Katherine C. Chang

发表

Akt Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis1

Ursula Bommhardt, Paul E. Swanson, R. Hotchkiss, 2004, The Journal of Immunology.

Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy

Kathryn Trinkaus, Hiroyuki Kashiwagi, Robert H Mach, 2007, Molecular Cancer.

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

R. Hotchkiss, R. Mach, Katherine C. Chang, 2011, Nature communications.

Septic Mice with Cancer Increases Mortality Prevention of Lymphocyte Apoptosis in

W. Dunne, Katherine C. Chang, D. Linehan, 2011 .

Prevention of Lymphocyte Apoptosis in Septic Mice with Cancer Increases Mortality

C. Coopersmith, W. Dunne, Katherine C. Chang, 2011, The Journal of Immunology.

TARGETED DELIVERY OF siRNA TO CELL DEATH PROTEINS IN SEPSIS

C. Coopersmith, R. Hotchkiss, W. Schierding, 2009, Shock.

MODULATION OF THE BCL-2 FAMILY BLOCKS SEPSIS-INDUCED DEPLETION OF DENDRITIC CELLS AND MACROPHAGES

R. Hotchkiss, J. McDunn, H. Perlman, 2009, Shock.

Follicular Dendritic Cells Depletion of Splenic Interdigitating and Sepsis Induces Apoptosis and Profound

R. Hotchkiss, Katherine C. Chang, P. Swanson, 2003 .

Improves Survival in Sepsis Akt Decreases Lymphocyte Apoptosis and

R. Hotchkiss, U. Bommhardt, Katherine C. Chang, 2004 .

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis

R. Hotchkiss, Katherine C. Chang, K. Tinsley, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis.

R. Hotchkiss, Katherine C. Chang, K. Tinsley, 2003, Proceedings of the National Academy of Sciences of the United States of America.

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

C. Coopersmith, R. Hotchkiss, J. McDunn, 2009, The Journal of Immunology.

Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis

R. Hotchkiss, S. Krishnan, J. Suzich, 2014, Critical Care.

Delayed administration of anti‐PD‐1 antibody reverses immune dysfunction and improves survival during sepsis

R. Hotchkiss, J. McDunn, Katherine C. Chang, 2010, Journal of leukocyte biology.

Dose-Dependent Effect of Anti-CTLA-4 on Survival in Sepsis

R. Hotchkiss, Katherine C. Chang, S. Inoue, 2011, Shock.

Improves Survival in Sepsis and Adaptive Immune Dysfunction, and IL-15 Prevents Apoptosis, Reverses Innate

C. Coopersmith, R. Hotchkiss, J. McDunn, 2009 .

The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation

Katherine C. Chang, K. Luehrsen, Bradford A. Youngblood, 2022, Frontiers in Immunology.

p53-Dependent and -Independent Pathways of Apoptotic Cell Death in Sepsis1

R. Hotchkiss, Katherine C. Chang, P. Swanson, 2000, The Journal of Immunology.

p53-Dependent and -Independent Pathways

R. Hotchkiss, Katherine C. Chang, P. Swanson, 2000 .

Apoptotic Cell Death in Sepsis p 53-Dependent and-Independent Pathways

R. Hotchkiss, Katherine C. Chang, P. Swanson, 2000 .

p 53-Dependent and-Independent Pathways of Apoptotic Cell Death in Sepsis 1

R. Hotchkiss, Katherine C. Chang, P. Swanson, 2000 .

Sepsis Induces Apoptosis and Profound Depletion of Splenic Interdigitating and Follicular Dendritic Cells1

R. Hotchkiss, Katherine C. Chang, P. Swanson, 2003, The Journal of Immunology.

CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis

C. Coopersmith, R. Hotchkiss, Katherine C. Chang, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Accelerated Lymphocyte Death in Sepsis Occurs by both the Death Receptor and Mitochondrial Pathways1

C. Coopersmith, R. Hotchkiss, Katherine C. Chang, 2005, The Journal of Immunology.

Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis*

C. Coopersmith, R. Hotchkiss, W. Dunne, 2010, Critical care medicine.

in Decreases Apoptosis and Improves Survival Overexpression of Bcl-2 in Transgenic Mice

S. Korsmeyer, R. Hotchkiss, J. Cobb, 1999 .

Targeting AKT with the proapoptotic peptide, TAT‐CTMP: A novel strategy for the treatment of human pancreatic adenocarcinoma

R. Hotchkiss, J. McDunn, Katherine C. Chang, 2009, International journal of cancer.

Surviving sepsis : bcl-2 overexpression modulates splenocyte transcriptional responses in vivo

J Perren Cobb, R. Hotchkiss, J. Cobb, 2007 .

BIM siRNA DECREASES LYMPHOCYTE APOPTOSIS AND IMPROVES SURVIVAL IN SEPSIS

R. Hotchkiss, J. McDunn, Katherine C. Chang, 2008, Shock.

Multiple triggers of cell death in sepsis: death receptor and mitochondrial‐mediated apoptosis

R. Hotchkiss, A. Strasser, Katherine C. Chang, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

TAT-BH4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo1

C. Coopersmith, R. Hotchkiss, J. Cobb, 2006, The Journal of Immunology.

TAT-BH 4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo 1

C. Coopersmith, R. Hotchkiss, J. Cobb, 2006 .

Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice

C. Coopersmith, R. Hotchkiss, Katherine C. Chang, 2002, Critical care medicine.

Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans1

R. Hotchkiss, J. Cobb, Katherine C. Chang, 2001, The Journal of Immunology.

Peptide‐mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis

R. Hotchkiss, L. Rachdi, W. Dunne, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Lymphocyte phenotyping to distinguish septic from nonseptic critical illness.

C. Coopersmith, R. Hotchkiss, Katherine C. Chang, 2008, Journal of the American College of Surgeons.

BOTH GRAM-NEGATIVE AND GRAM-POSITIVE EXPERIMENTAL PNEUMONIA INDUCE PROFOUND LYMPHOCYTE BUT NOT RESPIRATORY EPITHELIAL CELL APOPTOSIS

R. Hotchkiss, K. Reinhart, W. Dunne, 2006, Shock.

Blockade ofthe negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis

R. Hotchkiss, A. Korman, C. Burnham, 2013, Critical Care.

Deletion of MyD88 markedly attenuates sepsis‐induced T and B lymphocyte apoptosis but worsens survival

R. Hotchkiss, J. McDunn, Katherine C. Chang, 2008, Journal of leukocyte biology.

Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.

R. Hotchkiss, R. Mach, Katherine C. Chang, 2012, Cancer research.

Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

R. Hotchkiss, R. Mach, J. McDunn, 2009, Journal of Translational Medicine.

Anti-PD-L1 peptide improves survival in sepsis.

R. Hotchkiss, M. Ramachandra, Katherine C. Chang, 2017, The Journal of surgical research.

Anti-Programed Cell Death Ligand 1 Peptide Improves Survival in Sepsis

R. Hotchkiss, M. Ramachandra, Katherine C. Chang, 2016 .

Characterization and Evaluation of Two Novel Fluorescent Sigma-2 Receptor Ligands as Proliferation Probes

R. Hotchkiss, R. Mach, M. Goldberg, 2011, Molecular imaging.

Frontline Science: Defects in immune function in patients with sepsis are associated with PD‐1 or PD‐L1 expression and can be restored by antibodies targeting PD‐1 or PD‐L1

R. Hotchkiss, Katherine C. Chang, D. Osborne, 2016, Journal of leukocyte biology.

TAT-Bim Induces Extensive Apoptosis in Cancer Cells

R. Hotchkiss, K. Trinkaus, D. Piwnica-Worms, 2007, Annals of Surgical Oncology.

T cells from patients with Candida sepsis display a suppressive immunophenotype

R. Hotchkiss, C. Burnham, Katherine C. Chang, 2015, Critical Care.

Prevention of lymphocyte cell death in sepsis improves survival in mice.

S. Korsmeyer, R. Hotchkiss, J. Cobb, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Sigma-2 ligands induce tumour cell death by multiple signalling pathways

R. Hotchkiss, R. Mach, Katherine C. Chang, 2012, British Journal of Cancer.

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis.

S. Korsmeyer, R. Hotchkiss, J. Cobb, 1999, Journal of immunology.

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

R. Hotchkiss, R. Mach, Katherine C. Chang, 2011, Nature communications.

An anti-apoptotic peptide improves survival in lethal total body irradiation.

P. Grigsby, R. Hotchkiss, J. McDunn, 2009, Biochemical and biophysical research communications.

Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.

R. Hotchkiss, R. Mach, J. McDunn, 2012, Cancer research.

Molecular Cancer Selective Sigma-2 Ligands Preferentially Bind to Pancreatic Adenocarcinomas: Applications in Diagnostic Imaging and Therapy

R. Hotchkiss, R. Mach, K. Trinkaus, 2022 .