B. Varnum

发表

Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis

M. Hung, Wei-Ping Lee, Y. Wen, 2002, Oncogene.

endothelial cell activation by Axl tyrosine kinase receptor mediated - Inhibition of vascular endothelial growth factor receptor 2

B. Varnum, F. Bussolino, M. Gallicchio, 2013 .

Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor.

B. Varnum, F. Bussolino, M. Gallicchio, 2005, Blood.

The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat

B. Varnum, H. Herschman, Q. Ma, 1991, Molecular and cellular biology.

Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters.

R. Koski, B. Varnum, H. Herschman, 1991, The Journal of biological chemistry.

Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of primary-response TIS genes in both proliferating and terminally differentiated myeloid cells

J. Greenberger, B. Varnum, H. Herschman, 1989, Molecular and cellular biology.

Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells.

M. Blostein, B. Varnum, I. Hasanbasic, 2004, American journal of physiology. Heart and circulatory physiology.

Gas6 anti-apoptotic signaling requires NF-kappa B activation.

R. Verardo, C. Schneider, C. Brancolini, 2001, The Journal of biological chemistry.

Receptor tyrosine kinases expressed in metastatic colon cancer

E. Liu, W. Cance, S. Srivastava, 1995, International journal of cancer.

Noninsulin‐dependent diabetes mellitus occurs in mice ectopically expressing the human Axl tyrosine kinase receptor

D. Danilenko, B. Varnum, K. Stark, 1999, Journal of cellular physiology.

Autophosphorylation Docking Site Tyr-867 in Mer Receptor Tyrosine Kinase Allows for Dissociation of Multiple Signaling Pathways for Phagocytosis of Apoptotic Cells and Down-modulation of Lipopolysaccharide-inducible NF-κB Transcriptional Activation*

R. Birge, B. Varnum, Veera D’mello, 2008, Journal of Biological Chemistry.

The Growth Arrest-Specific Gene Product Gas6 Promotes the Survival of Human Oligodendrocytes via a Phosphatidylinositol 3-Kinase-Dependent Pathway

M. Cammer, B. Varnum, F. Mcmorris, 2003, The Journal of Neuroscience.

Receptor Tyrosine Kinase Axl Modulates the Osteogenic Differentiation of Pericytes

R. Boot-Handford, B. Varnum, J. Ohanian, 2003, Circulation research.

Tumor promoter-inducible genes are differentially expressed in the developing mouse

B. Varnum, H. Herschman, R. Lim, 1988, Molecular and cellular biology.

A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.

B. Varnum, P. Henson, D. Graham, 2007, Blood.

GAS6 Mediates Adhesion of Cells Expressing the Receptor Tyrosine Kinase Axl*

B. Varnum, Y. Fridell, E. Liu, 1997, The Journal of Biological Chemistry.

Human chondrocyte expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: potential role in autocrine signaling in cartilage.

E. Liu, B. Varnum, R. Loeser, 1997, Arthritis and rheumatism.

The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation

C. Schneider, S. Goruppi, M. Gostissa, 1997, FEBS letters.

clearance of apoptotic cells and platelet aggregation A soluble form of the Mer receptor tyrosine kinase inhibits macrophage

B. Varnum, D. Graham, Karla D. Kenyon, 2013 .

GAS6, the ligand of Axl and Rse receptors, is expressed in hematopoietic tissue but lacks mitogenic activity.

L. Gammaitoni, M. Aglietta, B. Varnum, 1997, Experimental hematology.

Gas6/Axl Signaling Activates the Phosphatidylinositol 3-Kinase/Akt1 Survival Pathway to Protect Oligodendrocytes from Tumor Necrosis Factorα-Induced Apoptosis

C. Brosnan, Mimi Kim, B. Varnum, 2006, The Journal of Neuroscience.

Activation of the Axl receptor tyrosine kinase induces mitogenesis and transformation in 32D cells.

E. Liu, R. Koski, B. Varnum, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

The tis genes, primary response genes induced by growth factors and tumor promoters in 3T3 cells.

S. Reddy, B. Varnum, H. Herschman, 1994, Progress in nucleic acid research and molecular biology.

Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways

B. Varnum, H. Herschman, R. Lim, 1989, Molecular and cellular biology.

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass*

Thomas M. Dillon, Alain Balland, Gregory C. Flynn, 2008, Journal of Biological Chemistry.

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue.

B. Varnum, H. Herschman, R. Lim, 1991, The Journal of biological chemistry.

Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology

Xuesong He, Lihong Guo, W. Shi, 2015, Proceedings of the National Academy of Sciences.

Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.

M. K. Meintzer, K. Heidenreich, B. Varnum, 1999, Molecular endocrinology.

Transiently Induced Sequences as Potential Mediators of Cellular Proliferation and Differentiation

B. Varnum, H. Herschman, R. Lim, 1988 .

Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras

E. Ruaro, C. Schneider, S. Goruppi, 1999, Oncogene.

Novel Mechanism for Gonadotropin-Releasing Hormone Neuronal Migration Involving Gas6/Ark Signaling to p38 Mitogen-Activated Protein Kinase

E. Kandel, K. Heidenreich, B. Varnum, 2002, Molecular and Cellular Biology.

The Transforming Receptor Tyrosine Kinase, Axl, Is Post-translationally Regulated by Proteolytic Cleavage (*)

R. Koski, B. Varnum, Y. Fridell, 1995, The Journal of Biological Chemistry.

Gas6 Induces Growth, β-Catenin Stabilization, and T-Cell Factor Transcriptional Activation in Contact-Inhibited C57 Mammary Cells

M. E. Ruaro, C. Schneider, S. Goruppi, 2001, Molecular and Cellular Biology.

Gas 6 Induces Growth , b-Catenin Stabilization , and T-Cell Factor Transcriptional Activation in Contact-Inhibited C 57 Mammary Cells

M. E. Ruaro, C. Schneider, S. Goruppi, 2000 .

Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase

E. Liu, G. Spizz, C. Der, 1996, Molecular and cellular biology.

Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons

B. Varnum, A. L. Prieto, C. Lai, 2007, Neuroscience.

B61 is a ligand for the ECK receptor protein-tyrosine kinase

Yosef Yarden, Tony Hunter, T. Hunter, 1994, Nature.

Gas6 Anti-apoptotic Signaling Requires NF-κB Activation*

R. Verardo, C. Schneider, C. Brancolini, 2001, The Journal of Biological Chemistry.

Mer Receptor Tyrosine Kinase Signaling

B. Varnum, N. Mahajan, K. Guttridge, 2002, The Journal of Biological Chemistry.

Expression of the Receptor Tyrosine Kinase Axl Promotes Ocular Melanoma Cell Survival

D. Albert, B. Varnum, L. Subramanian, 2004, Cancer Research.

In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation

J. Backer, B. Varnum, Ying Yan, 2008, Journal of neurochemistry.

K. Heidenreich, B. Varnum, J. Pawlowski, 2007, Endocrinology.

Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis.

T. Kita, T. Doi, B. Varnum, 2001, The American journal of pathology.

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

H R Herschman, B. Varnum, H. Herschman, 1987, Oncogene.

GAS6 inhibits granulocyte adhesion to endothelial cells.

U. Dianzani, G. Bellomo, L. Gammaitoni, 1998, Blood.

Regulation of Microglial Phagocytosis and Inflammatory Gene Expression by Gas6 Acting on the Axl/Mer Family of Tyrosine Kinases

J. Koenigsknecht-Talboo, C. Grommes, G. Landreth, 2008, Journal of Neuroimmune Pharmacology.

Induction of transiently expressed genes in PC-12 pheochromocytoma cells.

B. Varnum, H. Herschman, R. Lim, 1987, Oncogene.

Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate.

V. Sukhatme, B. Varnum, H. Herschman, 1989, Oncogene.

Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts

E. Ruaro, C. Schneider, S. Goruppi, 1997, Molecular and cellular biology.

NIH 3 T 3 fibroblasts . Gas 6-Axl mitogenic and survival activities in 3-kinase-dependent pathway and Src for Requirement of phosphatidylinositol

E. Ruaro, C. Schneider, S. Goruppi, 1997 .

Gas 6 promotes Axl-mediated survival in pulmonary endothelial cells.

B. Varnum, H. Farber, J. Schwartz, 2001, American journal of physiology. Lung cellular and molecular physiology.

In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells.

D. Lacey, V. Shalhoub, David A. Martin, 2003, Critical reviews in eukaryotic gene expression.

Characterization of TIS7, a gene induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate.

B. Varnum, H. Herschman, R. Lim, 1989, Oncogene.

Identification and tissue expression of a splice variant for the growth arrest‐specific gene gas6

C. Schneider, S. Goruppi, M. Gostissa, 1997, FEBS letters.

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

H. Yamane, B. Varnum, G. Elliott, 1995, Nature.

Mer Receptor Tyrosine Kinase Signaling PREVENTION OF APOPTOSIS AND ALTERATION OF CYTOSKELETAL ARCHITECTURE WITHOUT STIMULATION OR PROLIFERATION*

B. Varnum, N. Mahajan, K. Guttridge, 2002 .

Monotonicity of interleukin-1 receptor-ligand binding with respect to antagonist in the presence of decoy receptor.

Gilles Gnacadja, Mark Durst, M. Gresser, 2007, Journal of theoretical biology.

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG 2 Subclass *

Douglas S Rehder, T. Dillon, P. Bondarenko, 2008 .

Synthesis, degradation, and subcellular localization of proteins encoded by the primary response genes TIS7/PC4 and TIS21/PC3

R. Koski, S. Reddy, B. Varnum, 1994, Journal of cellular physiology.

clearance of apoptotic cells and platelet aggregation A soluble form of the Mer receptor tyrosine kinase inhibits macrophage

B. Varnum, D. Graham, Karla D. Kenyon, 2013 .

Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor.

B. Varnum, F. Bussolino, M. Gallicchio, 2005, Blood.

clearance of apoptotic cells and platelet aggregation A soluble form of the Mer receptor tyrosine kinase inhibits macrophage

B. Varnum, D. Graham, Karla D. Kenyon, 2013 .