Y. Fukushima

发表

Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.

T. Asano, H. Katagiri, Y. Oka, 2003, Diabetes.

Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.

Y. Uchijima, N. Horike, T. Asano, 2008, American journal of physiology. Endocrinology and metabolism.

Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif.

T. Kodama, T. Asano, H. Katagiri, 2002, Molecular endocrinology.

Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.

T. Asano, M. Funaki, H. Katagiri, 2000, Diabetes.

Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts.

Y. Yazaki, T. Kadowaki, Y. Fukushima, 1997, Endocrinology.

Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.

T. Asano, M. Funaki, H. Katagiri, 2001, Molecular endocrinology.

A Novel Isoform of Syntaxin-binding Protein Homologous to Yeast Sec1 Expressed Ubiquitously in Mammalian Cells (*)

J. Miyazaki, Y. Yazaki, J. Terasaki, 1995, The Journal of Biological Chemistry.

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling

H. Nishimatsu, Toru Suzuki, T. Kadowaki, 2002, Nature Medicine.

Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes.

Y. Gotoh, T. Asano, H. Katagiri, 2003, Molecular endocrinology.

High-Salt Diet Enhances Insulin Signaling and Induces Insulin Resistance in Dahl Salt-Sensitive Rats

T. Asano, Hiraku Ono, H. Sakoda, 2002, Hypertension.

Protein Levels and Tyrosine Phosphorylation of the Insulin Receptor ( IR ) and IRSs

H. Aburatani, I. Komuro, T. Asano, 2002 .

Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling

H. Aburatani, I. Komuro, T. Asano, 2002, Hypertension.

Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.

T. Asano, Hiraku Ono, H. Sakoda, 2001, Diabetes.

Outbreak of hepatitis C virus infection in an outpatient clinic

Y. Fukushima, R. Nagai, Tetsuro Suzuki, 2005, Journal of gastroenterology and hepatology.

Serum concentrations of resistin-like molecules β and γ are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow

Y. Uchijima, N. Horike, T. Asano, 2005, Diabetologia.

MKK6/3 and p38 MAPK Pathway Activation Is Not Necessary for Insulin-induced Glucose Uptake but Regulates Glucose Transporter Expression*

Y. Gotoh, T. Asano, M. Funaki, 2001, The Journal of Biological Chemistry.

Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis.

Y. Fukushima, Y. Liao, M. Kitakaze, 2014, Clinical science.

Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

H. Aburatani, I. Komuro, Y. Gotoh, 2004, Diabetologia.

Different Subcellular Distribution and Regulation of Expression of Insulin Receptor Substrate (IRS)-3 from Those of IRS-1 and IRS-2*

Y. Yazaki, T. Asano, M. Funaki, 1998, The Journal of Biological Chemistry.

Four mutant alleles of the insulin receptor gene associated with genetic syndromes of extreme insulin resistance.

Y. Yazaki, T. Kadowaki, S. Taylor, 1997, Biochemical and biophysical research communications.

Genotype-stratified treatment for monogenic insulin resistance: a systematic review

T. Okai, Y. Taketani, Y. Yazaki, 1997, Diabetologia.

Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.

Y. Uchijima, T. Asano, H. Kurihara, 2006, Diabetes research and clinical practice.

Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation.

T. Asano, H. Katagiri, Y. Oka, 2003, Biochemical and biophysical research communications.

Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif.

T. Kodama, T. Asano, H. Katagiri, 2002, Molecular endocrinology.

Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.

Y. Yazaki, T. Asano, M. Funaki, 1999, Diabetes.

glucose uptake by skeletal muscle but not adipocytes Activation of AMPK is essential for AICAR-induced

T. Asano, H. Katagiri, Y. Oka, 2016 .

Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes.

T. Asano, H. Katagiri, Y. Oka, 2002, American journal of physiology. Endocrinology and metabolism.

Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat.

Y. Yazaki, T. Asano, M. Funaki, 1999, Metabolism: clinical and experimental.

p85/p110-type Phosphatidylinositol Kinase Phosphorylates Not Only the D-3, but Also the D-4 Position of the Inositol Ring*

Y. Yazaki, T. Asano, M. Funaki, 1999, The Journal of Biological Chemistry.

Agonist‐induced internalization of histamine H2 receptor and activation of extracellular signal‐regulated kinases are dynamin‐dependent

Y. Fukushima, T. Yanagisawa, K. Yanai, 2008, Journal of neurochemistry.

Cloning and increased expression with fructose feeding of rat jejunal GLUT5.

Y. Yazaki, T. Asano, H. Katagiri, 1993, Endocrinology.

A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85 Gene (*)

Y. Yazaki, T. Asano, M. Funaki, 1996, The Journal of Biological Chemistry.

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.

Y. Yazaki, T. Asano, M. Funaki, 1997, The Journal of biological chemistry.

Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus.

Y. Yazaki, T. Kadowaki, Y. Fukushima, 1992, The Journal of clinical endocrinology and metabolism.

Alterations in Gastric Mucosal Lineages Before or After Acute Oxyntic Atrophy in Gastrin Receptor and H2 Histamine Receptor-Deficient Mice

M. Kaminishi, T. Matsui, Y. Fukushima, 2009, Digestive Diseases and Sciences.

Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H2-receptor knockout

T. Hibi, Y. Fukushima, K. Kangawa, 2007, Journal of Gastroenterology.

Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.

T. Matsui, T. Asano, H. Kurihara, 2004, European journal of pharmacology.

Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice.

T. Asano, Y. Kurihara, H. Kurihara, 2003, European journal of pharmacology.

Extremely Early Onset of Ranitidine Action on Human Histamine H2 Receptors Expressed in HEK293 Cells

T. Asano, M. Omata, H. Katagiri, 2004, Digestion.

Role of the C Terminus in Histamine H2 Receptor Signaling, Desensitization, and Agonist-induced Internalization*

Y. Yazaki, T. Asano, M. Funaki, 1997, The Journal of Biological Chemistry.

Desensitization of canine histamine H2 receptor expressed in Chinese hamster ovary cells.

T. Kodama, Y. Yazaki, T. Asano, 1993, Biochemical and biophysical research communications.

Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells.

Y. Yazaki, T. Asano, M. Funaki, 1996, The Biochemical journal.

G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure

T. Asano, M. Omata, M. Funaki, 2001, The Pharmacogenomics Journal.

Localization of the Histamine H2 Receptor, a Target for Antiulcer Drugs, in Gastric Parietal Cells

Y. Yazaki, T. Asano, M. Funaki, 1999, Digestion.

Potent and Long-Lasting Action of Lafutidine on the Human Histamine H2 Receptor

T. Kajiwara, M. Omata, M. Anai, 2001, Digestion.

Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein.

M. Shibuya, T. Asano, M. Funaki, 2001, Biochemical and biophysical research communications.

Five isoforms of the phosphatidylinositol 3‐kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations

T. Asano, M. Funaki, H. Katagiri, 2001, FEBS letters.

Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function

Y. Fukushima, Y. Liao, M. Kitakaze, 2013, Basic Research in Cardiology.

A Novel Protein Kinase B (PKB)/AKT-binding Protein Enhances PKB Kinase Activity and Regulates DNA Synthesis*

Y. Uchijima, N. Horike, T. Asano, 2005, Journal of Biological Chemistry.

Clinical relevance of heteroplasmic concentration of mitochondrial A 3243 G mutation in leucocytes

T. Asano, M. Funaki, H. Katagiri, 1999, Diabetologia.

Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.

H. Aburatani, I. Komuro, Y. Gotoh, 2004, Diabetologia.

Molecular cloning of Chinese hamster ceramide glucosyltransferase and its enhanced expression in peroxisome-defective mutant Z65 cells.

Y. Sakakihara, Y. Fukushima, Y. Fujiki, 2002, Archives of biochemistry and biophysics.

Oligomer formation of histamine H2 receptors expressed in Sf9 and COS7 cells 1

T. Asano, M. Funaki, H. Katagiri, 1997, FEBS letters.

Resistin-like Molecule β Activates MAPKs, Suppresses Insulin Signaling in Hepatocytes, and Induces Diabetes, Hyperlipidemia, and Fatty Liver in Transgenic Mice on a High Fat Diet*

Y. Uchijima, N. Horike, Koichi Nishiyama, 2005, Journal of Biological Chemistry.

Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity.

Y. Uchijima, N. Horike, T. Asano, 2005, American journal of physiology. Endocrinology and metabolism.

Nasal Allergic Response Mediated by Histamine H3 Receptors in Murine Allergic Rhinitis

K. Kaga, Y. Fukushima, M. Nakaya, 2005, The Laryngoscope.

14-3-3 Protein Binds to Insulin Receptor Substrate-1, One of the Binding Sites of Which Is in the Phosphotyrosine Binding Domain*

Y. Yazaki, T. Asano, M. Taoka, 1997, The Journal of Biological Chemistry.

Insulin Receptor Substrate (IRS)-2 Is Dephosphorylated More Rapidly than IRS-1 via Its Association with Phosphatidylinositol 3-Kinase in Skeletal Muscle Cells*

Y. Yazaki, T. Asano, M. Funaki, 1997, The Journal of Biological Chemistry.

Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet

Y. Yazaki, T. Asano, J. Terasaki, 1998, Diabetologia.

p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin*

Y. Yazaki, T. Asano, M. Funaki, 1997, The Journal of Biological Chemistry.

p110β Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity*

Y. Yazaki, C. Heldin, T. Asano, 2000, The Journal of Biological Chemistry.

A case showing an association between type 1 diabetes mellitus and Kabuki syndrome.

T. Asano, Y. Oka, T. Ogihara, 2003, Diabetes research and clinical practice.

Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules.

T. Asano, H. Katagiri, Y. Oka, 2002, Biochemical and biophysical research communications.

Influences of CYP2C19 polymorphism on recurrence of reflux esophagitis during proton pump inhibitor maintenance therapy.

K. Otsuka, Y. Fukushima, T. Saitoh, 2009, Hepato-gastroenterology.

Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.

Y. Uchijima, N. Horike, T. Asano, 2005, Diabetologia.

Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.

T. Asano, H. Katagiri, Y. Oka, 2002, Diabetes.

Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats

Y. Yazaki, T. Asano, J. Terasaki, 1998, Diabetes.

Effects of sulindac on sporadic colorectal adenomatous polyps.

Y. Yazaki, Y. Fukushima, A. Nakajima, 1997, Gut.

Structural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action.

Y. Yazaki, T. Asano, H. Katagiri, 1995, The Biochemical journal.

Regulation of gut-derived resistin-like molecule β expression by nutrients

Y. Uchijima, N. Horike, T. Asano, 2008 .

Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity*

Y. Gotoh, T. Asano, H. Katagiri, 2003, Journal of Biological Chemistry.

The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin.

T. Asano, M. Funaki, H. Katagiri, 2000, The Biochemical journal.

Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.

Y. Uchijima, N. Horike, T. Asano, 2007, American journal of physiology. Cell physiology.

Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting.

T. Asano, M. Omata, M. Funaki, 2001, Biochimica et biophysica acta.

Negative feedback regulation of acid secretion: Linkage of acid secretion and mucosal defense

Y. Yazaki, Y. Fukushima, N. Matsuhashi, 1993, Gastroenterologia Japonica.

Localization of sulfatides in the epithelial lining of gastric mucosa: studies with a monoclonal antibody to sulfatides.

Y. Yazaki, Y. Fukushima, M. Iwamori, 1995, Journal of Clinical Gastroenterology.

Targeting of GLUT1-GLUT5 chimeric proteins in the polarized cell line Caco-2.

Y. Yazaki, T. Asano, H. Katagiri, 1997, Molecular endocrinology.