D. Cantrell

发表

Protein kinase B (Akt) regulation and function in T lymphocytes.

D. Cantrell, 2002, Seminars in immunology.

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F.

B. Groner, B. Burgering, P. Brennan, 1997, Immunity.

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

K. Shokat, Z. Knight, A. Fisher, 2008, Proceedings of the National Academy of Sciences.

Notch-induced T cell development requires phosphoinositide-dependent kinase 1

David K. Finlay, E. Fiorini, D. Cantrell, 2007, The EMBO journal.

GTPases and T cell activation

D. Cantrell, 2003, Immunological reviews.

Ras regulation and function in lymphocytes.

E. Génot, D. Cantrell, 2000, Current opinion in immunology.

p21ras mediates control of IL‐2 gene promoter function in T cell activation.

J. Downward, D. Cantrell, S. Rayter, 1992, The EMBO journal.

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras

D. Olive, D. Cantrell, J. Nunès, 1994, The Journal of experimental medicine.

The regulation and function of p21ras during T-cell activation and growth.

D. Cantrell, K. Reif, M. Izquierdo Pastor, 1995, Immunology today.

Autocrine regulation of T-lymphocyte proliferation: differential induction of IL-2 and IL-2 receptor.

M. Crumpton, M. Collins, D. Cantrell, 1988, Immunology.

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

D. Cantrell, L. Vanes, V. Tybulewicz, 2013, Immunity.

University of Dundee Phosphoinositide-dependent protein kinase-1 ( PDK 1 )-independent activation of the protein kinase C substrate , protein kinase

D. Cantrell, C. David, Wood, 2012 .

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D

C. Wood, D. Cantrell, A. Kelly, 2007, FEBS letters.

Phosphoinositide‐dependent kinase l (PDK1) haplo‐insufficiency inhibits production of alpha/beta (α/β) but not gamma delta (γ/δ) T lymphocytes

D. Cantrell, R. Clarke, A. Kelly, 2006 .

Phosphoinositide 3-kinase signalling pathways.

D. Cantrell, 2001, Journal of cell science.

The T cell antigen receptor activates phosphatidylinositol 3‐kinase‐regulated serine kinases protein kinase B and ribosomal S6 kinase 1

A. Laurence, V. Lafont, D. Cantrell, 2000, FEBS letters.

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

David K. Finlay, Linda V. Sinclair, P. Oefner, 2018, Nature Communications.

Essential Role for Protein Kinase D Family Kinases in the Regulation of Class II Histone Deacetylases in B Lymphocytes

E. Olson, A. Scharenberg, T. McKinsey, 2006, Molecular and Cellular Biology.

Phosphatidylinositol 3-Kinase Links the Interleukin-2 Receptor to Protein Kinase B and p70 S6 Kinase*

B. Burgering, D. Cantrell, K. Reif, 1997, The Journal of Biological Chemistry.

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

E. Reinherz, Kendall A. Smith, S. Meuer, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Protein kinase D2 is a digital amplifier of T cell receptor–stimulated diacylglycerol signaling in naïve CD8+ T cells

D. Cantrell, M. Trost, M. N. Navarro, 2014, Science Signaling.

Single Cell Glucose Uptake Assays: A Cautionary Tale

Linda V. Sinclair, D. Cantrell, L. Sinclair, 2020, Immunometabolism.

T lymphocyte activation signals.

J. Downward, D. Cantrell, J. Graves, 1992, Ciba Foundation symposium.

T-cell activation.

D. Cantrell, M. Izquierdo, 1992, Trends in cell biology.

A Protein Kinase C Pseudosubstrate Peptide Blocks G—Protein and Mitogenic Lectin Induced Phosphorylation of the CD3 Antigen in Human T—Lymphocytes

M. Crumpton, D. Alexander, D. Cantrell, 1990 .

Evidence that protein kinase C differentially regulates the human T lymphocyte CD2 and CD3 surface antigens

M. Crumpton, A. Davies, D. Cantrell, 1988, European journal of immunology.

Inhibition by staurosporine of mitogen‐induced calcium mobilisation in human T lymphoblasts

J. Westwick, S. Ward, D. Cantrell, 1988, FEBS letters.

Association of phosphorylation of the T3 antigen with immune activation of T lymphocytes

M. Crumpton, A. Davies, D. Cantrell, 1987, Nature.

The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation.

M. Crumpton, J. Rothbard, P. Parker, 1987, The Journal of biological chemistry.

The regulation of T-cell proliferation: a role for protein kinase C.

M. Crumpton, A. Davies, D. Cantrell, 1987, Haematology and blood transfusion.

Interactions between protein kinase C and the T3/T cell antigen receptor complex

M. Crumpton, A. Davies, G. Krissansen, 1986 .

Evidence That SHIP-1 Contributes to Phosphatidylinositol 3,4,5-Trisphosphate Metabolism in T Lymphocytes and Can Regulate Novel Phosphoinositide 3-Kinase Effectors1

S. Ward, D. Cantrell, K. Wright, 2002, The Journal of Immunology.

G proteins in lymphocyte signalling.

D. Cantrell, 1994, Current opinion in immunology.

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

Linda V. Sinclair, M. Haniffa, A. Bertoletti, 2015, Nature Medicine.

A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function

D. Cantrell, K. Reif, S. Lucas, 1997, Current Biology.

University of Dundee PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

Linda V. Sinclair, K. Okkenhaug, D. Cantrell, 2012 .

Quantitative Analyses Reveal How Hypoxia Reconfigures the Proteome of Primary Cytotoxic T Lymphocytes

D. Cantrell, S. Ross, Christina M. Rollings, 2021, Frontiers in Immunology.

p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes

E. Génot, D. Cantrell, K. Reif, 1998, Oncogene.

Interleukin (IL)‐2 activation of p21ras in murine myeloid cells transfected with human IL‐2 receptor β chain

W. Leonard, J. Downward, D. Cantrell, 1992, European journal of immunology.

New insights into the regulation and function of serine/threonine kinases in T lymphocytes

D. Cantrell, S. Matthews, Sharon A. Matthews, 2009, Immunological reviews.

Analysis of the Role of Protein Kinase C-α, -ϵ, and -ζ in T Cell Activation (*)

E. Génot, P. Parker, D. Cantrell, 1995, The Journal of Biological Chemistry.

p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells

D. Cantrell, N. Clipstone, M. Woodrow, 1993, The Journal of experimental medicine.

The regulation and function of p21ras in signal transduction by the T cell antigen receptor.

D. Cantrell, M. Woodrow, M. I. Pastor, 1994, Advances in experimental medicine and biology.

Effectors Regulate Novel Phosphoinositide 3-Kinase Metabolism in T Lymphocytes and Can Phosphatidylinositol 3 , 4 , 5-Trisphosphate Evidence That SHIP-1 Contributes to Ward

S. Ward, D. Cantrell, K. Wright, 2002 .

University of Dundee Protein kinase D enzymes are dispensable for proliferation , survival and antigen receptor-regulated NFB activity in vertebrate B-cells

A. Scharenberg, D. Cantrell, S. Matthews, 2016 .

Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NF?B activity in vertebrate

A. Scharenberg, D. Cantrell, S. Matthews, 2012 .

Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFκB activity in vertebrate B-cells

A. Scharenberg, D. Cantrell, Ping Liu, 2007, FEBS letters.

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Linda V. Sinclair, D. V. van Aalten, K. Grzes, 2016, Nature Immunology.

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

Linda V. Sinclair, D. Cantrell, L. Sinclair, 2019, bioRxiv.

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.

S. Ward, D. Cantrell, E. Astoul, 2001, Trends in immunology.

Protein kinase C is not a downstream effector of p21ras in activated T cells

D. Williams, D. Cantrell, M. Woodrow, 1995, European journal of immunology.

p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells.

J. Downward, D. Cantrell, S. Rayter, 1993, Journal of immunology.

Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells

J. Downward, D. Cantrell, J. Graves, 1992, Molecular and cellular biology.

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

M. Crumpton, A. Davies, D. Cantrell, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Transient expression of interleukin 2 receptors. Consequences for T cell growth

D. Cantrell, K. Smith, 1983, The Journal of experimental medicine.

Differential regulation of T-cell growth by IL-2 and IL-15.

Linda V. Sinclair, D. Cantrell, L. Sinclair, 2006, Blood.

A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation.

M. Crumpton, D. Alexander, D. Cantrell, 1990, The Biochemical journal.

p21ras couples the T cell antigen receptor to extracellular signal- regulated kinase 2 in T lymphocytes

C. Marshall, D. Cantrell, S. Leevers, 1993, The Journal of experimental medicine.

Signal transduction through the T cell receptor-CD3 complex. Evidence for heterogeneity in receptor coupling.

D. Cantrell, M. Gullberg, G. Brattsand, 1990, Journal of immunology.

Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein.

D. Olive, J. Peyron, D. Cantrell, 1998, International immunology.

CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases.

J. Woodgett, D. Olive, D. Cantrell, 1996, Molecular immunology.

SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.

J. Downward, L. Buday, D. Cantrell, 1994, The Journal of biological chemistry.

The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor

D. Cantrell, M. Izquierdo, S. Bowden, 1994, The Journal of experimental medicine.

Temporal Differences in the Dependency on Phosphoinositide-Dependent Kinase 1 Distinguish the Development of Invariant Vα14 NKT Cells and Conventional T Cells

David K. Finlay, Linda V. Sinclair, D. Alessi, 2010, The Journal of Immunology.

Phosphoproteomic analysis reveals an intrinsic pathway for histone deacetylase 7 regulation that controls cytotoxic T lymphocyte function

D. Cantrell, N. Morrice, M. N. Navarro, 2011, Nature immunology.

Signaling in lymphocyte activation.

D. Cantrell, 2015, Cold Spring Harbor perspectives in biology.

Phenotype of rat natural killer cells defined by monoclonal antibodies marking rat lymphocyte subsets.

R. W. Baldwin, D. Cantrell, C. Brooks, 1982, Immunology.

Different functions of the GTPase Rho in prothymocytes and late pre-T cells.

D. Cantrell, R. Galandrini, S. Henning, 1997, Immunity.

Signaling and Function of Interleukin-2 in T Lymphocytes.

D. Cantrell, S. Ross, 2018, Annual review of immunology.

Of Mosaicism and Mechanisms: How JAK1 Goes Awry.

D. Cantrell, S. Ross, 2020, Immunity.

The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes.

P. Warne, J. Downward, D. Cantrell, 1992, Journal of immunology.

The Coordination of T-cell Function by Serine/Threonine Kinases

D. Cantrell, D. Finlay, 2011 .

The coordination of T-cell function by serine/threonine kinases.

David K. Finlay, D. Cantrell, D. Finlay, 2011, Cold Spring Harbor perspectives in biology.

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO 1 to Promote Tfh Cell Differentiation Highlights

E. Yang, A. Goldrath, E. Stone, 2015 .

Regulation and function of serine kinase networks in lymphocytes.

D. Cantrell, 2003, Current opinion in immunology.

Antigen receptor regulation of phosphoinositide‐dependent kinase 1 pathways during thymocyte development

D. Cantrell, R. Clarke, H. Hinton, 2006, FEBS letters.

The Impact of KLF2 Modulation on the Transcriptional Program and Function of CD8 T Cells

V. Cowling, N. Schurch, D. Cantrell, 2013, PloS one.

Regulation of PtdIns-3-kinase and the guanine nucleotide binding proteins p21ras during signal transduction by the T cell antigen receptor and the interleukin-2 receptor.

D. Cantrell, K. Reif, M. Woodrow, 1993, Seminars in immunology.

The Immunological Proteome Resource

David K. Finlay, Linda V. Sinclair, A. Lamond, 2022, bioRxiv.

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

A. Lamond, J. Arthur, D. Cantrell, 2022, iScience.

The active inner life of naive T cells

D. Cantrell, J. Marchingo, Julia M. Marchingo, 2020, Nature Immunology.

Loss of Rho function in the thymus is accompanied by the development of thymic lymphoma

D. Cantrell, P. Costello, S. Cleverley, 2000, Oncogene.

Inhibition of Rho at different stages of thymocyte development gives different perspectives on Rho function

D. Cantrell, S. Cleverley, S. Henning, 1999, Current Biology.

The regulation and function of p21ras in T cells.

J. Downward, D. Cantrell, J. Graves, 1992, Immunology today.

Protein Kinase D

D. Cantrell, E. Rozengurt, S. Matthews, 2000, The Journal of experimental medicine.

Spatial and temporal regulation of protein kinase D (PKD)

T. Iglesias, D. Cantrell, E. Rozengurt, 2000, The EMBO journal.

Commentary Vav‐1 and T cells

D. Cantrell, 2003, European journal of immunology.

A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.

J. Downward, L. Buday, D. Cantrell, 1994, The Journal of biological chemistry.

The real LAT steps forward.

D. Cantrell, 1998, Trends in cell biology.

Intracellular location and cell context-dependent function of protein kinase D.

D. Cantrell, U. Marklund, K. Lightfoot, 2003, Immunity.

Signal Transduction by CD28 Costimulatory Receptor on T Cells

D. Olive, D. Cantrell, J. Nunès, 1996, The Journal of Biological Chemistry.

Regulation and function of p21ras in T lymphocytes.

D. Cantrell, M. Woodrow, M. I. Pastor, 1995, Cancer surveys.

Single cell analysis of kynurenine and System L amino acid transport in T cells

D. Cantrell, L. Sinclair, G. Ramsay, 2018, Nature Communications.

Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes

M. Crumpton, A. Davies, D. Cantrell, 1985, Bioscience reports.

Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

S. Ward, D. Cantrell, S. Ley, 1992, European journal of immunology.

Heterogeneity of protein kinase C expression and regulation in T lymphocytes

P. Parker, D. Cantrell, R. Marais, 1990, FEBS letters.

Kinases and phosphatases in T-cell activation.

D. Alexander, D. Cantrell, 1989, Immunology today.

Temporal differences in the dependency on Phosphoinositide Dependent Kinase 1 distinguish the development of iNKT cells and conventional T cells

David K. Finlay, Linda V. Sinclair, D. Alessi, 2011 .

T cell activation and the cytoskeleton.

D. Cantrell, O. Acuto, D Cantrell, 2000, Annual review of immunology.

Multiple p21ras effector pathways regulate nuclear factor of activated T cells.

E. Génot, D. Cantrell, S. Cleverley, 1996, The EMBO journal.

Identification of pro‐interleukin 16 as a novel target of MAP kinases in activated T lymphocytes

A. Laurence, D. Cantrell, Sarah Hanrahan, 2004, European journal of immunology.

Interleukin‐2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

D. Cantrell, C. Beadling, J. Babbage, 1996, The EMBO journal.

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses

W. Birchmeier, D. Cantrell, G. Guarda, 2022, EMBO reports.

Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation.

I. Gout, M. Waterfield, D. Cantrell, 1993, The Journal of biological chemistry.

IL‐12 selectively regulates STAT4 via phosphatidylinositol 3‐kinase and Ras‐independent signal transduction pathways

D. Cantrell, H. Flotow, K. Hilyard, 2000, European journal of immunology.

Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes.

D. Cantrell, R. Clarke, H. Hinton, 2006, FEBS letters.

Intracellular events involved in CD5-induced human T cell activation and proliferation.

D. Cantrell, J. Alberola-Ila, F. Lozano, 1992, Journal of immunology.

Signaling requirements for the expression of the transactivating factor NF‐AT in human T lymphocytes

D. Cantrell, N. Clipstone, C. Hivroz-Burgaud, 1991, European journal of immunology.

Activation of human T lymphocytes via the CD2 antigen results in tyrosine phosphorylation of T cell antigen receptor zeta-chains.

M. Crumpton, D. Cantrell, M. Brown, 1990, Journal of immunology.

Protein tyrosine kinases couple the interleukin‐2 receptor to p21ras

D. Cantrell, M. Izquierdo, 1993, European journal of immunology.

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

C. Nobes, A. Hall, D. Cantrell, 1996, Current Biology.

Differential Requirement for RhoA GTPase Depending on the Cellular Localization of Protein Kinase D*

D. Cantrell, U. Marklund, M. Mullin, 2006, Journal of Biological Chemistry.

Regulation of an Activated S6 Kinase 1 Variant Reveals a Novel Mammalian Target of Rapamycin Phosphorylation Site*

P. Brennan, D. Cantrell, G. Thomas, 2002, The Journal of Biological Chemistry.

Protein Kinase D

D. Cantrell, E. Rozengurt, S. Matthews, 2000, The Journal of experimental medicine.

CD2 antigen mediated activation of the guanine nucleotide binding proteins p21ras in human T lymphocytes.

P. Warne, J. Downward, D. Cantrell, 1991, Journal of immunology.

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

David K. Finlay, Linda V. Sinclair, K. Okkenhaug, 2011, Immunity.

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

David K. Finlay, Linda V. Sinclair, Thijs J. Hagenbeek, 2008, Nature Immunology.

Corrigendum: Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

K. Okkenhaug, D. Cantrell, H. Spits, 2008, Nature Immunology.

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

D. Alessi, D. Cantrell, H. Hinton, 2004, Nature Immunology.

p56lck Signals for Regulating Thymocyte Development Can Be Distinguished by Their Dependency on Rho Function

D. Cantrell, S. Henning, 1998, The Journal of experimental medicine.

Super‐killer CTLs are generated by single gene deletion of Bach2

Arianne C. Richard, D. Cantrell, G. Griffiths, 2022, European journal of immunology.

Dual Phospholipase C/Diacylglycerol Requirement for Protein Kinase D1 Activation in Lymphocytes*

C. Wood, D. Cantrell, U. Marklund, 2005, Journal of Biological Chemistry.

The interleukin-2 T-cell system: a new cell growth model.

D. Cantrell, K. Smith, 1984, Science.

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

D. Hardie, S. Hawley, D. Cantrell, 2006, The Journal of experimental medicine.

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

P. Grandi, K. Read, M. Bantscheff, 2016, Nature Communications.

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

Linda V. Sinclair, A. Lamond, D. Cantrell, 2019, Nature Immunology.

Interleukin 2 regulates its own receptors.

D. Cantrell, K. Smith, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Sustained IL-12 Signaling Is Required for Th1 Development 1

D. Cantrell, H. Smits, C. Hilkens, 2004, The Journal of Immunology.

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.

D. Cantrell, M. Leitges, A. Poole, 2011, Blood.

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D 2

D. Cantrell, M. Leitges, A. Poole, 2011 .

T cell antigen receptor signal transduction pathways.

D. Cantrell, D Cantrell, 1996, Annual review of immunology.

Integrin Regulation by RhoA in Thymocytes1

D. Cantrell, H. Hinton, M. Gomez, 2005, The Journal of Immunology.

Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy

Linda V. Sinclair, K. Grzes, D. Cantrell, 2017, Leukemia.

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

David K. Finlay, Linda V. Sinclair, Carmen Feijoo, 2009, The Journal of experimental medicine.

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

E. Yang, A. Goldrath, E. Stone, 2015, Immunity.

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Linda V. Sinclair, V. Cowling, H. Macdonald, 2015, The EMBO journal.

Proteomic and functional comparison between human induced and embryonic stem cells

J. Swedlow, A. Lamond, A. Prescott, 2021, bioRxiv.

Characterization of Serine 916 as an in VivoAutophosphorylation Site for Protein Kinase D/Protein Kinase Cμ*

D. Cantrell, E. Rozengurt, Sharon A. Matthews, 1999, The Journal of Biological Chemistry.

The Dynamics of Protein Kinase B Regulation during B Cell Antigen Receptor Engagement

D. Cantrell, E. Astoul, S. Watton, 1999, The Journal of cell biology.

-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--.

A. von Kriegsheim, K. Dhaliwal, D. Cantrell, 2021, Wellcome open research.

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Linda V. Sinclair, D. Cantrell, Yunbo Shi, 2013, Nature Immunology.

The GTPase Rho has a critical regulatory role in thymus development

A. Hall, D. Cantrell, R. Galandrini, 1997, The EMBO journal.

Transgenic analysis of thymocyte signal transduction

D. Cantrell, 2002, Nature Reviews Immunology.

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

N. Hogg, D. Cantrell, M. Bracke, 2002, Nature Immunology.

LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

D. Cantrell, Marouan Zarrouk, J. Rolf, 2013, PloS one.

The Gtpase Rho Controls a P53-Dependent Survival Checkpoint during Thymopoiesis

D. Cantrell, P. Costello, R. Galandrini, 2000, The Journal of experimental medicine.

Protection of CD95‐mediated apoptosis by activation of phosphatidylinositide 3‐kinase and protein kinase B

D. Cantrell, K. Reif, A. Eramo, 1998, European journal of immunology.

Environmental and Metabolic Sensors That Control T Cell Biology

D. Cantrell, G. Ramsay, 2015, Front. Immunol..

Stimulation of p21ras upon T-cell activation

P. Warne, J. Downward, D. Cantrell, 1990, Nature.

Phosphoinositide 3-kinases in T lymphocyte activation.

S. Ward, D. Cantrell, S G Ward, 2001, Current opinion in immunology.

Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase.

D R Alessi, S. Dowler, D. Alessi, 2000, The Biochemical journal.

Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

I. Kerr, D. Cantrell, C. Beadling, 1995, European journal of immunology.

Metabolism, migration and memory in cytotoxic T cells

D. Cantrell, D. Finlay, 2011, Nature Reviews Immunology.

Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of rapamycin) pathways control T lymphocyte trafficking

Ager, David K. Finlay, Linda V. Sinclair, 2011 .

Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

S. Fagerholm, D. Cantrell, V. Morrison, 2012, European journal of immunology.

GTPases in antigen receptor signalling.

D. Cantrell, S. Henning, Doreen A. Cantrell, 1998, Current opinion in immunology.

Serine-threonine kinases in TCR signaling

D. Cantrell, M. N. Navarro, 2014, Nature Immunology.

T‐cell antigen receptor signal transduction

D. Cantrell, 2002, Immunology.

Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naïve Versus Effector CD8+ T Cell Transcriptional Programs

D. Cantrell, J. Marchingo, Julia M. Marchingo, 2021, Frontiers in Immunology.

Antigen receptor control of methionine metabolism in T cells

Linda V. Sinclair, A. Lamond, J. Locasale, 2018, bioRxiv.

Lymphocyte signalling: A coordinating role for Vav?

D. Cantrell, 1998, Current Biology.

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

David K. Finlay, Linda V. Sinclair, K. Okkenhaug, 2012, The Journal of experimental medicine.

University of Dundee PDK 1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD 8 T cells

David K. Finlay, Linda V. Sinclair, K. Okkenhaug, 2012 .

Phosphoinositide 3‐kinase and the mammalian target of rapamycin pathways control T cell migration

David K. Finlay, D. Cantrell, D. Finlay, 2010, Annals of the New York Academy of Sciences.

Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation

David K. Finlay, Linda V. Sinclair, D. Cantrell, 2009, Molecular and Cellular Biology.

The role of serine/threonine kinases in T-cell activation.

D. Cantrell, Sharon A. Matthews, 2006, Current opinion in immunology.

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

D. Cantrell, M. Gallagher, P. Costello, 2002, Nature Immunology.

Networking Rho family GTPases in lymphocytes.

D. Cantrell, K. Reif, 1998, Immunity.

Mathematical Models for Immunology: Current State of the Art and Future Research Directions

Raluca Eftimie, R. Eftimie, D. Cantrell, 2016, Bulletin of mathematical biology.

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8+ T Cells

P. Hawkins, L. Stephens, D. Cantrell, 2016, Immunity.

Resource Phosphoproteomic Analys es of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and-Independent Networks in CD 8 + T Cells Graphical Abstract Highlights

P. Hawkins, L. Stephens, D. Cantrell, 2016 .

Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens.

D. Cantrell, A. Beyers, M. Izquierdo, 1991, The EMBO journal.

Regulation of the Adapter Molecule Grb2 by the FcR1 in the Mast Cell Line RBL2H3 (*)

H. Turner, D. Cantrell, K. Reif, 1995, The Journal of Biological Chemistry.

Distinct Ras Effector Pathways Are Involved in FcεR1 Regulation of the Transcriptional Activity of Elk-1 and NFAT in Mast Cells

H. Turner, D. Cantrell, 1997, The Journal of experimental medicine.

A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

A. von Kriegsheim, K. Dhaliwal, D. Cantrell, 2021, Wellcome open research.

Proteomics identifies a type I IFN, prothrombotic hyperinflammatory circulating COVID-19 neutrophil signature distinct from non-COVID-19 ARDS

K. Dhaliwal, D. Cantrell, A. Kriegsheim, 2020, medRxiv.

Analysis of Thymocyte Development Reveals That the Gtpase Rhoa Is a Positive Regulator of T Cell Receptor Responses in Vivo

D. Cantrell, M. Gomez, I. Corre, 2001, The Journal of experimental medicine.

Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

D. Cantrell, V. Tybulewicz, M. Gomez, 2000, Nature Immunology.

Activation of JAK kinases and STAT proteins by interleukin‐2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

I. Kerr, D. Cantrell, C. Beadling, 1994, The EMBO journal.

Rac-1 Regulates Nuclear Factor of Activated T Cells (NFAT) C1 Nuclear Translocation in Response to Fcε Receptor Type 1 Stimulation of Mast Cells

H. Turner, D. Cantrell, M. Gomez, 1998, The Journal of experimental medicine.

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

B. Viollet, D. Hardie, K. Grzes, 2019, Cell reports.

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

David K. Finlay, A. Ashworth, D. Cantrell, 2009, European journal of immunology.

LKB 1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

David K. Finlay, A. Ashworth, D. Cantrell, 2009 .

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

D. Cantrell, L. Sinclair, H. Brady, 2018, Science Signaling.

STAT3 Is a Serine Kinase Target in T Lymphocytes

D. Cantrell, J. Ng, Julian Ng, 1997, The Journal of Biological Chemistry.

The cytotoxic T cell proteome and its shaping by mammalian Target of Rapamycin

Linda V. Sinclair, A. Lamond, P. Hawkins, 2015, Nature Immunology.

Protein synthesis, degradation, and energy metabolism in T cell immunity

D. Cantrell, J. Marchingo, Julia M. Marchingo, 2022, Cellular & molecular immunology.

Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation

Linda V. Sinclair, D. Cantrell, Yunbo Shi, 2013, Nature immunology.

p70s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

P. Brennan, D. Cantrell, G. Thomas, 1999, Molecular and Cellular Biology.

Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation

D. Cantrell, J. Marchingo, Julia M. Marchingo, 2020, bioRxiv.

The role of protein kinase C in the regulation of extracellular signal‐regulated kinase by the T cell antigen receptor

C. Marshall, A. Weiss, D. Cantrell, 1994, European journal of immunology.

The CD2 antigen associates with the T-cell antigen receptor CD3 antigen complex on the surface of human T lymphocytes

M. Crumpton, D. Cantrell, M. Gullberg, 1989, Nature.

Rat NK cells active against lymphoma and sarcoma tumor cells are probably identical.

R. W. Baldwin, D. Cantrell, J. Gray, 1982, Journal of immunology.

The GTPase Rac-1 controls cell fate in the thymus by diverting thymocytes from positive to negative selection.

D. Kioussis, D. Cantrell, M. Gomez, 2001, Immunity.

Rapid Protein Kinase D Translocation in Response to G Protein-coupled Receptor Activation

S. H. Young, D. Cantrell, E. Rozengurt, 2001, The Journal of Biological Chemistry.

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

P. Oefner, A. Lamond, D. Cantrell, 2018, Nature Communications.

AMPKα1: A glucose sensor that controls CD8 T-cell memory

David K. Finlay, B. Viollet, D. Cantrell, 2013, European journal of immunology.

Mitochondrial translation is required for sustained killing by cytotoxic T cells

D. Cantrell, J. Prudent, G. Griffiths, 2021, Science.

Th 1 Development Sustained IL-12 Signaling Is Required for Cantrell

D. Cantrell, H. Smits, C. Hilkens, 2003 .

Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response

A. Lamond, D. Cantrell, Sharadha Dayalan Naidu, 2021, bioRxiv.

Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism.

A. von Kriegsheim, D. Cantrell, B. Ghesquière, 2021, The Journal of clinical investigation.

Adenosine-Mono-Phosphate-Activated Protein Kinase-Independent Effects of Metformin in T Cells

David K. Finlay, B. Viollet, D. Cantrell, 2014, PloS one.

Rat lymphocyte subsets: cellular requirements for the generation of T-cell growth factor.

R. W. Baldwin, D. Cantrell, R. A. Robins, 1982, Cellular immunology.

A Comparison of the Interaction of Shc and the Tyrosine Kinase ZAP-70 with the T Cell Antigen Receptor ζ Chain Tyrosine-based Activation Motif (*)

H. Turner, N. Osman, D. Cantrell, 1995, The Journal of Biological Chemistry.

Phorbol esters regulate CD2- and CD3-mediated calcium responses in peripheral blood-derived human T cells.

J. Westwick, D. Cantrell, M. Gullberg, 1989, Journal of Immunology.

current as proteins in normal human T lymphocytes . The growth factor IL-2 activates p 21 ras

P. Warne, J. Downward, D. Cantrell, 2001 .

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

D. Cantrell, N. Morrice, M. N. Navarro, 2011, Nature Immunology.

Activation-dependent phosphorylation of endogenous protein kinase C substrates in quiescent human T lymphocytes.

D. Cantrell, M. Gullberg, B. Friedrich, 1988, Immunobiology.

Involvement of p21ras activation in T cell CD69 expression

R. Testi, L. Frati, D. Cantrell, 1994, European journal of immunology.

Guanine nucleotide regulation of inositol phospholipid hydrolysis and CD3-antigen phosphorylation in permeabilized T lymphocytes.

D. Alexander, D. Cantrell, J. Graves, 1990, The Biochemical journal.

Dynamic re‐distribution of protein kinase D (PKD) as revealed by a GFP‐PKD fusion protein: dissociation from PKD activation

T. Iglesias, D. Cantrell, E. Rozengurt, 1999, FEBS letters.

Quantitative Phosphoproteomics of Cytotoxic T Cells to Reveal Protein Kinase D 2 Regulated Networks*

D. Cantrell, J. Hukelmann, M. N. Navarro, 2014, Molecular & Cellular Proteomics.

Antigen receptor signal transduction: activating and inhibitory antigen receptors regulate STAT1 serine phosphorylation

D. Cantrell, T. Decker, Virginie Lafont, 2000, European journal of immunology.

The RhoA transcriptional program in pre-T cells

R. Lahesmaa, M. Miller, D. Cantrell, 2007, FEBS letters.

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Linda V. Sinclair, D. Cantrell, L. Sinclair, 2010, The Biochemical journal.

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

D. Cantrell, R. Clarke, L. Sinclair, 2012, The Biochemical journal.

A New Role for the p85-Phosphatidylinositol 3-Kinase Regulatory Subunit Linking FRAP to p70 S6 Kinase Activation*

D. Cantrell, N. Pullen, A. González-García, 2002, The Journal of Biological Chemistry.

The protein interactions of the immunoglobulin receptor family tyrosine‐based activation motifs present in the T cell receptor ζ subunits and the CD3 γ,δ and ϵ chains

H. Turner, N. Osman, D. Cantrell, 1996 .

Ligands, receptors and signal transduction in regulation of lymphocyte function Edited by J. C. Cambler Washington, DC: American Society for Microbiology. (1990). 421 pp. $63.00

D. Cantrell, 1991, Cell.

Protein kinase C and beyond

D. Cantrell, M. Spitaler, Martin Spitaler, 2004, Nature Immunology.

Diacylglycerol and protein kinase D localization during T lymphocyte activation.

C. Wood, D. Cantrell, M. Spitaler, 2006, Immunity.

NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease

P. Carmeliet, A. von Kriegsheim, D. Cantrell, 2023, American journal of respiratory and critical care medicine.

Activation Loop Ser744 and Ser748 in Protein Kinase D Are Transphosphorylated in Vivo *

T. Iglesias, D. Cantrell, E. Rozengurt, 2001, The Journal of Biological Chemistry.

Protein kinase D is a downstream target of protein kinase Ctheta.

A. Nel, D. Cantrell, E. Rozengurt, 2002, Biochemical and biophysical research communications.

A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes.

M. Crumpton, D. Alexander, D. Cantrell, 1989, The Biochemical journal.

Evidences for protein kinase C. Activation in T lymphocytes by stimulation of either the CD2 or CD3 antigens

D. Cantrell, M. Gullberg, B. Friedrich, 1989, European journal of immunology.

Evidence that a GTP binding protein regulates phosphorylation of the CD3 antigen in human T lymphocytes.

M. Crumpton, A. Davies, D. Cantrell, 1988, Biochemical and biophysical research communications.

Anti-CD3 antibody-induced expression of both p55 and p75 chains of the high affinity interleukin-2 receptor on human T lymphocytes is inhibited by cyclosporin A.

B. Ryffel, D. Cantrell, B. Foxwell, 1990, Immunology.

Move to metabolism

D. Cantrell, 2019, Nature Reviews Immunology.

The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor ζ chain tyrosine‐based activation motif

N. Osman, D. Cantrell, S. Lucas, 1995, European journal of immunology.

Protein kinase D is a downstream target of protein kinase Ctheta.

A. Nel, D. Cantrell, E. Rozengurt, 2002, Biochemical and biophysical research communications.

Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases.

M. Waterfield, D. Cantrell, S. Ley, 1992, Journal of Biological Chemistry.

Involvement of phosphoinositide 3‐kinase and Rac in membrane ruffling induced by IL‐2 in T cells

A. Trautmann, C. Arrieumerlou, G. Bismuth, 1998, European journal of immunology.

Approaches to Define Antigen Receptor-induced Serine Kinase Signal Transduction Pathways*

D. Alexander, A. Laurence, D. Cantrell, 2003, The Journal of Biological Chemistry.

Evidence that a kinase distinct from protein kinase C induces CD3 gamma-subunit phosphorylation without a concomitant down-regulation in CD3 antigen expression.

M. Crumpton, A. Davies, D. Cantrell, 1989, Journal of immunology.

The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor

D. Cantrell, M. Izquierdo, Sally Bowden, 1994, The Journal of experimental medicine.

Corrigendum: Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

D. Cantrell, Yunbo Shi, L. Sinclair, 2013, Nature Immunology.

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

David K. Finlay, K. Shokat, Z. Knight, 2008, Proceedings of the National Academy of Sciences.

New insights into the regulation and function of serine/threonine kinases in T lymphocytes

D. Cantrell, Sharon A. Matthews, 2009, Immunological reviews.

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

Linda V. Sinclair, D. Cantrell, H. Brady, 2018, Science Signaling.

Single cell analysis of kynurenine and System L amino acid transport in T cells

Linda V. Sinclair, D. Cantrell, G. Ramsay, 2018, Nature Communications.

Metabolism, migration and memory in cytotoxic T cells

David K. Finlay, D. Cantrell, D. Finlay, 2011, Nature Reviews Immunology.

Human CD2 is functional in CD2 transgenic mice.

D. Kioussis, M. Crumpton, R. Zamoyska, 1991, Immunology.

Signaling and Function of Interleukin-2 in T Lymphocytes.

D. Cantrell, S. Ross, 2018, Annual review of immunology.

p21ras couples the T cell antigen receptor to extracellular signal- regulated kinase 2 in T lymphocytes

D. Cantrell, S. Leevers, M. Izquierdo, 1993, The Journal of experimental medicine.

Proteomic and functional comparison between human induced and embryonic stem cells

Linda V. Sinclair, J. Swedlow, A. Lamond, 2021, bioRxiv.