Smitha Antony

发表

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

Yves Pommier, Kurt W Kohn, Olivier Sordet, 2004, Oncogene.

Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers

J. Weinstein, E. Kohn, Y. Pommier, 2008, Molecular Cancer Therapeutics.

Zalypsis (PM00104) is a potent inducer of γ-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition

Y. Pommier, Smitha Antony, J. Guirouilh-Barbat, 2009, Molecular Cancer Therapeutics.

Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells

E. Sausville, Y. Pommier, Smitha Antony, 2006, Cancer Chemotherapy and Pharmacology.

NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction

Han Liu, J. Doroshow, S. Gaur, 2017, The Journal of Biological Chemistry.

Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells

Han Liu, J. Doroshow, E. Polley, 2017, Oncotarget.

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Y. Pommier, K. Krajewski, P. Roller, 2006, Nucleic acids research.

NADPH oxidase 5 (NOX5)—induced reactive oxygen signaling modulates normoxic HIF‐1α and p27Kip1 expression in malignant melanoma and other human tumors

Han Liu, J. Doroshow, H. Makhlouf, 2017, Molecular carcinogenesis.

Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A

Han Liu, J. Doroshow, M. Hollingshead, 2016, Oncotarget.

Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody.

Han Liu, J. Doroshow, S. Hewitt, 2013, Free radical biology & medicine.

ABCG2 mediates differential resistance to SN-38 and homocamptothecins

Y. Pommier, S. Bates, R. Robey, 2004 .

Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases.

A. Monks, J. Doroshow, Smitha Antony, 2017, Biochemical pharmacology.

Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody

Han Liu, J. Doroshow, S. Hewitt, 2013, International journal of oncology.

Dexamethasone Inhibits Cytokine-Induced, DUOX2-Related VEGF-A Expression and DNA damage in Human Pancreatic Cancer Cells and Growth of Pancreatic Cancer Xenografts

J. Doroshow, Smitha Antony, K. Roy, 2022, bioRxiv.

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.

Y. Pommier, A. Robles, Z. Miao, 2007, Cancer research.

Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

Y. Pommier, Y. Rustum, Smitha Antony, 2005, Molecular Pharmacology.

Cellular Topoisomerase I Inhibition and Antiproliferative Activity

Y. Pommier, Y. Rustum, Smitha Antony, 2004 .

DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells.

E. Sausville, Y. Pommier, Smitha Antony, 2005, Cancer research.

Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin.

Y. Pommier, Danzhou Yang, Smitha Antony, 2005, Bioorganic & medicinal chemistry letters.

Bisindenoisoquinoline NSC 727357, a DNA intercalator and topoisomerase inhibitor with antitumor activity

Y. Pommier, S. Holbeck, Z. Miao, 2006 .

A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.

Y. Pommier, Smitha Antony, G. Kohlhagen, 2006, Journal of medicinal chemistry.

Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.

Y. Pommier, L. Stewart, A. Ioanoviciu, 2005, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.

Y. Pommier, Smitha Antony, G. Kohlhagen, 2003, Journal of medicinal chemistry.

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

K. Kohn, Y. Pommier, A. Burgin, 2006, Molecular Cancer Therapeutics.

Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors.

Yves Pommier, Andrew Morrell, Y. Pommier, 2007, Journal of medicinal chemistry.

Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.

Y. Pommier, Smitha Antony, G. Kohlhagen, 2004, Journal of medicinal chemistry.

Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors.

Y. Pommier, Smitha Antony, G. Kohlhagen, 2006, Bioorganic & medicinal chemistry letters.

Total synthesis and biological evaluation of 22-hydroxyacuminatine.

Y. Pommier, Smitha Antony, M. Cushman, 2006, Journal of medicinal chemistry.

Incorporation of TiO2 in hot dip zinc coating for efficient resistance to biogrowth

Smitha Antony, S.M.A. Shibli, V. S. Dilimon, 2006 .

Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity

Y. Pommier, S. Holbeck, Z. Miao, 2006, Molecular Pharmacology.

NADPH oxidases and cancer.

Han Liu, J. Doroshow, Smitha Antony, 2015, Clinical science.

NADPH oxidases: a perspective on reactive oxygen species production in tumor biology.

Han Liu, J. Doroshow, Smitha Antony, 2014, Antioxidants & redox signaling.

Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.

Y. Pommier, Smitha Antony, T. Dexheimer, 2007, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.

Y. Pommier, L. Stewart, Smitha Antony, 2003, Journal of medicinal chemistry.

Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures.

Yves Pommier, Keli Agama, Andrew Morrell, 2007, Journal of medicinal chemistry.

Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles.

Y. Pommier, A. Ioanoviciu, M. Hollingshead, 2006, Journal of medicinal chemistry.

Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.

Y. Pommier, J. Chaires, M. Hollingshead, 2006, Journal of medicinal chemistry.

On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex.

Y. Pommier, Smitha Antony, M. Cushman, 2005, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors.

Y. Pommier, Smitha Antony, G. Kohlhagen, 2004, Bioorganic & medicinal chemistry.

4-nitroquinoline-1-oxide induces the formation of cellular topoisomerase I-DNA cleavage complexes.

K. Kohn, Y. Pommier, Z. Miao, 2006, Cancer research.

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.

Iwona E. Weidlich, Y. Pommier, L. Gediya, 2009, Journal of medicinal chemistry.

A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.

Y. Pommier, W. Gmeiner, O. Sordet, 2005, Cancer research.

Repair of and checkpoint response to topoisomerase I-mediated DNA damage.

K. Kohn, Y. Pommier, C. Redon, 2003, Mutation research.

Decoding NADPH oxidase 4 expression in human tumors

A. Shah, J. Doroshow, H. Makhlouf, 2017, Redox biology.

Inhibiting the Activity of NADPH Oxidase in Cancer.

J. Doroshow, Smitha Antony, Mariam M. Konaté, 2020, Antioxidants & redox signaling.

Topoisomerase I-DNA Complexes Contribute to Arsenic Trioxide-induced Apoptosis*

Y. Pommier, O. Sordet, Smitha Antony, 2004, Journal of Biological Chemistry.

Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures.

Y. Pommier, Smitha Antony, P. Arimondo, 2004, Nucleic acids research.

Von Hippel-Lindau–Coupled and Transcription-Coupled Nucleotide Excision Repair–Dependent Degradation of RNA Polymerase II in Response to Trabectedin

Y. Pommier, V. Bohr, O. Sordet, 2008, Clinical Cancer Research.

ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins

Yves Pommier, Y. Pommier, S. Bates, 2004, Journal of Pharmacology and Experimental Therapeutics.

Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.

K. Kohn, Y. Pommier, Smitha Antony, 2003, Cancer research.

Molecular mechanisms underlying chronic inflammation-associated cancers.

James H Doroshow, J. Doroshow, Smitha Antony, 2014, Cancer letters.

NADPH oxidase 1 is highly expressed in human large and small bowel cancers

Han Liu, J. Doroshow, R. Chuaqui, 2020, PloS one.

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.

Yves Pommier, Y. Pommier, Smitha Antony, 2008, Anti-cancer agents in medicinal chemistry.

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

Yves Pommier, Andrew G. Stephen, Y. Pommier, 2007, Nucleic acids research.

Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.

Y. Pommier, A. Ioanoviciu, M. Hollingshead, 2006, Bioorganic & medicinal chemistry letters.

Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines.

Y. Pommier, Z. Miao, Smitha Antony, 2005, Bioorganic & medicinal chemistry letters.

Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel.

J. Doroshow, S. Holbeck, Smitha Antony, 2012, Biochemical pharmacology.

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA‐PK

Yves Pommier, Benu Brata Das, Shalu Gupta, 2009, The EMBO journal.

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals*

Y. Pommier, E. Solary, Q. Khan, 2004, Journal of Biological Chemistry.

Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.

Y. Pommier, Smitha Antony, K. Agama, 2011, Journal of medicinal chemistry.

Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine.

Y. Pommier, M. Redinbo, P. J. Brooks, 2004, Nucleic acids research.

Activity against Camptothecin-Resistant Topoisomerases I 706744 ) and Camptothecin : Base Sequence Analysis and Complexes by the Indenoisoquinoline MJ-III-65 ( NSC Differential Induction of Topoisomerase IDNA Cleavage Updated

K. Kohn, Y. Pommier, Smitha Antony, 2003 .

Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin.

Y. Pommier, Smitha Antony, B. D. Anderson, 2006, Bioorganic & medicinal chemistry.

Exogenous DNA enhances DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway.

J. Doroshow, Smitha Antony, K. Roy, 2023, Free radical biology & medicine.

Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-γ (IFN-γ)-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines*

J. Doroshow, Smitha Antony, K. Roy, 2011, The Journal of Biological Chemistry.

Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.

Y. Pommier, Smitha Antony, G. Kohlhagen, 2004, Bioorganic & medicinal chemistry letters.

Total synthesis of luotonin and a small library of AB-ring substituted analogues by cascade radical annulation of isonitriles

Y. Pommier, Smitha Antony, D. Curran, 2005 .

IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells

Han Liu, J. Doroshow, R. Chuaqui, 2019, The Journal of Immunology.

Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues.

J. Doroshow, R. Parchment, S. Kummar, 2014, Analytical Biochemistry.

Activation of TLR4 Is Required for the Synergistic Induction of Dual Oxidase 2 and Dual Oxidase A2 by IFN-γ and Lipopolysaccharide in Human Pancreatic Cancer Cell Lines

Han Liu, J. Doroshow, M. Hollingshead, 2013, The Journal of Immunology.

Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.

Marc C Nicklaus, Yves Pommier, Y. Pommier, 2010, Bioorganic & medicinal chemistry.

Virtual screening using ligand-based pharmacophores for inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1).

Y. Pommier, Smitha Antony, M. Nicklaus, 2010, Bioorganic & medicinal chemistry.

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase ( Tdp 1 ) inhibitors and characterization of furamidine ( NSC 305831 ) as an inhibitor of Tdp 1

Y. Pommier, A. Stephen, R. Fisher, 2007 .

Cancer Cell Lines Lipopolysaccharide in Human Pancreatic and γ Dual Oxidase A 2 by IFN-Synergistic Induction of Dual Oxidase 2 and Activation of TLR 4 Is Required for the Roy and

Han Liu, J. Doroshow, M. Hollingshead, 2013 .

Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues.

J. Doroshow, R. Parchment, S. Kummar, 2014, Analytical biochemistry.

NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1α and p27

Han Liu, J. Doroshow, H. Makhlouf, 2020 .

Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody.

Han Liu, J. Doroshow, S. Hewitt, 2013, Free radical biology & medicine.

Cancer Cell Lines Lipopolysaccharide in Human Pancreatic and γ Dual Oxidase A 2 by IFN-Synergistic Induction of Dual Oxidase 2 and Activation of TLR 4 Is Required for the Roy and

Han Liu, J. Doroshow, M. Hollingshead, 2013 .

Activation of TLR4 Is Required for the Synergistic Induction of Dual Oxidase 2 and Dual Oxidase A2 by IFN-g and Lipopolysaccharide in Human Pancreatic Cancer Cell Lines

Han Liu, J. Doroshow, M. Hollingshead, 2013 .