K. Pfizenmaier

K. Pfizenmaier, T. Müller, E. Schmid, 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Agonistic and Antagonistic Antibodies as a Tool to Study the Functional Role of Human Tumor Necrosis Factor Receptors

P. Scheurich, K. Pfizenmaier, M. Grell, 1993 .

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

P. Scheurich, K. Pfizenmaier, B. Thoma, 1987, Journal of immunology.

T-cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice

K. Heeg, K. Pfizenmaier, M. Röllinghoff, 1980, Nature.

Differential7-lnterferon Responseof HumanColonCarcinomaCells: Inhibition of Proliferationand Modulationof Immunogenicityas IndependentEffects of 7-lnterferon on TumorCell Growth1

B. Seliger, P. Scheurich, K. Pfizenmaier, 2006 .

PMA-responsive 5' flanking sequences of the human TNF gene.

K. Pfizenmaier, G. Hensel, M. Krönke, 1989, Lymphokine research.

Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

A. Herrmann, R. Kontermann, R. Fischer, 2018, Scientific Reports.

Anti-TNFR 1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

A. Herrmann, R. Kontermann, R. Fischer, 2018 .

Quantitation and Characterization of γ-Interferon Receptors on Human Tumor Cells

P. Scheurich, K. Pfizenmaier, H. Bartsch, 1986 .

IFN-γ Receptors on Human Tumor Cells: Relationship between Receptor Ligand Interactions and Induction of IFN-γ Response

P. Scheurich, K. Pfizenmaier, H. Bartsch, 1986 .

Identification of Potential Active-site Residues in the Hydroxynitrile Lyase from Manihot esculenta by Site-directed Mutagenesis*

H. Wajant, K. Pfizenmaier, 1996, The Journal of Biological Chemistry.

An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action.

A. Herrmann, P. Scheurich, Kirstin A. Zettlitz, 2013, Protein engineering, design & selection : PEDS.

Biological and biochemical characterization of a somatostatin-producing human carcinoma established by heterotransplantation.

K. Pfizenmaier, J. Conlon, E. Kunze, 1985, Cancer research.

Regulation of IFN-gamma-receptor expression in human monocytes by granulocyte-macrophage colony-stimulating factor.

G. Burmester, K. Pfizenmaier, K. Wiegmann, 1990, Journal of immunology.

Bruton's tyrosine kinase (Btk) associates with protein kinase C μ

P. Storz, T. Kawakami, K. Pfizenmaier, 1999 .

The role of the major histocompatibility gene complex in murine cytotoxic T cell responses.

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 1980, Advances in cancer research.

Bruton's tyrosine kinase (Btk) associates with protein kinase C mu.

P. Storz, T. Kawakami, K. Pfizenmaier, 1999, FEBS letters.

Shared determinants between virus‐infected and trinitrophenyl‐conjugated H‐2‐identical target cells detected in cell‐mediated lympholysis

A. Starzinski-Powitz, K. Pfizenmaier, M. Röllinghoff, 1976, European journal of immunology.

T–T cell collaboration during in vivo responses to antigens coded by the peripheral and central region of the MHC

A. Starzinski-Powitz, K. Pfizenmaier, H. Wagner, 1976, Nature.

Cell-mediated immunity in lumphocytic choriomeningitis. I. The specificity of the cytotoxic T lymphocytes.

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 1976, Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie.

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury

K. Moxon, R. Kontermann, R. Fischer, 2019, CNS neuroscience & therapeutics.

Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization.

A. Schauer, K. Pfizenmaier, S. Beissert, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Non-apoptotic Fas signaling.

Klaus Pfizenmaier, H. Wajant, K. Pfizenmaier, 2003, Cytokine & growth factor reviews.

Activation of CD95L fusion protein prodrugs by tumor-associated proteases

H. Wajant, K. Pfizenmaier, B. Schneider, 2007, Cell Death and Differentiation.

Sequential therapy with recombinant interferons gamma and alpha in patients with unfavorable prognosis of chronic myelocytic leukemia: Clinical responsiveness to recombinant ifn‐α correlates with the degree of receptor down‐regulation

P. Scheurich, K. Pfizenmaier, A. Hanusch, 1989, International journal of cancer.

Differential Regulation of Cell Membrane Receptors for Interferon-γ and -α on Peripheral Blood Cells of Patients with Chronic Myelogenous Leukemia During Interferon-γ/α Therapy

K. Pfizenmaier, H. Bartsch, G. Nagel, 1988 .

Protein kinase C mu is located at the Golgi compartment

J. Prestle, K. Pfizenmaier, J. Brenner, 1996, The Journal of cell biology.

Improving TNF as a cancer therapeutic: Tailor‐made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects

H. Wajant, K. Pfizenmaier, Jeannette Gerspach, 2009, BioFactors.

Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface

H. Wajant, K. Pfizenmaier, S. Münkel, 2006, Cancer Immunology, Immunotherapy.

Genetic control of the cytotoxic T cell response to SV40 tumor-associated specific antigen.

D. Solter, G. Trinchieri, K. Pfizenmaier, 1979, Journal of immunology.

Monitoring of scFv selected by phage display using detection of scFv-pIII fusion proteins in a microtiter scale assay.

M. Tesar, M. Little, K. Pfizenmaier, 1998, Journal of immunological methods.

Construction of a bispecific single chain antibody for recruitment of cytotoxic T cells to the tumour stroma associated antigen fibroblast activation protein.

K. Pfizenmaier, D. Moosmayer, T. Wüest, 2001, Journal of biotechnology.

Gamma interferon regulates long terminal repeat-controlled oncogene expression in transformed mouse fibroblasts at the level of mRNA transcription

B. Seliger, R. Schäfer, K. Pfizenmaier, 1988, Journal of virology.

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

A. Herrmann, R. Kontermann, P. Naudé, 2016, Proceedings of the National Academy of Sciences.

Selective Blocking of TNF Receptor 1 Attenuates Peritoneal Dialysis Fluid Induced Inflammation of the Peritoneum in Mice

P. Scheurich, M. Zeier, K. Pfizenmaier, 2016, PloS one.

Murine gamma interferon inhibits v-mos-induced fibroblast transformation via down regulation of retroviral gene expression

B. Seliger, K. Pfizenmaier, G. Kruppa, 1987, Journal of virology.

Postnatal development of functional T cell subsets in the mouse: a frequency analysis of mitogen reactive precursors of proliferating, of cytotoxic and of IL 2 producing T cells.

P. Scheurich, K. Pfizenmaier, W. Däubener, 1985, Immunobiology.

Angiotensin II Stimulates Protein Kinase D–Dependent Histone Deacetylase 5 Phosphorylation and Nuclear Export Leading to Vascular Smooth Muscle Cell Hypertrophy

E. Olson, T. McKinsey, K. Pfizenmaier, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Noncytocidal mechanisms of action of tumor necrosis factor-alpha on human tumor cells: enhancement of HLA gene expression synergistic with interferon-gamma.

P. Scheurich, K. Pfizenmaier, C. Schlüter, 1986, Immunobiology.

A Golgi PKD Activity Reporter Reveals a Crucial Role of PKD in Nocodazole‐Induced Golgi Dispersal

K. Pfizenmaier, A. Hausser, G. Bunt, 2009, Traffic.

Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells

K. Pfizenmaier, M. Röllinghoff, H. Rodt, 1976, The Journal of experimental medicine.

Temporary presence of self-reactive cytotoxic T lymphocytes during murine lymphocytic choriomeningitis

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 1975, Nature.

Intrathymic differentiation of cytotoxic T lymphocyte (CTL) precursors. I. The CTL immunocompetence of peanut agglutinin-positive (cortical) and negative (medullary) Lyt 123 thymocytes.

K. Pfizenmaier, M. Röllinghoff, C. Hardt, 1980, Journal of immunology.

T‐T Cell Interactions during Cytotoxic T Lymphocyte (CTL) Responses: T Cell Derived Helper Factor (Interleukin 2) as a Probe to Analyze CTL Responsiveness and Thymic Maturation of CTL Progenitors

W. Solbach, K. Heeg, K. Pfizenmaier, 1980, Immunological reviews.

Quantitative representation of all T cells committed to develop into cytotoxic effector cells and/or interleukin 2 activity‐producing helper cells within murine T lymphocyte subsets

P. Scheurich, K. Pfizenmaier, M. Röllinghoff, 1984, European journal of immunology.

The in vivo effects of interleukin 2 (TCGF).

K. Heeg, K. Pfizenmaier, M. Röllinghoff, 1982, Immunobiology.

Species-Crossreactive scFv Against the Tumor Stroma Marker “Fibroblast Activation Protein” Selected by Phage Display From an Immunized FAP−/− Knock-Out Mouse

K. Pfizenmaier, P. Garin‐Chesa, B. Brocks, 2001, Molecular medicine.

Herpes-simplex-virus-specific, H-2Dk-restricted T lymphocytes bear receptors for H-2Dd alloantigen

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 2005, Immunogenetics.

Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 2005, Immunogenetics.

T-T cell interactions during in vitro cytotoxic T lymphocyte responses. V. Precursor frequencies and specificity of alloreactive helper T cells

P. Scheurich, K. Pfizenmaier, M. Röllinghoff, 1982, Journal of Experimental Medicine.

T-cell-mediated cytotoxicity against herpes simplex virus-infected target cells

A. Starzinski-Powitz, K. Pfizenmaier, M. Röllinghoff, 1977, Nature.

Selective Inhibition of FLICE-like Inhibitory Protein (FLIP) Expression With Small Interfering RNA Oligonucleotides (siRNAs) Is Sufficient to Sensitize Tumor Cells for TRAIL-Induced Apoptosis

H. Wajant, P. Hadwiger, H. Vornlocher, 2002 .

Neurodegenerative and Neuroprotective Effects of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2

S. Mohand-Said, K. Pfizenmaier, U. Eisel, 2002, The Journal of Neuroscience.

Genetic engineering of death ligands for improvement of therapeutic activity.

N. Müller, H. Wajant, K. Pfizenmaier, 2011, Advances in experimental medicine and biology.

A single-chain TNF receptor antagonist is an effective inhibitor of TNF mediated cytotoxicity.

M. Little, S. Dübel, P. Scheurich, 1995, Therapeutic immunology.

Molecular cloning of hydroxynitrile lyase from Sorghum bicolor (L.). Homologies to serine carboxypeptidases

H. Wajant, K. Pfizenmaier, K. Mundry, 1994, Plant Molecular Biology.

Tumor necrosis factors in 1998.

P. Scheurich, H. Wajant, K. Pfeffer, 1998, Cytokine & growth factor reviews.

Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors

J. Klein, K. Pfizenmaier, M. Röllinghoff, 1980, The Journal of experimental medicine.

Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III β protects from dephosphorylation and stabilizes lipid kinase activity

K. Pfizenmaier, M. Hoene, A. Hausser, 2006, Journal of Cell Science.

Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity

R. Kontermann, A. Nussler, K. Pfizenmaier, 2012, Cell Death and Disease.

Cloning and characterization of promoter and 5'-UTR of the NMDA receptor subunit epsilon 2: evidence for alternative splicing of 5'-non-coding exon.

K. Pfizenmaier, F. Uhlmann, U. Eisel, 1998, Gene.

Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self- major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells

K. Pfizenmaier, M. Röllinghoff, H. Rodt, 1981, The Journal of experimental medicine.

Ligand and Glucocorticoid-Induced TNF Receptor Soluble Trimers of CD 27 L , CD 40 L , 41 BBL , Immobilization Improve the Activity of Antibody-Mediated Cell Surface Trimer Stabilization , Oligomerization , and Wajant

N. Müller, H. Wajant, K. Pfizenmaier, 2009 .

Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses

P. Scheurich, B. Rouse, K. Pfizenmaier, 1982, The Journal of experimental medicine.

Therapeutic targeting of CD95 and the TRAIL death receptors.

H. Wajant, K. Pfizenmaier, Jeannette Gerspach, 2011, Recent patents on anti-cancer drug discovery.

Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy.

G. Burmester, K. Pfizenmaier, J. Kalden, 1993, The Journal of clinical investigation.

PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration

K. Pfizenmaier, A. Hausser, T. Eiseler, 2007, FEBS letters.

H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 1981, The Journal of experimental medicine.

Fusion of the tissue factor extracellular domain to a tumour stroma specific single-chain fragment variable antibody results in an antigen-specific coagulation-promoting molecule.

R. Mattes, K. Pfizenmaier, D. Moosmayer, 2000, The Biochemical journal.

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

B. Sharrack, H. Davies, R. Fischer, 2012, The Journal of Immunology.

Endothelial Cells Barrier Breakdown in Human Brain Role of Caspases in Cytokine-Induced

B. Sharrack, H. Davies, R. Fischer, 2012 .

Preclinical Efficacy of Endoglin-Targeting Antibody–Drug Conjugates for the Treatment of Ewing Sarcoma

J. Mora, R. Kontermann, A. Amaral, 2018, Clinical Cancer Research.

The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes.

A. Starzinski-Powitz, K. Pfizenmaier, M. Röllinghoff, 1977, Journal of immunology.

A mouse bone marrow stromal cell line with skeletal stem cell characteristics to study osteogenesis in vitro and in vivo.

B. Sacchetti, U. Mau-Holzmann, K. Pfizenmaier, 2014, Stem cells and development.

Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses.

P. Scheurich, B. Rouse, K. Pfizenmaier, 1982 .

Tailoring the stealth properties of biocompatible polysaccharide nanocontainers.

K. Landfester, U. Şahin, R. Kontermann, 2015, Biomaterials.

Expression of the Zn2+-containing hydroxynitrile lyase from flax (Linum usitatissimum) in Pichia pastoris— utilization of the recombinant enzyme for enzymatic analysis and site-directed mutagenesis

H. Wajant, U. Schwaneberg, K. Pfizenmaier, 1998 .

Purification and Characterization of a Novel (R)-Mandelonitrile Lyase from the Fern Phlebodium aureum

H. Wajant, K. Pfizenmaier, D. Selmar, 1995, Plant physiology.

Acetone cyanohydrin lyase from Manihot esculenta (cassava) is serologically distinct from other hydroxynitrile lyases

H. Wajant, K. Pfizenmaier, F. Effenberger, 1995 .

Mapping of H–2 genes associated with T cell-mediated cytotoxic responses to SV40–tumour-associated specific antigens

D. Solter, G. Trinchieri, K. Pfizenmaier, 1978, Nature.

Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma.

Hao Liu, K. Pfizenmaier, S. Gottschalk, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice

W. Wurst, K. Pfizenmaier, C. Ferrari, 2011, Experimental Neurology.

TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways.

P. Scheurich, K. Pfizenmaier, M. Grell, 1994, Journal of immunology.

Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis

R. Kontermann, R. Fischer, K. Pfizenmaier, 2018, Arthritis & rheumatology.

Tumor therapeutics by design: targeting and activation of death receptors.

H. Wajant, K. Pfizenmaier, Jeannette Gerspach, 2005, Cytokine & growth factor reviews.

TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60.

P. Scheurich, H. Wajant, K. Pfizenmaier, 1998, Journal of immunology.

TNFR-Associated Factor 2 and Is Specific for TNFR 60-Induced Cell Death Is Mediated by TNFR 80-Dependent Enhancement of Scheurich and

P. Scheurich, H. Wajant, K. Pfizenmaier, 1998 .

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2

R. Kontermann, R. Fischer, K. Pfizenmaier, 2017, Scientific Reports.

Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis.

N. Kraut, K. Pfizenmaier, A. Weith, 2001, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

IL-2 production in human T lymphotropic virus I-infected leukemic T lymphocytes analyzed by in situ hybridization.

K. Pfizenmaier, M. Krönke, N. Goebels, 1988, Journal of immunology.

Human chromosome 21 is necessary and sufficient to confer human IFN gamma responsiveness to somatic cell hybrids expressing the cloned human IFN gamma receptor gene.

K. Pfizenmaier, M. Aguet, A. Rehm, 1990, Cytokine.

Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer.

K. Pfizenmaier, C. Knabbe, M. Stope, 2010, Cancer research.

Stable expression of a selectable myeloproliferative sarcoma virus in murine T lymphocyte and monocyte cell lines.

B. Seliger, K. Pfizenmaier, G. Kruppa, 1987, Immunobiology.

Rapid modulation of tumor necrosis factor membrane receptors by activators of protein kinase C.

P. Scheurich, K. Pfizenmaier, G. Zugmaier, 1986, Biochemical and biophysical research communications.

Human antibody derivatives against the fibroblast activation protein for tumor stroma targeting of carcinomas

K. Pfizenmaier, P. Garin‐Chesa, B. Brocks, 2001, International journal of cancer.

Escherichia coli Expression in Overcomes the Limitations of Periplasmic Leads to Active Product and mirabilis Proteus Secretion in L-Form Cells of Variable-Fragment ( scFv ) Antibodies : Procaryotic Expression of Single-Chain

M. Klein, R. Mattes, K. Pfizenmaier, 1998 .

Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells*

B. Maček, A. Nordheim, K. Pfizenmaier, 2012, Molecular & Cellular Proteomics.

P. Scheurich, H. Wajant, K. Pfizenmaier, 2002, Apoptosis.

Protein Kinase D Controls Actin Polymerization and Cell Motility through Phosphorylation of Cortactin*

K. Pfizenmaier, J. Van Lint, A. Hausser, 2010, The Journal of Biological Chemistry.

Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.

K. Pfizenmaier, M. Olayioye, A. Hausser, 2009, Cancer research.

Structural requirements for localization and activation of protein kinase C μ (PKCμ) at the Golgi compartment

Klaus Pfizenmaier, Angelika Hausser, K. Pfizenmaier, 2002, The Journal of cell biology.

Protein Kinase C μ Is Regulated by the Multifunctional Chaperon Protein p32*

P. Storz, K. Pfizenmaier, A. Hausser, 2000, The Journal of Biological Chemistry.

OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models

M. Hidalgo, R. Kontermann, P. López-Casas, 2020, Clinical Cancer Research.

Glycosylation of the human interferon-gamma receptor. N-linked carbohydrates contribute to structural heterogeneity and are required for ligand binding.

P. Scheurich, K. Pfizenmaier, B. Thoma, 1990, The Journal of biological chemistry.

N-glycosidase treatment of Colo 205 cells interferes with hIFN-gamma induced HLA-DR expression.

K. Pfizenmaier, K. Wiegmann, T. Fischer, 1989, Lymphokine research.

In vivo sensitization of T cells to hapten‐conjugated syngeneic structures of major histocompatibility complex. I. Effect of in vitro culture upon generation of cytotoxic T lymphocytes

A. Starzinski-Powitz, K. Pfizenmaier, M. Röllinghoff, 1976, European journal of immunology.

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

George Kollias, Peter Scheurich, Eleni Douni, 1995, Cell.

Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo

K. Pfizenmaier, M. Röllinghoff, C. Hardt, 1981, The Journal of experimental medicine.

Virion antigens introduced exogeneously into the cell membrane render syngeneic target cells susceptible for T cell-mediated cytolysis.

A. Starzinski-Powitz, K. Pfizenmaier, M. Röllinghoff, 1977, Zeitschrift fur Immunitatsforschung. Immunobiology.

Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons.

K. Schlett, I. Mansuy, K. Pfizenmaier, 2009, Molecular biology of the cell.

A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells

L. Pardo, R. Kontermann, K. Pfizenmaier, 2020, Frontiers in Pharmacology.

Superior serum half life of albumin tagged TNF ligands.

N. Müller, H. Wajant, K. Pfizenmaier, 2010, Biochemical and biophysical research communications.

Protein kinase D controls voluntary-running-induced skeletal muscle remodelling.

K. Pfizenmaier, A. Hausser, M. Wiekowski, 2011, The Biochemical journal.

TNF-Selectokine: a novel prodrug generated for tumor targeting and site-specific activation of tumor necrosis factor

K. Pfizenmaier, E. Gerlach, D. Moosmayer, 2002, Oncogene.

The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation

A. Herrmann, R. Kontermann, R. Fischer, 2021, Frontiers in Immunology.

Antibody-Mediated Inhibition of TNFR1 Attenuates Disease in a Mouse Model of Multiple Sclerosis

R. Fischer, K. Pfizenmaier, R. Diem, 2014, PloS one.

Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands.

H. Wajant, K. Pfizenmaier, Jeannette Gerspach, 2009, Results and problems in cell differentiation.

Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells.

P. Scheurich, K. Pfizenmaier, C. Schlüter, 1987, Journal of immunology.

T-cell-derived helper factor allows Lyt 123 thymocytes to differentiate into cytotoxic T lymphocytes

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 1979, Nature.

Protein Kinase C (PKC)η-mediated PKCμ Activation Modulates ERK and JNK Signal Pathways*

Peter Storz, Klaus Pfizenmaier, Angelika Hausser, 2002, The Journal of Biological Chemistry.

Regulation of T cell‐mediated cytotoxic allograft responses. I. Evidence for antigen‐specific suppressor T cells

A. Starzinski-Powitz, K. Pfizenmaier, M. Röllinghoff, 1976 .

Targeted lipid-coated nanoparticles: delivery of tumor necrosis factor-functionalized particles to tumor cells.

K. Landfester, P. Scheurich, R. Kontermann, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

C. Libert, R. Kontermann, M. Zenke, 2023, Nature Immunology.

Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses

P. Scheurich, K. Pfizenmaier, M. Grell, 1990, The Journal of experimental medicine.

Engineering death receptor ligands for cancer therapy.

H. Wajant, K. Pfizenmaier, Jeannette Gerspach, 2013, Cancer letters.

Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis.

H. Wajant, P. Hadwiger, H. Vornlocher, 2002, Molecular medicine.

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice

M. Manns, R. Kontermann, K. Schulze-Osthoff, 2020, Cell Death & Disease.

Enhanced Stability and Antitumoral Activity Single-Chain TNF, a TNF Derivative with

Ingo Grunwald, Klaus Pfizenmaier, Peter Scheurich, 2013 .

Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity1

P. Scheurich, D. Männel, K. Pfizenmaier, 2008, The Journal of Immunology.

Lymphocyte Adhesion to Human Endothelial Cells Induces Tissue Factor Expression via a Juxtacrine Pathway

K. Pfizenmaier, E. Schmid, R. Budzinski, 1995, Thrombosis and Haemostasis.

REGULATION OF HUMAN T CELL RESPONSES BY GAMMA INTERFERON (IFN-γ): STUDIES ON THE BINDING AND BIOLOGICAL EFFECTS OF IFN-γ ON DISTINCT T CELL SUBPOPULATIONS1

P. Scheurich, K. Pfizenmaier, H. Bartsch, 1985 .

The in vitro induction of antigen-specific cytotoxic T lymphocytes (CTL) 1 requires the collaboration between functionally dintinct T cell subpopulations (1-5). Studies at the population level have revealed that upon antigen-specific activation, helper T lymphocytes (HTL) release nonspecific mediato

P. Scheurich, K. Pfizenmaier, H. Wagner, 2003 .

Brief Definitive Report Dissection of the Proliferative and Differentiative Signals Controlling Murine Cytotoxic T Lymphocyte Responses* Il-2-producing Tlymphoma Cells. the Il-2-producing Ei~ Variant (13) Was Kindly Provided

P. Scheurich, B. Rouse, K. Pfizenmaier, 2022 .

Early events during primary activation of T cells: antigen receptor cross‐linking and interleukin 1 initiate proliferative response of human T cells

P. Scheurich, K. Pfizenmaier, M. Wrann, 1985, European journal of immunology.

Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative

P. Scheurich, H. Wajant, K. Pfizenmaier, 2001, Oncogene.

Phase I study of recombinant human tumor necrosis factor-alpha in patients with advanced malignancies.

K. Pfizenmaier, H. Bartsch, G. Nagel, 1988, Molecular biotherapy.

Characterization of activators and inhibitors of protein kinase C mu.

J. Prestle, K. Pfizenmaier, G. Link, 1995, European journal of biochemistry.

Regulation of Major Histocompatibility Complex Class I Gene Expression in Oncogene-Transformed Mouse Fibroblasts1

B. Seliger, K. Pfizenmaier, C. Huber, 1994 .

Preferential H-2 association in cytotoxic T cell responses to SV40 tumor-associated specific antigens.

K. Pfizenmaier, B. Knowles, S. Pan, 1980, Journal of immunology.

Generation of human high-affinity antibodies specific for the fibroblast activation protein by guided selection.

K. Pfizenmaier, P. Garin‐Chesa, E. Gerlach, 2001, European journal of biochemistry.

An antibody-TNF TNF inhibitor fusion protein (TNF-Selektokin) as target-specific for tumor therapy Prozytokin

P. Scheurich, K. Pfizenmaier, D. Moosmayer, 2000 .

Tumor necrosis factor-alpha affects LTR-controlled oncogene expression in transformed mouse fibroblasts at the post-transcriptional level.

B. Seliger, K. Pfizenmaier, G. Stark, 1988, Journal of Immunology.

Membrane Tumor Necrosis Factor (TNF) Induced Cooperative Signaling of TNFR60 and TNFR80 Favors Induction of Cell Death Rather Than Virus Production in HIV-infected T Cells

P. Scheurich, K. Woods-Cook, K. Pfizenmaier, 1997, The Journal of experimental medicine.

Characterization of different soluble TNF receptor (TNFR80) derivatives: positive influence of the intracellular domain on receptor/ligand interaction and TNF neutralization capacity.

H. Wajant, K. Pfizenmaier, B. Brocks, 1996, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

POST‐TRANSCRIPTIONAL DOWNREGULATION OF MHC CLASS I EXPRESSION IN ONCOGENE‐TRANSFORMED CELLS IS REVERTED BY IFN‐GAMMA AND TNF‐ALPHA

B. Seliger, K. Pfizenmaier, 1989, Journal of immunogenetics.

Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

A. Herrmann, R. Kontermann, R. Fischer, 2018, Scientific Reports.

Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis

Richard J Smeyne, R. Kontermann, R. Fischer, 2019, Brain, Behavior, and Immunity.

Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity

A. Herrmann, P. Scheurich, R. Kontermann, 2013, PloS one.

ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody

A. Herrmann, P. Scheurich, R. Kontermann, 2010, mAbs.

Antagonists of TNF action: clinical experience and new developments

Peter Scheurich, Klaus Pfizenmaier, P. Scheurich, 2009, Expert opinion on drug discovery.

Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits

F. Metzger, K. Schlett, E. Dere, 2004, Molecular and Cellular Neuroscience.

Tumor Necrosis Factor (TNF)-mediated Neuroprotection against Glutamate-induced Excitotoxicity Is Enhanced by N-Methyl-D-aspartate Receptor Activation

K. Schlett, K. Pfizenmaier, U. Eisel, 2004, Journal of Biological Chemistry.

Regulation of Raf‐1 kinase by TNF via its second messenger ceramide and cross‐talk with mitogenic signalling

G. Müller, W. Kolch, H. Mischak, 1998, The EMBO journal.

Protein Kinase C μ Is Negatively Regulated by 14-3-3 Signal Transduction Proteins*

P. Storz, A. Altman, K. Pfizenmaier, 1999, The Journal of Biological Chemistry.

A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression.

B. Groner, G. Müller, P. Storz, 1999, Analytical biochemistry.

Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway.

P. Scheurich, Matthias Naumer, R. Fischer, 2011, Cellular signalling.

An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes.

Eric Becker, Hitto Kaufmann, Klaus Pfizenmaier, 2008, Journal of biotechnology.

IgG-single-chain TRAIL fusion proteins for tumour therapy

R. Kontermann, K. Pfizenmaier, M. Siegemund, 2018, Scientific Reports.

Insulin selectively activates STAT5b, but not STAT5a, via a JAK2‐independent signalling pathway in Kym‐1 rhabdomyosarcoma cells

G. Müller, P. Storz, H. Döppler, 1999, FEBS letters.

Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein.

P. Scheurich, I. Maurer-Fogy, C. Stratowa, 1990, DNA and cell biology.

Regulation of the murine NMDA‐receptor‐subunit NR2C promoter by Sp1 and fushi tarazu factor1 (FTZ‐F1) homologues

K. Pfizenmaier, U. Eisel, Jeannette Gerspach, 1999, The European journal of neuroscience.

Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans

U. Şahin, R. Kontermann, K. Pfizenmaier, 2018, Oncoimmunology.

An optimized antibody-single-chain TRAIL fusion protein for cancer therapy

R. Kontermann, K. Pfizenmaier, M. Siegemund, 2016, mAbs.

Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases

T. Seufferlein, K. Pfizenmaier, T. Eiseler, 2014, Molecular biology of the cell.

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability

H. Wajant, K. Pfizenmaier, C. Warnke, 2005, The Journal of cell biology.

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice

M. Manns, R. Kontermann, K. Schulze-Osthoff, 2020, Cell Death & Disease.

Differential gamma-interferon response of human colon carcinoma cells: inhibition of proliferation and modulation of immunogenicity as independent effects of gamma-interferon on tumor cell growth.

B. Seliger, P. Scheurich, K. Pfizenmaier, 1985, Cancer research.

EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells

Monilola A. Olayioye, R. Kontermann, D. Delia, 2014, PloS one.

Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways.

Peter Storz, Klaus Pfizenmaier, Angelika Hausser, 2002, The Journal of biological chemistry.

Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes.

H. Wajant, K. Pfizenmaier, G. Link, 1998, European journal of biochemistry.

H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

K. Pfizenmaier, M. Röllinghoff, H. Rodt, 1980, Proceedings of the National Academy of Sciences of the United States of America.

T‐T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen‐specific T helper cells release nonspecific mediator(s) able to help induction of H‐2‐restricted cytotoxic T lymphocyte responses across cell‐impermeable membranes

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 1980, European journal of immunology.

Tumor necrosis factor inhibits MYC expression in HL-60 cells at the level of mRNA transcription.

K. Pfizenmaier, C. Schlüter, M. Krönke, 1987, Proceedings of the National Academy of Sciences of the United States of America.

In vitro activation and substrates of recombinant, baculovirus expressed human protein kinase Cμ

K. Pfizenmaier, G. Link, F. Johannes, 1996, FEBS letters.

Anti-inflammatory treatment in MPN: targeting TNFR1 and TNFR2 in JAK2-V617F–induced disease

K. Pfizenmaier, T. Fischer, F. Richter, 2021, Blood advances.

Sensitivity of leukemia cell lines to cytotoxic alkyl-lysophospholipids in relation to O-alkyl cleavage enzyme activities.

C. Unger, K. Pfizenmaier, H. Eibl, 1987, Journal of the National Cancer Institute.

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes

Kathryn A. Swanson, R. Kontermann, R. Fischer, 2019, Proceedings of the National Academy of Sciences.

A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death

P. Scheurich, H. Wajant, R. Fischer, 2011, PloS one.

A Humanized Tumor Necrosis Factor Receptor 1 (TNFR1)-specific Antagonistic Antibody for Selective Inhibition of Tumor Necrosis Factor (TNF) Action

P. Scheurich, R. Kontermann, K. Pfizenmaier, 2008, Journal of immunotherapy.

Primary in vitro sensitization of virus specific cytotoxic T lymphocytes.

A. Starzinski-Powitz, K. Pfizenmaier, M. Röllinghoff, 1978, Immunology.

Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation

K. Schlett, K. Tárnok, K. Pfizenmaier, 2015, The Journal of cell biology.

Superior Properties of Fc-comprising scTRAIL Fusion Proteins

R. Kontermann, K. Pfizenmaier, M. Siegemund, 2017, Molecular Cancer Therapeutics.

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS

R. Kontermann, K. Pfizenmaier, J. Laman, 2023, Journal of Neuroinflammation.

Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis

R. Kontermann, K. Pfizenmaier, R. Diem, 2023, Journal of Neuroinflammation.

Astrocyte‐specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor

R. Kontermann, H. Wajant, R. Fischer, 2014, Glia.

Frequency-Analysis of Precursors of Cytotoxic T Lymphocytes in Radiation Chimeras: Enumeration of Antigenspecific CTL-P Restricted to Thymic MHC- and Bone Marrow-MHC-Determinants

P. Scheurich, K. Pfizenmaier, M. Röllinghoff, 1984 .

Tumor necrosis factor (TNF)-functionalized nanostructured particles for the stimulation of membrane TNF-specific cell responses.

Peter Scheurich, Herwig Brunner, Klaus Pfizenmaier, 2005, Bioconjugate chemistry.

The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

R. Kontermann, A. Dolga, K. Pfizenmaier, 2023, Scientific reports.

Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32.

P. Storz, K. Pfizenmaier, A. Hausser, 2000, The Journal of biological chemistry.

CELL‐MEDIATED IMMUNITY TO H‐2 ANTIGENS: Characteristics of the Effector Cells as Detected in the Microcytotoxicity Assay

K. Pfizenmaier, M. Röllinghoff, H. Wagner, 1976, Transplantation.

Tumor necrosis factor-induced changes of gene expression in U937 cells. Differentiation-dependent plasticity of the responsive state.

P. Scheurich, K. Pfizenmaier, C. Schlüter, 1988, Journal of immunology.

Modulation of major histocompatibility complex (MHC) class I genes in adenovirus 12 transformed cells: interferon-gamma increases class I expression by a mechanism that circumvents E1A induced-repression and tumor necrosis factor enhances the effect of interferon-gamma.

R. Ricciardi, K. Pfizenmaier, K. Eager, 1989, Oncogene.

Biological effects of gamma-interferon on human tumor cells: quantity and affinity of cell membrane receptors for gamma-IFN in relation to growth inhibition and induction of HLA-DR expression.

P. Scheurich, K. Pfizenmaier, H. Bartsch, 1985, International journal of cancer.

IgG-single-chain TRAIL fusion proteins for tumour therapy

R. Kontermann, K. Pfizenmaier, M. Siegemund, 2018, Scientific Reports.

T‐T cell interactions during in vitro cytotoxic T cell responses. VI. The role of T cell‐derived colony‐stimulating factor in helper T cell activation

P. Scheurich, K. Heeg, K. Pfizenmaier, 1984, European journal of immunology.

Preferential expression of tumor necrosis factor receptor 55 (TNF-R55) on human articular chondrocytes: selective transcriptional upregulation of TNF-R75 by proinflammatory cytokines interleukin 1beta, tumor necrosis factor-alpha, and basis fibroblast growth factor.

H. Lorenz, K. Pfizenmaier, M. Grell, 1999, The Journal of rheumatology.

HIGH AFFINITY HUMAN IFN-7-BINDING CAPACITY I S ENCODED BY A SINGLE RECEPTOR GENE LOCATED IN PROXIMITY TO cros ON HUMAN CHROMOSOME REGION 6 q 16 TO 6 q 22 l

P. Scheurich, K. Pfizenmaier, K. Wiegmann, 2001 .

Generation of Cytotoxic T Lymphocytes Against Ly Alloantigen

A. Starzinski-Powitz, K. Pfizenmaier, M. Röllinghoff, 1977, Scandinavian journal of immunology.

Specific membrane receptors for human interferon-gamma (IFN-gamma).

P. Scheurich, K. Pfizenmaier, H. Bartsch, 1987, Behring Institute Mitteilungen.

TNFR1 Blockade Rather then TNFR2 Blockade Reduces Chronic Inflammation in JAK2+/V617F Mice

K. Pfizenmaier, T. Fischer, F. Richter, 2019, Blood.

T-T cell interactions during in vitro cytotoxic T lymphocyte responses. V. Precursor frequencies and specificity of alloreactive helper T cells

P. Scheurich, K. Pfizenmaier, M. Röllinghoff, 1982, The Journal of experimental medicine.

A new tool for the quantitative analysis of dendritic filopodial motility

K. Schlett, K. Tárnok, K. Pfizenmaier, 2015, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Enantioselective Synthesis of Aliphatic (S)‐Cyanohydrins in Organic Solvents Using Hydroxynitrile Lyase from Manihot esculenta

H. Wajant, K. Pfizenmaier, F. Effenberger, 1996, Annals of the New York Academy of Sciences.

Coexpression of the human TNF receptors TR60 and TR80 in insect cells: analysis of receptor complex formation.

P. Scheurich, K. Pfizenmaier, E. Gerlach, 1994, Lymphokine and cytokine research.

Guided selection of antibody fragments specific for human interferon gamma receptor 1 from a human VH- and VL-gene repertoire.

K. Pfizenmaier, D. Moosmayer, H. Watzka, 1998, Immunotechnology : an international journal of immunological engineering.

Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells

R. Kontermann, K. Pfizenmaier, O. Seifert, 2018, Oncotarget.

Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses

P. Scheurich, B. Rouse, K. Pfizenmaier, 1982, The Journal of experimental medicine.

Improving TNF as a cancer therapeutic: Tailor‐made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects

H. Wajant, K. Pfizenmaier, Jeannette Gerspach, 2009, BioFactors.

Protein kinase C mu is located at the Golgi compartment

K. Pfizenmaier, J. Brenner, F. Johannes, 1996, The Journal of cell biology.

A Humanized Tumor Necrosis Factor Receptor 1 (TNFR1)-specific Antagonistic Antibody for Selective Inhibition of Tumor Necrosis Factor (TNF) Action

P. Scheurich, R. Kontermann, K. Pfizenmaier, 2008, Journal of immunotherapy.

Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family.

K. Pfizenmaier, David Edmund Szymkowski, 2011, Advances in experimental medicine and biology.

Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment.

D. Maier, K. Pfizenmaier, A. Preiss, 2006, Gene expression patterns : GEP.

Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy.

K. Pfizenmaier, J. Kalden, N. Hain, 1993, Journal of Clinical Investigation.

A Golgi PKD Activity Reporter Reveals a Crucial Role of PKD in Nocodazole‐Induced Golgi Dispersal

K. Pfizenmaier, A. Hausser, G. Bunt, 2009, Traffic.