M. Anai

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Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.

T. Asano, H. Katagiri, Y. Oka, 2003, Diabetes.

Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.

Y. Uchijima, N. Horike, T. Asano, 2008, American journal of physiology. Endocrinology and metabolism.

Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.

T. Asano, M. Funaki, H. Katagiri, 2000, Diabetes.

Multiple isoforms of the regulatory subunit for phosphatidylinositol 3-kinase (PI3-kinase) are expressed in neurons in the rat brain.

T. Asano, M. Anai, K. Inukai, 1998, Biochemical and biophysical research communications.

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.

T. Kodama, K. Ikeda, M. Anai, 2015, Journal of atherosclerosis and thrombosis.

Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.

T. Asano, M. Funaki, H. Katagiri, 2001, Molecular endocrinology.

A Novel Isoform of Syntaxin-binding Protein Homologous to Yeast Sec1 Expressed Ubiquitously in Mammalian Cells (*)

J. Miyazaki, Y. Yazaki, J. Terasaki, 1995, The Journal of Biological Chemistry.

Mitochondrial diabetes mellitus: Prevalence and clinical characterization of diabetes due to mitochondrial tRNALeU(UUR) gene mutation in Japanese patients

Y. Yazaki, H. Katagiri, Y. Oka, 1994, Diabetologia.

The role of N‐glycosylation in the targeting and stability of GLUT1 glucose transporter

Y. Yazaki, T. Asano, H. Katagiri, 1993, FEBS letters.

Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats.

T. Asano, M. Anai, M. Kikuchi, 2000, American journal of physiology. Endocrinology and metabolism.

Rationale and Design of the STOP-OB Study for Evaluating the Effects of Tofogliflozin and Glimepiride on Fat Deposition in Type 2 Diabetes Patients Treated with Metformin/DPP-4 Inhibitor Dual Therapy

M. Anai, M. Fujishiro, H. Ishihara, 2018, Diabetes Therapy.

Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes.

Y. Gotoh, T. Asano, H. Katagiri, 2003, Molecular endocrinology.

Salt-Sensitive Rats High-Salt Diet Enhances Insulin Signaling and Induces Insulin Resistance in Dahl

T. Asano, Hiraku Ono, H. Sakoda, 2002 .

High-Salt Diet Enhances Insulin Signaling and Induces Insulin Resistance in Dahl Salt-Sensitive Rats

T. Asano, Hiraku Ono, H. Sakoda, 2002, Hypertension.

Protein Levels and Tyrosine Phosphorylation of the Insulin Receptor ( IR ) and IRSs

H. Aburatani, I. Komuro, T. Asano, 2002 .

Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling

H. Aburatani, I. Komuro, T. Asano, 2002, Hypertension.

Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.

T. Asano, Hiraku Ono, H. Sakoda, 2001, Diabetes.

Antidiabetic effect of T-1095, an inhibitor of Na(+)-glucose cotransporter, in neonatally streptozotocin-treated rats.

T. Asano, M. Anai, M. Nawano, 2000, European journal of pharmacology.

Glucose transporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugs.

Y. Uchijima, T. Asano, H. Kurihara, 2004, Current medicinal chemistry.

T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.

T. Asano, Y. Kanai, M. Anai, 1999, Diabetes.

Serum concentrations of resistin-like molecules β and γ are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow

Y. Uchijima, N. Horike, T. Asano, 2005, Diabetologia.

MKK6/3 and p38 MAPK Pathway Activation Is Not Necessary for Insulin-induced Glucose Uptake but Regulates Glucose Transporter Expression*

Y. Gotoh, T. Asano, M. Funaki, 2001, The Journal of Biological Chemistry.

Fasting tests of insulin secretion and sensitivity predict future prediabetes in Japanese with normal glucose tolerance

E. Boyko, W. Fujimoto, M. Anai, 2010, Journal of diabetes investigation.

Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area

H. Okuno, T. Manabe, H. Bito, 2022, Molecular Psychiatry.

Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

H. Aburatani, I. Komuro, Y. Gotoh, 2004, Diabetologia.

Different Subcellular Distribution and Regulation of Expression of Insulin Receptor Substrate (IRS)-3 from Those of IRS-1 and IRS-2*

Y. Yazaki, T. Asano, M. Funaki, 1998, The Journal of Biological Chemistry.

Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate

T. Kodama, M. Anai, J. Sakai, 2019, International journal of molecular sciences.

Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.

Y. Uchijima, T. Asano, H. Kurihara, 2006, Diabetes research and clinical practice.

Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus

J. Miyazaki, Y. Yazaki, T. Asano, 1992, The Lancet.

Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation.

T. Asano, H. Katagiri, Y. Oka, 2003, Biochemical and biophysical research communications.

Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets

J. Miyazaki, Y. Yazaki, T. Asano, 1993, Diabetologia.

Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.

Y. Yazaki, T. Asano, M. Funaki, 1999, Diabetes.

glucose uptake by skeletal muscle but not adipocytes Activation of AMPK is essential for AICAR-induced

T. Asano, H. Katagiri, Y. Oka, 2016 .

Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes.

T. Asano, H. Katagiri, Y. Oka, 2002, American journal of physiology. Endocrinology and metabolism.

Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat.

Y. Yazaki, T. Asano, M. Funaki, 1999, Metabolism: clinical and experimental.

Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle.

T. Asano, M. Funaki, Y. Oka, 2001, American journal of physiology. Endocrinology and metabolism.

p85/p110-type Phosphatidylinositol Kinase Phosphorylates Not Only the D-3, but Also the D-4 Position of the Inositol Ring*

Y. Yazaki, T. Asano, M. Funaki, 1999, The Journal of Biological Chemistry.

Hyperglycemia impairs the insulin signaling step between PI 3-kinase and Akt/PKB activations in ZDF rat liver.

T. Asano, M. Funaki, Y. Oka, 1999, Biochemical and biophysical research communications.

Cloning and increased expression with fructose feeding of rat jejunal GLUT5.

Y. Yazaki, T. Asano, H. Katagiri, 1993, Endocrinology.

A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85 Gene (*)

Y. Yazaki, T. Asano, M. Funaki, 1996, The Journal of Biological Chemistry.

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.

Y. Yazaki, T. Asano, M. Funaki, 1997, The Journal of biological chemistry.

Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.

T. Matsui, T. Asano, H. Kurihara, 2004, European journal of pharmacology.

Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice.

T. Asano, Y. Kurihara, H. Kurihara, 2003, European journal of pharmacology.

Extremely Early Onset of Ranitidine Action on Human Histamine H2 Receptors Expressed in HEK293 Cells

T. Asano, M. Omata, H. Katagiri, 2004, Digestion.

Role of the C Terminus in Histamine H2 Receptor Signaling, Desensitization, and Agonist-induced Internalization*

Y. Yazaki, T. Asano, M. Funaki, 1997, The Journal of Biological Chemistry.

Effects of N-alpha-methyl-histamine on human H2 receptors expressed in CHO cells

T. Kajiwara, M. Omata, M. Anai, 2002, Gut.

Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells.

Y. Yazaki, T. Asano, M. Funaki, 1996, The Biochemical journal.

G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure

T. Asano, M. Omata, M. Funaki, 2001, The Pharmacogenomics Journal.

Localization of the Histamine H2 Receptor, a Target for Antiulcer Drugs, in Gastric Parietal Cells

Y. Yazaki, T. Asano, M. Funaki, 1999, Digestion.

Potent and Long-Lasting Action of Lafutidine on the Human Histamine H2 Receptor

T. Kajiwara, M. Omata, M. Anai, 2001, Digestion.

Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein.

M. Shibuya, T. Asano, M. Funaki, 2001, Biochemical and biophysical research communications.

Five isoforms of the phosphatidylinositol 3‐kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations

T. Asano, M. Funaki, H. Katagiri, 2001, FEBS letters.

Human GLUT-2 overexpression does not affect glucose-stimulated insulin secretion in MIN6 cells.

J. Miyazaki, Y. Yazaki, T. Asano, 1995, The American journal of physiology.

Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic beta-cell line MIN6.

J. Miyazaki, Y. Yazaki, T. Asano, 1994, The Journal of biological chemistry.

A Novel Protein Kinase B (PKB)/AKT-binding Protein Enhances PKB Kinase Activity and Regulates DNA Synthesis*

Y. Uchijima, N. Horike, T. Asano, 2005, Journal of Biological Chemistry.

Comparison of tofogliflozin versus glimepiride as the third oral agent added to metformin plus a dipeptidyl peptidase‐4 inhibitor in Japanese patients with type 2 diabetes: A randomized, 24‐week, open‐label, controlled trial (STOP‐OB)

M. Anai, M. Fujishiro, H. Ishihara, 2020, Diabetes, obesity & metabolism.

Clinical relevance of heteroplasmic concentration of mitochondrial A 3243 G mutation in leucocytes

T. Asano, M. Funaki, H. Katagiri, 1999, Diabetologia.

[A case of nonarteritic anterior ischemic optic neuropathy with hypertension, diabetes mellitus, hyperlipidemia and severe stenosis of the internal carotid artery].

M. Anai, S. Hori, Y. Okada, 2008, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.

Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.

H. Aburatani, I. Komuro, Y. Gotoh, 2004, Diabetologia.

Oligomer formation of histamine H2 receptors expressed in Sf9 and COS7 cells 1

T. Asano, M. Funaki, H. Katagiri, 1997, FEBS letters.

Resistin-like Molecule β Activates MAPKs, Suppresses Insulin Signaling in Hepatocytes, and Induces Diabetes, Hyperlipidemia, and Fatty Liver in Transgenic Mice on a High Fat Diet*

Y. Uchijima, N. Horike, Koichi Nishiyama, 2005, Journal of Biological Chemistry.

Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity.

Y. Uchijima, N. Horike, T. Asano, 2005, American journal of physiology. Endocrinology and metabolism.

of Rat GLUT5 and Functional Analysis of Chime& Proteins of GLUT1 Glucose Transporter and - GLUT5 Fructose Transporter

Y. Yazaki, T. Asano, H. Katagiri, 1995 .

Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2.

H. Aburatani, M. Nakao, S. Yachida, 2019, Cell reports.

14-3-3 Protein Binds to Insulin Receptor Substrate-1, One of the Binding Sites of Which Is in the Phosphotyrosine Binding Domain*

Y. Yazaki, T. Asano, M. Taoka, 1997, The Journal of Biological Chemistry.

Insulin Receptor Substrate (IRS)-2 Is Dephosphorylated More Rapidly than IRS-1 via Its Association with Phosphatidylinositol 3-Kinase in Skeletal Muscle Cells*

Y. Yazaki, T. Asano, M. Funaki, 1997, The Journal of Biological Chemistry.

Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet

Y. Yazaki, T. Asano, J. Terasaki, 1998, Diabetologia.

PPARβ/δ activation of CD300a controls intestinal immunity

H. Aburatani, J. Auwerx, T. Kodama, 2014, Scientific Reports.

p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin*

Y. Yazaki, T. Asano, M. Funaki, 1997, The Journal of Biological Chemistry.

Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence

H. Aburatani, K. Miyazono, A. Kaneda, 2011, PLoS genetics.

Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.

H. Aburatani, A. Kaneda, M. Anai, 2016, World journal of biological chemistry.

p110β Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity*

Y. Yazaki, C. Heldin, T. Asano, 2000, The Journal of Biological Chemistry.

Characterization of rat GLUT5 and functional analysis of chimeric proteins of GLUT1 glucose transporter and GLUT5 fructose transporter.

Y. Yazaki, T. Asano, H. Katagiri, 1995, Endocrinology.

Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules.

T. Asano, H. Katagiri, Y. Oka, 2002, Biochemical and biophysical research communications.

Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.

Y. Uchijima, N. Horike, T. Asano, 2005, Diabetologia.

Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth

H. Aburatani, T. Kodama, M. Anai, 2018, Oncotarget.

Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content

H. Aburatani, M. Anai, J. Fruchart, 2020, Scientific Reports.

Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study

Y. Iwamoto, M. Anai, M. Noda, 2021, Journal of diabetes investigation.

Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.

T. Asano, H. Katagiri, Y. Oka, 2002, Diabetes.

Nuclear location of the regulatory protein of glucokinase in rat liver and translocation of the regulator to the cytoplasm in response to high glucose.

M. Anai, I. Miwa, Y. Toyoda, 1995, Biochemical and biophysical research communications.

Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis

H. Aburatani, T. Kodama, M. Anai, 2022, Cells.

Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats

Y. Yazaki, T. Asano, J. Terasaki, 1998, Diabetes.

SGLT as a therapeutic target

Y. Uchijima, T. Asano, H. Kurihara, 2004 .

Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content

H. Aburatani, T. Kodama, M. Anai, 2020, Scientific Reports.

Regulation of gut-derived resistin-like molecule β expression by nutrients

Y. Uchijima, N. Horike, T. Asano, 2008 .

Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity*

Y. Gotoh, T. Asano, H. Katagiri, 2003, Journal of Biological Chemistry.

Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling.

T. Kodama, M. Anai, Y. Shibasaki, 2017, Biochemical and biophysical research communications.

The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin.

T. Asano, M. Funaki, H. Katagiri, 2000, The Biochemical journal.

Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.

Y. Uchijima, N. Horike, T. Asano, 2007, American journal of physiology. Cell physiology.

Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting.

T. Asano, M. Omata, M. Funaki, 2001, Biochimica et biophysica acta.

Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling.

T. Kodama, M. Anai, Y. Shibasaki, 2017, Biochemical and biophysical research communications.

No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes.

H Katagiri, Y. Yazaki, T. Asano, 1999, Diabetes.