann, H. Joost, W. Becker, 1995, The Journal of Biological Chemistry.

Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine.

H. Joost, B. Hellwig, 1991, Molecular pharmacology.

Sequence Characteristics, Subcellular Localization, and Substrate Specificity of DYRK-related Kinases, a Novel Family of Dual Specificity Protein Kinases*

H. Joost, Hans-Georg Joost, F. Tejedor, 1998, The Journal of Biological Chemistry.

Association of AHSG Gene Polymorphisms With Fetuin-A Plasma Levels and Cardiovascular Diseases in the EPIC-Potsdam Study

Heiner Boeing, Andreas Fritsche, Norbert Stefan, 2009, Circulation. Cardiovascular genetics.

Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice.

R. Schwenk, A. Schürmann, H. Joost, 2015, Biochimica et biophysica acta.

Findings from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam Study

M. Schulze, E. Ford, H. Boeing, 2008 .

Comparison of points of departure between subchronic and chronic toxicity studies on food additives, food contaminants and natural food constituents.

Barbara E Engeli, J. Hengstler, P. Steinberg, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Comparison of the effects of insulin, PDGF, interleukin-6, and interferon-g on glucose transport in 3T3-L1 cells: lack of cross-talk between tyrosine kinase receptors and JAK/STAT pathways

P. Heinrich, H. Joost, W. Becker, 1996, Diabetologia.

A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes

E. Wolf, M. Blüher, H. Vogel, 2018, Human molecular genetics.

Nitrate and nitrite in the diet: how to assess their benefit and risk for human health.

S. Vieths, P. Steinberg, D. Marko, 2015, Molecular nutrition & food research.

Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.

H. Lodish, D. James, M. Birnbaum, 2002, American journal of physiology. Endocrinology and metabolism.

Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study

M. Schulze, T. Pischon, H. Boeing, 2006, Diabetologia.

Physiology: Does gut hormone PYY3–36 decrease food intake in rodents?

D. Allison, R. Seeley, M. Tschöp, 2004, Nature.

Arf-like protein 3

A. Schürmann, H. Joost, 2005 .

ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues.

R. Kahn, H. Joost, A. Schurmann, 1994, The Journal of biological chemistry.

ADP‐ribosylation factor (ARF)‐like 4, 6, and 7 represent a subgroup of the ARF family characterized by rapid nucleotide exchange and a nuclear localization signal

A. Schürmann, H. Joost, Y. Weber, 1999 .

Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo.

A. Schürmann, H. Joost, S. Klaus, 2008, Physiological genomics.

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.

T. Horvath, P. Pfluger, M. Tschöp, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Effects of obestatin on energy balance and growth hormone secretion in rodents.

P. Pfluger, M. Tschöp, W. Langhans, 2007, Endocrinology.

Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes.

M. Schulze, T. Pischon, H. Boeing, 2015, The American journal of clinical nutrition.

Reliability of Serum Metabolite Concentrations over a 4-Month Period Using a Targeted Metabolomic Approach

T. Pischon, T. Illig, R. Wang-Sattler, 2011, PloS one.

Liver Enzymes and Incident Diabetes

M. Schulze, E. Ford, H. Boeing, 2008, Diabetes Care.

Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress

M. Schulze, E. Schleicher, T. Pischon, 2012, European Journal of Nutrition.

Nutrition: Red meat and T2DM|[mdash]|the difficult path to a proof of causality

H. Joost, 2013 .

Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans.

P. B. Jensen, H. Hauner, H. Joost, 1996, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Insulin-stimulated glucose transport in rat adipose cells. Modulation of transporter intrinsic activity by isoproterenol and adenosine.

H. Joost, I. Simpson, S. Cushman, 1986, The Journal of biological chemistry.

Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells

G. King, H. Joost, E. Cerasi, 1996, British journal of pharmacology.

Association of a diabetes risk score with risk of myocardial infarction, stroke, specific types of cancer, and mortality: a prospective study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort

U. Nöthlings, M. Schulze, T. Pischon, 2009, European Journal of Epidemiology.

Structural and functional heterogeneity of insulin receptors.

H. Joost, 1995, Cellular signalling.

Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.

A. Gruber, A. Schürmann, M. Moser, 2010, Biochemical and biophysical research communications.

Consuming fructose-sweetened beverages increases body adiposity in mice.

C. Koebnick, M. Tschöp, M. Ristow, 2005, Obesity research.

GLP-1–oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice

M. Tschöp, R. Schwenk, A. Schürmann, 2014, Diabetologia.

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses

M. Nitsche, U. Nöthlings, S. Vieths, 2020, Archives of Toxicology.

Use of Multiple Metabolic and Genetic Markers to Improve the Prediction of Type 2 Diabetes: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study

M. Schulze, T. Pischon, H. Boeing, 2009 .

The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice

A. Schürmann, H. Joost, Nadja Schulz, 2015, Diabetologia.

Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain.

B. Taylor, H. Joost, W. Becker, 1998, Journal of molecular endocrinology.

Impact of the Adipokine Adiponectin and the Hepatokine Fetuin-A on the Development of Type 2 Diabetes: Prospective Cohort- and Cross-Sectional Phenotyping Studies

F. Hu, M. Schulze, F. Schick, 2014, PloS one.

Novel biomarkers for pre-diabetes identified by metabolomics

Christian Gieger, Thomas Meitinger, Monica Campillos, 2012, Molecular systems biology.

ADP-ribosylation Factor-like GTPase ARFRP1 Is Required for Trans-Golgi to Plasma Membrane Trafficking of E-cadherin*

A. Schürmann, S. Florian, W. Hong, 2008, Journal of Biological Chemistry.

High-Fat, Carbohydrate-Free Diet Markedly Aggravates Obesity but Prevents β-Cell Loss and Diabetes in the Obese, Diabetes-Susceptible db/db Strain

H. Vogel, A. Schürmann, H. Joost, 2008, Obesity Facts.

Dissociation of the effects of training on oxidative metabolism, glucose utilisation and GLUT4 levels in skeletal muscle of streptozotocin-diabetic rats

H. Joost, H. Kainulainen, V. Vihko, 1994, Pflügers Archiv.

In vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT4 in heart and various types of skeletal muscle from streptozotocin-diabetic rats.

A. Schürmann, H. Joost, H. Kainulainen, 1994, Biochimica et biophysica acta.

Prostaglandin E2 differentiates between two forms of glucose transport inhibition by lipolytic agents

H. Joost, H. Steinfelder, S. Schramm, 1987, Naunyn-Schmiedeberg's Archives of Pharmacology.

The regulation of glucose transport in insulin-sensitive cells

H. Joost, T. M. Weber, 1989, Diabetologia.

Modulation of glucose transport in hamster adipocytes by insulin and byβ- andα2-adrenoceptor agonists

H. Joost, H. Steinfelder, J. Strodt, 1986, Diabetologia.

Effects of theophylline on insulin receptors and insulin action in the adipocyte

H. Joost, H. Steinfelder, 2004, Molecular and Cellular Biochemistry.

Localization of the binding domain of the inhibitory ligand forskolin in the glucose transporter GLUT-4 by photolabeling, proteolytic cleavage and a site-specific antiserum.

A. Schürmann, H. Joost, M. Shanahan, 1992, Biochimica et biophysica acta.

Quantitative dissociation of glucose transport stimulation and insulin receptor tyrosine kinase activation in isolated adipocytes with a covalent insulin dimer (B29,B29'-suberoyl-insulin).

H. Joost, R. Göke, C. Schmitz-Salue, 1989, Biochemical pharmacology.

Differential sensitivity to guanine nucleotides of basal and insulin‐stimulated glucose transporter activity reconstituted from adipocyte membrane fractions

A. Schürmann, H. Joost, K. Hinsch, 1989, FEBS letters.

Phosphorylation of G-protein alpha-subunits in intact adipose cells: evidence against a mediating role in insulin-dependent metabolic effects.

G. Schultz, H. Joost, K. Hinsch, 1989, European journal of pharmacology.

Inhibition of insulin‐stimulated glucose transport in rat adipocytes by nucleoside transport inhibitors

H. Joost, H. Steinfelder, 1988, FEBS letters.

The inhibition of rat adipocyte ecto-5'-nucleotidase by xanthines is not related to lipolysis.

H. Joost, H. Steinfelder, 1986, Biochemical pharmacology.

Dual effect of isoprenaline on glucose transport and response to insulin in isolated adipocytes.

H. Joost, R. Göke, H. Steinfelder, 1985, Biochemical pharmacology.

Insulin-like stimulation of glucose transport in isolated adipocytes by fatty acids.

H. Joost, H. Steinfelder, 1985, Biochemical and biophysical research communications.

Effects of islet‐activating protein on insulin‐ and isoprenaline‐stimulated glucose transport in isolated rat adipocytes

H. Joost, R. Göke, 1984, FEBS letters.

Effects of tolbutamide on insulin binding to isolated fat cells of the rat.

H. Joost, W. Arend, S. Holze, 1982, Biochemical pharmacology.

Insulin binding and response to insulin of adipocytes from thyroxine-treated rats.

H. Joost, A. Hasselblatt, E. Heise, 1982, Endocrinology.

In vitro effects of theophylline on insulin receptors in adipocytes: correlation with the lipolytic action of the agent.

H. Joost, H. Steinfelder, 1982, Biochemical and biophysical research communications.

Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese [db/db mice, fa/fa rats) rodents

H. Joost, W. Becker, H. Kainulainen, 1996, Diabetologia.

In-vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT3 in brain tissue from streptozotocin-diabetic rats.

A. Schürmann, H. Joost, P. Vilja, 1993, Acta physiologica Scandinavica.

Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose.

A. Schürmann, H. Joost, H. Doege, 2001, Biochemical and biophysical research communications.

Metabolic syndrome and risk of incident diabetes : findings from the European Prospective Investigation into Cancer and NutritionPotsdam NutritionPotsdam NutritionPotsdam Study

M. Schulze, T. Pischon, E. Ford, 2015 .

Ghrelin-induced hypothermia: A physiological basis but no clinical risk

T. Horvath, M. Tschöp, D. Blum, 2011, Physiology & Behavior.

Identification of Susceptibility Loci for Obesity, Insulin Resistance, and Hyperglycemia in a Backcross Model of New Zealand Obese (NZO) and Lean SJL Mice

L. Plum, H. Joost, R. Kluge, 2002 .

Extrapancreatic effects of hypoglycemic sulfonylureas: still a controversial issue

H. Joost, 1985 .

The signaling potential of the receptors for insulin and insulin‐like growth factor I (IGF‐I) in 3t3‐l1 adipocytes: Comparison of glucose transport activity, induction of oncogene c‐fos, glucose transporter mRNA, and DNA‐synthesis

A. Schürmann, H. Joost, F. Bahr, 1991, Journal of cellular physiology.

Liver Enzymes and Incident Diabetes: Findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study

Thamer, M. Schulze, E. Ford, 2008 .

Regulation of the Forkhead Transcription Factor FKHR (FOXO1a) by Glucose Starvation and AICAR, an Activator of AMP-Activated Protein Kinase.

A. Barthel, D. Schmoll, H. Joost, 2002, Endocrinology.

NO to obesity: does nitric oxide regulate fat oxidation and insulin sensitivity?

M. Tschöp, H. Joost, 2007, Endocrinology.

Nutritional genomics : impact on health and disease

R. Brigelius-Flohé, H. Joost, 2006 .

The ARF-Like GTPase ARFRP1 Is Essential for Lipid Droplet Growth and Is Involved in the Regulation of Lipolysis

M. Blüher, H. Vogel, A. Schürmann, 2009, Molecular and Cellular Biology.

Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport

H. Joost, J. Loffing, G. Holman, 2014, Diabetes.

The genetic basis of obesity and type 2 diabetes: lessons from the new zealand obese mouse, a polygenic model of the metabolic syndrome.

H. Joost, 2010, Results and problems in cell differentiation.

Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation.

G. Chrousos, S. Bornstein, D. Torpy, 1998, Endocrinology.

Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse.

H. Joost, W. Becker, M. Igel, 1997, Endocrinology.

GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern

A. Schürmann, H. Beck-Nielsen, H. Joost, 2004, Pflügers Archiv.

Appetite Regulatory Peptides PYY 3-36 as an anti-obesity drug target

D. Allison, R. Seeley, M. Tschöp, 2005 .

Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans

T. Schulz, M. Blüher, P. Fischer-Posovszky, 2018, Diabetologia.

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity

A. Voigt, A. Schürmann, H. Joost, 2015, Genes & Nutrition.

Concentration-dependent stimulatory and inhibitory effect of troglitazone on insulin-induced fatty acid synthase expression and protein kinase B activity in 3T3-L1 adipocytes

A. Barthel, K. Krüger, H. Joost, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Subcellular distribution and activity of glucose transporter isoforms GLUT1 and GLUT4 transiently expressed in COS-7 cells.

A. Schürmann, H. Joost, I. Monden, 1992, Biochimica et biophysica acta.

Effect of Hyperinsulinemia and Type 2 Diabetes-Like Hyperglycemia on Expression of Hepatic Cytochrome P450 and GlutathioneS-Transferase Isoforms in a New Zealand Obese-Derived Mouse Backcross Population

L. Plum, H. Joost, W. Becker, 2002, Journal of Pharmacology and Experimental Therapeutics.

The role of dual leucine zipper kinase (DLK) in β-cell apoptosis: a potential target for the prevention and treatment of type 2 diabetes?

H. Joost, 2017, Naunyn-Schmiedeberg's Archives of Pharmacology.

Mutation of two conserved arginine residues in the glucose transporter GLUT4 supresses transport activity, but not glucose-inhibitable binding of inhibitory ligands

A. Schürmann, H. Joost, W. Becker, 1995, Naunyn-Schmiedeberg's Archives of Pharmacology.

The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa

H. Axer, A. Schürmann, H. Joost, 2002, Cell and Tissue Research.

Characterization of GLUT5 domains responsible for fructose transport.

H. Joost, E. Cerasi, A. Buchs, 1998, Endocrinology.

Substitution of conserved tyrosine residues in helix 4 (Y143) and 7 (Y293) affects the activity, but not IAPS‐forskolin binding, of the glucose transporter GLUT4

H. Joost, W. Becker, M. Shanahan, 1994, FEBS letters.

Whole-grain consumption and transcription factor-7-like 2 (TCF7L2) rs7903146: gene–diet interaction in modulating type 2 diabetes risk

M. Schulze, H. Boeing, E. Fisher, 2008, British Journal of Nutrition.

Reversible reduction of insulin receptor affinity by ATP depletion in rat adipocytes.

H. Joost, H. Steinfelder, 1983, The Biochemical journal.

Thyroid function and insulin secretion from the perfused pancreas in the rat.

H. Joost, S. Lenzen, A. Hasselblatt, 1976, Endocrinology.

Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome.

A. Schürmann, H. Joost, R. Kluge, 2012, Methods in molecular biology.

Animal Models in Diabetes Research

A. Schürmann, H. Joost, H. Al-Hasani, 2012, Methods in Molecular Biology.

Cloning of a novel member (ARL5) of the ARF-family of Ras-related GTPases.

A. Schürmann, H. Joost, W. Becker, 1996, Biochimica et biophysica acta.

Inhibition of the renin-angiotensin system ameliorates genetically determined hyperinsulinemia.

F. Eitner, J. Floege, G. Hollweg, 2002, European journal of pharmacology.

Inhibition of insulin and glucagon release from the perfused rat pancreas by cyproheptadine (Periactinol®, Nuran®)

H. Joost, S. Lenzen, W. Poser, 1976, Diabetologia.

Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin

A. Schürmann, H. Joost, K. Aktories, 1998, Naunyn-Schmiedeberg's Archives of Pharmacology.

Glucose deprivation induces Akt-dependent synthesis and incorporation of GLUT1, but not of GLUT4, into the plasma membrane of 3T3-L1 adipocytes.

A. Schürmann, A. Barthel, H. Joost, 2000, European journal of cell biology.

Biphasic Alteration of Glucose Transport in 3T3-L1 Cells During Differentiation to the Adipocyte-Like Phenotype

A. Schürmann, H. Joost, M. Weiland, 1993, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Development of the hormone-sensitive glucose transport activity in differentiating 3T3-L1 murine fibroblasts. Role of the two transporter species and their subcellular localization.

A. Schürmann, H. Joost, W. Schmidt, 1990, The Biochemical journal.

Activity and phosphorylation state of glucose transporters in plasma membranes from insulin-, isoproterenol-, and phorbol ester-treated rat adipose cells.

H. Joost, I. Simpson, S. Cushman, 1987, The Journal of biological chemistry.

Modulation of insulin sensitivity by adenosine. Effects on glucose transport, lipid synthesis, and insulin receptors of the adipocyte.

H. Joost, H. Steinfelder, 1982, Molecular pharmacology.

Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse.

H. Joost, W. Becker, M. Igel, 1997, Endocrinology.

Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase.

A. Barthel, D. Schmoll, K. Krüger, 2002, Endocrinology.

Deletion of Both Rab-GTPase–Activating Proteins TBC14KO and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport. Diabetes 2015;64:746–759

H. Joost, J. Loffing, G. Holman, 2015, Diabetes.

The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium

H. Koepsell, A. Schürmann, R. Brigelius-Flohé, 2012, Human molecular genetics.

Abundance and subcellular distribution of GTP-binding proteins in 3T3-L1 cells before and after differentiation to the insulin-sensitive phenotype.

A. Schürmann, H. Joost, C. Huppertz, 1993, European journal of biochemistry.

Tyrosine kinase activity of insulin receptors from human placenta. Effects of autophosphorylation and cyclic AMP-dependent protein kinase.

H. Joost, C. Schmitz-Salue, H. Steinfelder, 1986, The Biochemical journal.

Subcellular B cell calcium and insulin secretion in vitro

G. Bommer, G. Klöppel, H. Joost, 1978, Virchows Archiv A.

Modulation of glucose transport in hamster adipocytes by insulin and by beta- and alpha 2-adrenoceptor agonists.

H. Joost, H. Steinfelder, J. Strodt, 1986, Diabetologia.

Angiogenesis in the New Zealand obese mouse model fed with high fat diet

H. Joost, A. Dembińska-kieć, R. Tomaszewska, 2009, Lipids in Health and Disease.

Subcellular fractionation of adipocytes and 3T3-L1 cells.

A. Schürmann, H. Joost, 2001, Methods in molecular biology.

The ADP-ribosylation Factor (ARF)-related GTPase ARF-related Protein Binds to the ARF-specific Guanine Nucleotide Exchange Factor Cytohesin and Inhibits the ARF-dependent Activation of Phospholipase D*

K. Jakobs, A. Schürmann, H. Joost, 1999, The Journal of Biological Chemistry.

The inhibition of insulin secretion from the perfused rat pancreas after thyroxine treatment

H. Joost, S. Lenzen, A. Hasselblatt, 1976, Diabetologia.

Insulin release by tolbutamide and glibenclamide

H. Joost, A. Hasselblatt, 1979, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of polymer-linked sulfonylurea derivatives on insulin release

H. Joost, A. Hasselblatt, 1977, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of insulin release from the rat pancreas by cyproheptadine and tricyclic antidepressants

H. Joost, W. Poser, U. Panten, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

INHIBITION OF INSULIN SECRETION FROM THE PERFUSED PANCREAS OF THE RAT BY PIZOTIFEN

H. Joost, 1979, British journal of pharmacology.

Effects of bicyclic leucine analogues on insulin release from the perfused rat pancreas and fluorescence of reduced pyridine nucleotides from perifused pancreatic islets.

H. Joost, W. Poser, U. Panten, 1975, Life sciences.

Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action.

H. Joost, I. Simpson, A. Laurenza, 1988, Molecular pharmacology.

Review Process File

Yixue Li, Ying He, Tao Xu, 2012 .

Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction

A. Schürmann, V. Haucke, M. K. Diril, 2009, The FEBS journal.

Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.

H. Joost, W. Becker, J. Schultz, 1994, The Journal of biological chemistry.

Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes.

A. Schürmann, H. Joost, H. Doege, 2000, The Biochemical journal.

The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models

A. Schürmann, H. Joost, 2014, Mammalian Genome.

Impaired leptin activity in New Zealand Obese mice: model of angiogenesis

H. Joost, A. Dembińska-kieć, R. Tomaszewska, 2008, Genes & Nutrition.

Regulation of subcellular distribution of GLUT4 in cardiomyocytes: Rab4A reduces basal glucose transport and augments insulin responsiveness.

A. Schürmann, H. Joost, I. Uphues, 2012, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Uptake of tolbutamide by islets of Langerhans and other tissues

H. Joost, S. Holze, 1978, Experientia.

Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa

A. Schürmann, M. Moser, G. Wennemuth, 2008, Molecular membrane biology.

ARP Is a Plasma Membrane-associated Ras-related GTPase with Remote Similarity to the Family of ADP-ribosylation Factors (*)

A. Schürmann, H. Joost, S. Maßmann, 1995, The Journal of Biological Chemistry.

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity

A. Voigt, A. Schürmann, H. Joost, 2015, Genes & Nutrition.

Appetite Control

H. Joost, A. Kleinridders, John Blundell, 2012, Handbook of Experimental Pharmacology.

Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity Is Dependent on Tyrosine Residues between Subdomains VII and VIII (*)

A. Schürmann, A. Wilmes, H. Joost, 1996, The Journal of Biological Chemistry.

The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members

H. Joost, B. Thorens, 2001, Molecular membrane biology.

Qualitative and quantitative comparison of glucose transport activity and glucose transporter concentration in plasma membranes from basal and insulin-stimulated rat adipose cells.

H. Joost, S. Cushman, S W Cushman, 1988, The Biochemical journal.

The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function.

A. Schürmann, H. Joost, Andrea Scheepers, 2004, JPEN. Journal of parenteral and enteral nutrition.

Contribution to the ongoing discussion on fluoride toxicity

M. Nitsche, U. Nöthlings, S. Vieths, 2021, Archives of Toxicology.

Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers.

P. Heinrich, I. Behrmann, A. Barthel, 2002, Molecular endocrinology.

HDL cholesterol in SM/J and NZB/B1NJ inbred mice Quantitative trait locus mapping of genes that regulate

G. Churchill, R. Korstanje, S. Mohan, 2015 .

Akt Modulates STAT3-mediated Gene Expression through a FKHR (FOXO1a)-dependent Mechanism*

P. Heinrich, I. Behrmann, M. Kortylewski, 2003, The Journal of Biological Chemistry.

Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes

M. Schulze, N. Stefan, H. Boeing, 2008, Diabetes.

Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity.

H. Joost, W. Becker, W. Becker, 1999, Progress in nucleic acid research and molecular biology.

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation

H. Vogel, A. Schürmann, H. Joost, 2015, PLoS genetics.

Differential Transcriptome Analysis of Diabetes-Resistant and -Sensitive Mouse Islets Reveals Significant Overlap With Human Diabetes Susceptibility Genes

R. Schwenk, A. Schürmann, H. Joost, 2014, Diabetes.

Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction

M. Tschöp, M. Blüher, A. Schürmann, 2007, Diabetologia.

Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice.

Sylvia Ortmann, M. Tschöp, A. Schürmann, 2006, Physiological genomics.

A meta-analysis of QTL for diabetes-related traits in rodents.

J. Schuchhardt, Nina Gonzaludo, Sarah Strunk, 2008, Physiological genomics.

Identification of Novel Potential Type 2 Diabetes Genes Mediating β-Cell Loss and Hyperglycemia Using Positional Cloning

G. Brockmann, D. Arends, H. Vogel, 2020, Frontiers in Genetics.

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity

Rob C Hoeben, Alexandra Chadt, Tanja Dreja, 2008, Nature Genetics.

Estimation of the contribution of biomarkers of different metabolic pathways to risk of type 2 diabetes

M. Schulze, E. Schleicher, T. Pischon, 2010, European Journal of Epidemiology.

Use of Multiple Metabolic and Genetic Markers to Improve the Prediction of Type 2 Diabetes: the EPIC-Potsdam Study

Heiner Boeing, Andreas Fritsche, Hadi Al-Hasani, 2009, Diabetes Care.

Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice

A. Hoeflich, R. Schwenk, A. Schürmann, 2016, Human molecular genetics.

GLUT8, the enigmatic intracellular hexose transporter.

A. Schürmann, H. Joost, S. Schmidt, 2009, American journal of physiology. Endocrinology and metabolism.

PSCA expression is regulated by phorbol ester and cell adhesion in the bladder carcinoma cell line RT112.

G. Jakse, H. Joost, G. Bahrenberg, 2001, Cancer letters.

Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors.

G. Jakse, H. Joost, G. Bahrenberg, 2000, Biochemical and biophysical research communications.

Diabetes and cancer: Epidemiology and potential mechanisms

H. Joost, 2014, Diabetes & vascular disease research.

Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6-phosphatase gene expression.

R. Walther, A. Barthel, D. Schmoll, 2001, The Biochemical journal.

Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.

H. Himmelbauer, J. Zierath, H. Joost, 2013, Endocrinology.

Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke

M. Schulze, T. Pischon, N. Stefan, 2008, Circulation.

Specificity Determinants of Substrate Recognition by the Protein Kinase DYRK1A*

H. Joost, W. Becker, R. Frank, 2000, The Journal of Biological Chemistry.

Mice without the Regulator Gene Rsc1A1 Exhibit Increased Na+-d-Glucose Cotransport in Small Intestine and Develop Obesity

K. Knobeloch, H. Koepsell, H. Joost, 2005, Molecular and Cellular Biology.

GLUT8, a Novel Member of the Sugar Transport Facilitator Family with Glucose Transport Activity*

Andreas Brauers, A. Schürmann, H. Joost, 2000, The Journal of Biological Chemistry.

Effects of a Possible Beta-Cell Membrane Label, Metahexamide-lsothiocyanate, on Insulin Release

H. Joost, 1979, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

An Interval of the Obesity QTL Nob3.38 within a QTL Hotspot on Chromosome 1 Modulates Behavioral Phenotypes

H. Vogel, A. Schürmann, H. Joost, 2013, PloS one.

A two-step association study identifies CAV2 rs2270188 single nucleotide polymorphism interaction with fat intake in type 2 diabetes risk.

H. Boeing, E. Fisher, H. Joost, 2011, The Journal of nutrition.

Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A.

T. Blundell, H. Joost, W. Becker, 2001, The Biochemical journal.

Cloning of two splicing variants of the novel Ras-related GTPase Rab29 which is predominantly expressed in kidney.

A. Schürmann, H. Joost, S. Maßmann, 1997, Biochimica et biophysica acta.

K. Broman, M. Roden, D. Arends, 2020, Journal of hepatology.

ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal.

A. Schürmann, H. Joost, Y. Weber, 1999, FEBS letters.

Structure-function relationship of glucose transporters catalyzing facilitated diffusion

A. Schürmann, H. Joost, S. Wandel, 2009, Experimental and clinical endocrinology.

Horizons in nutritional science : The case for strategic international alliances to harness nutritional genomics for public and personal health.

Jean-Daniel Zucker, Peter Morgan, Berthold Koletzko, 2005 .

Gamma‐glutamyltransferase, cardiovascular disease and mortality in individuals with diabetes mellitus

U. Nöthlings, H. Boeing, H. Joost, 2012, Diabetes/Metabolism Research Reviews.

A meta-analysis of QTL associated with body weight and adiposity in mice

H. Joost, H. Al-Hasani, S. Wuschke, 2006 .

Potential effects of reduced red meat compared with increased fiber intake on glucose metabolism and liver fat content: a randomized and controlled dietary intervention study.

M. Schulze, N. Stefan, J. Machann, 2019, The American journal of clinical nutrition.

Pathogenesis, Risk Assessment and Prevention of Type 2 Diabetes mellitus

H. Joost, 2008, Obesity Facts.

Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter.

H. Joost, H. Steinfelder, 1987, Molecular pharmacology.

Positional Cloning of Zinc Finger Domain Transcription Factor Zfp69, a Candidate Gene for Obesity-Associated Diabetes Contributed by Mouse Locus Nidd/SJL

Matthias Blüher, Hadi Al-Hasani, S. Herzig, 2009, PLoS genetics.

The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism

M. Tschöp, A. Schürmann, U. Schweizer, 2012, Physiology & Behavior.

Arf-like protein 6

A. Schürmann, H. Joost, 2008 .

Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity.

M. Blüher, H. Vogel, A. Schürmann, 2012, Human molecular genetics.

[Test strips for the detection of high bromide concentrations in body fluids].

H. Joost, S. Poser, W. Poser, 1974, Der Nervenarzt.

Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases.

H. Joost, W. Becker, W. Becker, 1996, European journal of biochemistry.

Nutrition-/diet-induced changes in gene expression in white adipose tissue.

H. Joost, H. Al-Hasani, 2005, Best practice & research. Clinical endocrinology & metabolism.

Unusual function of the activation loop in the protein kinase DYRK1A.

H. Joost, W. Becker, J. Grötzinger, 2003, Biochemical and biophysical research communications.

cDNA cloning and characterization of rat Clk3, a LAMMER kinase predominately expressed in testis.

H. Joost, W. Becker, H. Kentrup, 1996, Biochimica et Biophysica Acta.

Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

J. Tavernier, H. Joost, W. Becker, 2004, The FEBS journal.

UvA-DARE ( Digital Academic Repository ) Role of Medium-and Short-Chain L-3-Hydroxyacyl-CoA Dehydrogenase in the Regulation of Body Weight and Thermogenesis

H. Himmelbauer, K. Suhre, H. Vogel, 2011 .

Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation

U. Nöthlings, L. Kreienbrock, P. Steinberg, 2018, Archives of Toxicology.

Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1.

H. Vogel, A. Schürmann, F. Rüschendorf, 2009, Physiological genomics.

Non-fasting lipids and risk of cardiovascular disease in patients with diabetes mellitus

D. van der A, U. Nöthlings, H. Boeing, 2010, Diabetologia.

Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases.

X. Estivill, H. Joost, W. Becker, 1999, Biochemical and biophysical research communications.

Distribution of the mRNA for protein phosphatase T in rat brain.

Manuel Buttini, H. Boddeke, H. Joost, 1996, Brain research. Molecular brain research.

Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the β2-adaptin subunit of the AP-2 adaptor complex

A. Schürmann, H. Joost, H. Al-Hasani, 2006, Journal of Cell Science.

Update of the German Diabetes Risk Score and external validation in the German MONICA/KORA study.

C. Meisinger, W. Rathmann, A. Peters, 2014, Diabetes research and clinical practice.

Microsomal triglyceride transfer protein -164 T > C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study

S. Willich, S. Moebus, S. Pechlivanis, 2013, BMC Medical Genetics.

Prevention of complex diseases by genotype-based nutrition: realistic concept or fiction?

H. Joost, 2007, Journal of Molecular Medicine.

Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study.

M. Schulze, H. Boeing, H. Joost, 2011, The American journal of clinical nutrition.

Molecular links between Obesity and Diabetes: “Diabesity”

H. Joost, H. Al-Hasani, S. Scherneck, 2014 .

Association of the FTO rs9939609 Single Nucleotide Polymorphism With C‐reactive Protein Levels

M. Schulze, T. Pischon, N. Stefan, 2009, Obesity.

Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity.

C. Meyer, R. Wehr, A. Schürmann, 2007, Endocrinology.

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses

M. Nitsche, U. Nöthlings, S. Vieths, 2020, Archives of Toxicology.

Heterogeneity of the Stearoyl-CoA desaturase-1 (SCD1) Gene and Metabolic Risk Factors in the EPIC-Potsdam Study

D. Corella, N. Stefan, H. Boeing, 2012, PloS one.

Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.

A. Schürmann, H. Joost, W. Becker, 1994, The Journal of biological chemistry.

Medical Antihyperglycaemic Treatment of Type 2 Diabetes Mellitus*

H. Joost, A. Fritsche, S. Matthaei, 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Arf-Like Proteins

A. Schürmann, H. Joost, 2004 .

Reduced Sperm Count and Normal Fertility in Male Mice with Targeted Disruption of the ADP-Ribosylation Factor-Like 4 (Arl4) Gene

P. Saftig, A. Schürmann, G. Wennemuth, 2002, Molecular and Cellular Biology.

Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini.

A. Schürmann, H. Joost, W. Becker, 1996, European journal of biochemistry.

A dual role of the N-terminal FQQI motif in GLUT4 trafficking

F. Carlotti, H. Joost, H. Al-Hasani, 2009, Biological chemistry.

The central melanocortin system directly controls peripheral lipid metabolism.

S. O’Rahilly, S. Woods, P. Howles, 2007, The Journal of clinical investigation.

Characterization of GTP-binding proteins in Golgi-associated membrane vesicles from rat adipocytes.

G. Schultz, A. Schürmann, H. Joost, 1992, The Biochemical journal.

Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis

Barbara E Engeli, U. Nöthlings, S. Vieths, 2022, Archives of Toxicology.

Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value).

Barbara E Engeli, U. Nöthlings, S. Vieths, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5.

L. Plum, H. Joost, J. Ortlepp, 2003, Biochemical and biophysical research communications.

GTPase ARFRP1 Is Essential for Normal Hepatic Glycogen Storage and Insulin-Like Growth Factor 1 Secretion

A. Schürmann, H. Joost, K. Petzke, 2012, Molecular and Cellular Biology.

Preparation of recombinant histone H3 as a substrate for protein kinase assays.

H. Joost, W. Becker, S. Himpel, 1999, Analytical Biochemistry.

Sensory and Metabolic Control of Energy Balance

H. Joost, W. Meyerhof, U. Beisiegel, 2010 .

Metabolic syndrome and risk of incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study

M. Schulze, T. Pischon, E. Ford, 2008, Cardiovascular diabetology.

Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle.

H. Axer, A. Schürmann, H. Joost, 2001, The Biochemical journal.

Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice.

H. Himmelbauer, A. Schürmann, H. Joost, 2008, American journal of physiology. Endocrinology and metabolism.

Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.

H. Vogel, A. Schürmann, H. Joost, 2010, Results and problems in cell differentiation.

Phosphorylation of the adipose/muscle-type glucose transporter (GLUT4) and its relationship to glucose transport activity.

A. Schürmann, H. Joost, G. Mieskes, 1992, The Biochemical journal.

The Value of Genetic Information for Diabetes Risk Prediction – Differences According to Sex, Age, Family History and Obesity

Heiner Boeing, M. Schulze, H. Boeing, 2013, PloS one.

Antagonistic effects of a covalently dimerized insulin derivative on insulin receptors in 3T3-L1 adipocytes.

H. Joost, M. Weiland, C. Brandenburg, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties.

A. Barthel, H. Joost, W. Becker, 2003, The Biochemical journal.

Role of conserved arginine and glutamate residues on the cytosolic surface of glucose transporters for transporter function.

A. Schürmann, H. Joost, H. Doege, 1997, Biochemistry.

An Accurate Risk Score Based on Anthropometric, Dietary, and Lifestyle Factors to Predict the Development of Type 2 Diabetes

M. Schulze, A. Pfeiffer, H. Joost, 2007, Diabetes Care.

Effects of chemical sympathectomy on insulin receptors and insulin action in isolated rat adipocytes.

H. Joost, S. Quentin, 1984, Journal of Pharmacology and Experimental Therapeutics.

Variation in the HHEX–IDE gene region predisposes to type 2 diabetes in the prospective, population-based EPIC-Potsdam cohort

M. Schulze, H. Boeing, E. Fisher, 2007, Diabetologia.

Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue

C. Cheeseman, A. Manolescu, A. Schürmann, 2005, Molecular membrane biology.

Construction and characterization of a conditionally active construct of the insulin-regulated forkhead transcription factor FKHR.

A. Barthel, D. Schmoll, Hans-Martin Orth, 2002, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Personalized Prevention of Type 2 Diabetes

H. Joost, 2007 .

Subcellular distribution and phosphorylation state of insulin receptors from insulin- and isoproterenol-treated rat adipose cells.

H. Joost, I. Simpson, S. Cushman, 1991, Cellular signalling.

Barbara E Engeli, U. Nöthlings, S. Vieths, 2022, Archives of Toxicology.

Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells

A. Schürmann, S. Florian, W. Hong, 2006, Molecular membrane biology.

Effects of pimozide and apomorphine on insulin secretion from the perfused rat pancreas.

H. Joost, B. Göke, A. Hasselblatt, 1983, Archives internationales de pharmacodynamie et de therapie.

Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells.

A. Schürmann, H. Joost, S. Cushman, 2001, The Biochemical journal.

A. Schürmann, H. Joost, A. G. Mueller, 2002, Biochemical and biophysical research communications.