B. Fleckenstein

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Promoter 1-Dependent Domains in the CD 95 Ligand Positive Regulatory IFN-Regulatory Factor Activation-Induced Cell Death Via Two Viral IFN-Regulatory Factors Inhibit

E. Meinl, P. Krammer, M. Li‐Weber, 2002 .

Viral IFN-Regulatory Factors Inhibit Activation-Induced Cell Death Via Two Positive Regulatory IFN-Regulatory Factor 1-Dependent Domains in the CD95 Ligand Promoter1

Sven Baumann, Andreas Krueger, Edgar Meinl, 2002, The Journal of Immunology.

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells

B. Fleckenstein, Sebastian Millen, Lina Meretuk, 2020, Retrovirology.

Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins

N. Jones, C. Swanton, G. Peters, 1997, Nature.

Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri.

R. Desrosiers, B. Fleckenstein, J. Jung, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The Product of the Herpesvirus saimiri Open Reading Frame 1 (Tip) Interacts with T Cell-specific Kinase p56lck in Transformed Cells (*)

F. Emmrich, B. Fleckenstein, J. Bolen, 1995, The Journal of Biological Chemistry.

Alternative NF-κB Signaling Discriminates Induction of the Tumor Marker Fascin by the Viral Oncoproteins Tax-1 and Tax-2 of Human T-Cell Leukemia Viruses

B. Fleckenstein, Andrea K. Thoma-Kress, C. Mohr, 2022, Cancers.

Immortalization of human T cells by Herpesvirus saimiri.

R. Hohlfeld, E. Meinl, H. Wekerle, 1995, Immunology today.

Cell Surface Heparan Sulfate Is a Receptor for Human Herpesvirus 8 and Interacts with Envelope Glycoprotein K8.1

F. Neipel, B. Fleckenstein, A. Ensser, 2001, Journal of Virology.

Herpesvirus Saimiri Transforms Human T-Cell Clones to Stable Growth without Inducing Resistance to Apoptosis

J. Tschopp, E. Meinl, B. Fleckenstein, 1998, Journal of Virology.

Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture

J. Sodroski, W. Haseltine, B. Fleckenstein, 1992, Journal of virology.

Cell Surface Markers in HTLV-1 Pathogenesis

B. Fleckenstein, Andrea K. Kress, R. Grassmann, 2011, Viruses.

Interactions between autologous CD4+ and CD8+ T lymphocytes and human squamous cell carcinoma of the head and neck.

T. Whiteside, B. Fleckenstein, S. Yasumura, 1997, Cellular immunology.

NF‐κB activation by the viral oncoprotein StpC enhances IFN‐γ production in T cells

B. Fleckenstein, B. Biesinger, N. Isakov, 2008, Immunology and cell biology.

Cytokine Dependence of Human to Mouse Graft‐versus‐Host Disease

B. Fleckenstein, H. Fickenscher, B. Hart, 1994, Scandinavian journal of immunology.

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

D. Chaussabel, J. Casanova, P. Li, 2018, Science Immunology.

The tumor marker Fascin is induced by the Epstein-Barr virus-encoded oncoprotein LMP1 via NF-κB in lymphocytes and contributes to their invasive migration

B. Fleckenstein, A. Kieser, M. Kalmer, 2014, Cell Communication and Signaling.

Species restriction of Herpesvirus saimiri and Herpesvirus ateles: human lymphocyte transformation correlates with distinct signaling properties of viral oncoproteins.

B. Fleckenstein, I. Müller-Fleckenstein, S. J. de Jong, 2012, Virus research.

Tyrosine Phosphorylation of the Tio Oncoprotein Is Essential for Transformation of Primary Human T Cells

B. Fleckenstein, I. Müller-Fleckenstein, Monika Schmidt, 2005, Journal of Virology.

Herpesvirus saimiri Replaces ZAP-70 for CD3- and CD2-mediated T Cell Activation*

T. Derfuss, E. Meinl, B. Fleckenstein, 2001, The Journal of Biological Chemistry.

NFκB Signaling Is Induced by the Oncoprotein Tio through Direct Interaction with TRAF6*

B. Fleckenstein, B. Biesinger, J. Albrecht, 2006, Journal of Biological Chemistry.

Transduction of Herpesvirus saimiri‐Transformed T Cells with Exogenous Genes of Interest

J. Casanova, B. Fleckenstein, J. Markle, 2016, Current protocols in immunology.

Peptides Derived from a Distinct Region of GB Virus C Glycoprotein E2 Mediate Strain-Specific HIV-1 Entry Inhibition

B. Fleckenstein, Kristin Eissmann, Holger Wend, 2011, Journal of Virology.

Growth transformation of antigen-specific T cell lines from rhesus monkeys by herpesvirus saimiri.

R. Hohlfeld, E. Meinl, R. de Waal Malefyt, 1997, Virology.

Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys.

E. Meinl, R. Bontrop, R. de Waal Malefyt, 1995, International immunology.

The Monoclonal Antibody 6B9 Recognizes CD44 and Not Cell Surface Transglutaminase 2

F. Lund-Johansen, L. Sollid, B. Fleckenstein, 2008, Scandinavian journal of immunology.

EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency

A. Borkhardt, U. Fischer, B. Fleckenstein, 2018, Front. Immunol..

A novel homozygous Fas ligand mutation leads to early protein truncation, abrogation of death receptor and reverse signaling and a severe form of the autoimmune lymphoproliferative syndrome.

A. Borkhardt, M. Kuhlen, U. Fischer, 2014, Clinical immunology.

CD2-mediated Autocrine Growth of Herpes Virus Saimiri-tranfformed Human T Lymphocytes By Hans-Willi Mittr/icker, Ingrid Mfiller-Fleckenstein,*

B. Fleckenstein, B. Fleischer, 1992 .

Polyclonal B cell activation induced by herpesvirus saimiri-transformed human CD4+ T cell clones. Role for membrane TNF-alpha/TNF-alpha receptors and CD2/CD58 interactions.

M. de Carli, M. D’Elios, B. Fleckenstein, 1994, Journal of immunology.

Activation induces apoptosis in Herpesvirus saimiri‐transformed T cells independent of CD95 (Fas, APO‐1)

E. Meinl, B. Fleckenstein, B. Fleischer, 1997, European journal of immunology.

Engagement of the CD4 receptor inhibits the interleukin‐2‐dependent proliferation of human T cells transformed by Herpesvirus saimiri

F. Emmrich, B. Fleckenstein, J. Bolen, 1994, European journal of immunology.

Antioxidants Selectively Suppress Activation ofNF-idB by HumanT-Cell Leukemia Virus TypeITaxProtein

B. Fleckenstein, R. Schreck, R. Grassmann, 1992 .

A pair of selectable herpesvirus vectors for simultaneous gene expression in human lymphoid cells.

B. Fleckenstein, M. Alt, R. Grassmann, 1991, Gene.

In vitro binding of human T-cell leukemia virus rex proteins to the rex-response element of viral transcripts

C. Ballaun, B. Fleckenstein, S. Berchtold, 1991, Journal of virology.

Signaling lymphocytic activation molecule (SLAM) regulates T cellular cytotoxicity

T. Derfuss, E. Meinl, B. Fleckenstein, 2001, European journal of immunology.

KSHV-infected primary effusion lymphoma cells The viral interferon regulatory factor-3 is required for the survival of

E. Kremmer, F. Neipel, B. Fleckenstein, 2013 .

The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells.

E. Kremmer, F. Neipel, B. Fleckenstein, 2008, Blood.

Karyotypic characterization of human T‐cell lines immortalized by Herpesvirus saimiri

F. Emmrich, B. Fleckenstein, H. Fickenscher, 1994, International journal of cancer.

Revisiting Human IL-12R&bgr;1 Deficiency: A Survey of 141 Patients From 30 Countries

Smita Y. Patel, A. Al-ghonaium, Sami Al-Hajjar, 2010, Medicine.

Inherited human IFNγ deficiency underlies mycobacterial disease.

J. Casanova, R. Geha, W. Al-Herz, 2020, The Journal of clinical investigation.

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

J. Casanova, A. Sette, S. Tangye, 2018, Science Immunology.

Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant

J. Casanova, H. Ochs, S. Tangye, 2018, Science Immunology.

T-Cell Growth Transformation by Herpesvirus Saimiri Is Independent of STAT3 Activation

B. Fleckenstein, A. Ensser, I. Müller-Fleckenstein, 2005, Journal of Virology.

Ingrid STAT 3 Activation Herpesvirus Saimiri Is Independent of T-Cell Growth Transformation

B. Fleckenstein, A. Ensser, I. Müller-Fleckenstein, 2005 .

Herpesvirus Ateles Gene Product Tio Interacts with Nonreceptor Protein Tyrosine Kinases

S. Feller, B. Fleckenstein, B. Biesinger, 1999, Journal of Virology.

The superantigen-homologous viral immediate-early gene ie14/vsag in herpesvirus saimiri-transformed human T cells

B. Fleckenstein, H. Hofmann, H. Fickenscher, 1997, Journal of virology.

Dominant clones in immortalized T-cell lines from rheumatoid arthritis synovial membranes.

B. Fleckenstein, M. Thomsen, A. Cantagrel, 1997, Tissue antigens.

Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus Saimiri

E. Meinl, B. Fleckenstein, H. Fickenscher, 1997, Journal of virology.

Functional Phenotype of Transformed Human aband gdT Cells Determined by Different Subgroup C Strains of Herpesvirus Saimiri

E. Meinl, B. Fleckenstein, H. Fickenscher, 1997 .

Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes

B. Fleckenstein, H. Fickenscher, B. Biesinger, 1996, Journal of virology.

Viral transformation of human T lymphocytes.

R. Desrosiers, B. Fleckenstein, R. Grassmann, 1994, Advances in cancer research.

Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease

A. Borkhardt, M. Kuhlen, U. Fischer, 2015, Haematologica.

Cell type-specific induction of the major immediate early enhancer of human cytomegalovirus by cyclic AMP.

B. Fleckenstein, T. Stamminger, H. Fickenscher, 1990, The Journal of general virology.

Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein

B. Fleckenstein, P. Baeuerle, P A Baeuerle, 1992, Journal of virology.

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood

J. Casanova, E. Cesarman, C. Picard, 2013, The Journal of experimental medicine.

TUMOR VIRUSES – HUMAN

H. Pfister, B. Fleckenstein, R. Grassmann, 2008 .

Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor

K. Ozato, F. Neipel, B. Fleckenstein, 1998, Journal of Virology.

Chemokine receptors and chemokine-inducing molecules of lymphotropic herpesviruses.

E. Meinl, B. Fleckenstein, H. Fickenscher, 1996, Immunology today.

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

J. Casanova, L. Notarangelo, E. Crestani, 2016, The Journal of experimental medicine.

Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24

A. Borkhardt, B. Kempkes, B. Fleckenstein, 2016, Journal of Clinical Immunology.

Anti-apoptotic strategies of lymphotropic viruses.

E. Meinl, B. Fleckenstein, J. Tschopp, 1998, Immunology today.

Antiapoptotic Activity of the Herpesvirus Saimiri-Encoded Bcl-2 Homolog: Stabilization of Mitochondria and Inhibition of Caspase-3-Like Activity

T. Derfuss, E. Meinl, B. Fleckenstein, 1998, Journal of Virology.

Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.

A. Schäffer, U. Kölsch, T. Jakob, 2014, The Journal of allergy and clinical immunology.

High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

J. Casanova, A. Bousfiha, S. Tangye, 2021, The Journal of experimental medicine.

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

D. Chaussabel, J. Casanova, A. Bousfiha, 2015, The Journal of experimental medicine.

Selectable recombinant herpesvirus saimiri is capable of persisting in a human T-cell line

B. Fleckenstein, R. Grassmann, 1989, Journal of virology.

Physical mapping of human cytomegalovirus genes: Identification of DNA sequences coding for a virion phosphoprotein of 71 kDa and a viral 65-kDa polypeptide

A. Levine, P. Sarnow, B. Fleckenstein, 1984, Virology.

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

J. Sodroski, W. Haseltine, B. Fleckenstein, 1989, Proceedings of the National Academy of Sciences of the United States of America.

ZNF341 controls STAT3 expression and thereby immunocompetence

A. Schäffer, J. Casanova, C. Bossen, 2018, Science Immunology.

Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation

B. Fleckenstein, Andrea K. Thoma-Kress, H. Sticht, 2021, International journal of molecular sciences.

The transcription elongation factor ELL2 is specifically upregulated in HTLV-1-infected T-cells and is dependent on the viral oncoprotein Tax.

B. Fleckenstein, Andrea K. Kress, Sarah Strobel, 2014, Virology.

Transformation of human T-cell clones by Herpesvirus saimiri: intact antigen recognition by autonomously growing myelin basic protein-specific T cells.

R. Hohlfeld, E. Meinl, F. Weber, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Immortalization of human T cell clones by Herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors.

F. Emmrich, B. Fleckenstein, I. Müller-Fleckenstein, 1993, Journal of immunology.

CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes

H. Mittrücker, B. Fleckenstein, I. Müller-Fleckenstein, 1992, The Journal of experimental medicine.

A high proportion of early response genes are constitutively activated in T cells by HTLV-I.

W. Greene, H. Mitsuya, B. Fleckenstein, 1992, Oncogene.

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

A. Fischer, K. Köhrer, A. Borkhardt, 2012, Leukemia.

A rev/β‐galactosidase fusion protein binds in vitro transcripts spanning the rev‐responsive element of human immunodeficiency virus type 1 (HIV‐1)

B. Fleckenstein, M. Bröker, C. Aepinus, 1990, FEBS letters.

Elevated Cyclic AMP Levels in T Lymphocytes Transformed by Human T-Cell Lymphotropic Virus Type 1

K. Pichler, B. Fleckenstein, M. Kalmer, 2010, Journal of Virology.

Herpesvirus Ateles Tio Can Replace Herpesvirus Saimiri StpC and Tip Oncoproteins in Growth Transformation of Monkey and Human T Cells

B. Fleckenstein, A. Ensser, I. Müller-Fleckenstein, 2004, Journal of Virology.

Persistence of selectable herpesvirus saimiri in various human haematopoietic and epithelial cell lines.

B. Fleckenstein, E. Platzer, M. Alt, 1991, The Journal of general virology.

Interleukine-6 virale

F. Neipel, B. Fleckenstein, A. Friedman-kien, 1996 .

The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-kappaB signals.

B. Fleckenstein, M. Kalmer, Bernhard Fleckenstein, 2011, Blood.

The tumor marker Fascin is induced by the Epstein-Barr virus-encoded oncoprotein LMP1 via NF-κB in lymphocytes and contributes to their invasive migration

B. Fleckenstein, A. Kieser, M. Kalmer, 2014, Cell Communication and Signaling.

Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency

J. Casanova, A. Bousfiha, S. Ehl, 2022, The Journal of experimental medicine.

Herpes virus saimiri-transformed human T lymphocytes: normal functional phenotype and preserved T cell receptor signalling.

H. Mittrücker, B. Fleckenstein, I. Müller-Fleckenstein, 1993, International immunology.

Growth Transformation of Human T Cells by Herpesvirus Saimiri Requires Multiple Tip-Lck Interaction Motifs

B. Fleckenstein, A. Ensser, I. Müller-Fleckenstein, 2006, Journal of Virology.

A Herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice.

T. Kirchner, U. Rüther, B. Fleckenstein, 1996, Oncogene.

Epithelial tumours induced by a herpesvirus oncogene in transgenic mice.

H. Müller-Hermelink, R. Desrosiers, U. Rüther, 1994, Oncogene.

Immortalization with herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones.

M. de Carli, M. D’Elios, B. Fleckenstein, 1993, Journal of immunology.

HIV-1 seroreversion following antiretroviral therapy in an HIV-infected child initially presenting with acquired immunodeficiency syndrome.

K. Korn, A. Borkhardt, B. Fleckenstein, 2010, AIDS.

Herpesvirus saimiri transformed human T cell lines: a permissive system for human immunodeficiency viruses.

S. Nick, B. Fleckenstein, G. Jahn, 1993, Virology.

Germline Mutations within the IL2-Inducible T Cell Kinase Impede T Cell Differentiation or Survival, Cause Protein Destabilisation, Loss of Membrane Recruitment and Lead to Severe EBV Lymphoproliferation

K. Köhrer, A. Borkhardt, B. Schraven, 2010 .

Presence of Human Herpesvirus Type 6 in Sporadic Lymphoproliferative Disorders: A Comparative Study

H. Müller-Hermelink, C. Hallas, F. Neipel, 1996, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin

F. Neipel, B. Fleckenstein, Jae U. Jung, 1997, Journal of virology.

Nucleic Acids Research

T. Dingermann, R. Marschalek, B. Fleckenstein, 2003 .

Human herpesvirus 8 encodes a homolog of interleukin-6

F. Neipel, B. Fleckenstein, A. Ensser, 1997, Journal of virology.

Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity?

F. Neipel, B. Fleckenstein, B. Fleckenstein, 1997, Journal of virology.

Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors.

W. Haseltine, B. Oberg, K. Uberla, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Specific antibody deficiency and autoinflammatory disease extend the clinical and immunological spectrum of heterozygous NFKB1 loss-of-function mutations in humans

A. Borkhardt, U. Fischer, E. Yefenof, 2016, Haematologica.

Revisiting Human IL-12R&bgr;1 Deficiency: A Survey of 141 Patients From 30 Countries

Smita Y. Patel, A. Al-ghonaium, Sami Al-Hajjar, 2010, Medicine.

Virus-specific transcription in a Herpesvirus saimiri-transformed lymphoid tumor cell line

B. Fleckenstein, B. Fleckenstein, E. Knust, 1983, Journal of virology.

Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

R. Desrosiers, B. Fleckenstein, I. Müller-Fleckenstein, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Peptides Derived from a Distinct Region of GB Virus C Glycoprotein E2 Mediate Strain-Specific HIV-1 Entry Inhibition

B. Fleckenstein, Kristin Eissmann, Holger Wend, 2011, Journal of Virology.

Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24

A. Borkhardt, B. Kempkes, B. Fleckenstein, 2016, Journal of Clinical Immunology.

CD 2-mediated Autocrine Growth of Herpes Virus Saimiri-tranfformed Human T Lymphocytes

B. Fleckenstein, B. Fleischer, Ingrid Mfiller-Fleckenstein, 2003 .

Genes for the synthesis of deoxythymidylate monophosphate in T-cell lymphoma-inducing herpesviruses of nonhuman primates.

R. Desrosiers, B. Fleckenstein, J. Trimble, 1989, Current topics in microbiology and immunology.