Z. Fan

发表

The epidermal growth factor receptor mediates radioresistance.

K Kian Ang, Zhen Fan, K. Ang, 2003, International journal of radiation oncology, biology, physics.

Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells

K. Liang, Z. Fan, W. Jin, 2003, British Journal of Cancer.

Targeting the Phosphatidylinositol 3-Kinase / Akt Pathway for Enhancing Breast Cancer Cells to Radiotherapy 1

Gordon B Mills, Zhen Fan, G. Mills, 2003 .

Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody

J. Mendelsohn, Z. Fan, Bolin Liu, 2001, Oncogene.

Protection against chemotherapy-induced cytotoxicity by cyclin-dependent kinase inhibitors (CKI) in CKI-responsive cells compared with CKI-unresponsive cells

Z. Fan, Mathias Schmidt, 2001, Oncogene.

Brk/PTK6 Sustains Activated EGFR Signaling through Inhibiting EGFR Degradation and Transactivating EGFR

G. Mills, M. Hung, J. Hsu, 2011, Oncogene.

Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer.

Shi Ke, Sunkuk Kwon, Eva M Sevick-Muraca, 2007, Journal of biomedical optics.

Targeting Doxorubicin to Epidermal Growth Factor Receptors by Site-Specific Conjugation of C225 to Poly(L-Glutamic Acid) Through a Polyethylene Glycol Spacer

Chun Xing Li, S. Wallace, Z. Fan, 2003, Pharmaceutical Research.

Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.

G. Mills, J. Mendelsohn, Z. Siddik, 2007, Cancer research.

Differential Roles of Phosphoinositide-Dependent Protein Kinase-1 and Akt1 Expression and Phosphorylation in Breast Cancer Cell Resistance to Paclitaxel, Doxorubicin, and Gemcitabine

G. Mills, R. Glazer, K. Liang, 2006, Molecular Pharmacology.

Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin.

N. Rosen, J. Mendelsohn, Z. Fan, 1995, The Journal of clinical investigation.

Responses of human colorectal tumor cells to treatment with the anti-epidermal growth factor receptor monoclonal antibody ICR62 used alone and in combination with the EGFR tyrosine kinase inhibitor gefitinib.

H. Modjtahedi, Z. Fan, H. Thomas, 2006, Cancer research.

ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.

Z. Fan, Yang Lu, Haiquan Lu, 2016, Cancer letters.

Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies.

J. Mendelsohn, Z. Fan, H. Masui, 1993, Cancer research.

Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition

A. Deblasio, J. Mendelsohn, Z. Fan, 1995, The Journal of cell biology.

The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway

Z. Fan, Bolin Liu, 2001, Oncogene.

Dual functions of autophagy in the response of breast tumor cells to radiation

D. Gewirtz, Xu Di, Z. Fan, 2012, Autophagy.

Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition

K. Liang, Z. Fan, Yang Lu, 2013, Cancer biology & therapy.

Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers

H. Modjtahedi, Z. Fan, A. Seddon, 2015, British Journal of Cancer.

Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells

Yiling Lu, K. Liang, Z. Fan, 2006, Oncogene.

Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-κb signaling pathway with the anti-epidermal growth factor antibody IMC-C225

Douglas B. Evans, P. Chiao, Z. Fan, 2003, Journal of Gastrointestinal Surgery.

Autophosphorylation of Akt at Threonine 72 and Serine 246

G. Mills, K. Liang, Z. Fan, 2006, Journal of Biological Chemistry.

Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs.

Z. Fan, Zhixia Qiu, Xijing Chen, 2013, Journal of pharmaceutical sciences.

Redirecting host preexisting influenza A virus immunity for cancer immunotherapy

Z. Fan, Yang Lu, B. Ozpolat, 2021, Cancer Immunology, Immunotherapy.

Requirement of hypoxia-inducible factor-1α down-regulation in mediating the antitumor activity of the anti–epidermal growth factor receptor monoclonal antibody cetuximab

J. Mendelsohn, K. Liang, Z. Fan, 2008, Molecular Cancer Therapeutics.

Autocrine/paracrine erythropoietin regulates migration and invasion potential and the stemness of human breast cancer cells

K. Liang, Z. Fan, Yang Lu, 2014, Cancer biology & therapy.

The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex.

Z. Fan, Xinqun Li, 2010, Cancer research.

Differential roles of p21(Waf1) and p27(Kip1) in modulating chemosensitivity and their possible application in drug discovery studies.

G. Lozano, J. Parant, T. Beckers, 2001, Molecular pharmacology.

Prolonged Induction of p21CiplmAFI/CDK2/PCNA Complex by Epidermal Growth Factor Receptor Activation Mediates Ligand-induced A431 Cell Growth Inhibition

A. Deblasio, J. Mendelsohn, Z. Fan, 2002 .

Regulation of epidermal growth factor receptor in NIH3T3/HER14 cells by antireceptor monoclonal antibodies.

R. Kumar, J. Mendelsohn, Z. Fan, 1993, The Journal of biological chemistry.

Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells

K. Liang, Z. Fan, Bolin Liu, 2005, Breast Cancer Research.

A Novel Single Amino Acid Deletion Caspase-8 Mutant in Cancer Cells That Lost Proapoptotic Activity*

Z. Fan, W. Jin, Bolin Liu, 2002, The Journal of Biological Chemistry.

Reciprocal changes in p27(Kip1) and p21(Cip1) in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors.

J. Chou, J. Mendelsohn, Z. Fan, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells.

H. Modjtahedi, Z. Fan, H. Thomas, 2008, International journal of oncology.

Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line.

Wei Guo, B. Fang, Z. Fan, 2005, Neoplasia.

C225 antiepidermal growth factor receptor antibody enhances the efficacy of docetaxel chemoradiotherapy.

K. Ang, L. Milas, N. Hunter, 2003, International journal of radiation oncology, biology, physics.

HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain.

Z. Fan, Yang Lu, Midan Ai, 2013, Cellular signalling.

Differential Roles of PDK1 and Akt1 Expression and Phosphorylation in Breast Cancer Cell Resistance to Paclitaxel, Doxorubicin, and Gemcitabine Molecular

G. Mills, R. Glazer, K. Liang, 2006 .

Therapeutic application of anti‐growth factor receptor antibodies

J. Mendelsohn, Z. Fan, 1998, Current opinion in oncology.

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells

G. Mills, J. Mendelsohn, K. Liang, 2003, Oncogene.

Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts.

J. Baselga, J. Mendelsohn, Z. Fan, 1993, Cancer research.

Reciprocal Changes in 27 Kq and p 2 lC in Growth Inhibition Mediated by Blockade or Overstimulation of Epidermal Growth Factor Receptors 1

J. Chou, J. Mendelsohn, Z. Fan, 2005 .

EGF Receptor Inhibition by Antibody as Anticancer Therapy

J. Chou, J. Baselga, J. Mendelsohn, 1997 .

AND EGF RECEPTOR BLOCKADE

J. Baselga, J. Mendelsohn, Z. Fan, 1996 .

Combination Therapy with Cisplatinum and EGF Receptor Blockade

J. Baselga, J. Mendelsohn, Z. Fan, 1996 .

ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine‐addicted OSCC cells

Z. Fan, B. Cheng, Qinchao Hu, 2020, Cancer medicine.

Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145.

H. Scher, J. Mendelsohn, Z. Fan, 1996, Cancer research.

Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion.

G. Calin, C. Ivan, L. Weiner, 2018, Cancer letters.

Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.

G. Tortora, F. Ciardiello, R. Bianco, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.

G. Mills, G. Hortobagyi, M. Hung, 2010, Cancer cell.

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson's Disease

J. Jankovic, Z. Fan, W. Le, 2011, Neurosignals.

Constitutive overexpression of cyclin D1 in human breast epithelial cells does not prevent G1 arrest induced by deprivation of epidermal growth factor

J. Chou, N. Rosen, J. Mendelsohn, 1999, Breast Cancer Research and Treatment.

Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c- jun N-terminal kinase activity

J. Mendelsohn, Z. Fan, B. Liu, 2000, British Journal of Cancer.

A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells.

J. Xu, Z. Fan, Yang Lu, 2013, Cancer letters.

Tumor-suppressor activity of RRIG1 in breast cancer

P. Brown, Z. Fan, Xìao-chun Xu, 2011, BMC Cancer.

Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients.

J. Gu, Xifeng Wu, C. Dinney, 2010, Carcinogenesis.

Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells

G. Mills, Z. Fan, B. Liu, 2001, British Journal of Cancer.

The Effect of miR-361-3p Targeting TRAF6 on Apoptosis of Multiple Myeloma Cells

Z. Fan, Zhiwei Wu, Bo Yang, 2020, Journal of microbiology and biotechnology.

From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway

Wadih Arap, Renata Pasqualini, Richard L. Sidman, 2010, Proceedings of the National Academy of Sciences.

AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis.

J. Qin, Yi Wang, Z. Fan, 2017, Cancer letters.

Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.

K. Liang, Z. Fan, Yang Lu, 2011, Cancer letters.

Roles of autophagy in cetuximab-mediated cancer therapy against EGFR

Z. Fan, Yang Lu, T. Pan, 2010, Autophagy.

Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells.

J. Mendelsohn, Z. Fan, Y. Lu, 1994, The Journal of biological chemistry.

Differential modulation of paclitaxel-mediated apoptosis by p21Waf1 and p27Kip1

J. Mendelsohn, Z. Fan, Mathias Schmidt, 2000, Oncogene.

Augmentation of a humanized Anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225

J. Mendelsohn, Z. Fan, D. Ye, 1999, Oncogene.

Emodin inhibits zinc-induced neurotoxicity in neuroblastoma SH-SY5Y cells

F. Gao, Z. Fan, Wenzhou Liu, 2019, Bioscience reports.

Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1α

K. Liang, Z. Fan, Yang Lu, 2007, Molecular Cancer.

Role of Epidermal Growth Factor Receptor and Its Inhibition in Radiotherapy

K. Ang, L. Milas, K. Mason, 2003 .

In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody.

K. Ang, J. Mendelsohn, L. Milas, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Epidermal growth factor receptor family and chemosensitization.

J. Mendelsohn, Z. Fan, 1997, Journal of the National Cancer Institute.

Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism.

Z. Fan, Yang Lu, Songbo Qiu, 2016, Cancer letters.

Breast Cancer Therapy Using Monoclonal Antibodies Against Epidermal Growth Factor Receptor and HER-2

J. Mendelsohn, Z. Fan, 1999 .

Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice.

C. Dinney, D. Hicklin, T. Shuin, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production.

C. Dinney, D. Hicklin, B. Mian, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Anti-Vascular Endothelial Growth Factor Receptor 2 Antibody Reduces Tumorigenicity and Metastasis in Orthotopic Prostate Cancer Xenografts via Induction of Endothelial Cell Apoptosis and Reduction of Endothelial Cell Matrix Metalloproteinase Type 9 Production 1

C. Dinney, D. Hicklin, B. Mian, 2002 .

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

J. Mendelsohn, Z. Fan, Yang Lu, 2005, Oncogene.

Functional cooperation between HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR.

Z. Fan, Yang Lu, S. Meng, 2018, Lung cancer.

Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody.

M. Rubin, J. Mendelsohn, Z. Fan, 1996, Oncogene.

Epidermal growth factor receptor as a target to improve treatment of lung cancer.

K. Ang, R. Komaki, Z. Liao, 2004, Clinical lung cancer.

Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion

Z. Fan, Yang Lu, Dean Anthony Lee, 2016, Oncoimmunology.

Sensitization of breast cancer cells to radiation by trastuzumab.

K. Ang, L. Milas, K. Liang, 2003, Molecular cancer therapeutics.

Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma.

Z. Fan, Yang Lu, Haiquan Lu, 2019, JCI insight.

An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis

Z. Fan, Z. Chang, M. Ding, 2015, Oncogene.

Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.

Z. Fan, Yang Lu, Qiang Li, 2017, Cancer letters.

Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell

Z. Fan, Jun Hu, K. Sai, 2023, Cell Death & Disease.

Overexpression of retinoblastoma-binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3-kinase/protein kinase B pathway suppression

Lujun Yang, Z. Fan, X. Jin, 2018, Molecular medicine reports.

C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability.

K. Ang, L. Milas, Z. Fan, 2001, International journal of radiation oncology, biology, physics.

The anti-EGFR antibody cetuximab sensitizes human head and neck squamous cell carcinoma cells to radiation in part through inhibiting radiation-induced upregulation of HIF-1α.

K. Liang, Z. Fan, Yang Lu, 2012, Cancer letters.

Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells

Z. Fan, Yang Lu, Songbo Qiu, 2016, Oncotarget.

Cetuximab Reverses the Warburg Effect by Inhibiting HIF-1–Regulated LDH-A

Z. Fan, Haiquan Lu, Zhongguang Luo, 2013, Molecular Cancer Therapeutics.

Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies.

K. Ang, L. Milas, Z. Fan, 2004, International journal of radiation oncology, biology, physics.

Antitumor effect of an HER2‐specific antibody–toxin fusion protein on human prostate cancer cells

W. Wels, Z. Fan, B. Liu, 2001, The Prostate.

AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab

Yang Lu, Z. Fan, Yang Lu, 2015, Oncotarget.

Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145.

H. Scher, J. Mendelsohn, Z. Fan, 1996, Cancer research.

Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer.

Wei Guo, Z. Fan, H. F. Epstein, 2011, Journal of molecular biology.

Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells.

J. Mendelsohn, Z. Fan, D. Ye, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.

K. Liang, Z. Fan, Bolin Liu, 2005, Breast cancer research : BCR.