Zhulun Wang

发表

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

Xiaohong Liu, N. Walker, T. Perlmann, 2003, Nature.

Novel inhibitors of hepatitis C virus RNA-dependent RNA polymerases.

N. Walker, Zhulun Wang, J. Anzola, 2006, Journal of molecular biology.

SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase.

N. Walker, James M. Chen, Zhulun Wang, 2006, Journal of medicinal chemistry.

Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.

N. Walker, Hiroshi Yamamoto, Zhulun Wang, 2008, Bioorganic & medicinal chemistry.

Dynamic light scattering study of internal motions of polymer coils in dilute solution

Zhulun Wang, B. Chu, Jiqun Yu, 1991 .

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Jinhai Gao, Zhulun Wang, W. He, 2004, Nature.

Kinetic study of coil-to-globule transition

Zhulun Wang, B. Chu, Jiqun Yu, 1992 .

Discovery of 6-Oxo-4-Phenyl-Hexanoic Acid Derivatives as RORγt Inverse Agonists Showing Favorable ADME Profile.

S. Shuto, Keiko Kumazawa, Zhulun Wang, 2021, Bioorganic & medicinal chemistry letters.

Discovery of [1,2,4]Triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists.

S. Shuto, Zhulun Wang, Xiaoshan Min, 2020, ACS medicinal chemistry letters.

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.

D. Bates, Zhulun Wang, Haoda Xu, 2020 .

Generation of novel long-acting globular adiponectin molecules.

D. Penny, B. Lemon, N. Hawkins, 2010, Journal of molecular biology.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

K. Pattabiraman, Zhulun Wang, C. Quéva, 2014, Journal of medicinal chemistry.

Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).

Zhulun Wang, C. Mohr, F. Garces, 2020, Cell reports.

Study of large DNA fragments in agarose gels by transient electric birefringence

R. Xu, Zhulun Wang, M. Lalande, 1990, Biopolymers.

DNA electrophoretic mobility and deformation in agarose gels

Zhulun Wang, B. Chu, 1991 .

Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.

P. Coward, N. Walker, Zhulun Wang, 2014, Bioorganic & medicinal chemistry letters.

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex

T. Arora, Zhulun Wang, L. Sekirov, 2012, Science Translational Medicine.

A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling

W. Richards, Zhongqi Zhang, Zhulun Wang, 2018, Scientific Reports.

The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering

Zhulun Wang, I. Foltz, K. Walker, 2020, The Journal of Biological Chemistry.

FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation

B. Lemon, Zhulun Wang, R. Lindberg, 2009, The Journal of Biological Chemistry.

INT131: a selective modulator of PPAR gamma.

M. Lindstrom, N. Walker, Zhulun Wang, 2009, Journal of Molecular Biology.

Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.

Dong Liu, Kristin L. Andrews, Zhulun Wang, 2018, Journal of medicinal chemistry.

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.

M. Lindstrom, Zhulun Wang, Xiaoshan Min, 2011, Bioorganic & medicinal chemistry letters.

The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21.

B. Lemon, Zhulun Wang, R. Lindberg, 2011, Journal of molecular biology.

Transition of linear polymer dimension from .THETA. to collapsed regime. Intrinsic viscosity

Zhulun Wang, B. Chu, 1989 .

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

N. Walker, Zhulun Wang, J. Jaén, 2006, Bioorganic & medicinal chemistry letters.

Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2009, Bioorganic & medicinal chemistry letters.

Structural Characterization and Pharmacodynamic Effects of an Orally Active 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor

Zhulun Wang, Haoda Xu, Xiaoshan Min, 2007, Chemical biology & drug design.

The selectivity of tyrosine 280 of human 11β‐hydroxysteroid dehydrogenase type 1 in inhibitor binding

Zhulun Wang, S. Svensson, Minghan Wang, 2007, FEBS letters.

Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4.

N. Walker, Z. Cao, Zhulun Wang, 2015, Bioorganic & medicinal chemistry letters.

Expression liabilities in a four‐chain bispecific molecule

R. Hubert, Zhulun Wang, Marissa L Mock, 2021, Biotechnology and bioengineering.

Structure-guided Discovery of Dual-recognition Chemibodies

A. Cheng, Zhulun Wang, Xiaoshan Min, 2018, Scientific Reports.

Structure-guided Discovery of Dual-recognition Chemibodies

A. Cheng, Zhulun Wang, Xiaoshan Min, 2018, Scientific Reports.

Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.

N. Walker, Zhulun Wang, Jinsong Liu, 2012, Bioorganic & medicinal chemistry letters.

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.

N. Walker, Zhulun Wang, Jinsong Liu, 2010, Bioorganic & medicinal chemistry letters.

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

N. Walker, Zhulun Wang, Haoda Xu, 2012, Journal of medicinal chemistry.

Viscosity characterization of an alternating copolymer of ethylene and tetrafluoroethylene

W. H. Buck, Zhulun Wang, B. Chu, 1990 .

IRAK-4 Inhibitors for Inflammation

N. Walker, W. Yeh, Zhulun Wang, 2009, Current topics in medicinal chemistry.

Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket*

Elizabeth J. Goldsmith, Jerry L. Adams, E. Goldsmith, 1998, The Journal of Biological Chemistry.

Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.

N. Walker, Zhulun Wang, Jinsong Liu, 2013, Structure.

Movement of fluorescence pattern after photobleaching: An accelerated procedure for DNA electrophoretic mobility analysis

Zhulun Wang, B. Chu, 1992, Electrophoresis.

T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor γ Binding Properties*

M. Lindstrom, Xiaohong Liu, N. Walker, 2008, Journal of Biological Chemistry.

INT131: A Selective Modulator of PPARγ

M. Lindstrom, N. Walker, Zhulun Wang, 2009 .

Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability

K. Rex, A. Coxon, N. Walker, 2013, PloS one.

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

Hantao Liu, Zhulun Wang, Xiaoshan Min, 2017, Science Translational Medicine.

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)

Zhihua Ma, Frank Kayser, Timothy J Carlson, 2011, Proceedings of the National Academy of Sciences.

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

N. Walker, Z. Cao, O. Plotnikova, 2012, The Journal of Biological Chemistry.

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.

N. Walker, Zhulun Wang, Jinsong Liu, 2006, Structure.

Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design

D. Gong, Xinchao Yu, Zhulun Wang, 2021, Frontiers in Immunology.

Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)

B. Lemon, Z. Wang, Zhulun Wang, 2010, Proceedings of the National Academy of Sciences.

Light scattering and small-angle X-ray scattering studies of an ionomer poly(styrene-sodium 2-(acrylamido)-2-methylpropanesulfonate) in polar solvents

Zhulun Wang, B. Chu, W. Shuely, 1991 .

Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.

O. Plotnikova, Zhulun Wang, Jinsong Liu, 2013, Bioorganic & medicinal chemistry letters.

Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2

A. Lim, Zhongqi Zhang, Zhulun Wang, 2018, The Journal of Biological Chemistry.

Diffusion of Polymer in Binary and Ternary Semidilute Solutions

Zhulun Wang, B. Chu, L. Fetters, 1989 .

Structure guided design of a series of sphingosine kinase (SphK) inhibitors.

Holger Wesche, Frank Kayser, Alan C Cheng, 2013, Bioorganic & medicinal chemistry letters.

Crystal structure of a single‐chain trimer of human adiponectin globular domain

N. Walker, B. Lemon, Zhulun Wang, 2012, FEBS letters.

Rational selection of building blocks for the assembly of bispecific antibodies

D. Gong, Zhulun Wang, C. Spahr, 2021, mAbs.

Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo*

P. Coward, N. Walker, Zhulun Wang, 2009, Journal of Biological Chemistry.

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2)*

C. Gabel, O. Silvennoinen, N. Walker, 2015, The Journal of Biological Chemistry.

The high-resolution crystal structure of human LCAT1

N. Walker, Zhulun Wang, S. Thibault, 2015, Journal of Lipid Research.

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

D. Bates, C. Murawsky, Zhulun Wang, 2018, Science Translational Medicine.

An Inhibitory Antibody against Dipeptidyl Peptidase IV Improves Glucose Tolerance in Vivo

N. Walker, P. Cao, Zhulun Wang, 2012, The Journal of Biological Chemistry.

Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.

Yang Li, Peter Coward, Alex Zhang, 2009, Bioorganic & medicinal chemistry letters.

Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies

Xinchao Yu, Zhulun Wang, Xiaoshan Min, 2021, Communications biology.

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

D. Bates, Zhulun Wang, Haoda Xu, 2020, mAbs.

A modified centrifugal apparatus for coexistence curve measurements―Polystyrene in methylcyclohexane

Zhulun Wang, B. Chu, Q. Ying, 1991 .

Precision capillary viscometer

Zhulun Wang, B. Chu, H. Dhadwal, 1987 .

An extended universal coexistence curve for polymer solutions

Zhulun Wang, B. Chu, 1988 .

High temperature capillary viscometer

I. Park, Zhulun Wang, B. Chu, 1989 .

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

W. Chiu, Xinchao Yu, Zhulun Wang, 2020, Science Advances.

Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.

M. Monshouwer, N. Walker, R. Hungate, 2008, Journal of medicinal chemistry.

The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate.

Zhulun Wang, S. Svensson, Minghan Wang, 2006, Biochimica et biophysica acta.

A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling

W. Richards, Zhongqi Zhang, Zhulun Wang, 2018, Scientific Reports.

Imidazo-pyrazine derivatives as potent CXCR3 antagonists.

B. Lemon, Zhulun Wang, S. Miao, 2009, Bioorganic & medicinal chemistry letters.

Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions

Xinchao Yu, Zhulun Wang, Xiaoshan Min, 2018, The Journal of Biological Chemistry.

Small molecule 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Zhulun Wang, Minghan Wang, Daqing Sun, 2011, Current Topics in Medicinal Chemistry.

Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.

M. Lindstrom, N. Walker, P. Timmermans, 2013, Bioorganic & medicinal chemistry.

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).

N. Walker, Zhulun Wang, Jinsong Liu, 2009, Bioorganic & medicinal chemistry letters.

Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

N. Walker, Zhulun Wang, S. Miao, 2008, Bioorganic & Medicinal Chemistry Letters.

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2011, Bioorganic & medicinal chemistry letters.

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.

Xiaolin Hao, Holger Wesche, Shou-Hua Xiao, 2008, Bioorganic & medicinal chemistry letters.

Next generation Fc scaffold for multispecific antibodies

D. Gong, D. Whittington, Zhulun Wang, 2021, iScience.

Structure-guided Discovery of Dual-recognition Chemibodies

A. Cheng, Zhulun Wang, Xiaoshan Min, 2018, Scientific Reports.

Structural basis of inhibitor selectivity in MAP kinases.

E. Goldsmith, J. Boehm, J. Adams, 1998, Structure.

The structure of mitogen-activated protein kinase p38 at 2.1-A resolution.

E. Goldsmith, Jiahuai Han, Z. Wang, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Transient electric birefringence of N4 DNA (71 kb) in solution

R. Xu, Zhulun Wang, B. Chu, 1990 .

Mouse ECD with Fab1

D. Bates, Zhulun Wang, Haoda Xu, 2020 .

Basis of substrate binding by the chaperonin GroEL.

L. Gierasch, Zhulun Wang, L M Gierasch, 1999, Biochemistry.

Imidazo-pyrazine derivatives as potent CXCR3 antagonists.

B. Lemon, Zhulun Wang, S. Miao, 2009, Bioorganic & medicinal chemistry letters.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

K. Pattabiraman, Zhulun Wang, C. Quéva, 2014, Journal of medicinal chemistry.

The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21.

B. Lemon, Zhulun Wang, R. Lindberg, 2011, Journal of molecular biology.