A. Hoffbrand

G. Janossy, K. Ganeshaguru, A. Hoffbrand, 1979, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

TERMINAL DEOXYNUCLEOTIDYL-TRANSFERASE LEVELS AND MEMBRANE PHENOTYPES IN DIAGNOSIS OF ACUTE LEUKÆMIA

M. Greaves, D. Catovsky, G. Janossy, 1977, The Lancet.

Iron chelators induce apoptosis in proliferating cells

A. Hoffbrand, P. Panayiotidis, D. Hileti, 1995, British journal of haematology.

Biochemical Basis of Megaloblastosis

A. Hoffbrand, R. Wickremasinghe, 1989 .

Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis

A. Hoffbrand, C. Camaschella, C. Hershko, 2007 .

Purine degradative enzymes in circulating malignant cells of patients with chronic B cell neoplasia

A. Ho, A. Hoffbrand, W. Knauf, 1987, Hematological oncology.

5'nucleotidase, adenosine deaminase and purine nucleoside phosphorylase activities in acute leukaemia.

M. Greaves, H. Prentice, A. Hoffbrand, 1982, Leukemia research.

Antibody to hepatitis C virus in multiply transfused patients with thalassaemia major.

A. Hoffbrand, G. Dusheiko, David Brown, 1990, Journal of clinical pathology.

Reversal of desferrioxamine induced auditory neurotoxicity during treatment with Ca-DTPA.

A. Hoffbrand, B. Wonke, M. Aldouri, 1989, Archives of disease in childhood.

IMPROVEMENT IN IRON STATUS AND LIVER FUNCTION IN PATIENTS WITH TRANSFUSIONAL IRON OVERLOAD WITH LONG-TERM SUBCUTANEOUS DESFERRIOXAMINE

A. Hoffbrand, J. Economidou, M. Hussain, 1979, The Lancet.

Platelet function in beta-thalassaemia major.

A. Hoffbrand, R. Hutton, M. Hussain, 1979, Journal of clinical pathology.

Serum ferritin in megaloblastic anaemia.

A. Hoffbrand, M. Laulicht, S. Hussein, 2009, Scandinavian journal of haematology.

Value of serum ferritin estimation in sickle cell anaemia.

A. Hoffbrand, L. Davis, M. Hussain, 1978, Archives of disease in childhood.

Differential toxicity of α‐keto hydroxypyridine iron chelators and desferrioxamine to human haemopoietic precursors in vitro

A. Hunter, A. Hoffbrand, L. Sheppard, 1994, European journal of haematology.

5 Results of long-term subcutaneous desferrioxamine therapy

A. Hoffbrand, B. Wonke, 1989 .

Differentiation restriction in the neutrophil-granulocyte, macrophage, eosinophil-granulocyte pathway: analysis by equilibrium density centrifugation.

A. Hoffbrand, J. E. Guimarães, G. Francis, 1982, Leukemia research.

Blood product support in patients undergoing chemotherapy and autologous or allogeneic bone marrow transplantation for haematological malignancies.

H. Prentice, A. Hoffbrand, A. Mehta, 2008, Clinical and laboratory haematology.

Long‐term trial with the oral iron chelator 1,2‐dimethyl‐3‐hydroxypyrid‐4‐one (L1) I. IRON CHELATION AND METABOLIC STUDIES

A. Hoffbrand, A. Bartlett, G. Kontoghiorghes, 1990, British journal of haematology.

Hepatic iron clearance from serum in treated hemochromatosis

S. Sherlock, R. Batey, A. Hoffbrand, 1978 .

Effect of platelet-derived growth factor on enriched populations of haemopoietic progenitors from patients with chronic myeloid leukaemia.

J. Goldman, A. Hoffbrand, R. Michalevicz, 1987, Leukemia research.

Hyperinsulinism in iron overload

A. Hoffbrand, P. Dandona, D. Flynn, 1984, Diabetologia.

Non‐benign sickle cell anaemia in western Saudi Arabia

K. Ganeshaguru, A. Hoffbrand, J. Acquaye, 1985, British journal of haematology.

The human thymic microenvironment: an immunohistologic study.

A. McMichael, G. Janossy, G. Pizzolo, 1980, Journal of immunology.

Expression of c-fos and c-jun proteins and AP-1 binding activity during cell cycle progression of HL60 cells and phytohemagglutinin-stimulated lymphocytes.

A. Hoffbrand, D. Tay, G. Wickremasinghe, 1996, Experimental hematology.

Mycophenolate mofetil for the treatment of refractory auto‐immune haemolytic anaemia and auto‐immune thrombocytopenia purpura

A. Hoffbrand, A. Mehta, J. Howard, 2002, British journal of haematology.

Cell Surface and Enzyme Markers of Cord Blood Lymphocytes

R. Foà, D. Catovsky, K. Ganeshaguru, 1980, British journal of haematology.

The Effect of Androstanes on Granulopoiesis in Vitro and in Vivo

A. Hoffbrand, J. Berney, G. E. Francis, 1977, British journal of haematology.

Stimulation of Human Haemopoietic Cells by Colony Stimulating Factors: Adherent Cell Dependent Colony Stimulating Activity in Human Serum

A. Hoffbrand, G. Francis, J. Berney, 1977, British journal of haematology.

Platelet‐derived growth factor stimulates growth of highly enriched multipotent haemopoietic progenitors

G. Janossy, A. Hoffbrand, P. Stroobant, 1986, British journal of haematology.

Differential expression of TRAP Isoenzyme in B-CLL Cells Treated with Different Inducers.

R. Roberts, H. Drexler, A. Hoffbrand, 1990, Leukemia & lymphoma.

Terminal deoxynucleotidyl-transferase levels and membrane phenotypes in diagnosis of acute leukaemia.

M. Greaves, D. Catovsky, G. Janossy, 1977, Lancet.

A technique for rapid isolation of bone marrow mononuclear cells using Ficoll‐Metrizoate and the IBM 2991 blood cell processor

G. Janossy, H. Prentice, A. Hoffbrand, 1982, British journal of haematology.

ELIMINATION OF T‐LYMPHOCYTES FROM HUMAN BONE MARROW WITH MONOCLONAL T‐ANTIBODIES AND CYTOLYTIC COMPLEMENT

G. Janossy, A. Hoffbrand, H. Blacklock, 1982, British journal of haematology.

Deferiprone‐associated myelotoxicity

A. Hoffbrand, B. Wonke, F. Al‐Refaie, 1994, European journal of haematology.

1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE, AN ORALLY ACTIVE CHELATOR FOR TREATMENT OF IRON OVERLOAD

A. Hoffbrand, G. Kontoghiorghes, L. Sheppard, 1987, The Lancet.

Expression of the multidrug resistance-associated protein (MRP) in acute leukaemia.

K. Ganeshaguru, H. Prentice, A. Hoffbrand, 1994, Leukemia.

Results of long‐term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators

A. Hoffbrand, N. Olivieri, C. Hershko, 1995, British journal of haematology.

Enzyme and membrane markers in leukaemia: recent developments.

G. Janossy, A. Hoffbrand, 1981, Journal of clinical pathology.

Enzymeandmembrane markers inleukaemia: recent developments

G. Janossy, A. Hoffbrand, 1981 .

Terminal deoxynucleotidyl transferase activity in lymphoma.

J. Habeshaw, K. Ganeshaguru, A. Hoffbrand, 1979, British Journal of Cancer.

Intensive induction and consolidation chemotherapy for adults and children with acute myeloid leukaemia (AML) joint AML trial 1982-1985.

R. Marcus, D. Catovsky, J. Goldman, 1987, Haematology and blood transfusion.

Molecular detection of minimal residual disease in adult and childhood acute lymphoblastic leukaemia reveals differences in treatment response

L. Foroni, H. Prentice, A. Hoffbrand, 1997, Leukemia.

The binding of ligands to the 55 kDa component of the interleukin‐2 receptor triggers increased turnover of phosphate bound to an 85 kDa protein

A. Mire-Sluis, A. Hoffbrand, R. Wickremasinghe, 1989, FEBS letters.

Failure of purged autologous bone marrow transplantation in high risk acute lymphoblastic leukaemia in first complete remission.

A. Hunter, H. Prentice, A. Hoffbrand, 1991, Bone marrow transplantation.

Variable Philadelphia breakpoints and potential lineage restriction of bcr rearrangement in acute lymphoblastic leukemia

E. Coustan-Smith, J. Norton, A. Hoffbrand, 1988 .

Human large granular lymphocytes induce immunoglobulin synthesis after bone marrow transplantation

H. Prentice, A. Hoffbrand, M. Brenner, 1987, European journal of immunology.

DNA synthetic and degradative pathways in malignant lymphomas

A. Hoffbrand, A. Ho, 1985 .

The effect of the leukemic cell line HL60 and acute myeloblastic leukemic cells before and after induction of differentiation on normal pluripotent hematopoietic progenitors (CFU-GEMM).

A. Hoffbrand, R. Michalevicz, F. Katz, 1985, Leukemia research.

Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine.

A. Tefferi, A. Hoffbrand, J. Butterfield, 2004, Leukemia research.

FLAG-idarubicin and allogeneic stem cell transplantation for Ph-positive ALL beyond first remission

L. Foroni, H. Prentice, A. Hoffbrand, 1998, Bone Marrow Transplantation.

Alpha‐interferon (α‐IFN) protects B‐chronic lymphocytic leukaemia cells from apoptotic cell death in vitro

K. Ganeshaguru, A. Hoffbrand, P. Panayiotidis, 1994, British journal of haematology.

Rearrangement of TCR gamma chain gene involving JP1 suggests early thymocyte origin of peripheral T‐cell lymphoma

J. Norton, A. Hoffbrand, P. Amlot, 1989, European journal of haematology.

Mitogen treatment of permeabilized human T lymphocytes stimulates rapid tyrosine and serine phosphorylation of a 42 kDa protein

A. Hoffbrand, R. Wickremasinghe, A. Mire, 1986, FEBS letters.

The membrane phenotype of T-prolymphocytic leukaemia.

M. Greaves, D. Catovsky, E. Matutes, 2009, Scandinavian journal of haematology.

Homozygous protein C deficiency with delayed onset of symptoms at 7 to 10 months.

A. Hoffbrand, E. Tuddenham, Angela E. Thomas, 1989, Thrombosis research.

Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients.

A. Hoffbrand, B. Wonke, J. Cochrane, 1998, Blood.

Differential expression of MHC class II antigens in chronic B-cell disorders.

H. Drexler, G. Janossy, E. Coustan-Smith, 1988, Clinical and experimental immunology.

Recent Advances in the Understanding of Iron Metabolism and Iron-Related Diseases

A. Hoffbrand, 2009, Acta Haematologica.

The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation.

G. Janossy, A. Hoffbrand, D. Ma, 1983, Immunology today.

The ontogeny of terminal deoxynucleotidyl transferase positive cells in the human fetus.

G. Janossy, A. Hoffbrand, F. Bollum, 1983, Blood.

Anaemia in adult coeliac disease.

A. Hoffbrand, 1974, Clinics in gastroenterology.

Analysis of signal transduction in B chronic lymphocytic leukemia cells.

H. Drexler, E. Coustan-Smith, H. Drexler, 1988, Blood.

Phytohemagglutinin treatment of T lymphocytes stimulates rapid increases in activity of both particulate and cytosolic protein kinase C.

A. Hoffbrand, R. Wickremasinghe, A. Mire, 1986, Biochemical and biophysical research communications.

Natural killer cell activity following T‐cell depleted allogeneic bone marrow transplantation

C. Rooney, A. Hoffbrand, M. Brenner, 1986, British journal of haematology.

Effect of thymosin and phorbol ester on purine metabolic enzymes and cell surface phenotype in a malignant T-cell line (MOLT-3).

A. Hoffbrand, D. Ma, G. Price, 1983, Leukemia research.

USE OF ANTI-T-CELL MONOCLONAL ANTIBODY OKT3 TO PREVENT ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA

G. Janossy, H. Prentice, A. Hoffbrand, 1982, The Lancet.

Reactivity of Monoclonal Antibodies with Human Myeloid Precursor Cells

G. Janossy, H. Prentice, A. Hoffbrand, 1981, British journal of haematology.

Induction of tissue factor expression in human monocyte/endothelium cocultures

A. Hoffbrand, K. Pasi, K. Yong, 1995, British journal of haematology.

Pharmacokinetics of the oral iron chelator deferiprone (L1) in patients with iron overload

A. Hoffbrand, L. Sheppard, B. Wonke, 1995, British journal of haematology.

Do leukotrienes play a role in the regulation of proliferation of normal and leukemic hemopoietic cells?

A. Hoffbrand, R. Wickremasinghe, M. Khan, 1993, Prostaglandins, leukotrienes, and essential fatty acids.

"Pre-B" phenotypes in blast crisis of Ph1 positive CML: evidence for a pluripotential stem cell "target".

M. Greaves, M. Greaves, A. Hoffbrand, 1979, Leukemia research.

Inosine monophosphate dehydrogenase activity in acute leukaemia.

A. Hoffbrand, J. Evans, G. Price, 1987, Leukemia research.

The mechanisms of action of three fluorine substituted cytosine analogs: implications for cancer chemotherapy.

M. Tattersall, K. Ganeshaguru, A. Hoffbrand, 1974, Biochemical pharmacology.

Adenosine deaminase concentrations in leukaemia and lymphoma: relation to cell phenotypes.

J. Habeshaw, M. Greaves, D. Catovsky, 1981, Leukemia research.

DNA synthesis in isolated lymphocyte nuclei. Effects of megaloblastic anaemia due to folate or vitamin B-12 deficiency or antimetabolite drugs.

A. Hoffbrand, J. Hooton, 1977, Biochimica et biophysica acta.

Thymidine Kinase in Megaloblastic Anaemia

A. Hoffbrand, J. Hooton, A. V. Hoffbrand, 1976, British journal of haematology.

Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience

A. Hoffbrand, A. Taher, A. El‐Beshlawy, 2008, Annals of Hematology.

Deferiprone therapy for transfusional iron overload

A. Hoffbrand, 2005 .

Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in thalassemia major.

A. Hoffbrand, G. Kontoghiorghes, B. Wonke, 1992, Blood.

L1 (1,2‐dimethyl‐3‐hydroxypyrid‐4‐one) for oral iron chelation in patients with beta‐thalassaemia major

A. Hoffbrand, A. Hirt, G. Kontoghiorghes, 1990, British journal of haematology.

Ironstate andhepatic disease inpatients with thalassaemia major, treated withlongterm subcutaneous desferrioxamine

A. Hoffbrand, B. Wonke, M. Aldouri, 2011 .

The role of monoclonal antibodies in the prevention of graft versus host disease

G. Janossy, H. Prentice, A. Hoffbrand, 1984, Medical oncology and tumor pharmacotherapy.

Enzymes of purine metabolism in human peripheral lymphocyte subpopulations.

G. Janossy, A. Hoffbrand, D. Ma, 1982, Clinical and experimental immunology.

Adherent cell dependent colony-stimulating activity in human serum: A granulopoietic regulator?

A. Hoffbrand, G. Francis, V. Murray, 2009, Scandinavian journal of haematology.

and calcium ionophore lymphocytic leukemia cells during differentiation induced by phorbol ester Rapid expression of protooncogenes c-fos and c-myc in B-chronic

H. Drexler, A. Hoffbrand, M. Brenner, 2013 .

Rapid expression of protooncogenes c-fos and c-myc in B-chronic lymphocytic leukemia cells during differentiation induced by phorbol ester and calcium ionophore.

H. Drexler, A. Hoffbrand, M. Brenner, 1989, Blood.

Expression of tartrate‐resistant acid phosphatase in B‐CLL treated with phorbol ester or phorbol ester plus calcium ionophore

H. Drexler, A. Hoffbrand, M. Brenner, 1988, European journal of haematology.

Two major tyrosine protein kinases of resting human T lymphocytes are down‐regulated following mitotic stimulation

A. Hoffbrand, R. Wickremasinghe, B. Hall, 1987, FEBS letters.

Synergistic action of calcium ionophore A23187 and phorbol ester TPA on B-chronic lymphocytic leukemia cells.

H. Drexler, E. Coustan-Smith, A. Hoffbrand, 1987, Blood.

Interleukin-2 induces rapid phosphorylation of an 85 kilodalton protein in permeabilized lymphocytes.

A. Hoffbrand, R. Wickremasinghe, R. Michalevicz, 1985, Biochimica et biophysica acta.

Macrocytosis in alcohol-related liver disease: its value for screening.

S. Sherlock, A. Hoffbrand, M. Morgan, 1981, Clinical and laboratory haematology.

Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant hemopoietic cell lines.

A. Hoffbrand, R. Wickremasinghe, J. E. Tateson, 1993, Leukemia research.

Biochemical and immunological differentiation of human thymocytes induced by thymic hormones.

A. Hoffbrand, D. Ma, G. Price, 1983, Immunology.

Monoclonal Antibodies in Bone Marrow Transplantation

G. Janossy, H. Prentice, A. Hoffbrand, 1982 .

Terminal transferase positive cells in the human bone marrow and thymus.

G. Janossy, A. Hoffbrand, F. Bollum, 1982, Advances in experimental medicine and biology.

Antioxidants impair the coupling of cell-surface ligand receptors to the inositol lipid signalling pathway in human T lymphocytes but not in Jurkat T lymphoblastic leukemia cells. Evidence that leukotrienes are not involved in the coupling mechanism.

A. Hoffbrand, R. Wickremasinghe, J. Jeremy, 1993, Biochimica et biophysica acta.

Clinical trial of deferiprone iron chelation therapy in β‐thalassaemia/haemoglobin E patients in Thailand

A. Hoffbrand, S. Fucharoen, U. Kachintorn, 2003, British journal of haematology.

Genetic and acquired predisposing factors and treatment of osteoporosis in thalassaemia major.

A. Hoffbrand, J. Agnew, M. Lalloz, 1998, Journal of pediatric endocrinology & metabolism : JPEM.

High incidence of osteoporosis in thalassaemia major.

A. Hoffbrand, J. Agnew, R. Morris, 1998, Journal of pediatric endocrinology & metabolism : JPEM.

Iron chelation therapy

A. Hoffbrand, B. Wonke, 1997, Journal of internal medicine. Supplement.

The role of platelet-derived growth factor on human pluripotent progenitor (CFU-GEMM) growth in vitro.

A. Hoffbrand, R. Michalevicz, G. Francis, 1985, Leukemia research.

human fetus The ontogeny of terminal deoxynucleotidyl transferase positive cells in the

G. Janossy, A. Hoffbrand, F. Bollum, 2011 .

Distribution of terminal deoxynucleotidyl transferase and purine degradative and synthetic enzymes in subpopulations of human thymocytes.

G. Janossy, A. Hoffbrand, D. Ma, 1982, Journal of immunology.

Oxidative effects of iron on erythrocytes.

C. Rice-Evans, A. Hoffbrand, G. Kontoghiorghes, 1985, Free radical research communications.

Progressive Arterial Thrombosis in a Patient with Non-Hodgkin's Lymphoma, a Lupus Anticoagulant, Factor V Leiden Mutation and Paraprotein, Following Chemotherapy

A. Hoffbrand, D. Perry, B. Shaw, 2001, Leukemia & lymphoma.

Recovery of immurioglobulin isotypes following T‐cell depleted allogeneic bone marrow transplantation

G. Asherson, A. Hoffbrand, M. Brenner, 1986 .

Production of anti‐cytomegalovirus antibody following T‐cell depleted bone marrow transplant

H. Prentice, A. Hoffbrand, M. Brenner, 1986, British journal of haematology.

Regulation of transcription factors NFκB and AP‐1 following tumour necrosis factor‐α treatment of cells from chronic B cell leukaemia patients

A. Hoffbrand, R. Wickremasinghe, S. Jabbar, 1994 .

Interleukin-4 (IL-4) inhibits proliferation and spontaneous cytokine release by chronic lymphocytic leukaemia cells.

A. Hoffbrand, J. Reittie, 1994, Leukemia research.

Effects of anti‐TNF monoclonal antibody infusion in patients with hairy cell leukaemia

A. Hoffbrand, S. Stephens, M. Brenner, 1992, British journal of haematology.

Possible mechanism of action of interferon alpha in chronic B‐cell malignancies

H. Heslop, K. Ganeshaguru, A. Hoffbrand, 1991, British journal of haematology.

Alpha interferon therapy for haematological malignancies: correlation between in vivo induction of the 2′,5′ oligoadenylate system and clinical response

F. Giles, K. Ganeshaguru, A. Hoffbrand, 1990, British journal of haematology.

Delayed Induction of Proto-Oncogene Expression in B-CLL Cells by Tumor Necrosis Factor.

H. Heslop, H. Drexler, A. Hoffbrand, 1990, Leukemia & lymphoma.

Virological and serological diagnosis of cytomegalovirus infection in bone marrow allograft recipients

H. Prentice, A. Hoffbrand, D. Panjwani, 1985, Journal of medical virology.

Bone Marrow Transplantation in First CR of Acute Leukaemia using T-Depleted Marrow from HLA Identical Sibling Donors

G. Janossy, H. Prentice, A. Hoffbrand, 1986 .

Possible mechanism of selective killing of myeloid leukemic blast cells by lymphokine-activated killer cells.

H. Heslop, P. Veys, H. Prentice, 1991, Blood.

CLINICAL TRIALS WITH ORAL IRON CHELATOR L1

A. Hoffbrand, G. Kontoghiorghes, 1989, The Lancet.

Deletion of 13q14.3 and not 13q12 is the most common genetic abnormality detected in chronic lymphocytic leukemia cells.

L. Foroni, K. Ganeshaguru, A. Hoffbrand, 1997, Blood.

Prevention of urate nephropathy in the tumour lysis syndrome.

H. Prentice, A. Hoffbrand, N. O'connor, 1989, Clinical and laboratory haematology.

Long‐term trial with the oral iron chelator 1,2‐dimethy1‐3‐hydroxypyrid‐4‐one (L1) II. CLINICAL OBSERVATIONS

A. Hoffbrand, A. Bartlett, G. Kontoghiorghes, 1990, British journal of haematology.

Haem Synthesis in Sideroblastic Anaemia

A. Hoffbrand, L. Konopka, 1979, British journal of haematology.

Haem synthesis in sideroblastic anaemia.

A. Hoffbrand, L. Konopka, 1976, Ciba Foundation symposium.

CD5-positive B cells after T cell depleted bone marrow transplantation.

H. Drexler, G. Janossy, H. Prentice, 1987, Clinical and experimental immunology.

hematopoietic progenitor cells Surface antigenic determinants on human pluripotent and unipotent

A. Hoffbrand, M. Bodger, C. Izaguirre, 2011 .

Combination therapy with interferon alpha and ribavirin for chronic hepatitis C virus infection in thalassaemic patients

J. Garson, A. Hoffbrand, P. Grant, 1997, British journal of haematology.

Studies on long‐term T‐cell‐mediated immunity to epstein‐barr virus in immunosuppressed renal allograft recipients

G. Janossy, A. Hoffbrand, D. Crawford, 1981, International journal of cancer.

T Depletion Using MBG6 and RFT8 Monoclonal Antibody Combination and Complement Lysis Prevents Significant Acute and Chronic GvHD in HLA Matched Allogeneic Marrow Transplants

G. Janossy, H. Prentice, A. Hoffbrand, 1985 .

THERAPEUTIC SELECTIVITY OF AND PREDICTION OF RESPONSE TO 2'-DEOXYCOFORMYCIN IN ACUTE LEUKAEMIA

A. Piga, J. Smyth, N. Russell, 1981, The Lancet.

Transport of Methotrexate into Normal Haemopoietic Cells and into Leukaemic Cells and its Effects on DNA Synthesis

D. Catovsky, A. Hoffbrand, K. Das, 1973, British journal of haematology.

A novel delivery system for continuous desferrioxamine infusion in transfusional iron overload

A. MacDowell, A. Hoffbrand, B. Wonke, 1996, British journal of haematology.

Oral iron chelation.

A. Hoffbrand, 1996, Seminars in hematology.

LONG-TERM T-CELL-MEDIATED IMMUNITY TO EPSTEIN-BARR VIRUS IN RENAL-ALLOGRAFT RECIPIENTS RECEIVING CYCLOSPORIN A

G. Janossy, A. Hoffbrand, D. Crawford, 1981, The Lancet.

Differentiation of human acute myeloid leukaemia cells in response to exogenous and endogenous stimuli: different patterns of response suggested by a bioassay system.

A. Hoffbrand, J. E. Guimarães, G. Francis, 1985, Leukemia research.

Observations on the Biochemical Basis of Megaloblastic Anaemia

A. Hoffbrand, A. Waters, 1972, British journal of haematology.

Clonal growth of metastatic carcinoma of bronchus in bone marrow culture.

A. Hoffbrand, G. E. Francis, J. E. Broadbent, 1979, Blood.

Haematology at the Hammersmith Hospital and Royal Postgraduate Medical School 1934–1994

A. Hoffbrand, 2003, British journal of haematology.

Graft rejection following HLA matched T‐lymphocyte depleted bone marrow transplantation

J. Gribben, G. Janossy, J. Goldman, 1986, British journal of haematology.

Haematology at a Glance

Atul Mehta, A. V. Hoffbrand, A. Hoffbrand, 2000 .

Iron chelation therapy.

A. Hoffbrand, 2000, Current opinion in hematology.

Changes in transferrin saturation after treatment with the oral iron chelator deferiprone in patients with iron overload.

A. Hoffbrand, B. Wonke, C. E. de Silva, 1995, Journal of clinical pathology.

Zinc concentration in patients with iron overload receiving oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one or desferrioxamine.

A. Hoffbrand, Y. Aydinok, B. Wonke, 1994, Journal of clinical pathology.

Comparison of Three Methods for Measuring Vitamin B12 in Serum: Radioisotopic, Euglena gracilis and Lactobacillus leichmannii

A. Hoffbrand, J. L. Raven, J. Morgan, 1972, British journal of haematology.

Red cell aplasia following prolonged D-penicillamine therapy.

S. Sherlock, A. Hoffbrand, J. Gollan, 1976, Journal of clinical pathology.

Folate deficiency and neurological disease.

A. Hoffbrand, D. G. Wells, H. Grant, 1965, Lancet.

Platelet function inbeta-thalassaemi a major

A. Hoffbrand, R. Hutton, M. Hussain, 2011 .

Comparative study of iron mobilization from haemosiderin, ferritin and iron(III) precipitates by chelators.

A. Hoffbrand, G. Kontoghiorghes, S. Chambers, 1987, The Biochemical journal.

REMISSION INDUCTION WITH ADENOSINE-DEAMINASE INHIBITOR 2'-DEOXYCOFORMYCIN IN THY-LYMPHOBLASTIC LEUKÆMIA

G. Janossy, J. Smyth, K. Ganeshaguru, 1980, The Lancet.

Reduced rate of DNA replication fork movement in megaloblastic anemia.

A. Hoffbrand, R. Wickremasinghe, 1980, The Journal of clinical investigation.

Metabolism of thymine nucleotides synthesized via the 'de novo' mechanism in normal, megaloblastic and methotrexate-treated human cells and in a lymphoblastoid cell line.

A. Hoffbrand, R. Wickremasinghe, M. Taheri, 1981, The Biochemical journal.

The effect of external deoxyribonucleosides on deoxyribonucleoside triphosphate concentrations in human lymphocytes.

M. Tattersall, K. Ganeshaguru, A. Hoffbrand, 1975, Biochemical pharmacology.

Deoxyribonucleoside Triphosphates in Human Cells: Changes in Disease and Following Exposure to Drugs

K. Ganeshaguru, A. Hoffbrand, M. Tattersall, 1975, European journal of clinical investigation.

MULTIPLE IMMUNE COMPLEXES AND HYPOCOMPLEMENTÆMIA IN DERMATITIS HERPETIFORMIS AND CŒLIAC DISEASE

E. Holborow, A. Hoffbrand, B. Thompson, 1976, The Lancet.

Uptake of Vitamin B12 by Phytohaemagglutinin‐Transformed Lymphocytes

A. Hoffbrand, K. Das, E. Tripp, 1973, British journal of haematology.

METHYMALONIC ACIDURIA

A. Hoffbrand, D. Gompertz, 1970, British journal of haematology.

PARENTERAL ACYCLOVIR THERAPY FOR HERPESVIRUS INFECTIONS IN MAN

H. Prentice, A. Hoffbrand, T. Mcelwain, 1979, The Lancet.

Pyoderma gangrenosum outside the context of inflammatory bowel disease treated successfully with infliximab

A. Hoffbrand, M. Rustin, M. Saha, 2005, Clinical and experimental dermatology.

Microbial aspects of patients with leukaemia

A. Hoffbrand, 1978 .

E2A/HLF fusion cDNAs and the use of RT-PCR for the detection of minimal residual disease in t(17;19)(q22;p13) acute lymphoblastic leukemia.

D. Samson, L. Foroni, H. Prentice, 1994, Leukemia.

Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis.

A. Hoffbrand, R. Wickremasinghe, A. Mire-Sluis, 1987, Biochemical and biophysical research communications.

AGRANULOCYTOSIS AND THROMBOCYTOPENIA IN PATIENT WITH BLACKFAN-DIAMOND ANAEMIA DURING ORAL CHELATOR TRIAL

P. Veys, A. Hoffbrand, A. Bartlett, 1989, The Lancet.

10 Oral iron-chelating therapy: the L1 experience

A. Hoffbrand, F. Al‐Refaie, 1994 .

Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other alpha-ketohydroxypyridines.

A. Hoffbrand, A. Bartlett, G. Kontoghiorghes, 1989, Progress in clinical and biological research.

Effect of various iron chelating agents on DNA synthesis in human cells.

A. Cerami, K. Ganeshaguru, A. Hoffbrand, 1980, Biochemical pharmacology.

Orally active α‐ketohydroxy pyridine iron chelators intended for clinical use: in vivo studies in rabbits

A. Hoffbrand, G. Kontoghiorghes, 1986, British journal of haematology.

Megaloblastic anaemia.

A. Hoffbrand, 2021, Transactions of the Medical Society of London.

Terminal Transferase Enzyme Assay and Immunological Membrane Markers in the Diagnosis of Leukaemia: a Multiparameter Analysis of 300 Cases

T. Lister, M. Greaves, G. Janossy, 1980, British journal of haematology.

Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells.

H. Drexler, A. Hoffbrand, C. S. Scott, 1989, Blood.

Role of double-stranded RNA-activated protein kinase in human hematological malignancies.

K. Ganeshaguru, A. Hoffbrand, P. Panayiotidis, 1997, Cancer research.

Phytohemagglutinin-induced changes in tyrosine protein kinase and its endogenous substrates in human lymphocytes.

A. Piga, A. Hoffbrand, R. Wickremasinghe, 1985, Experimental cell research.

Tyrosine protein kinases and their substrates in human leukemia cells.

A. Piga, A. Hoffbrand, R. Wickremasinghe, 1985, Leukemia research.

Higher tyrosine protein kinase activity in resting lymphocytes than in proliferating normal or leukaemic blood cells.

A. Piga, A. Hoffbrand, R. Wickremasinghe, 1984, Biochemical and biophysical research communications.

DNA Synthesis in Thymic‐Acute Lymphoblastic Leukaemia

A. Piga, K. Ganeshaguru, A. Hoffbrand, 1981, British journal of haematology.

Retrogression in testicular seminoma with viable metastases

A. Hoffbrand, J. Azzopardi, 1965, Journal of clinical pathology.

Nucleotide metabolism and enzyme inhibitors in thymic acute lymphoblastic leukaemia.

A. Hoffbrand, D. Ma, H. G. Prentice, 1983, Haematology and blood transfusion.

Nucleoside incorporation into DNA and RNA in acute leukaemia: differences between the various leukaemia sub‐types

A. Piga, K. Ganeshaguru, H. Prentice, 1982, British journal of haematology.

Alternative metabolic fates of thymine nucleotides in human cells.

A. Hoffbrand, R. Wickremasinghe, M. Taheri, 1981, The Biochemical journal.

Subpopulations of normal and leukemic human thymocytes: an analysis with the use of monoclonal antibodies.

C. Milstein, A. McMichael, G. Janossy, 1980, Journal of the National Cancer Institute.

Thymidine concentrations in human sera: variations in patients with leukaemia and megaloblastic anaemia.

M. Tattersall, A. Hoffbrand, L. Holden, 1980, European journal of cancer.

Binding of G-CSF, GM-CSF, tumor necrosis factor-alpha, and gamma-interferon to cell surface receptors on human myeloid leukemia cells triggers rapid tyrosine and serine phosphorylation of a 75-Kd protein.

A. Hoffbrand, R. Wickremasinghe, J. Evans, 1990, Blood.

Lymphocyte Transformation in Megaloblastic Anaemia: Morphology and DNA Synthesis

A. Hoffbrand, K. Das, 1970, British journal of haematology.

Studies of Folate Uptake by Phytohaemagglutinin‐Stimulated Lymphocytes

A. Hoffbrand, K. Das, 1970, British journal of haematology.

HOFFBRAND'S ESSENTIAL HAEMATOLOGY

A. V. Hoffbrand, A. Hoffbrand, P. A. H. Moss, 2016 .

The role of serum ferritin in the management of idiopathic haemochromatosis.

S. Sherlock, A. Hoffbrand, R. Batey, 1978, Scandinavian journal of gastroenterology.

Serum ferritin levels in beta-thalassaemia trait.

A. Hoffbrand, E. Letsky, M. Laulicht, 1976, British medical journal.

Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human Cells

K. Ganeshaguru, A. Hoffbrand, J. Hooton, 1976, British journal of haematology.

Rapid down‐regulation of protein kinase C and membrane association in phorbol ester‐treated leukemia cells

D. Campana, A. Piga, A. Hoffbrand, 1985, FEBS letters.

Acid Phosphatase Isoenzyme Profiles in Acute and Chronic Leukemias.

H. Drexler, H. Quentmeier, A. Hoffbrand, 1991, Leukemia & lymphoma.

Retinoic acid-induced granulocytic differentiation of HL60 human promyelocytic leukemia cells is preceded by downregulation of autonomous generation of inositol lipid-derived second messengers.

A. Hoffbrand, R. Wickremasinghe, E. Porfiri, 1991, Blood.

macrophage progenitors to the macrophage lineage Role of ADP-ribosyl transferase in differentiation of human granulocyte-

A. Hoffbrand, G. Francis, J. Berney, 2011 .

DNA strand breakage and ADP-ribosyl transferase mediated DNA ligation during stimulation of human bone marrow cells by granulocyte-macrophage colony stimulating activity.

A. Ho, A. Hoffbrand, D. Ma, 1984, Leukemia research.

Relation of “lymphoid” phenotype and response to chemotherapy incorporating vincristine‐prednisolone in the acute phase of Ph1 positive leukemia

T. Lister, M. Greaves, G. Janossy, 1979, Cancer.

Thalassaemia intermedia: a new molecular basis

A. Hoffbrand, S. Thein, I. al-Hakim, 1984, British journal of haematology.

A and B blood group antigen expression on mixed colony cells and erythroid precursors: relevance for human allogeneic bone marrow transplantation

A. Hoffbrand, R. Michalevicz, H. Blacklock, 1984, British journal of haematology.

Serum Lysozyme and Vitamin B12 Binding Capacity in Myeloproliferative Disorders

D. Catovsky, A. Hoffbrand, L. Szur, 1971, British journal of haematology.

APAAP IMMUNOPHENOTYPING OF HAEMATOLOGICAL MALIGNANCIES

D. J. King, D. Campana, G. Janossy, 1986, The Lancet.

biochemical changes in circulating malignant cells in vivo Clinical response to deoxycoformycin in chronic lymphoid neoplasms and

K. Ganeshaguru, A. Hoffbrand, W. Knauf, 2011 .

Clinical response to deoxycoformycin in chronic lymphoid neoplasms and biochemical changes in circulating malignant cells in vivo.

K. Ganeshaguru, A. Hoffbrand, W. Knauf, 1988, Blood.

Potential use of purine nucleosides and enzyme inhibitors for selective depletion of Thy-lymphoblasts from human bone marrow.

N. Russell, A. Hoffbrand, A. Bellingham, 1986, Leukemia research.

Effects of DDMP and DDEP on the deoxyribonucleoside triphosphate concentrations in human cells.

K. Ganeshaguru, A. Hoffbrand, 1977, Biochemical pharmacology.

Solubilization and partial characterization of a multienzyme complex of DNA synthesis from human lymphoblastoid cells.

A. Hoffbrand, R. Wickremasinghe, J. Yaxley, 1982, European journal of biochemistry.

ABO-INCOMPATIBLE BONE-MARROW TRANSPLANTATION: REMOVAL OF RED BLOOD CELLS FROM DONOR MARROW AVOIDING RECIPIENT ANTIBODY DEPLETION

H. Prentice, A. Hoffbrand, D. Ma, 1982, The Lancet.

the microenvironment lymphocytic leukemia cells: potential for reversal of cytoprotection by cytotoxic agents induced by interleukin-4 treatment of chronic The JAK3-selective inhibitor PF-956980 reverses the resistance to

A. Hoffbrand, R. Wickremasinghe, A. Prentice, 2011 .

The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment.

A. Hoffbrand, R. Wickremasinghe, M. Lowdell, 2010, Blood.

Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro

L. Foroni, K. Ganeshaguru, A. Hoffbrand, 1996, British journal of haematology.

The Detection of Minimal Residual Disease in Acute Leukemia

L. Foroni, A. Hoffbrand, L. Coyle, 2020 .

Detection of minimal residual disease in ALL.

A. Hoffbrand, M. Deane, Victor Hoffbrand, 1993, Cancer treatment and research.

The effect of folate analogues and vitamin B12 on provision of thymine nucleotides for DNA synthesis in megaloblastic anemia.

A. Hoffbrand, R. Wickremasinghe, M. Taheri, 1982, Blood.

Correction of the DNA synthesis defect in vitamin B12 deficiency by tetrahydrofolate: evidence in favour of the methyl‐folate trap hypothesis as the cause of megaloblastic anaemia in vitamin B12 deficiency

A. Hoffbrand, B. Jackson, 1993, British journal of haematology.

THE METHYLFOLATE TRAP

A. Hoffbrand, 1975, The Lancet.

Biochemical and genetic control of apoptosis: relevance to normal hematopoiesis and hematological malignancies.

A. Hoffbrand, R. Wickremasinghe, 1999, Blood.

Multiple tyrosine protein kinases structurally related to p56 lck are down-regulated following mitogenic stimulation of human T lymphocytes.

A. Hoffbrand, R. Wickremasinghe, B. Hall, 1990, Biochemical and biophysical research communications.

Quantitative expression of G6PD activity of different phenotypes of G6PD and haemoglobin in a Sudanese population.

A. Hoffbrand, N. Saha, A. Omer, 1981, Human heredity.

Polymerase chain reaction (PCR)‐ and reverse transcription PCR‐based minimal residual disease detection in long‐term follow‐up of childhood acute lymphoblastic leukaemia

L. Foroni, A. Hoffbrand, P. Gameiro, 2002, British journal of haematology.

Okadaic acid‐induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl‐2 mRNA and downregulation of bcl‐2 protein

L. Foroni, A. Hoffbrand, A. Mehta, 1998, FEBS letters.

Appendix I: Normal Values

A. Green, D. Catovsky, A. Hoffbrand, 2010 .

The identification of mixed granulocytic-erythrocytic colonies in vitro.

A. Hoffbrand, G. Francis, J. Berney, 1984, Experimental hematology.

Multiparameter studies in lymphoid leukemias.

R. Foà, M. Greaves, D. Catovsky, 1979, American journal of clinical pathology.

Therapeutic and prognostic implications of glucocorticoid receptors and terminal deoxynucleotidyl transferase in acute leukemia.

A. Ho, K. Ganeshaguru, A. Hoffbrand, 1982, Leukemia research.

Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia

L. Foroni, A. Hoffbrand, C. Rowntree, 2002, Leukemia.

USE OF BONE-MARROW CULTURE IN PREDICTION OF ACUTE LEUKAEMIC TRANSFORMATION IN PRELEUKAEMIA

A. Hoffbrand, B. Wonke, J. Berney, 1983, The Lancet.

Unusual megaloblastic anaemia wiht multinucleate erythroblasts: two cases with septicaemia and acute renal failure.

A. Hoffbrand, M. Saary, W. Davies, 1975, Journal of clinical pathology.

Haem deficiency and chain synthesis

A. Hoffbrand, J. M. White, 1974, Nature.

Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation

H. Drexler, A. Hoffbrand, S. Gignac, 1990, European journal of immunology.

Use of the X-chromosome linked hypoxanthine phosphoribosyl transferase gene as a marker of cell monoclonality in hemopoietic malignancies.

J. Norton, A. Hoffbrand, P. Browett, 1988, Leukemia research.

Detection of Minimal Residual Disease in B-Lineage Leukemia by Immunoglobulin Gene Fingerprinting

J. Norton, A. Hoffbrand, H. G. Prentice, 1992 .

Circulating monoclonal B lymphocytes in multiple myeloma

A. Mehta, K. Ganeshaguru, A. Hoffbrand, 1989, British journal of haematology.

Terminal Transferase Expression in Relapsed Acute Myeloid Leukaemia

M. Chilosi, G. Pizzolo, K. Ganeshaguru, 1981, British journal of haematology.

The Role of Deferiprone in Iron Chelation.

A. Hoffbrand, R. Hider, 2018, The New England journal of medicine.

Recombinant interleukin 2 and anti-Tac influence the growth of enriched multipotent hemopoietic progenitors: proposed hypotheses for different responses in early and late progenitors.

D. Campana, G. Janossy, A. Hoffbrand, 1988, Leukemia research.

The inter- and intra-tribal distribution of red cell G6PD phenotypes in Sudan.

A. Hoffbrand, N. Saha, A. Omer, 1983, Human heredity.

The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro

M W Lowdell, J. North, K. Ganeshaguru, 2006, Leukemia.

Flow cytometric assessment of multidrug resistance (MDR) phenotype in acute myeloid leukaemia.

K. Ganeshaguru, H. Prentice, A. Hoffbrand, 1993, Leukemia & lymphoma.

Postgraduate Haematology: Hoffbrand/Postgraduate Haematology

A. Green, D. Catovsky, A. Hoffbrand, 2010 .

Agranulocytosis in a patient with thalassaemia major during treatment with the oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one.

P. Veys, A. Hoffbrand, B. Wonke, 1993, Acta haematologica.

Malignant plasma cells are sensitive to LAK cell lysis: pre‐clinical and clinical studies of interleukin 2 in the treatment of multiple myeloma

H. Heslop, A. Hoffbrand, M. Brenner, 1990, British journal of haematology.

Enzyme activities of leukemic cells and biochemical changes induced by deoxycoformycin in vitro--lack of correlation with clinical response.

K. Ganeshaguru, A. Hoffbrand, W. Knauf, 1989, Leukemia research.

Infection with Yersinia enterocolitica in patients with iron overload.

A. Hoffbrand, D. Politis, D. Flynn, 1986, British medical journal.

Diagnosing myocardial iron overload.

A. Hoffbrand, 2001, European heart journal.

The relative sensitivity of peripheral blood T-lymphocyte colony forming cells and bone marrow CFU-GM to deoxyadenosine and 2'deoxycoformycin.

N. Russell, A. Hoffbrand, J. Carron, 1985, Leukemia research.

A Technique for the Concentration of Nucleated Bone Marrow Cells for in vitro Manipulation or Cryopreservation Using the IBM 2991 Blood Cell Processor

H. Prentice, A. Hoffbrand, H. Blacklock, 1983, Vox sanguinis.

Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload.

S. Sherlock, A. Hoffbrand, D. Politis, 1982, Journal of clinical pathology.

Biochemical mechanisms of deoxycoformycin toxicity in chronic leukemias.

A. Piga, A. Ho, D. Catovsky, 1987, Leukemia research.

Enzymes of purine metabolism in hairy cell leukemia

A. Hoffbrand, R. Schwartz, A. Ho, 1986, Cancer.

Selective toxicity of purine nucleosides to human leukaemic cells.

A. Piga, K. Ganeshaguru, A. Hoffbrand, 1989, Advances in experimental medicine and biology.

Mechanisms of deoxyadenosine toxicity in human lymphoid cells in vitro: relevance to the therapeutic use of inhibitors of adenosine deaminase

A. Piga, R. Foà, N. Russell, 1984, British journal of haematology.

Increase in 2′,5′‐oligoadenylate synthetase caused by deoxycoformycin in hairy cell leukaemia

D. Catovsky, A. Mehta, C. Dearden, 1992, British journal of haematology.

Increase in 2',5'-oligoadenylate synthetase caused by deoxycoformycin in hairy cell leukaemia.

D. Catovsky, C. Dearden, K. Ganeshaguru, 1991, Advances in experimental medicine and biology.

Divergent sensitivities of leukaemic cells to human placental conditioned medium and leucocyte feeder layers.

A. Hoffbrand, G. Francis, J. Berney, 1980, Leukemia research.

Surface antigenic determinants on human pluripotent and unipotent hematopoietic progenitor cells.

A. Hoffbrand, H. Blacklock, M. Bodger, 1983, Blood.

High incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation.

A. Hoffbrand, J. Agnew, Andrew J.W. Hilson, 1990, Acta haematologica.

Arthropathy in thalassaemia patients receiving deferiprone

A. Hoffbrand, N. Olivieri, B. Wonke, 1994, The Lancet.

Results of long-term subcutaneous desferrioxamine therapy.

A. Hoffbrand, B. Wonke, 1989, Bailliere's clinical haematology.

DEFICIENCY OF DAF AND CD16 ON PNH NEUTROPHILS

A. Hoffbrand, J. Fehr, M. Bessler, 1990, British journal of haematology.

Iron deficiency and overload.

Ernest Beutler, J. Cook, A. Hoffbrand, 2003, Hematology. American Society of Hematology. Education Program.

Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis.

G. Janossy, A. Hoffbrand, D. Crawford, 1981, Clinical and experimental immunology.

Inability of poly-ADP-ribosylation inhibitors to protect peripheral blood lymphocytes from the toxic effects of ADA inhibition.

A. Piga, K. Ganeshaguru, A. Hoffbrand, 1989 .

TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW

H. Prentice, A. Hoffbrand, M. Brenner, 1986, The Lancet.

Sexual performance and fertility potential in patients with beta thalassemia major.

A. Hoffbrand, B. Bagni, V. De Sanctis, 1989, Progress in clinical and biological research.

Gamma-interferon and tumor necrosis factor production after bone marrow transplantation is augmented by exposure to marrow fibroblasts infected with cytomegalovirus.

H. Heslop, H. Prentice, A. Hoffbrand, 1990, Blood.

Analysis of Rejection in HLA Matched T-Depleted Bone Marrow Transplants

J. Gribben, G. Janossy, J. Goldman, 1985 .

Distinct T lymphocyte subsets affect granulo-monocytic differentiation and proliferation.

G. Janossy, A. Hoffbrand, N. Tidman, 1982, Stem cells.

Proceedings: Sideroblastic anaemia.

A. Hoffbrand, J. White, L. Konopka, 1974, British journal of haematology.

Subcutaneous desferrioxamine: the effect of three years' treatment on liver, iron, serum ferritin, and comments on echocardiography.

A. Hoffbrand, D. Politis, D. Flynn, 1982, Birth defects original article series.

The history of folic acid

A. Hoffbrand, D. Weir, 2001, British journal of haematology.

Result of the chromosomal anomaly

F. Behm, S. Raimondi, D. Samson, 1999 .

Recombinant alpha 2B interferon (IFN) in the treatment of chronic hepatitis C disease in thalassaemia major (TM).

A. Hoffbrand, P. Scheuer, G. Dusheiko, 1993, Bone marrow transplantation.

transcription-independent mechanism p53-mediated apoptosis of CLL cells: evidence for a

L. Vassilev, A. Hoffbrand, A. Prentice, 2013 .

p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism.

L. Vassilev, A. Hoffbrand, R. Wickremasinghe, 2008, Blood.

Base composition of normal and megaloblastic bone marrow DNA.

A. Hoffbrand, A. Pegg, 1972, Nature: New biology.

Thymidylate concentration in megaloblastic anaemia

M. Tattersall, K. Ganeshaguru, A. Hoffbrand, 1974, Nature.

Two new mutations in the HIF2A gene associated with erythrocytosis

M. McMullin, C. Harrison, A. Hoffbrand, 2012, American journal of hematology.

Pancreatic lipase in serum of patients with beta-thalassemia major.

A. Hoffbrand, P. Dandona, A. Katrak, 1983, Clinical chemistry.

Hypoparathyroidism and hypocalcaemia during treatment for acute leukaemia.

H. Prentice, A. Hoffbrand, P. Dandona, 1982, British medical journal.

Autocrine and paracrine growth loops in chronic lymphocytic leukemia.

K. Ganeshaguru, A. Hoffbrand, P. Panayiotidis, 1993, Seminars in hematology.

Nutritional and biochemical aspects of vitamin B12

A. Hoffbrand, 1979 .

Human leukocyte function‐associated antigens on lympho‐hemopoietic precursor cells

D. Campana, G. Janossy, A. Hoffbrand, 1986, European journal of immunology.

NITROUS OXIDE AND MEGALOBLASTOSIS: BIOCHEMICAL MECHANISM

A. Hoffbrand, E. Quadros, J. Linnell, 1978, The Lancet.

A comparison of histocompatibility antigens in dermatitis herpetiformis and adult coeliac disease

J. W. Kearney, A. Hoffbrand, J. Mowbray, 1976, The British journal of dermatology.

Effects of interferon-alpha (IFN) on the expression of interleukin 1-beta (IL-1), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF) in acute myeloid leukemia (AML) blasts.

K. Ganeshaguru, A. Hoffbrand, A. Mehta, 1992, Leukemia.

Human thymus/leukaemia-associated antigen (a low-molecular weight form of adenosine deaminase) and the phenotype of leukaemic cells.

M. Greaves, A. Hoffbrand, J. Rao, 1980, Leukemia research.

Pernicious Anaemia

A. Hoffbrand, 1983, Scottish medical journal.

Characterization of Hodgkin's disease derived cell line HDLM-2.

B. Leber, H. Drexler, H. Drexler, 1989, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Platelet monoamine oxidase activity in megaloblastic anaemia.

A. Hoffbrand, M. Sandler, V. Glover, 1980, Journal of clinical pathology.

nucleotides for DNA synthesis in megaloblastic anemia The effect of folate analogues and vitamin B12 on provision of thymine

Taheri, A. Hoffbrand, R. Wickremasinghe, 2011 .

The Effect of Deoxyuridine, Vitamin B12, Folate and Alcohol on the Uptake of Thymidine and on the Deoxynucleoside Triphosphate Concentrations in Normal and Megaloblastic Cells

K. Ganeshaguru, A. Hoffbrand, 1978, British journal of haematology.

ALPHA-INTERFERON THERAPY FOR ESSENTIAL THROMBOCYTHAEMIA

A. Mehta, F. Giles, A. Hoffbrand, 1988, The Lancet.

52Fe Studies of the Effects of Treatment on Erythropoiesis in Megaloblastic Anaemia

A. Hoffbrand, A. Bruce-Tagoe, M. Short, 1973, British journal of haematology.

Inhibition by aphidicolin and dideoxythymidine triphosphate of a multienzyme complex of DNA synthesis from human cells

A. Hoffbrand, R. Wickremasinghe, 1983, FEBS letters.

Recurrence of acute leukemia in donor cells after bone marrow transplantation: documentation by in situ DNA hybridization.

H. Prentice, A. Hoffbrand, M. Mouratidou, 1993, Bone marrow transplantation.

Indices of granulocyte activity in inflammatory bowel disease

A. Hoffbrand, G. Neale, S. Kane, 1974, Gut.

Immunological monitoring of residual disease in treated thymic acute lymphoblastic leukaemia.

G. Janossy, H. Prentice, A. Hoffbrand, 1981, Leukemia research.

Serum immunoreactive trypsin in beta-thalassaemia major.

A. Hoffbrand, P. Dandona, S. Fedail, 1981, Journal of clinical pathology.

Clinical haematology : Sandoz atlas

A. Hoffbrand, J. Pettit, 1988 .

Heterogeneous Blast Cell Crises in Philadelphia Negative Chronic Granulocytic Leukaemia

G. Janossy, A. Hoffbrand, B. Mcverry, 1981, British journal of haematology.

Color Atlas of Clinical Hematology

A. Hoffbrand, J. Pettit, 1994 .

Granulocyte-macrophage progenitor cell proliferation and differentiation.

A. Hoffbrand, G. Francis, J. Berney, 1983, Haematology and blood transfusion.

Relative and absolute deficiency of bone marrow endogenous colony stimulating activity in acute myeloid leukemia: relation to response to chemotherapy.

A. Hoffbrand, G. Francis, J. Berney, 1982, Leukemia research.

Response of neutropenia and anaemia to immunosuppressive therapy: report and bone marrow culture studies.

A. Hoffbrand, P. Kennedy, B. Hoffbrand, 2008, Clinical and laboratory haematology.

Stimulation of Human Haemopoietic Cells by Colony Stimulating Factors: Sensitivity of Leukaemic Cells

A. Hoffbrand, P. Chipping, J. Berney, 1979, British journal of haematology.

Defective DNA synthesis in megaloblastic anaemia. Studies employing velocity sedimentation in alkaline sucrose gradients.

A. Hoffbrand, R. Wickremasinghe, 1979, Biochimica et biophysica acta.

Conversion of partially single-stranded replicating DNA to double-stranded DNA is delayed in megaloblastic anaemia.

A. Hoffbrand, R. Wickremasinghe, 1980, Biochimica et biophysica acta.

Evidence that inositol phospholipids, but not choline phospholipids, are a potential source of growth-regulating second messenger molecules in HL60 leukaemia cells.

A. Hoffbrand, R. Wickremasinghe, E. Porfiri, 1993, Leukemia research.

Interferon 3' Inhibits Apoptotic Cell Death in B Cell Chronic Lymphocytic Leukemia

D. Campana, A. Hoffbrand, C. Richard, 2003 .

2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

Mark W Lowdell, Andrew J Steele, Anastasios Chanalaris, 2009, Blood.

Iron chelation with oral deferiprone in patients with thalassemia.

A. Hoffbrand, P. Telfer, B. Wonke, 1998, The New England journal of medicine.

Hepatic iron concentration combined with long‐term monitoring of serum ferritin to predict complications of iron overload in thalassaemia major

A. Hoffbrand, B. Wonke, S. Holden, 2000, British journal of haematology.

Immunofluorescent and Biochemical Studies of Terminal Deoxynucleotidyl Transferase in Treated Acute Leukaemia

G Janossy, G. Janossy, K. Ganeshaguru, 1981, British journal of haematology.

A myelokathexis‐like variant of myelodysplasia

A. Hoffbrand, P. Roderick, S. Rassam, 1989, European journal of haematology.

Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia

J. Norton, A. Hoffbrand, P. Browett, 1988, European journal of haematology.

INDUCTION OF IMMUNOLOGICAL UNRESPONSIVENESS BY MULTIPLE BLOOD TRANSFUSION IN URAEMIC PATIENTS

Z. Varghese, A. Hoffbrand, P. Sweny, 1981, The Lancet.

Importance of platelet-free preparations for evaluating lymphocyte nucleotide levels in inherited or acquired immunodeficiency syndromes.

H. Simmonds, A. Hoffbrand, A. Goday, 1983, Clinical science.

Induction of Noxa Via Generation of Reactive Oxygen Species Plays a Key Role in Induction of CLL Cell Apoptosis by Two Novel p53-Independent Cytotoxic Agents.

A. Hoffbrand, R. Wickremasinghe, A. Prentice, 2009 .

Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia

L. Foroni, A. Hoffbrand, M. Papaioannou, 1996, British journal of haematology.

Effect of Chronic Nutritional Iron Deficiency on the Small Intestinal Disaccharidase Activities of Growing Dogs∗

A. Hoffbrand, S. Broitman, 1969, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

The effects of deoxycoformycin and deoxyadenosine on deoxyribonucleotide concentrations in leukaemic cells

A. Piga, K. Ganeshaguru, A. Hoffbrand, 1982, British journal of haematology.

Purine degradative enzymes and immunological phenotypes in chronic B‐lymphocytic leukaemia: indications that leukaemic immunocytoma is a separate entity

B. Dörken, A. Ho, A. Hoffbrand, 1986, British journal of haematology.

Occurrence of particular isoenzymes in fresh and cultured leukemia‐lymphoma cells. III. Esterase isoenzyme in monocytes

G. Gaedicke, H. Drexler, A. Hoffbrand, 1987, Cancer.

LACK OF CLONAL BCRA2 GENE DELETION ON CHROMOSOME 13 IN CHRONIC LYMPHOCYTIC LEUKAEMIA: AN UPDATE OF RECENT SCIENTIFIC REPORTS

L. Foroni, A. Hoffbrand, P. Panayiotidis, 1998, British journal of haematology.

Appendix II: World Health Organization Classification of Tumours of the Haematopoietic and Lymphoid Tissues

A. Green, D. Catovsky, A. Hoffbrand, 2010 .

Deoxyribonucleoside triphosphate pools in human bone marrow and leukaemic cells.

M. Tattersall, K. Ganeshaguru, A. Hoffbrand, 1980, Antibiotics and chemotherapy.

Standardization of T‐cell depletion in HLA matched bone marrow transplantation

G. Janossy, A. Hoffbrand, S. Graphakos, 1986, British journal of haematology.

Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis

S. Sherlock, A. Hoffbrand, M. Morgan, 1982, Digestive Diseases and Sciences.

Heterogeneity of VH–JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL

L. Foroni, A. Hoffbrand, P. Gameiro, 2001, Leukemia.

Tyrosine protein kinase substrates in Philadelphia-positive human chronic granulocytic leukemia derived cell lines (K562 and BV173): detection by using an immunoblotting technique.

A. Hoffbrand, R. Wickremasinghe, J. Evans, 1987, Leukemia.

Serum vitamin B12 and transcobalamin levels in early HIV disease

A. Hoffbrand, W. Luck, C. Costello, 1994, American journal of hematology/oncology.

The influence of extent of resection, type of anastomosis, and ulcer site on the haematological side‐effects of gastrectomy

A. Hoffbrand, H. Johnson, 1970, The British journal of surgery.

Allogeneic bone marrow transplantation: the monitoring of granulocyte macrophage colonies following the collection of bone marrow mononuclear cells and after the subsequent in‐vitro cytolysis of OKT3 positive lymphocytes

G. Janossy, A. Hoffbrand, M. Gilmore, 1983, British journal of haematology.

Comparison of purine degradative enzymes and terminal deoxynucleotidyl transferase in T cell leukaemias and in normal thymic and post‐thymic T cells

A. Hoffbrand, M. Massaia, G. Price, 1983, British journal of haematology.

Esterase Isoenzyme Profiles in Acute and Chronic Leukemias.

H. Drexler, A. Hoffbrand, J. Minowada, 1991, Leukemia & lymphoma.

DETECTION OF LEUKÆMIC LYMPHOBLASTS IN CSF BY IMMUNOFLUORESCENCE FOR TERMINAL TRANSFERASE

G. Janossy, A. Hoffbrand, E. Papageorgiou, 1980, The Lancet.

Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells

A. Hoffbrand, A. Mehta, R. Wickremasinghe, 1998, Oncogene.

Studies on the Biochemical Sequelae of Therapy in Thy‐Acute Lymphoblastic Leukaemia with the Adenosine Deaminase Inhibitor 2’Deoxycoformycin

A. Piga, J. Smyth, K. Ganeshaguru, 1981, British journal of haematology.

The effect of deferiprone (L1) and desferrioxamine on myelopoiesis using a liquid culture system

A. Hoffbrand, B. Wonke, S. Wilkes, 1994, British journal of haematology.

Research conduct and the case of Nancy Olivieri

A. Hoffbrand, 2005, The Lancet.

Paraneoplastic pemphigus associated with systemic mastocytosis

A. Hoffbrand, M. Rustin, C. McNamara, 2009, American journal of hematology.

Inactivation of calcium ion-regulating inositol polyphosphate second messengers is impaired in subpopulations of human leukemia cells.

A. Hoffbrand, R. Wickremasinghe, K. Nye, 1994, Leukemia.

Defective spectrin dimer–dimer association in a family with transfusion dependent homozygous hereditary elliptocytosis

A. Hoffbrand, A. Baines, I. Hann, 1983, British journal of haematology.

Oral iron-chelating therapy: the L1 experience.

A. Hoffbrand, F. Al‐Refaie, 1994, Bailliere's Clinical Haematology.

Rearrangement and expression of T cell antigen receptor genes in B cell chronic lymphocytic leukemia

J. Norton, A. Hoffbrand, A. V. Hoffbrand, 1988 .

Folate uptake by lymphocytes.

A. Hoffbrand, K. Das, 1969, British journal of haematology.

Serum ferritin and binding of serum ferritin to concanavalin A as a tumor marker in patients with primary liver cell cancer and chronic liver disease

S. Sherlock, A. Hoffbrand, M. Bassendine, 1982, Digestive Diseases and Sciences.

Hepatic iron clearance from serum in treated hemochromatosis.

S. Sherlock, A. Hoffbrand, R. Batey, 1978, Gastroenterology.

Endogenously generated activated killer cells circulate after autologous and allogeneic marrow transplantation but not after chemotherapy.

H. Heslop, H. Drexler, H. Drexler, 1989, Blood.

Cardiac complications in homozygous beta-thalassemia.

A. Hoffbrand, B. Wonke, M. Aldouri, 1989, Progress in clinical and biological research.

Differential cytotoxicity of deoxyguanosine and 8‐aminoguanosine for human leukemic cell lines and normal bone marrow progenitor cells

A. Hoffbrand, R. Michalevicz, D. Gray, 1984, Hematological oncology.

Multidrug Resistance in Acute Leukaemia: A Comparative Study of Immunocytochemical and RNA Slot Blot Detection of P-glycoprotein Expression.

K. Ganeshaguru, H. Prentice, A. Hoffbrand, 1991, Leukemia & lymphoma.

Combined therapy with deferiprone and desferrioxamine

Wright, A. Hoffbrand, Hoffbrand, 1998, British journal of haematology.

Folic acid fortification in the prevention of neural tube defects.

M. Law, N. Wald, A. Hoffbrand, 2004, The American journal of clinical nutrition.

Terminal Differentiation of Cord Blood Lymphocytes Induced by Thymosin Fraction 5 and Thymosin Alpha1

A. Hoffbrand, A. Ho, W. Hunstein, 1985, Scandinavian journal of immunology.

Purine degradative enzymes in the malignant cells of patients with B-cell leukemia

B. Dörken, A. Hoffbrand, W. Hunstein, 1985 .

Binding of serum ferritin to concanavalin A in patients with iron overload and with chronic liver disease.

S. Sherlock, A. Hoffbrand, M. Hussain, 1982, Journal of clinical pathology.

Investigation of psychotropic drug-induced blood agranulocytosis

A. Hoffbrand, S. Wilkes, P. Veys, 1992, Journal of psychopharmacology.

Clone size potential and sensitivity to colony-stimulating activity: differentiation-linked properties of granulocyte-macrophage progenitor cells.

A. Hoffbrand, G. Francis, M. Bodger, 1981, Stem cells.

Rapid recovery of helper activity following T cell depleted allogeneic marrow transplant.

H. Drexler, H. Prentice, A. Hoffbrand, 1987, Clinical and experimental immunology.

Indices ofgranulocyte activity ininflammatory bowel disease

A. Hoffbrand, G. Neale, 1974 .

Deoxycoformycin in the Treatment of Leukemias and Lymphomas a

J. Smyth, A. Hoffbrand, H. G. Prentice, 1985, Annals of the New York Academy of Sciences.

Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload.

S. Sherlock, A. Hoffbrand, D. Politis, 1982, Journal of clinical pathology.

Significance of Large Red Blood Cells

A. Hoffbrand, I. Chanarin, J. England, 1973, British journal of haematology.