D. Offen

Abraham Weizman, D. Offen, R. Mechoulam, 2014, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice

D. Offen, Liat Edry, T. Kimchi, 2016, Autism research : official journal of the International Society for Autism Research.

Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cells.

E. Melamed, D. Offen, T. Ben-Zur, 2009, Stem cells and development.

Dopamine-melanin is actively phagocytized by PC12 cells and cerebellar granular cells: possible implications for the etiology of Parkinson's disease

E. Melamed, Z. Malik, S. Gorodin, 1999, Neuroscience Letters.

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

S. Korsmeyer, M. Vila, R. Djaldetti, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Prediction of synonymous corrections by the BE-FF computational tool expands the targeting scope of base editing

D. Offen, S. Abadi, R. Rabinowitz, 2020, Nucleic acids research.

Prediction of synonymous corrections by the BE-FF computational tool expands the targeting scope of base editing

D. Offen, S. Abadi, R. Rabinowitz, 2020, bioRxiv.

In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles.

Menachem Motiei, Oshra Betzer, Tamar Sadan, 2017, ACS nano.

Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes

D. Offen, R. Guy, 2020, Biomolecules.

Reply to "Comment on ' In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles'".

D. Offen, M. Motiei, R. Popovtzer, 2018, ACS nano.

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.

H. Senderowitz, M. B. Major, D. Offen, 2018, ChemPlusChem.

Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection.

E. Melamed, D. Offen, O. Sadan, 2010, Investigative ophthalmology & visual science.

Genes to treat excitotoxicity ameliorate the symptoms of the disease in mice models of multiple system atrophy

G. Wenning, N. Stefanova, D. Offen, 2020, Journal of Neural Transmission.

Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy

D. Offen, T. Ben-Zur, Y. Barhum, 2016, PloS one.

Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application

S. Mandel, E. Melamed, D. Offen, 2010, EPMA Journal.

Induction of human mesenchymal stem cells into dopamine-producing cells with different differentiation protocols.

E. Melamed, D. Offen, T. Ben-Zur, 2008, Stem cells and development.

Extracellular Vesicles Tracking and Quantification Using CT and Optical Imaging in Rats.

D. Offen, S. Levenberg, S. Landau, 2020, Bio-protocol.

Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity.

E. Melamed, O. Bernard, S. Gorodin, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Combined Gene Therapy to Reduce the Neuronal Damage in the Mouse Model of Focal Ischemic Injury

L. Molcho, D. Offen, T. Ben-Zur, 2018, Journal of Molecular Neuroscience.

A Novel Rodent Model of Hypertensive Cerebral Small Vessel Disease with White Matter Hyperintensities and Peripheral Oxidative Stress

U. Nevo, D. Offen, E. Auriel, 2022, International journal of molecular sciences.

Harnessing neurogenesis for the possible treatment of Parkinson's disease

E. Melamed, D. Offen, J. Ganz, 2014, The Journal of comparative neurology.

Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease.

E. Melamed, D. Offen, Y. Levy, 2008, Cytotherapy.

Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells

E. Melamed, D. Offen, Y. Levy, 2007, Journal of Molecular Neuroscience.

A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2

E. Melamed, D. Offen, N. Regev, 2015, PloS one.

ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction

D. Offen, P. Jose, P. Latham, 2020, International journal of molecular sciences.

Spinal Cord mRNA Profile in Patients with ALS: Comparison with Transgenic Mice Expressing the Human SOD-1 Mutant

E. Melamed, D. Offen, G. Ransmayr, 2009, Journal of Molecular Neuroscience.

Activation of nuclear transcription factor kappa B (NF‐κB) is essential for dopamine‐induced apoptosis in PC12 cells

A. Barzilai, E. Melamed, D. Daily, 2001, Journal of neurochemistry.

Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier

E. Melamed, D. Offen, Y. Gilgun-Sherki, 2001, Neuropharmacology.

DJ-1 Knockout Augments Disease Severity and Shortens Survival in a Mouse Model of ALS

D. Offen, Y. Barhum, I. Lotan, 2015, PloS one.

DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.

E. Melamed, H. Cohen, D. Offen, 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

Knocking Out DJ-1 Attenuates Astrocytes Neuroprotection Against 6-Hydroxydopamine Toxicity

E. Melamed, D. Offen, T. Ben-Zur, 2013, Journal of Molecular Neuroscience.

DJ-1 Changes in G93A-SOD1 Transgenic Mice: Implications for Oxidative Stress in ALS

E. Melamed, D. Offen, Y. Barhum, 2009, Journal of Molecular Neuroscience.

Prevention of Dopamine-Induced Cell Death by Thiol Antioxidants: Possible Implications for Treatment of Parkinson's Disease

I. Ziv, E. Melamed, D. Offen, 1996, Experimental Neurology.

Dopamine-induced programmed cell death in mouse thymocytes.

A. Barzilai, I. Ziv, E. Melamed, 1995, Biochimica et biophysica acta.

Levodopa Toxicity and Apoptosis

A. Barzilai, R. Djaldetti, I. Ziv, 1998, Annals of neurology.

Enhanced Oxidative Stress and Altered Antioxidants in Brains of Bcl‐2‐Deficient Mice

S. Korsmeyer, I. Ziv, E. Melamed, 1998, Journal of neurochemistry.

Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons — A possible novel pathogenetic mechanism in Parkinson's disease

A. Barzilai, A. Achiron, I. Ziv, 1994, Neuroscience Letters.

Dopamine–melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease

A. Barzilai, I. Ziv, E. Melamed, 1997, Neurochemistry International.

Glial fibrillary acidic protein as a marker of astrocytic activation in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

D. Offen, F. Benninger, M. Glat, 2016, Journal of Clinical Neuroscience.

Multifactorial Gene Therapy Enhancing the Glutamate Uptake System and Reducing Oxidative Stress Delays Symptom Onset and Prolongs Survival in the SOD1-G93A ALS Mouse Model

D. Offen, T. Ben-Zur, Y. Barhum, 2015, Journal of Molecular Neuroscience.

Dopaminergic-Like Neurons Derived from Oral Mucosa Stem Cells by Developmental Cues Improve Symptoms in the Hemi-Parkinsonian Rat Model

D. Offen, Y. Barhum, S. Pitaru, 2014, PloS one.

Catechol-O-Methyltransferase Decreases Levodopa Toxicity In Vitro

E. Melamed, D. Offen, R. Galili-Mosberg, 2001, Clinical neuropharmacology.

Levodopa – an exotoxin or a therapeutic drug?

I. Ziv, E. Melamed, D. Offen, 2000, Journal of Neurology.

Levodopa induces apoptosis in cultured neuronal cells—A possible accelerator of nigrostriatal degeneration in Parkinson's disease?

A. Barzilai, I. Ziv, E. Melamed, 1997, Movement disorders : official journal of the Movement Disorder Society.

Dopamine-induced, genotoxic activation of programmed cell death. A role in nigrostriatal neuronal degeneration in Parkinson's disease?

I. Ziv, E. Melamed, A. Achiron, 1996, Advances in neurology.

Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents

E. Melamed, D. Offen, Y. Barhum, 2006, Neuroscience Letters.

Protective effect of insulin-like-growth-factor-1 against dopamine-induced neurotoxicity in human and rodent neuronal cultures: possible implications for Parkinson’s disease

Abraham Weizman, D. Offen, I. Gil-ad, 2001, Neuroscience Letters.

Bax deficiency reduces infarct size and improves long-term function after myocardial infarction

D. Offen, E. Birk, Y. Barhum, 2007, Cell Biochemistry and Biophysics.

Nigrostriatal neuronal death in Parkinson's disease--a passive or an active genetically-controlled process?

I. Ziv, E. Melamed, D. Offen, 1997, Journal of neural transmission. Supplementum.

Hemin-induced apoptosis in PC12 and neuroblastoma cells: Implications for local neuronal death associated with intracerebral hemorrhage

E. Melamed, D. Offen, Y. Levy, 2009, Neurotoxicity Research.

A Chemical Chaperone‐Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

S. Petri, H. Senderowitz, M. Shubely, 2015, ChemMedChem.

The proto-oncogene Bcl-2 inhibits cellular toxicity of dopamine: possible implications for Parkinson's Disease

I. Ziv, E. Melamed, D. Offen, 2004, Apoptosis.

Dopamine-Induced Apoptosis Is Inhibited in PC12 Cells Expressing Bcl-2

I. Ziv, E. Melamed, D. Offen, 1997, Cellular and Molecular Neurobiology.

Modulation of control mechanisms of dopamine-induced apoptosis--a future approach to the treatment of Parkinson's disease?

I. Ziv, E. Melamed, D. Offen, 1997, Journal of neural transmission. Supplementum.

Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease

E. Melamed, D. Offen, O. Sadan, 2012, PLoS currents.

Oxidative stress and neuroprotection in Parkinson's disease: implications from studies on dopamine-induced apoptosis.

I. Ziv, E. Melamed, S. Gorodin, 1999, Advances in neurology.

Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease 1 This manuscript is based on a poster presented at the Brain Research Interactive Symposium on “Neuropeptides at the Millennium”, Miami, October 1999. 1

E. Melamed, D. Offen, I. Gozes, 2000, Brain Research.

Transplantation of Placenta-Derived Mesenchymal Stem Cells in the EAE Mouse Model of MS

E. Melamed, D. Offen, O. Sadan, 2012, Journal of Molecular Neuroscience.

Intracerebroventricular Transplantation of Human Mesenchymal Stem Cells Induced to Secrete Neurotrophic Factors Attenuates Clinical Symptoms in a Mouse Model of Multiple Sclerosis

E. Melamed, D. Offen, Merav Bahat-Stromza, 2010, Journal of Molecular Neuroscience.

Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model

D. Offen, Y. Barhum, I. Steiner, 2017, International journal of molecular sciences.

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials.

E. Melamed, T. Ben-Hur, D. Offen, 2016, JAMA neurology.

Safety and Clinical Effects ofMesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in PatientsWith Amyotrophic Lateral Sclerosis Results of Phase 1 / 2 and 2 a Clinical Trials

T. Ben-Hur, D. Offen, D. Karussis, 2016 .

Monoamine-Induced Apoptotic Neuronal Cell Death

A. Barzilai, I. Ziv, E. Melamed, 1997, Cellular and Molecular Neurobiology.

Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B

D. Offen, E. Elliott, O. Oron, 2020, Molecular Autism.

Bone marrow stem cells: possible source for cell therapy in Parkinson’s disease

E. Melamed, D. Offen, Y. Levy, 2005 .

Extracellular vesicles over adeno-associated viruses: Advantages and limitations as drug delivery platforms in precision medicine.

D. Offen, R. Guy, N. Yom-Tov, 2022, Advanced drug delivery reviews.

Intranasal delivery of mesenchymal stem cells‐derived extracellular vesicles for the treatment of neurological diseases

D. Offen, Shay Herman, Idan Fishel, 2021, Stem cells.

CrisPam: SNP-derived PAM analysis web tool and human pathogenic SNPs database for CRISPR allele-specific targeting

D. Offen, R. Rabinowitz, R. Darnell, 2019 .

Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase.

I. Ziv, E. Melamed, D. Offen, 2002, Journal of molecular neuroscience : MN.

Prediction of synonymous corrections by the BE-FF computational tool expands the targeting scope of base editing

D. Offen, R. Rabinowitz, S. Almog, 2020, Nucleic Acids Res..

Running title: Neural differentiation and lipid metabolism

D. Offen, R. Mesilati-Stahy, P. Green, 2021 .

Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice.

N. Maulik, H. Otani, D. Offen, 2003, American journal of physiology. Heart and circulatory physiology.

Immunohistochemical analysis of sympathetic involvement in the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis

V. Drory, A. Korczyn, D. Offen, 2013, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Rare combination of myasthenia and motor neuronopathy, responsive to Msc‐Ntf stem cell therapy

E. Melamed, T. Ben-Hur, D. Offen, 2014, Muscle & nerve.

Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells

D. Offen, N. Abramov, A. Harel, 2014, Clinical and Translational Medicine.

Integral therapeutic potential of bone marrow mesenchymal stem cells.

E. Melamed, D. Offen, I. Kan, 2005, Current drug targets.

The molecular mechanisms of dopamine toxicity.

A. Barzilai, I. Ziv, E. Melamed, 2003, Advances in neurology.

Comparative characterization of bone marrow-derived mesenchymal stromal cells from four different rat strains.

E. Melamed, D. Offen, O. Sadan, 2009, Cytotherapy.

The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.

Abraham Weizman, S. Janelidze, D. Offen, 2016, Journal of affective disorders.

Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism

Michael London, Ran Barzilay, Daniel Offen, 2017, Behavioural Brain Research.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

V. Drory, A. Korczyn, D. Offen, 2013 .

Exosomes derived from adipose mesenchymal stem cells: a potential non-invasive intranasal treatment for autism

D. Offen, E. Elliott, O. Oron, 2020 .

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury.

D. Offen, S. Levenberg, I. Michaelevski, 2019, ACS nano.

CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology.

B. Mollenhauer, R. Djaldetti, D. Offen, 2022, Brain : a journal of neurology.

Wnt Signaling Enhances Neurogenesis and Improves Neurological Function after Focal Ischemic Injury

E. Melamed, D. Offen, T. Ben‐Zur, 2012, PloS one.

Mutant and wild-type α-synuclein interact with mitochondrial cytochrome C oxidase

I. Ziv, E. Melamed, D. Offen, 2002, Journal of Molecular Neuroscience.

Increased RNA editing in maternal immune activation model of neurodevelopmental disease

T. Sofer, E. Levanon, D. Offen, 2020, Nature Communications.

The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy

Daniel Offen, E. Melamed, D. Offen, 2004, Journal of Neurology.

Cell and gene therapy in Alzheimer's disease.

D. Offen, M. Glat, 2013, Stem cells and development.

Antioxidant Therapy in Acute Central Nervous System Injury: Current State

E. Melamed, D. Offen, Y. Gilgun-Sherki, 2002, Pharmacological Reviews.

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders.

D. Offen, U. Ashery, Ronit Shapira, 2019, Nano letters.

Role of DJ-1 in parkinson’s disease

E. Melamed, D. Offen, N. Lev, 2007, Journal of Molecular Neuroscience.

Role of DJ-1 in Parkinson's disease

Daniel Offen, E. Melamed, D. Offen, 2007, Journal of Molecular Neuroscience.

Introducing Transcription Factors to Multipotent Mesenchymal Stem Cells: Making Transdifferentiation Possible

E. Melamed, D. Offen, R. Barzilay, 2009, Stem cells.

Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson's disease.

E. Melamed, D. Offen, Y. Levy, 2007, Journal of neural transmission. Supplementum.

Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β‐peptide

E. Melamed, D. Offen, H. Eldar-Finkelman, 2011, Journal of neurochemistry.

Ectopic Muscle Expression of Neurotrophic Factors Improves Recovery After Nerve Injury

D. Offen, Y. Barhum, D. Yaffe, 2015, Journal of Molecular Neuroscience.

Mice overexpressing Bcl-2 in their neurons are resistant to myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE)

E. Melamed, A. Ben-nun, O. Bernard, 2000, Journal of Molecular Neuroscience.

Caspase-6 Knockout in the 5xFAD Model of Alzheimer’s Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks

D. Offen, Ariel Angel, Rotem Volkman, 2020, International journal of molecular sciences.

Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer’s Disease

D. Offen, B. Garty, Rotem Volkman, 2019, Front. Neurosci..

Altered astrocytic response to activation in SOD1G93A mice and its implications on amyotrophic lateral sclerosis pathogenesis

D. Offen, Y. Barhum, Chen Benkler, 2013, Glia.

Bax ablation protects against hepatic ischemia/reperfusion injury in transgenic mice

D. Offen, O. Pappo, J. Sulkes, 2007, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Implantation of 3D Constructs Embedded with Oral Mucosa-Derived Cells Induces Functional Recovery in Rats with Complete Spinal Cord Transection

D. Offen, S. Levenberg, I. Michaelevski, 2017, Front. Neurosci..

Cell replacement therapy for Parkinson’s disease: how close are we to the clinic?

E. Melamed, D. Offen, J. Ganz, 2011, Expert review of neurotherapeutics.

The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.

E. Melamed, D. Offen, R. Mechoulam, 2003, Pharmacology & toxicology.

Molecular biology of dopamine-induced apoptosis : possible implications for Parkinson's disease.

I. Ziv, E. Melamed, D. Offen, 2001, Methods in molecular medicine.

Apoptosis as a general cell death pathway in neurodegenerative diseases.

E. Melamed, D. Offen, H. Elkon, 2000, Journal of neural transmission. Supplementum.

Therapeutic Potential of Neurotrophic Factors in Neurodegenerative Diseases

E. Melamed, D. Offen, Y. Levy, 2012, BioDrugs.

Cannabidiol as a suggested candidate for treatment of autism spectrum disorder

Abraham Weizman, D. Offen, P. Golubchik, 2019, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder

B. Barak, N. Shomron, D. Offen, 2021, Translational Psychiatry.

Mesenchymal Stem Cells Stimulate Endogenous Neurogenesis in the Subventricular Zone of Adult Mice

E. Melamed, D. Offen, I. Kan, 2011, Stem Cell Reviews and Reports.

Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases

E. Melamed, D. Offen, O. Sadan, 2009, Expert opinion on biological therapy.

Oxidative stress, induced by 6-hydroxydopamine, reduces proteasome activities in PC12 cells

E. Melamed, D. Offen, H. Elkon, 2007, Journal of Molecular Neuroscience.

Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage

Daniel Offen, E. Melamed, D. Offen, 2006, Neuroscience Letters.

6-Hydroxydopamine Increases Ubiquitin-Conjugates and Protein Degradation: Implications for the Pathogenesis of Parkinson's Disease

E. Melamed, D. Offen, H. Elkon, 2001, Cellular and Molecular Neurobiology.

Polymorphism in candidate genes: implications for the risk and treatment of idiopathic Parkinson's disease

R. Djaldetti, E. Melamed, D. Offen, 2004, The Pharmacogenomics Journal.

Knocking Out DJ-1 Attenuates Astrocytes Neuroprotection Against 6-Hydroxydopamine Toxicity

E. Melamed, D. Offen, Y. Barhum, 2013, Journal of Molecular Neuroscience.

Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment.

D. Michaelson, D. Offen, Y. Barhum, 2016, Journal of Alzheimer's disease : JAD.

Placental mesenchymal stromal cells induced into neurotrophic factor-producing cells protect neuronal cells from hypoxia and oxidative stress.

E. Melamed, D. Offen, M. Hod, 2012, Cytotherapy.

Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: A potential therapy for Huntington's disease

Y. Cohen, Y. Assaf, N. Shemesh, 2012, Experimental Neurology.

Striatal Microinjection of Sydenham Chorea Antibodies: Using a Rat Model to Examine the Dopamine Hypothesis

D. Offen, O. Sadan, H. Ben-Pazi, 2011, Journal of Molecular Neuroscience.

Neurogenesis in the aged and neurodegenerative brain

E. Melamed, D. Offen, Adi Shruster, 2010, Apoptosis.

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.

D. Ehrnhoefer, M. Hayden, D. Offen, 2015, Human molecular genetics.

Alginate‐coated magnetic nanoparticles for noninvasive MRI of extracellular calcium

Y. Cohen, Smadar Cohen, L. Avram, 2014, NMR in biomedicine.

A low molecular weight copper chelator crosses the blood–brain barrier and attenuates experimental autoimmune encephalomyelitis

E. Melamed, D. Offen, D. Atlas, 2004, Journal of neurochemistry.

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

Michael London, Daniel Offen, Stav Hertz, 2018, Molecular Autism.

Computational normal mode analysis accurately replicates the activity and specificity profiles of CRISPR-Cas9 and high-fidelity variants

D. Offen, F. Benninger, O. Shor, 2022, Computational and structural biotechnology journal.

Antioxidant treatment in alzheimer’s disease

E. Melamed, D. Offen, Y. Gilgun-Sherki, 2003, Journal of Molecular Neuroscience.

Developmental changes in antioxidant enzymes and oxidative damage in kidneys, liver and brain of bcl-2 knockout mice.

H. Liang, E. Melamed, D. Offen, 2000, Cellular and molecular biology.

Autotransplantation of bone marrow-derived stem cells as a therapy for neurodegenerative diseases.

E. Melamed, D. Offen, I. Kan, 2007, Handbook of experimental pharmacology.

Combined Gene Therapy to Reduce the Neuronal Damage in the Mouse Model of Focal Ischemic Injury

L. Molcho, D. Offen, Y. Barhum, 2018, Journal of Molecular Neuroscience.

Multifactorial Gene Therapy Enhancing the Glutamate Uptake System and Reducing Oxidative Stress Delays Symptom Onset and Prolongs Survival in the SOD1-G93A ALS Mouse Model

D. Offen, Y. Barhum, Chen Benkler, 2015, Journal of Molecular Neuroscience.

Voluntary exercise improves cognitive deficits in female dominant-negative DISC1 transgenic mouse model of neuropsychiatric disorders

D. Offen, R. Barzilay, H. Segal‐Gavish, 2019, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Induction of Adult Human Bone Marrow Mesenchymal Stromal Cells into Functional Astrocyte-Like Cells: Potential for Restorative Treatment in Parkinson’s Disease

E. Melamed, D. Offen, Y. Levy, 2009, Journal of Molecular Neuroscience.

Striatal Microinjection of Sydenham Chorea Antibodies: Using a Rat Model to Examine the Dopamine Hypothesis

D. Offen, O. Sadan, H. Ben-Pazi, 2011, Journal of Molecular Neuroscience.

Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases.

Y. Cohen, N. Shemesh, E. Melamed, 2009, The Israel Medical Association journal : IMAJ.

Stem Cells as a Source for Cell Replacement in Parkinson’s Disease

E. Melamed, D. Offen, Y. Levy, 2006 .

A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models

D. Offen, G. Lederkremer, M. Shenkman, 2020, Scientific Reports.

Antibodies from ALS patients inhibit dopamine release mediated by L-type calcium channels

E. Melamed, D. Offen, D. Atlas, 1998, Neurology.

Apoptosis and Parkinson's disease

E. Melamed, D. Offen, N. Lev, 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases

D. Offen, Rotem Volkman, 2017, Stem cells.

Embryonic and adult stem cells as a source for cell therapy in Parkinson’s disease

E. Melamed, D. Offen, Y. Levy, 2007, Journal of Molecular Neuroscience.

The Involvement of p53 in Dopamine-Induced Apoptosis of Cerebellar Granule Neurons and Leukemic Cells Overexpressing p53

A. Barzilai, I. Ziv, E. Melamed, 1999, Cellular and Molecular Neurobiology.

BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction

I. Slutsky, Abraham Weizman, A. Sawa, 2017, Human molecular genetics.

Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia

T. Sofer, D. Offen, Y. Goldshmit, 2020, Translational Psychiatry.

The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo.

D. Michaelson, D. Offen, Ariel Angel, 2019, Current Alzheimer research.

Anti-inflammatory drugs in the treatment of neurodegenerative diseases: current state.

E. Melamed, D. Offen, Y. Gilgun-Sherki, 2006, Current pharmaceutical design.

The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity.

A. Barzilai, I. Ziv, E. Melamed, 2000, Journal of neural transmission. Supplementum.

Stem Cells as a Source for Cell Therapy in Parkinson’s Disease

D. Offen, J. Ganz, N. Lev, 2014 .

Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience Eilat, Israel, November 25–27, 2007

Yonina C. Eldar, Karl J. Friston, Leslie G. Ungerleider, 2008, Neural plasticity.

Docosahexaenoic acid and arachidonic acid are fundamental supplements for the induction of neuronal differentiation Published, JLR Papers in Press, December 21, 2006.

E. Melamed, D. Offen, P. Green, 2007, Journal of Lipid Research.

Riluzole suppresses experimental autoimmune encephalomyelitis: implications for the treatment of multiple sclerosis

E. Melamed, D. Offen, Hana Panet, 2003, Brain Research.

Axonal damage is reduced following glatiramer acetate treatment in C57/bl mice with chronic-induced experimental autoimmune encephalomyelitis

D. Offen, V. Holdengreber, Hana Panet, 2003, Neuroscience Research.

Computationally Engineered CRISPR-SpyCas9 High-Fidelity Variants with Improved Specificity and Reduced Non-specific DNA Damage

U. Ben-David, D. Offen, F. Benninger, 2023, bioRxiv.

Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis.

Daniel Offen, E. Melamed, D. Offen, 2006, Antioxidants & redox signaling.

Single-Base Resolution: Increasing the Specificity of the CRISPR-Cas System in Gene Editing.

D. Offen, R. Rabinowitz, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Bax-ablation attenuates experimental autoimmune encephalomyelitis in mice

E. Melamed, D. Offen, Y. Barhum, 2004, Neuroscience Letters.

Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model

Daniel Offen, J. Rabey, D. Offen, 2007, Experimental Neurology.

DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury

L. Molcho, D. Offen, Y. Barhum, 2018, PloS one.

Progressive damage along the optic nerve following induction of crush injury or rodent anterior ischemic optic neuropathy in transgenic mice

D. Weinberger, D. Offen, Y. Barhum, 2008, Molecular vision.

Repeated Behavioral Patterns in Animal Models of Autism

D. Offen, N. Perets, Nisim Perets, 2021 .

Toll‐like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE‐induced epilepsy in mice

D. Offen, E. Okun, Tomer Illouz, 2017, Epilepsia.

Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpinemodel of SE-induced epilepsy inmice

D. Offen, Tomer Illouz, Ravit Madar, 2017 .

Treatment of mesenchymal stem cells derived exosomes leads to significant behavioral improvement of both genetic and idiopathic autism

M. London, D. Offen, E. Elliott, 2019, Cytotherapy.

Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.

Daniel Offen, E. Melamed, D. Offen, 2008, Neurotoxicology.

A Multifunctional Biocompatible Drug Candidate is Highly Effective in Delaying Pathological Signs of Alzheimer's Disease in 5XFAD Mice.

D. Offen, B. Fischer, Y. Barhum, 2017, Journal of Alzheimer's disease : JAD.

A Novel Brain-Targeted Antioxidant (AD4) Attenuates Haloperidol-Induced Abnormal Movement in Rats:: Implications for Tardive Dyskinesia

E. Melamed, D. Offen, D. Atlas, 2005, Clinical neuropharmacology.

Toxic causes of parkinsonism.

E. Melamed, D. Offen, N. Lev, 2007, Handbook of clinical neurology.

DJ-1 protects against dopamine toxicity

Daniel Offen, E. Melamed, D. Offen, 2009, Journal of Neural Transmission.

Liposome-based targeting of dopamine to the brain: a novel approach for the treatment of Parkinson’s disease

Abraham Weizman, M. Gavish, D. Offen, 2020, Molecular Psychiatry.

Analysis of gene expression in MOG-induced experimental autoimmune encephalomyelitis after treatment with a novel brain-penetrating antioxidant

E. Melamed, D. Offen, D. Atlas, 2007, Journal of Molecular Neuroscience.

Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro

Abraham Weizman, D. Offen, O. Sadan, 2013, European Neuropsychopharmacology.

Intracerebral adult stem cells transplantation increases brain-derived neurotrophic factor levels and protects against phencyclidine-induced social deficit in mice

Abraham Weizman, E. Melamed, D. Offen, 2011, Translational Psychiatry.

CD44 Deficiency Is Associated with Increased Susceptibility to Stress-Induced Anxiety-like Behavior in Mice

Abraham Weizman, S. Janelidze, D. Offen, 2016, Journal of Molecular Neuroscience.

A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models

D. Offen, G. Lederkremer, M. Shenkman, 2020, Scientific Reports.

Transplanted Modified Muscle Progenitor Cells Expressing a Mixture of Neurotrophic Factors Delay Disease Onset and Enhance Survival in the SOD1 Mouse Model of ALS

E. Perlson, D. Offen, Y. Barhum, 2015, Journal of Molecular Neuroscience.

Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience Eilat, Israel, November 25–27, 2007

Yonina C. Eldar, Karl J. Friston, Leslie G. Ungerleider, 2008, Neural plasticity.

Labeling and tracking exosomes within the brain using gold nanoparticles

Oshra Betzer, Rachela Popovtzer, Nisim Perets, 2018, BiOS.

Chapter 13 – The Role of Oxidative Stress in the Pathogenesis of Multiple Sclerosis: Current State

E. Melamed, D. Offen, N. Lev, 2007 .

Early perceptual loss in depression

Yonina C. Eldar, Karl J. Friston, Charles R. Seger, 2007 .

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Proposed Therapy in a Rat Model of Cerebral Small Vessel Disease

H. Benyamini, D. Offen, M. Pasmanik-Chor, 2022, International journal of molecular sciences.

Dopaminergic differentiation of human mesenchymal stem cells—Utilization of bioassay for tyrosine hydroxylase expression

E. Melamed, D. Offen, Y. Levy, 2007, Neuroscience Letters.

A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson's disease

E. Melamed, D. Offen, A. Barzilai, 2005, The European journal of neuroscience.

Haloperidol – induced neurotoxicity – possible implications for tardive dyskinesia

Abraham Weizman, E. Melamed, D. Offen, 2000, Journal of Neural Transmission.

Stem cells treatment for sciatic nerve injury

Daniel Offen, E. Melamed, D. Offen, 2011, Expert opinion on biological therapy.

The role of neurotransmitters and neuropeptides in Parkinson's disease: implications for therapy

E. Melamed, D. Offen, M. Hellmann, 2004 .

Abstracts of the 15th Annual Meeting of the Israel Society for Neuroscience Eilat, Israel, December 3–5, 2006

Leslie G. Ungerleider, D. Amit, H. Seung, 2006, Neural Plasticity.

Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease

D. Offen, Adi Shruster, 2014, Behavioural Brain Research.

Adult stem cells for neuronal repair.

E. Melamed, D. Offen, Y. Levy, 2006, The Israel Medical Association journal : IMAJ.

Longitudinal MRI and MRSI characterization of the quinolinic acid rat model for excitotoxicity: peculiar apparent diffusion coefficients and recovery of N‐acetyl aspartate levels

Y. Cohen, N. Shemesh, E. Melamed, 2010, NMR in biomedicine.

Haloperidol Induces Neurotoxicity in Mouse Embryo Brain Tissue

Abraham Weizman, D. Offen, I. Gil-ad, 1998 .

Riluzole, an inhibitor of glutamatergic transmission, suppresses levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.

I. Ziv, E. Melamed, D. Offen, 2003, Pharmacology & toxicology.

In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles.

G. Yadid, D. Offen, M. Motiei, 2017, ACS nano.

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders.

D. Offen, U. Ashery, Ronit Shapira, 2019, Nano letters.

Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice

D. Offen, Liat Edry, T. Kimchi, 2016, Autism research : official journal of the International Society for Autism Research.

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.

H. Senderowitz, D. Offen, Zhengyu Jiang, 2018, ChemPlusChem.