R. Wange

发表

Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN.

M. Seminario, R. Wange, 2002, Seminars in immunology.

T Cell Receptor Signaling: Beyond Complex Complexes*

Yanping Huang, R. Wange, Yanping Huang, 2004, Journal of Biological Chemistry.

Involvement of Hematopoietic Progenitor Kinase 1 in T Cell Receptor Signaling*

M. C. Hu, P. Ling, M. Hu, 2001, The Journal of Biological Chemistry.

Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.

Jongsun Park, R. Wange, Y. Volkov, 2007, Cellular signalling.

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

P. Schwartzberg, R. Wange, Yusen Liu, 2000, Molecular and Cellular Biology.

An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs).

D. Mendrick, Jackye Peretz, R. Wange, 2020, Regulatory toxicology and pharmacology : RTP.

Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line

R. Abraham, L. Samelson, R. Wange, 1998, Molecular and Cellular Biology.

Complex complexes: signaling at the TCR.

L. Samelson, R. Wange, 1996, Immunity.

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70 (*)

R. Aebersold, J. Watts, L. Samelson, 1995, The Journal of Biological Chemistry.

Purification and Characterization of Human ZAP-70 Protein-tyrosine Kinase from a Baculovirus Expression System*

R. Aebersold, J. Watts, L. Samelson, 1996, The Journal of Biological Chemistry.

PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression

M. Gorospe, M. Seminario, R. Wange, 2003, Oncogene.

Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T Cells*

R. Wange, J. Martindale, Yanping Huang, 2005, Journal of Biological Chemistry.

IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making

Shruti V. Kabadi, Nisha S. Sipes, J. Wambaugh, 2022, Toxics.

The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: study design, data analysis, interpretation.

H. Ochs, H. Lebrec, R. Wange, 2014, Regulatory toxicology and pharmacology : RTP.

Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment*

R. Wange, Xiaochuan Shan, 1999, The Journal of Biological Chemistry.

The T cell antigen receptor tyrosine kinase pathway.

P. Thomas, L. Samelson, R. Wange, 1992, Advances in experimental medicine and biology.

ZAP-70 and SLP-76 Regulate Protein Kinase C-θ and NF-κB Activation in Response to Engagement of CD3 and CD28

R. Wange, G. Tsokos, Xiaochuan Shan, 2001, The Journal of Immunology.

phosphatase activity of tumor suppressor PTEN Negative regulation of CXCR4-mediated chemotaxis by the lipid

R. Wange, P. Gao, J. Oppenheim, 2013 .

A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor.

A. Kong, L. Samelson, R. Wange, 1992, The Journal of biological chemistry.

ZAP-70-dependent and -independent Activation of Erk in Jurkat T Cells

R. Wange, Weiguo Zhang, C. E. Griffith, 1998, The Journal of Biological Chemistry.

Electrospray Ionization Mass Spectrometric Investigation of Signal Transduction Pathways: Determination of Sites of Inducible Protein Phosphorylation in Activated T Cells

R. Aebersold, M. Affolter, J. Watts, 1996 .

CD28 Regulates the Translation of Bcl-xL via the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Pathway1

K. Okkenhaug, T. Mak, R. Wange, 2005, The Journal of Immunology.

CD 28 Regulates the Translation of Bcl-xL via the Phosphatidylinositol 3-Kinase / Mammalian Target of Rapamycin Pathway 1

K. Okkenhaug, T. Mak, R. Wange, 2004 .

Lipid phosphatases in the regulation of T cell activation: living up to their PTEN‐tial

M. Seminario, R. Wange, 2003, Immunological reviews.

Receptors Ly-49 D and Inhibitory Ly-49 G 2 NK Structure / Function Relationship of Activating McVicar

S. Anderson, R. Wange, J. Ortaldo, 1999 .

Structure/function relationship of activating Ly-49D and inhibitory Ly-49G2 NK receptors.

S. Anderson, R. Wange, J. Ortaldo, 1999, Journal of immunology.

Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN

M. Seminario, R. Wange, R. Wernyj, 2005, Oncogene.

Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton1

N. Caplen, P. Schwartzberg, R. Wange, 2005, The Journal of Immunology.

Actin Cytoskeleton TCR-Induced Regulation of Vav and the Kinase-Independent Functions for Itk in

N. Caplen, P. Schwartzberg, R. Wange, 2005 .

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

L. Samelson, W. Langdon, R. Wange, 1994, The Journal of biological chemistry.

ZAP-70-Independent Ca2+ Mobilization and Erk Activation in Jurkat T Cells in Response to T-Cell Antigen Receptor Ligation

M. Seminario, R. Wange, J. Madrenas, 2001, Molecular and Cellular Biology.

Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteins.

P. Sternweis, R. Wange, J. Exton, 1991, The Journal of biological chemistry.

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.

J. O’Shea, R. Wange, P. Changelian, 1997, Proceedings of the National Academy of Sciences of the United States of America.

TCR Signaling: Another Abl-Bodied Kinase Joins the Cascade

R. Wange, 2004, Current Biology.

Identification and characterization of a substrate specific for the T cell protein tyrosine kinase ZAP‐70

R. Aebersold, J. Watts, L. Samelson, 1996, FEBS letters.

Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.

R. Aebersold, M. Affolter, J. Watts, 1994, The Journal of biological chemistry.

Membrane Raft-Dependent Regulation of Phospholipase Cγ-1 Activation in T Lymphocytes

I. Reischl, B. Rellahan, M. Seminario, 2001, Molecular and Cellular Biology.

PTEN permits acute increases in D3‐phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt

D. Taub, M. Seminario, R. Wange, 2004, European journal of immunology.

LAT, the Linker for Activation of T Cells: A Bridge Between T Cell-Specific and General Signaling Pathways

R. Wange, 2000, Science's STKE.

The role of tyrosine kinases and phosphotyrosine‐containing recognition motifs in regulation of the T cell‐antigen receptor‐mediated signal transduction pathway

L. Samelson, R. Wange, N. Isakov, 1994, Journal of leukocyte biology.

Specific CD3 epsilon association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation.

R. Wange, J. Madrenas, T. Torphy, 1999, Journal of immunology.

Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.

R. Wange, P. Gao, J. Oppenheim, 2005, Blood.

F(Pmp)-TAM, a Novel Competitive Inhibitor of the Binding of ZAP-70 to the T Cell Antigen Receptor, Blocks Early T Cell Signaling (*)

R. Aebersold, J. Watts, P. Roller, 1995, The Journal of Biological Chemistry.

Signal Transduction Mediated by the T‐Cell Antigen Receptor

L. Samelson, R. Wange, J. Donovan, 1995, Annals of the New York Academy of Sciences.

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity

R. Aebersold, J. Watts, L. Samelson, 1995, The Journal of experimental medicine.

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

S. Malek, S. Desiderio, L. Samelson, 1993, The Journal of biological chemistry.

Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.

R. Wange, C. Lynch, P. Blackmore, 1989, The Journal of clinical investigation.

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

Benjamin S. Freedman, J. Polli, S. Heyward, 2021, Clinical and translational science.

Implementation of the Principles of the 3Rs of Animal Testing at CDER: Past, Present and Future.

R. Wange, Paul C. Brown, K. Davis-Bruno, 2021, Regulatory toxicology and pharmacology : RTP.

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

L. Samelson, R. Wange, J. Madrenas, 1995, Science.

FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations.

R. Wange, W. Halpern, T. Bourcier, 2022, Regulatory toxicology and pharmacology : RTP.