A. Wickrema

T. Walsh, M. King, R. Larson, 2015, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells

J. Ulaszek, D. Mahmud, A. Wickrema, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Erythroblast Enucleation

A. Wickrema, J. Crispino, G. Keerthivasan, 2011, Stem cells international.

Erythropoiesis Hypomethylation during Adult Human Reveals Widespread Functional High Resolution Methylome Analysis

J. Greally, A. Verma, U. Steidl, 2013 .

High Resolution Methylome Analysis Reveals Widespread Functional Hypomethylation during Adult Human Erythropoiesis*

J. Greally, A. Verma, U. Steidl, 2013, The Journal of Biological Chemistry.

Utilization of leukapheresis and CD4 positive selection in Treg isolation and the ex-vivo expansion for a clinical application in transplantation and autoimmune disorders

A. Wickrema, J. Millis, P. Witkowski, 2016, Oncotarget.

Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function.

Kirby D. Johnson, A. Cantor, E. Bresnick, 2007, Blood.

Tetrodotoxin-sensitive Na+ channels and muscarinic and purinergic receptors identified in human erythroid progenitor cells and red blood cell ghosts.

S. Dib-Hajj, A. Wickrema, J. Hoffman, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Purified CD34+ Lin- Thy+ stem cells do not contain clonal myeloma cells.

B. Barlogie, S. Jagannath, G. Tricot, 1995, Blood.

AP1 Regulation of Proliferation and Initiation of Apoptosis in Erythropoietin-Dependent Erythroid Cells

M. Birrer, A. Wickrema, S. Sawyer, 1998, Molecular and Cellular Biology.

Erythroid Cells Apoptosis in Erythropoietin-Dependent AP 1 Regulation of Proliferation and Initiation of

M. Birrer, A. Wickrema, S. Sawyer, 1997 .

Cell banking for regulatory T cell-based therapy: strategies to overcome the impact of cryopreservation on the Treg viability and phenotype

J. Fung, A. Wickrema, J. Millis, 2018, Oncotarget.

Defective expression of the SHP-1 phosphatase in polycythemia vera.

T. Yi, L. Platanias, R. Hoffman, 1999, Experimental hematology.

Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells).

A. Wickrema, K. Penta, H. Bao, 1999, Blood.

The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells

O. Potapova, A. Wickrema, W. Joiner, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Interferon gamma delays apoptosis of mature erythroid progenitor cells in the absence of erythropoietin.

A. Wickrema, I. Choi, H. Nawata, 2000, Blood.

Growth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3

T. Zimmerman, J. Ulaszek, S. Uddin, 2008, Leukemia & lymphoma.

The demise of islet allotransplantation in the United States: A call for an urgent regulatory update

J. Gaglia, L. Philipson, Y. Becker, 2021 .

The demise of islet allotransplantation in the United States: A call for an urgent regulatory update

J. Gaglia, L. Philipson, Y. Becker, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Pre-treatment C-reactive Protein (CRP) is a Predictor for Allogeneic Hematopoietic Cell Transplantation Outcomes

R. Larson, J. Ulaszek, W. Stock, 2009 .

Low incidence of CMV viremia and disease after allogeneic peripheral blood stem cell transplantation. Role of pretransplant ganciclovir and post-transplant acyclovir

W. Stock, A. Wickrema, D. Peace, 2003, Bone Marrow Transplantation.

Phase II study of autologous transplantation with interleukin-2-incubated peripheral blood stem cells and posttransplantation interleukin-2 in relapsed or refractory non-Hodgkin lymphoma.

J. Sosman, W. Stock, A. Wickrema, 2004, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

hase II Study of Autologous Transplantation with nterleukin-2 – Incubated Peripheral Blood Stem Cells nd Posttransplantation Interleukin-2 in Relapsed r Refractory Non-Hodgkin Lymphoma

J. Sosman, W. Stock, A. Wickrema, 2004 .

Downregulation of Ribosomal Proteins Is Seen in Non 5q-MDS

B. Ebert, J. Greally, A. Verma, 2008 .

Tumor necrosis factor-alpha expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia.

P. Dent, Daniel P. Bailey, A. Wickrema, 2003, Blood.

Immune reconstitution after combined haploidentical and umbilical cord blood transplant

R. Larson, J. Ulaszek, W. Stock, 2013, Leukemia & lymphoma.

Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene.

T. Tang, A. Wickrema, Guang Yang, 2009, Blood.

Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival

R. Larson, P. Hari, W. Stock, 2016, Haematologica.

Ineffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice

A. Wickrema, P. Ji, Juehua Gao, 2016, Haematologica.

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.

K. Pradhan, Chuan He, R. Levine, 2019, Cancer discovery.

Engagement of Gab1 and Gab2 in Erythropoietin Signaling*

Arun Sharma, T. Hirano, L. Platanias, 1999, The Journal of Biological Chemistry.

Vesicle trafficking plays a novel role in erythroblast enucleation.

A. Wickrema, Hui Liu, J. Crispino, 2010, Blood.

Erythroid-Specific Processing of Human p Spectrin I Pre-mRNA

Sanford, A. Wickrema, Z. Chu, 2002 .

Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver.

Roberta B. Nowak, J. Li, V. Fowler, 2014, Blood.

RED CELLS , IRON , AND ERYTHROPOIESIS Tropomodulin 3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver

Roberta B. Nowak, J. Li, V. Fowler, 2014 .

Purification and Culture of Erythroid Progenitor Cells

A. Wickrema, C. Dai, S. Krantz, 2002 .

Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant

W. Stock, A. Wickrema, D. Peace, 2001, Bone Marrow Transplantation.

Hemopoietic Suppression in Aplastic Anemia Pathway Mediates Cytokine-Induced Mitogen-Activated Protein Kinase Signaling Cutting Edge: Activation of the p38

Amit Verma, S. Kambhampati, S. Uddin, 2002 .

Safety and outcome after fludarabine–thiotepa–TBI conditioning for allogeneic transplantation: a prospective study of 30 patients with hematologic malignancies

J. Sosman, R. Hoffman, F. Ravandi, 2003, Bone Marrow Transplantation.

R. Hoffman, F. Ravandi, W. Stock, 2003, Bone Marrow Transplantation.

Erythroid-specific processing of human beta spectrin I pre-mRNA.

A. Wickrema, S. Krantz, Z. Chu, 1994, Blood.

Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions.

R. Larson, J. Cunningham, W. Stock, 2011, Blood.

CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors.

D. J. Van Den Berg, L. Platanias, B. Druker, 1999, Experimental hematology.

Epigenetic modifiers in normal and aberrent erythropoeisis.

U. Steidl, A. Wickrema, S. Sundaravel, 2021, Seminars in hematology.

Survival or death of individual proerythroblasts results from differing erythropoietin sensitivities: a mechanism for controlled rates of erythrocyte production.

M. Koury, S. Koury, L. Kelley, 1993, Blood.

Abundance and stability of erythropoietin receptor mRNA in mouse erythroid progenitor cells.

A. Wickrema, M. Bondurant, S. Krantz, 1991, Blood.

Changes in cytoskeletal proteins and their mRNAs during maturation of human erythroid progenitor cells

S. Koury, A. Wickrema, C. Dai, 1994, Journal of cellular physiology.

Differential requirements for survivin in hematopoietic cell development.

A. Wickrema, J. Crispino, S. Gurbuxani, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis.

Tyson A. Clark, Jeong-Ah Kang, Tyson A Clark, 2009, Blood.

Na pump isoforms in human erythroid progenitor cells and mature erythrocytes

O. Potapova, A. Wickrema, J. Hoffman, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening.

A. Wickrema, M. Schipma, Reiner Bleher, 2016, Developmental cell.

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells.

Sheng Wei, A. Verma, U. Steidl, 2015, Blood.

Aberrant Epigenetic and Genetic Marks Are Seen in Myelodysplastic Leukocytes and Reveal Dock4 as a Candidate Pathogenic Gene on Chromosome 7q*

O. Abdel-Wahab, A. Melnick, Jinghang Zhang, 2011, The Journal of Biological Chemistry.

HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia.

A. Wickrema, L. Godley, Hui Liu, 2020, Blood advances.

NF-Y Recruits Both Transcription Activator and Repressor to Modulate Tissue- and Developmental Stage-Specific Expression of Human γ-Globin Gene

D. Tuan, A. Wickrema, W. Pi, 2012, PloS one.

Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase.

M. Bitzer, A. Verma, L. Platanias, 2011, Cancer research.

Receptor I Kinase β in MDS that Can Be Reversed by a Specific Inhibitor of TGF-Signaling β Reduced SMAD 7 Leads to Overactivation of TGF-Updated

M. Bitzer, A. Verma, L. Platanias, 2011 .

Reduced SMAD7 Leads to Overactivation of TGF-b Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-b

M. Bitzer, A. Verma, L. Platanias, 2010 .

Erythroid and megakaryocytic transformation

A. Wickrema, J. Crispino, A Wickrema, 2007, Oncogene.

Reduced-Intensity Allogeneic Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome Using Combined CD34-Selected Haploidentical Graft and a Single Umbilical Cord Unit Compared with Matched Unrelated Donor Stem Cells in Older Adults.

R. Larson, W. Stock, M. Bishop, 2017, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

erythroid progenitor cells Abundance and stability of erythropoietin receptor mRNA in mouse

A. Wickrema, M. Bondurant, S. Krantz, 2011 .

Activation of the p38 Mitogen-activated Protein Kinase Mediates the Suppressive Effects of Type I Interferons and Transforming Growth Factor-β on Normal Hematopoiesis*

A. Verma, L. Platanias, J. Varga, 2002, The Journal of Biological Chemistry.

Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells.

A. Wickrema, M. Bondurant, J. Winkelmann, 1992, Blood.

Clofarabine-associated acute kidney injury in patients undergoing hematopoietic stem cell transplant

P. O’Donnell, W. Stock, A. Wickrema, 2014, Leukemia & lymphoma.

Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes

A. Wickrema, Hui Liu, P. Ji, 2019, Cancer medicine.

Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks

A. Verma, A. Wickrema, T. Bhagat, 2019, Clinical Cancer Research.

Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.

Amit Verma, Bruce T Lahn, Chuan He, 2014, Cell reports.

Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors.

T. Pan, S. Uddin, A. Wickrema, 2013, Cytokine.

Distinct roles of erythropoietin, insulin-like growth factor I, and stem cell factor in the development of erythroid progenitor cells.

A. Wickrema, K. Muta, M. Bondurant, 1994, The Journal of clinical investigation.

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

W. Vainchenker, L. Platanias, A. Migliaccio, 2017, The Journal of clinical investigation.

Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.

M. Bitzer, A. Verma, S. Kambhampati, 2008, Blood.

Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS. Commentary

M. Bitzer, A. Verma, S. Kambhampati, 2008 .

Patterns and kinetics of T-cell chimerism after allo transplant with alemtuzumab-based conditioning: mixed chimerism protects from GVHD, but does not portend disease recurrence

R. Larson, W. Stock, A. Wickrema, 2009, Leukemia & lymphoma.

Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia.

A. Wickrema, L. Godley, J. Madzo, 2012, Blood.

Frequency and Risk Factors Associated with Cord Graft Failure after Transplant with Single-Unit Umbilical Cord Cells Supplemented by Haploidentical Cells with Reduced-Intensity Conditioning.

R. Larson, W. Stock, M. Bishop, 2016, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Older age but not donor health impairs allogeneic granulocyte colony-stimulating factor (G-CSF) peripheral blood stem cell mobilization.

A. Wickrema, K. van Besien, J. Anastasi, 2009, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations

T. Bowman, K. Pradhan, Amit Verma, 2022, bioRxiv.

Haplo-Cord UCB SCT with Low Cell Dose, Well Matched UCB Units. a Prospective Multicenter Study

R. Larson, J. Cunningham, W. Stock, 2014 .

Haplo+cord transplantation: Neutrophil and platelet recovery and long-term survival compared to double umbilical cord blood (UCB) transplantation--A case-cohort analysis.

R. Larson, P. Hari, W. Stock, 2014 .

Activation of Protein Kinase Cη by Type I Interferons*

A. Redig, L. Platanias, A. Wickrema, 2009, Journal of Biological Chemistry.

Cutting Edge: Activation of the p38 Mitogen-Activated Protein Kinase Signaling Pathway Mediates Cytokine-Induced Hemopoietic Suppression in Aplastic Anemia1

A. Verma, S. Kambhampati, L. Platanias, 2002, The Journal of Immunology.

Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients

S Miyano, S Imoto, S. Miyano, 2015, Bone Marrow Transplantation.

Loss of Specific Chaperones Involved in Membrane Glycoprotein Biosynthesis during the Maturation of Human Erythroid Progenitor Cells*

R. Reithmeier, A. Wickrema, Jeong-Ah Kang, 2009, Journal of Biological Chemistry.

High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma.

T. Pan, J. Goodenbour, A. Wickrema, 2009, Biochemical and biophysical research communications.

Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation.

R. Larson, J. Ulaszek, W. Stock, 2008, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Navigating Dilemmas in Treatment Choice: Our Approach to Supplemental Apheresis Prior to Enrollment in Early- Phase Cellular Therapy Clinical Trials.

P. Riedell, M. Bishop, A. Wickrema, 2021, Transplantation and Cellular Therapy.

Essential Role for the Mnk Pathway in the Inhibitory Effects of Type I Interferons on Myeloproliferative Neoplasm (MPN) Precursors*

J. Licht, A. Verma, L. Platanias, 2013, The Journal of Biological Chemistry.

The prognostic value of serum C-reactive protein, ferritin, and albumin prior to allogeneic transplantation for acute myeloid leukemia and myelodysplastic syndromes

M. Pasquini, A. Wickrema, U. Popat, 2016, Haematologica.

Stable transcriptional status in the apoptotic erythroid genome.

J. Ulaszek, S. Wang, A. Wickrema, 2007, Biochemical and biophysical research communications.

P. falciparum Modulates Erythroblast Cell Gene Expression in Signaling and Erythrocyte Production Pathways

K. Haldar, A. Wickrema, Hui Liu, 2011, PloS one.

malaria infection falciparum Plasmodium Stage-specific susceptibility of human erythroblasts to

K. Haldar, A. Wickrema, Hui Liu, 2010 .

Stage-specific susceptibility of human erythroblasts to Plasmodium falciparum malaria infection.

K. Haldar, A. Wickrema, Hui Liu, 2009, Blood.

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

H. Deeg, J. Greally, A. Verma, 2014 .

PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation

K. Pradhan, Amit Verma, R. Levine, 2022, Blood cancer discovery.

Identification of a novel microRNA cluster miR-193b-365 in multiple myeloma

T. Zimmerman, L. Platanias, A. Wickrema, 2009, Leukemia & lymphoma.

Erythroid-specific processing of human beta spectrin I pre-mRNA.

A. Wickrema, S. Krantz, Z. Chu, 1994, Blood.

BET inhibitors enhance embryonic and fetal globin expression in erythroleukemia cell lines

A. Wickrema, L. Godley, John Z Cao, 2021, Haematologica.

Expression of functional folate receptors in multiple myeloma

P. Low, S. Karmakar, A. Wickrema, 2018, Leukemia and Lymphoma.

Phase I-II Study of Clofarabine-Melphalan-Alemtuzumab Conditioning for Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Advanced Hematologic Malignancies: Unexpected Renal Toxicity

R. Larson, W. Stock, A. Wickrema, 2009 .

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

T. Bowman, K. Pradhan, A. Verma, 2019, Blood.

Prognostic significance of WT-1 levels in patients with myelodysplastic syndrome and leukemia after reduced-intensity allogeneic transplantation.

J. Ulaszek, D. Huo, W. Stock, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Phase I-II Study of Clofarabine-Melphalan-Alemtuzumab (CMA) Conditioning for Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Advanced Hematologic Malignancies: Determination of MTD and Outcomes.

R. Larson, W. Stock, A. Wickrema, 2009 .

Endocytosis and Erythroblast Enucleation Are Linked by the Action of a Survivin-EPS15-Clathrin Complex

A. Wickrema, Hui Liu, J. Crispino, 2008 .

Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes

M. L. Le Beau, S. Karmakar, A. Verma, 2015, Proceedings of the National Academy of Sciences.

Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells.

A. Wickrema, M. Bondurant, J. Winkelmann, 1992, Blood.

Analysis of the kinetics of band 3 diffusion in human erythroblasts during assembly of the erythrocyte membrane skeleton

P. Low, K. Ritchie, A. Wickrema, 2010, British journal of haematology.

Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis.

Tyson A. Clark, A. Schweitzer, J. Conboy, 2009, Blood.

Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.

R. Grossman, Chuan He, R. Levine, 2014, Cell reports.

Older age but not donor health impairs allogeneic granulocyte colony-stimulating factor (G-CSF) peripheral blood stem cell mobilization.

A. Wickrema, K. van Besien, J. Anastasi, 2009, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Frequency and Risk Factors Associated with Cord Graft Failure after Transplant with Single-Unit Umbilical Cord Cells Supplemented by Haploidentical Cells with Reduced-Intensity Conditioning.

R. Larson, W. Stock, M. Bishop, 2016, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Molecular Basis of Hematopoiesis

B. Kee, A. Wickrema, Amittha Wickrema, 2009 .