D. Klein

发表

Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex A Role for Scaffolding in Enzyme Regulation

R. Ghirlando, F. Dyda, T. Obsil, 2001, Cell.

Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer/E box interaction.

D. Klein, N. W. Chong, M. Bernard, 2000, The Journal of biological chemistry.

The Structural Basis of Ordered Substrate Binding by Serotonin N-Acetyltransferase Enzyme Complex at 1.8 Å Resolution with a Bisubstrate Analog

David C. Klein, Fred Dyda, F. Dyda, 1999, Cell.

Kinetic Analysis of the Catalytic Mechanism of Serotonin N-Acetyltransferase (EC 2.3.1.87)*

P. Cole, D. Klein, J. De Angelis, 1998, The Journal of Biological Chemistry.

De novo discovery of serotonin N-acetyltransferase inhibitors.

R. Abagyan, P. Cole, Marc A. Holbert, 2007, Journal of medicinal chemistry.

FACT maintains pluripotency factor expression through gene-distal regulation in embryonic stem cells

D. Klein, Sarah J. Hainer, Santana M. Lardo, 2021 .

MATERNAL-FETAL TRANSFER OF MELATONIN IN THE NON-HUMAN PRIMATE

S. Reppert, D. Klein, R. Chez, 1978, Pediatric Research.

Photoneural regulation of the mammalian pineal gland.

D. Klein, 1985, Ciba Foundation symposium.

MicroRNAs in the Pineal Gland

D. Klein, P. Lau, S. Clokie, 2012, The Journal of Biological Chemistry.

Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205.

D. Klein, S. Ganguly, B. Malpaux, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Suprachiasmatic nucleus : the mind's clock

David C. Klein, Steven M. Reppert, S. Reppert, 1991 .

Rat pineal α1‐adrenoceptor subtypes: studies using radioligand binding and reverse transcription‐polymerase chain reaction analysis

D. Klein, D. Sugden, N. Anwar, 1996 .

Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site.

P. Skolnick, D. Klein, A. Basile, 1986, Brain research.

Transcriptome analysis of the zebrafish pineal gland

J. Epstein, R. Toyama, I. Dawid, 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation.

D. Klein, J. Gastel, P. Roseboom, 1998, Science.

Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina.

D. Klein, S. Coon, L. Klitten, 2008, Experimental eye research.

Pineal Enzymes: Regulation of Avian Melatonin Synthesis

C. L. Ralph, D. Klein, S. Binkley, 1973, Science.

Melatonin pathway: breaking the 'high-at-night' rule in trout retina.

D. Klein, G. Boeuf, S. Coon, 2006, Experimental eye research.

Selective Genomic Targeting by FRA-2/FOSL2 Transcription Factor

D. Klein, J. Davies, D. Carter, 2011, The Journal of Biological Chemistry.

The effects of environmental lighting on the daily melatonin rhythm in primate cerebrospinal fluid

S. Reppert, D. Klein, L. Tamarkin, 1981, Brain Research.

Protein kinase C: subcellular redistribution by increased Ca2+ influx. Evidence that Ca2+-dependent subcellular redistribution of protein kinase C is involved in potentiation of beta-adrenergic stimulation of pineal cAMP and cGMP by K+ and A23187.

W. Anderson, D. Klein, T. Thomas, 1988, The Journal of biological chemistry.

pY RNA1-s2: A Highly Retina-Enriched Small RNA That Selectively Binds to Matrin 3 (Matr3)

Fumiyoshi Yamazaki, C. Wilusz, D. Klein, 2014, PloS one.

pY RNA 1s 2 : A Highly Retina-Enriched Small RNA That Selectively Binds to Matrin 3 ( Matr 3 )

Fumiyoshi Yamazaki, D. Klein, P. Lau, 2022 .

Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland.

R. Baler, D. Klein, S. Coon, 1996, Endocrinology.

RADIOMETRIC ASSAY OF TOTAL TRYPTOPHAN HYDROXYLATION BY INTACT CULTURED PINEAL GLANDS

W. Lovenberg, D. Klein, J. Weller, 1974, Journal of neurochemistry.

Systematic Identification of Rhythmic Genes Reveals camk1gb as a New Element in the Circadian Clockwork

Shahar Alon, Eli Eisenberg, Gideon Rechavi, 2012, PLoS genetics.

Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior

E. Eisenberg, D. Vallone, N. Foulkes, 2016, PLoS genetics.

Arylalkylamine N-Acetyltransferase: “the Timezyme”*

D. Klein, 2007, Journal of Biological Chemistry.

Transcripts encoding two melatonin synthesis enzymes in the teleost pineal organ: circadian regulation in pike and zebrafish, but not in trout.

D. Klein, V. Bégay, S. Coon, 1998, Endocrinology.

Zebrafish serotonin N-acetyltransferase-2: marker for development of pineal photoreceptors and circadian clock function.

D. Klein, Y. Gothilf, M. Namboodiri, 1999, Endocrinology.

Night/Day Changes in Pineal Expression of >600 Genes

Michael J. Bailey, R. Baler, P. Munson, 2009, Journal of Biological Chemistry.

Evolution of AANAT: expansion of the gene family in the cephalochordate amphioxus

E. Koonin, M. Omelchenko, D. Klein, 2010, BMC Evolutionary Biology.

Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat.

D. Klein, F. Morin, M. F. Rath, 2007, Experimental eye research.

Photic regulation of the melatonin rhythm: monkey and man are not the same

R. Wyatt, S. Reppert, D. Klein, 1980, Brain Research.

Induction of adrenal tyrosine hydroxylase in organ culture.

S. Silberstein, J. Axelrod, D. Klein, 1972, Neuropharmacology.

Pineal hydroxyindole-O-methyl transferase activity in the growing rat.

D. Klein, S. Lines, 1969, Endocrinology.

Thin-layer chromatographic separation of pineal gland derivatives of serotonin-14C.

D. Klein, A. Ntides, 1969, Analytical biochemistry.

Melatonin Synthesis: Adenosine 3',5'-Monophosphate and Norepinephrine Stimulate N-Acetyltransferase

D. Klein, J. Weller, G. R. Berg, 1970, Science.

Dual receptor regulation of cyclic nucleotides: alpha 1-adrenergic potentiation of vasoactive intestinal peptide stimulation of pinealocyte adenosine 3',5'-monophosphate.

D. Klein, A. Ho, C. Chik, 1988, Endocrinology.

Rapid and reversible activation of acetyl CoA hydrolase in intact pineal cells by disulfide exchange.

D. Klein, M. Namboodiri, J. Weller, 1980, Biochemical and biophysical research communications.

Evidence of inactivation of pineal indoleamine N-acetyltransferase by protein thiol:disulfide exchange.

D. Klein, M. Namboodiri, J. Weller, 1980, The Journal of biological chemistry.

Activation of pineal and brain acetyl-COA hydrolase by cystamine: an apparent case of disulfide exchange.

D. Klein, M. Namboodiri, J. Favilla, 1979, Biochemical and biophysical research communications.

Rat arylalkylamine N-acetyltransferase gene: upstream and intronic components of a bipartite promoter.

R. Baler, D. Klein, S. Covington, 1999, Biology of the cell.

Rat arylalkylamine N‐acetyltransferase gene: Upstream and intronic components of a bipartite promoter

R. Baler, D. Klein, S. Covington, 1999 .

Evolution of melatonin as a night signal: Contribution from a primitive photosynthetic organism

D. Klein, P. Roseboom, S. J. Donohue, 1992, Molecular and Cellular Neuroscience.

Bovine hydroxyindole-O-methyltransferase. Significant sequence revision.

D. Klein, P. Roseboom, S. J. Donohue, 1992, The Journal of biological chemistry.

Taurine: Stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism

D. Klein, J. Weller, G. H. Wheler, 1979, Brain Research.

Transcripts Encoding Two Melatonin Synthesis Enzymes in the Teleost Pineal Organ: Circadian Regulation in Pike and Zebrafish, But Not in Trout.

D. Klein, S. Coon, G. Cahill, 1998, Endocrinology.

Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug.

P. Cole, D. Klein, S. Ganguly, 2007, Bioorganic & medicinal chemistry.

Subfornical organ: Effects of salt loading and water deprivation on in vitro radioamino acid incorporation into individual proteins

D. Jacobowitz, D. Klein, G. J. Creed, 1986, Brain Research.

Adenosine stimulates adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate accumulation in rat pinealocytes: evidence for a role for adenosine in pineal neurotransmission.

D. Klein, O. Nikodijević, 1989, Endocrinology.

A diurnal melatonin rhythm in primate cerebrospinal fluid.

S. Reppert, D. Klein, L. Tamarkin, 1979, Endocrinology.

Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) on protein kinase C activity and adrenergic stimulation of cAMP and cGMP in rat pinealocytes.

D. Klein, A. Ho, C. Chik, 1988, Biochemical pharmacology.

Chick Pineal Melatonin Synthesis

D. Klein, J. Gastel, M. Zatz, 2000, Journal of neurochemistry.

The Molecular Basis of the Pineal Melatonin Rhythm: Regulation of Serotonin N-Acetylation

R. Baler, V. Cassone, D. Klein, 1998, Handbook of Behavioral State Control.

Drastic neofunctionalization associated with evolution of the timezyme AANAT 500 Mya

E. Koonin, Y. Wolf, P. J. Steinbach, 2013, Proceedings of the National Academy of Sciences.

NeuroD1: developmental expression and regulated genes in the rodent pineal gland

Michael J. Bailey, D. Klein, S. Coon, 2007, Journal of neurochemistry.

Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland.

R. Baler, D. Klein, S. Coon, 1996, Endocrinology.

Alpha 1D L-type Ca(2+)-channel currents: inhibition by a beta-adrenergic agonist and pituitary adenylate cyclase-activating polypeptide (PACAP) in rat pinealocytes.

D. Klein, M. Zylka, A. Ho, 1997, Journal of neurochemistry.

Regulation of Rat Pineal α1‐Adrenoceptors

D. Klein, D. Sugden, D. C. Klein, 1985 .

Biosynthesis of biopterin: adrenergic cyclic adenosine monophosphate-dependent inhibition in the pineal gland.

S. Kaufman, D. Klein, J. Weller, 1981, Science.

Retinal S-antigen: immunocytochemical and immunochemical studies on distribution in animal photoreceptors and pineal organs.

R. Elofsson, M. Mochizuki, D. Klein, 1986, Experimental biology.

PINEAL SEROTONIN N‐ACETYLTRANSFERASE ACTIVITY: PROTECTION OF STIMULATED ACTIVITY BY ACETYL‐CoA AND RELATED COMPOUNDS

D. Klein, J. Weller, S. Binkley, 1976, Journal of neurochemistry.

Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA.

D. Klein, H. Illnerová, P. Roseboom, 1993, DNA and cell biology.

Sympathetic nerve endings in the pineal gland protect against acute stress-induced increase in N-acetyltransferase (EC 2.3.1.5.) activity.

D. Klein, A. Parfitt, 1976, Endocrinology.

Regulation of pineal rhythms in chickens: refractory period and nonvisual light perception.

C. L. Ralph, D. Klein, S. Binkley, 1975, Endocrinology.

Regulation of “peripheral-type” binding sites for benzodiazepines in the pineal gland

P. Skolnick, D. Klein, B. Weissman, 1984, Pharmacology Biochemistry and Behavior.

Regulation of Pineal α1B-Adrenergic Receptor mRNA: Day/Night Rhythm and β-Adrenergic Receptor/Cyclic AMP Control

D. Klein, D. Sugden, S. Coon, 1997 .

Regulation of pineal alpha1B-adrenergic receptor mRNA: day/night rhythm and beta-adrenergic receptor/cyclic AMP control.

D. Klein, D. Sugden, S. Coon, 1997, Molecular pharmacology.

Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina.

D. Klein, N. W. Chong, M. Bernard, 1999, Reproduction, nutrition, development.

Rat pineal acx-adrenoceptor subtypes: studies using radioligand binding and reverse transcription-polymerase chain reaction analysis

D. Klein, D. Sugden, N. Anwar, 2006 .

Alternative Isoform Analysis of Ttc8 Expression in the Rat Pineal Gland Using a Multi-Platform Sequencing Approach Reveals Neural Regulation

Stephen W. Hartley, J. Mullikin, Morgan Park, 2016, PloS one.

Recoverin in pineal organs and retinae of various vertebrate species including man

D. Klein, H. Korf, B. White, 1992, Brain Research.

alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates.

D. Klein, H. Korf, P. Gierschik, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Rhodopsin kinase activity in the mammalian pineal gland and other tissues.

D. Klein, R. Somers, 1984, Science.

Forskolin stimulates pinealocyte cGMP accumulation Dramatic potentiation by an α1‐adrenergic → [Ca2+]i mechanism involving protein kinase C

D. Klein, A. Ho, C. Chik, 1989 .

Melatonin synthesis in retina: cAMP‐dependent transcriptional regulation of chicken arylalkylamine N‐acetyltransferase by a CRE‐like sequence and a TTATT repeat motif in the proximal promoter

R. Haque, D. Klein, N. W. Chong, 2011, Journal of neurochemistry.

ADRENERGIC REGULATION OF CYCLIC AMP AND CYCLIC GMP IN RAT PINEALOCYTES

D. Klein, D. Sugden, 1986 .

Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine.

D. Klein, J. Engel, J. E. Martin, 1977, Endocrinology.

Cardiac glycosides stimulate phospholipase C activity in rat pinealocytes.

D. Klein, V. Ceña, A. Ho, 1987, Biochemical and biophysical research communications.

Multiple Forms of Arylalkylamine N‐Acetyltransferases in the Rat Pineal Gland: Purification of One Molecular Form

M. Brownstein, D. Klein, M. Namboodiri, 1987, Journal of pineal research.

Purification of Rat Pineal Hydroxyindole‐O‐Methyltransferase Using S‐Adenosyl‐L‐Homocysteine Agarose Chromatography

D. Klein, D. Sugden, P. Voisin, 1986, Journal of pineal research.

Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.

D. Klein, M. Namboodiri, P. Voisin, 1984, The Journal of biological chemistry.

Reciprocal day/night relationship between serotonin oxidation and N-acetylation products in the rat pineal gland.

J. Barchas, D. Klein, D. Sugden, 1983, Endocrinology.

Development of MEKA (phosducin), Gβ, Gγ and S-antigen in the rat pineal gland and retina

W. Simonds, D. Klein, T. Shinohara, 1992, Brain Research.

Selective Adrenergic/Cyclic AMP‐Dependent Switch‐Off of Proteasomal Proteolysis Alone Switches on Neural Signal Transduction

D. Klein, H. Korf, C. Schomerus, 2000, Journal of neurochemistry.

A subpopulation of neonatal gonadotropin-releasing hormone-sensitive pituitary cells is responsive to melatonin.

J. Vanecek, D. Klein, 1993, Endocrinology.

Melatonin and puberty.

D. Klein, 1984, Science.

α1-Adrenergic Potentiation of Vasoactive Intestinal Peptide Stimulation of Rat Pinealocyte Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′- Monophosphate: Evidence for a Role of Calcium and Protein Kinase-C

D. Klein, A. Ho, C. Chik, 1988 .

Transmembrane receptor cross-talk: Concurrent VIP and α1-adrenergic activation rapidly elevates pinealocyte cGMP > 100-fold

D. Klein, A. Ho, C. Chik, 1987 .

Protein kinase C is involved in adrenergic stimulation of pineal cGMP accumulation.

D. Klein, A. Ho, C. Chik, 1987, The Journal of biological chemistry.

Isolation of cDNAs for Bovine S-Antigen

D. Klein, I. Gery, C. Craft, 1986 .

Methionine Adenosyltransferase:Adrenergic-cAMP Mechanism Regulates a Daily Rhythm in Pineal Expression*

C. Cepko, S. Blackshaw, D. Klein, 2005, Journal of Biological Chemistry.

Circadian Expression of Transcription Factor Fra-2 in the Rat Pineal Gland (*)

R. Baler, D. Klein, D. C. Klein, 1995, The Journal of Biological Chemistry.

Ovine arylalkylamine N-acetyltransferase in the pineal and pituitary glands: differences in function and regulation.

D. Klein, P. Morgan, P. Barrett, 1999, Endocrinology.

Neural Adrenergic/Cyclic AMP Regulation of the Immunoglobulin E Receptor α-Subunit Expression in the Mammalian Pinealocyte

D. Klein, S. Ganguly, D. Sugden, 2007, Journal of Biological Chemistry.

RGS2 is a feedback inhibitor of melatonin production in the pineal gland

D. Klein, S. Coon, M. Matsuo, 2013, FEBS letters.

On GABA function and physiology in the pineal gland

D. Klein, J. Weller, B. Schrier, 1976, Brain Research.

Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase.

D. Klein, D. Sugden, J. Weller, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of pineal melatonin in the Syrian hamster.

S. Reppert, D. Klein, L. Tamarkin, 1979, Endocrinology.

Regulation of pineal serotonin N-acetyltransferase activity.

D. Klein, J. Weller, L. Yu, 1992, Biochemical Society transactions.

Pineal N-acetyltransferase activity in blinded and anosmic male rats.

R. Reiter, D. Klein, J. Weller, 1971, Endocrinology.

Genomic methods in profiling DNA accessibility and factor localization

D. Klein, Sarah J. Hainer, 2019, Chromosome Research.

The melatonin rhythm generating system: developmental aspects.

D. Klein, M. Namboodiri, D. A. Auerbach, 1981, Life sciences.

The pineal family of aromatic amine N‐acetyltransferases

D. Klein, M. Namboodiri, P. Voisin, 1985, BioEssays : news and reviews in molecular, cellular and developmental biology.

Global daily dynamics of the pineal transcriptome

Michael J. Bailey, D. Klein, D. Sugden, 2011, Cell and Tissue Research.

Role of adenosine-3',5'-monophosphate in the hormonal regulation of bone resorption: studies with cultured fetal bone.

D. Klein, L. Raisz, 1971, Endocrinology.

Prostaglandins: stimulation of bone resorption in tissue culture.

D. Klein, D C Klein, L. Raisz, 1970, Endocrinology.

Pineal N-acetyltransferase is inactivated by disulfide-containing peptides: insulin is the most potent.

D. Klein, M. Namboodiri, D C Klein, 1981, Science.

2-Fluoro-L-histidine, an inhibitor of enzyme induction.

D. Klein, J. Weller, K. Kirk, 1976, Molecular pharmacology.

Alpha 1-adrenoceptor activation elevates cytosolic calcium in rat pinealocytes by increasing net influx.

D. Klein, D. Sugden, L. Sugden, 1987, The Journal of biological chemistry.

Essential role of calcium influx in the adrenergic regulation of cAMP and cGMP in rat pinealocytes.

D. Klein, D. Sugden, A. Sugden, 1986, The Journal of biological chemistry.

Atypical synergistic α1- and β-adrenergic regulation of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in rat pinealocytes

J. Vanecek, D. Klein, D. Sugden, 1985 .

Blockade by ouabain or elevated potassium ion concentration of the adrenergic and adenosine cyclic 3',5'-monophosphate-induced stimulation of pineal serotonin N-acetyltransferase activity.

D. Klein, B. Marks, J. Weller, 1975, Molecular pharmacology.

Evidence of alpha 1-adrenergic----protein kinase C----Na+/H+ antiporter-dependent increase in pinealocyte intracellular pH. Role in the adrenergic stimulation of cGMP accumulation.

D. Klein, J. Weller, A. Ho, 1989, The Journal of biological chemistry.

Postsynaptic a-adrenergic receptors potentiate the ,8-adrenergic stimulation of pineal serotonin N-acetyltransferase

D. Klein, D. Sugden, J. Weller, 2022 .

Beta adrenergic-blockers decrease adrenergically stimulated N-acetyltransferase activity in pineal glands in organ culture

D. Klein, J. Weller, A. Parfitt, 1976, Neuropharmacology.

Control of the circadian rhythm in pineal serotonin N-acetyltransferase activity: possible role of protein thiol: disulfide exchange

D. Klein, M. Namboodiri, 1982 .

Inactivation of pineal N-acetyltransferase by disulfide exchange: a possible role of S-S peptides

D. Klein, M. Namboodiri, 1981 .

14‐3‐3 Proteins in Pineal Photoneuroendocrine Transduction: How Many Roles?

F. Dyda, T. Obsil, D. Klein, 2003, Journal of neuroendocrinology.

Absence of choline acetyltransferase in rat and rabbit pineal gland.

D. Klein, D C Klein, B. Schrier, 1974, Brain research.

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

J. Vanecek, W. Anderson, D. Klein, 1985, Nature.

Ethanol inhibits dual receptor stimulation of pineal cAMP and cGMP by vasoactive intestinal peptide and phenylephrine.

D. Klein, A. Ho, C. Chik, 1987, Biochemical and biophysical research communications.

Alpha-adrenergic potentiation of beta-adrenergic stimulation of rat pineal N-acetyltransferase. Studies using cirazoline and fluorine analogs of norepinephrine.

D. Klein, D. Sugden, J. Weller, 1984, Biochemical pharmacology.

The pineal gland: a model of neuroendocrine regulation.

D. Klein, 1978, Research publications - Association for Research in Nervous and Mental Disease.

Chromatin regulation and dynamics in stem cells.

D. Klein, Sarah J. Hainer, 2020, Current topics in developmental biology.

Preliminary observations on the reproductive effects of the pineal gland in blinded, anosmic male rats.

R. Reiter, D. Klein, R. Donofrio, 1969, Journal of reproduction and fertility.

Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity.

D. Klein, R. Moore, R Y Moore, 1974, Brain research.

Daily Rhythm in Plasma N-acetyltryptamine

C. Mason, P. Backlund, D. Klein, 2017, Journal of biological rhythms.

Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N-acetyltransferase activity.

D. Klein, R. Moore, J. Weller, 1971, Proceedings of the National Academy of Sciences of the United States of America.

Ovine Pineal Indoles: Effects of l‐Tryptophan or l‐5‐Hydroxytryptophan Administration

D. Klein, D. Sugden, I. Mefford, 1985, Journal of neurochemistry.

Photic Regulation of Arylalkylamine N-Acetyltransferase Binding to 14-3-3 Proteins in Retinal Photoreceptor Cells

R. Haque, H. Fu, Yuhong Du, 2006, The Journal of Neuroscience.

Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase.

R. Haque, J. Zawilska, D. Klein, 2002, Investigative ophthalmology & visual science.

Melatonin biosynthesis in chicken retina. Regulation of tryptophan hydroxylase and arylalkylamine N-acetyltransferase.

D. Klein, M. Bernard, K. B. Thomas, 1999, Advances in experimental medicine and biology.

Pineal gland in organ culture. I. Inhibition by harmine of serotonin-14C oxidation, accompanied by stimulation of melatonin-14C production.

D. Klein, J. Rowe, 1970, Molecular pharmacology.

Melatonin inhibition of GnRH-induced LH release from neonatal rat gonadotroph: involvement of Ca2+ not cAMP.

J. Vanecek, D. Klein, 1995, The American journal of physiology.

Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic→ spinal cord circuit in the melatonin rhythm generating system

D. Jacobowitz, D. Klein, J. Weller, 1983, Brain Research Bulletin.

Studies on the daily pattern of pineal melatonin in the Syrian hamster.

S. Reppert, D. Klein, L. Tamarkin, 1980, Endocrinology.

Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells.

J. Vanecek, D. Klein, 1992, Endocrinology.

cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation.

M. Rollag, D. Klein, H. Korf, 2001, The Journal of biological chemistry.

Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells.

J. Vanecek, D. Klein, 1992, Endocrinology.

Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor.

D. Klein, J. E. Martin, 1976, Science.

Chapter 19 – The Pineal Gland and Melatonin

D. Klein, 2016 .

The 2004 Aschoff/Pittendrigh Lecture: Theory of the Origin of the Pineal Gland— A Tale of Conflict and Resolution

D. Klein, 2004, Journal of biological rhythms.

Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina

R. Haque, D. Klein, G. Tosini, 2005, Progress in Retinal and Eye Research.

Pinealocyte projections into the mammalian brain revealed with S-antigen antiserum.

D. Klein, H. Korf, I. Gery, 1986, Science.

Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus

D. Klein, R. Moore, 1979, Brain Research.

Effects of 6-hydroxy-, 6-fluoro-, and 4,6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone.

D. Klein, K. Kirk, J. E. Martin, 1980, Endocrinology.

[68] Hydroxyindole O-methyltransferase

D. Klein, D. Sugden, V. Ceña, 1987 .

Beta-adrenergic receptor control of rat pineal hydroxyindole-O-methyltransferase.

D. Klein, D. Sugden, 1983, Endocrinology.

Adrenergic stimulation of rat pineal hydroxyindole-O-methyltransferase

D. Klein, D. Sugden, 1983, Brain Research.

Effect of norepinephrine on the concentration of adenosine 3',5'-monophosphate of rat pineal gland in organ culture.

B. Weiss, D. Klein, J. Weller, 1972, Endocrinology.

Long-term organ culture of rat anterior pituitary glands.

D. Klein, J. E. Martin, 1976, Endocrinology.

S-antigen-like immunoreactivity in a human pineocytoma

D. Klein, H. Korf, I. Gery, 2004, Acta Neuropathologica.

Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species

D. Klein, H. Korf, I. Gery, 2004, Cell and Tissue Research.

Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression

Michael C. Kelly, M. Kelley, D. Klein, 2018, PloS one.

Evolution of cell-cell signaling in animals: did late horizontal gene transfer from bacteria have a role?

E. Koonin, L. Aravind, L. Iyer, 2004, Trends in genetics : TIG.

Developmental appearance of pineal adrenergic-->guanosine 3',5'-monophosphate response is determined by a process down-stream from elevation of intracellular Ca2+: possible involvement of a diffusible factor.

D. Klein, B. White, 1993, Endocrinology.

Pineal nitric oxide synthase: characteristics, adrenergic regulation and function

D. Klein, S. Coon, A. Lin, 1994, Brain Research.

The pineal adrenergic----cyclic GMP response develops two weeks after the adrenergic----cyclic AMP response.

D. Klein, J. Weller, 1992, Brain research. Developmental brain research.

Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation of pineal phospholipase A2 activity.

D. Klein, A. Ho, 1987, The Journal of biological chemistry.

Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation.

D. Klein, C. Woodard, G. Aurbach, 1981, Endocrinology.

Adrenergic control of pineal N-acetyltransferase activity: developmental aspects.

D. Klein, J. Weller, M. Buda, 1977, The American journal of physiology.

AN IMPROVED APPARATUS FOR THE DETERMINATION OF AMINO GROUPS

D. Klein, 1911 .

14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin.

F. Dyda, T. Obsil, D. Klein, 2001, Biochemical Society transactions.

Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis

Steven L. Coon, David C. Klein, Jean A. Boutin, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland

Shahar Alon, Eli Eisenberg, Jasmine Jacob-Hirsch, 2009, Bioinform..

Avian Melatonin Synthesis: Photic and Circadian Regulation of Serotonin N‐Acetyltransferase mRNA in the Chicken Pineal Gland and Retina

V. Cassone, D. Klein, M. Bernard, 1997, Journal of neurochemistry.

CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N‐acetyltransferase mRNA in chicken cone photoreceptors

R. Haque, D. Klein, Jane Abey, 2010, Journal of neurochemistry.

Temporal–spatial characterization of chicken clock genes: circadian expression in retina, pineal gland, and peripheral tissues

R. Haque, D. Klein, P. Iuvone, 2003, Journal of neurochemistry.

Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87).

W. Young, D. Klein, S. Coon, 2002, The Journal of clinical endocrinology and metabolism.

Serotonin N-Acetyltransferase

D. Klein, 2002 .

Zebrafish Serotonin N-Acetyltransferase-2: Marker for Development of Pineal Photoreceptors and Circadian Clock Function1.

R. Toyama, D. Klein, Y. Gothilf, 1999, Endocrinology.

Two Arylalkylamine N-Acetyltransferase Genes Mediate Melatonin Synthesis in Fish*

D. Klein, S. Coon, J. Falcón, 1999, The Journal of Biological Chemistry.

Circadian expression of tryptophan hydroxylase mRNA in the chicken retina.

V. Cassone, D. Klein, M. Bernard, 1998, Brain research. Molecular brain research.

Expression of melatonin synthesis genes is controlled by a circadian clock in the pike pineal organ but not in the trout

D. Klein, S. Coon, J. Falcón, 1998 .

Expression of melatonin synthesis genes is controlled by a circadian clock in the pike pineal organ but not in the trout.

D. Klein, S. Coon, J. Falcón, 1998, Biology of the cell.

Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture.

D. Klein, M. Bernard, M. Zatz, 1997, Proceedings of the National Academy of Sciences of the United States of America.

New light is shining on the melatonin rhythm enzyme The first postcloning view

D. Klein, S. Coon, P. Roseboom, 1996, Trends in Endocrinology & Metabolism.

The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression.

I. Rodriguez, K. Mazuruk, D. Klein, 1996, Genomics.

Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells

D. Klein, M. Bernard, S. J. Donohue, 1995, Brain Research.

Pineal serotonin N-acetyltransferase activity: abrupt decrease in adenosine 3',5'-monophosphate may be signal for "turnoff".

D. Klein, G. Krishna, M. Buda, 1978, Science.

2-Fluoro-L-Histidine: A Histidine Analog Which Inhibits Enzyme Induction

D. Klein, K. Kirk, 1976 .

Pineal gland: stimulation of melatonin production by norepinephrine involves cyclic AMP-mediated stimulation of N-acetyltransferase.

D. Klein, G. R. Berg, Bergus Gr, 1970, Advances in biochemical psychopharmacology.

Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation

Weiping Zheng, P. Cole, D. Klein, 2003, Nature Structural Biology.

Serum melatonin and pineal indoleamine metabolism in a species with a small day/night N-acetyltransferase rhythm.

D. Klein, D. Sugden, I. Mefford, 1985, Comparative biochemistry and physiology. B, Comparative biochemistry.

Characterization of the Saccharomyces cerevisiae Homolog of the Melatonin Rhythm Enzyme Arylalkylamine N-Acetyltransferase (EC 2.3.1.87)*

P. J. Steinbach, D. Klein, S. Ganguly, 2001, The Journal of Biological Chemistry.

Molecular Evolution of Multiple Arylalkylamine N-Acetyltransferase (AANAT) in Fish

S. Bransburg-Zabary, D. Klein, Y. Gothilf, 2011, Marine drugs.

Evolution of arylalkylamine N-acetyltransferase: Emergence and divergence

D. Klein, S. Coon, 2006, Molecular and Cellular Endocrinology.

Starting the zebrafish pineal circadian clock with a single photic transition.

D. Klein, Y. Gothilf, Robin Vuilleumier, 2006, Endocrinology.

Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation

D. Klein, S. Ganguly, S. Coon, 2002, Cell and Tissue Research.

Regulation of Arylalkylamine N-Acetyltransferase-2 (AANAT2, EC 2.3.1.87) in the Fish Pineal Organ: Evidence for a Role of Proteasomal Proteolysis.

D. Klein, S. Coon, J. Weller, 2001, Endocrinology.

F. Dyda, D. Klein, A. Hickman, 2000, Annual review of biophysics and biomolecular structure.

The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.

R. Baler, I. Rodriguez, V. Cassone, 1997, Recent progress in hormone research.

Use of charcoal adsorption for the microassay of acetyl-CoA-hydrolase.

D. Klein, M. Namboodiri, 1979, Analytical biochemistry.

Mechanism of melatonin signal transduction in the neonatal rat pituitary

J. Vanecek, D. Klein, 1995, Neurochemistry International.

Evolution of The Vertebrate Pineal Gland: The Aanat Hypothesis

D. Klein, 2006, Chronobiology international.

Rodent Aanat: Intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland

R. Baler, D. Klein, T. Wells, 2007, Molecular and Cellular Endocrinology.

Characterization of the Chicken SerotoninN-Acetyltransferase Gene

D. Klein, M. Bernard, N. Chong, 2000, The Journal of Biological Chemistry.

Genetic, Temporal and Developmental Differences Between Melatonin Rhythm Generating Systems in the Teleost Fish Pineal Organ and Retina

D. Klein, Y. Gothilf, G. Boeuf, 2003, Journal of neuroendocrinology.

Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli

D. Klein, H. Korf, J. Olcese, 2002, Cell and Tissue Research.

Rapid Nocturnal Increase in Ovine Pineal N‐Acetyltransferase Activity and Melatonin Synthesis: Effects of Cycloheximide

D. Klein, D. Sugden, I. Mefford, 1985, Journal of neurochemistry.

The Timezyme and Melatonin: Essential Elements of Vertebrate Timekeeping

D. Klein, S. Ganguly, Surajit Ganguly, 2017 .

Ontogeny of the pineal melatonin rhythm in the Syrian (Mesocricetus auratus) and Siverian (Phodopus sungorus) hamsters and in the rat.

S. Reppert, D. Klein, L. Tamarkin, 1980, Endocrinology.

Evidence for the placental transfer of 3 H-acetyl-melatonin.

D. Klein, David C. Klein, 1972, Nature: New biology.

Adrenergic-adenosine 3',5'-monophosphate regulation of serotonin N-acetyltransferase activity and the temporal relationship of serotonin N-acetyltransferase activity synthesis of 3H-N-acetylserotonin and 3H-melatonin in the cultured rat pineal gland.

D. Klein, J. Weller, 1973, The Journal of pharmacology and experimental therapeutics.

Single Cell Sequencing of the Pineal Gland: The Next Chapter

Michael C. Kelly, Steven W. Hartley, J. Mullikin, 2019, Front. Endocrinol..

Homeobox Genes in the Rodent Pineal Gland: Roles in Development and Phenotype Maintenance

D. Klein, K. Rohde, M. F. Rath, 2013, Neurochemical Research.

Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is Strongly Expressed in a Subpopulation of Pinealocytes in the Male Rat Pineal Gland.

D. Klein, S. Coon, J. Weller, 2016, Endocrinology.

Genetic variability in plasma melatonin in sheep is due to pineal weight, not to variations in enzyme activities.

D. Klein, B. Malpaux, P. Chemineau, 1999, The American journal of physiology.

Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase.

I. Rodriguez, D. Zimonjic, D. Klein, 1998, Brain research. Molecular brain research.

Regulation of pineal rhythms in chickens: effects of blinding, constant light, constant dark, and superior cervical ganglionectomy.

C. L. Ralph, D. Klein, S. Binkley, 1975, Endocrinology.

Orphan nuclear receptor RZRbeta: cyclic AMP regulates expression in the pineal gland.

R. Baler, D. Klein, S. Coon, 1996, Biochemical and biophysical research communications.

A COMPARATIVE STUDY OF PINEAL ACETYL‐CoA HYDROLASE AND N‐ACETYLTRANSFERASE ACTIVITIES

D. Klein, M. Namboodiri, J. Weller, 1979, Journal of neurochemistry.

Pineal function: Impact of microarray analysis

Michael J. Bailey, P. Munson, D. Klein, 2010, Molecular and Cellular Endocrinology.

Characterization of the alpha +-like Na+,K+-ATPase which mediates ouabain inhibition of adrenergic induction of N-acetyltransferase (EC 2.3.1.87) activity: studies with isolated pinealocytes.

D. Klein, V. Ceña, C. González-García, 1987, Molecular pharmacology.

The circadian rhythm of oxytocin in primate cerebrospinal fluid: effects of destruction of the suprachiasmatic nuclei

David C. Klein, Leslie G. Ungerleider, Steven M. Reppert, 1984, Brain Research.

Biosynthesis and release of glycoproteins by pineal gland in organ culture.

D. Klein, I. Lott, R. Quarles, 1972, Biochimica et biophysica acta.

Increase caused by desmethylimipramine in the production of [3H]melatonin by isolated pineal glands.

D. Klein, A. Parfitt, 1977, Biochemical pharmacology.

Histamine mediation of nicotine effects on postganglionic sympathetic neuroeffector junctions

D. Klein, C. Chiou, J. Trzeciakowski, 1976, Neuropharmacology.

The Lhx9 homeobox gene controls pineal gland development and prevents postnatal hydrocephalus

Fumiyoshi Yamazaki, D. Klein, S. Clokie, 2014, Brain Structure and Function.

Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina

Ryan K. Dale, C. Mason, Charles Wang, 2020, Journal of pineal research.

Circadian changes in long noncoding RNAs in the pineal gland

J. Mullikin, P. Munson, P. Cherukuri, 2012, Proceedings of the National Academy of Sciences.

An improved method for the determination of tryptophane with p-dimethylaminobenzaldehyde.

D. Klein, C. E. Graham, S. W. Hier, 1947 .

Arylalkylamine N-acetyltransferase from mammalian pineal gland.

D. Klein, M. Namboodiri, R. Dubbels, 1987, Methods in enzymology.

Zebrafish serotonin-N-acetyltransferase-2 gene regulation: pineal-restrictive downstream module contains a functional E-box and three photoreceptor conserved elements.

R. Baler, L. Appelbaum, R. Toyama, 2004, Molecular endocrinology.

[67] Arylalkylamine N-acetyltransferase from mammalian pineal gland

D. Klein, M. Namboodiri, R. Dubbels, 1987 .

NeuroD1 is required for survival of photoreceptors but not pinealocytes: Results from targeted gene deletion studies

S. Goebbels, D. Klein, S. Coon, 2012, Journal of neurochemistry.

Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta-adrenergic receptor/cyclic AMP mechanism.

D. Klein, P. Roseboom, 1995, Molecular pharmacology.

Evidence for the secretion of thyrocalcitonin at normal and subnormal plasma calcium levels.

D. Klein, R. Talmage, 1968, Endocrinology.

Cloning and Characterization of the ∈ and ζ Isoforms of the 14-3-3 Proteins

J. Moffett, A. Aitken, D. Klein, 1994 .

Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins.

J. Moffett, A. Aitken, D. Klein, 1994, DNA and Cell Biology.

Immunoreactive S-antigen in cerebrospinal fluid: a marker of pineal parenchymal tumors?

M. Rollag, D. Klein, H. Korf, 1989, Journal of neurosurgery.

Immunocytochemical demonstration of rod-opsin, S-antigen, and neuron-specific proteins in the human pineal gland

D. Klein, H. Korf, Shih-Kai Huang, 1992, Cell and Tissue Research.

Monoamine oxidase in rat placenta, human placenta, and cultured choriocarcinoma.

D. Klein, J. C. Robinson, C. H. Chen, 1976, Journal of reproduction and fertility.

Function and Regulation of Taurine in the Pineal Gland

D. Klein, G. H. Wheler, G. Wheler, 1981 .

Taurine release from the pineal gland is stimulated via a β-adrenergic mechanism

D. Klein, G. H. Wheler, G. Wheler, 1980, Brain Research.

Evidence That Proline Focuses Movement of the Floppy Loop of Arylalkylamine N-Acetyltransferase (EC 2.3.1.87)*

D. Sackett, S. Hassan, D. Klein, 2008, Journal of Biological Chemistry.

Pineal and Retinal Relationships

D. Klein, P. O’Brien, Retinal Relationships, 2012 .

Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism.

F. Dyda, D. Klein, A. Hickman, 2000, Molecular cell.

NGFI‐B (Nurr77/Nr4a1) orphan nuclear receptor in rat pinealocytes: circadian expression involves an adrenergic‐cyclic AMP mechanism

R. Baler, D. Klein, D. Carter, 2004, Journal of neurochemistry.

Regulation of arylalkylamine N-acetyltransferase-2 (AANAT2, EC 2.3.1.87) in the fish pineal organ: evidence for a role of proteasomal proteolysis.

D. Klein, S. Coon, J. Weller, 2001, Endocrinology.

Localization of the hydroxyindole-O-methyltransferase gene to the pseudoautosomal region: implications for mapping of psychiatric disorders.

O. Mcbride, D. Klein, H. Yi, 1993, Human molecular genetics.

Neurotranscriptomics: The Effects of Neonatal Stimulus Deprivation on the Rat Pineal Transcriptome

J. Mullikin, D. Klein, S. Hartley, 2015, PloS one.

Effect of Thyrocalcitonin, Administered During Peritoneal Lavage, on Removal of Bone Salts and Their Radioisotopes.∗ ‡

D. Klein, R. Talmage, H. Morh, 1967, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Genetic variability in plasma melatonin in sheep is due to pineal weight, not to variations in enzyme activities.

D. Klein, B. Malpaux, P. Chemineau, 1999, American journal of physiology. Endocrinology and metabolism.

Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4)

Michael J. Bailey, D. Klein, D. Sugden, 2010, Molecular and Cellular Endocrinology.

The Lhx4 homeobox transcript in the rat pineal gland: Adrenergic regulation and impact on transcripts encoding melatonin‐synthesizing enzymes

D. Klein, S. Coon, K. Rohde, 2020, Journal of pineal research.

Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland

D. Klein, S. Coon, K. Rohde, 2019, Journal of pineal research.

Deletion of the secretory vesicle proteins IA‐2 and IA‐2β disrupts circadian rhythms of cardiovascular and physical activity

D. Weaver, D. Klein, H. Piggins, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH.

S. Stojilkovic, D. Klein, S. Clokie, 2013, Molecular endocrinology.

Observations on the pineal gland, the Harderian glands, the retina, and the reproductive organs of adult female rats exposed to continuous light.

R. Reiter, D. Klein, 1971, The Journal of endocrinology.

Catechol-O-methyltransferase in rat placenta, human placenta and choriocarcinoma grown in culture.

D. Klein, J. C. Robinson, C. H. Chen, 1974, Journal of reproduction and fertility.

A Novel Pineal-specific Product of the Oligopeptide Transporter PepT1 Gene

V. Ganapathy, D. Klein, D. Carter, 2005, Journal of Biological Chemistry.

cDNA Array Analysis of Pineal Gene Expression Reveals Circadian Rhythmicity of the Dominant Negative Helix‐Loop‐Helix Protein‐Encoding Gene, Id‐1

R. Baler, D. Klein, D. Carter, 2002, Journal of neuroendocrinology.

Input and output signals in a model neural system: The regulation of melatonin production in the pineal gland

D. Klein, J. Weller, 1970, In Vitro.

Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling.

Michael J. Bailey, D. Klein, S. Coon, 2009, Endocrinology.

The Mammalian Melatonin Rhythm Generating System

D. Klein, 1993 .

Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.

S. Stojilkovic, D. Klein, H. Zemkova, 2011, Endocrinology.

Norepinephrine stimulates potassium efflux from pinealocytes: evidence for involvement of biochemical "AND" gate operated by calcium and adenosine 3',5'-monophosphate.

D. Klein, V. Ceña, J. I. Halperin, 1991, Endocrinology.

Single-cell [Ca2+]i analysis and biochemical characterization of pinealocytes immobilized with novel attachment peptide preparation

D. Klein, H. Korf, J. Russell, 1993, Brain Research.

A suspension culture of pinealocytes: regulation of N-acetyltransferase activity.

D. Klein, M. Buda, 1978, Endocrinology.

Photoneural control of the synthesis and phosphorylation of pineal MEKA (phosducin).

D. Klein, T. Shinohara, N. Schaad, 1991, Endocrinology.

Negative feedback mechanisms: evidence that desensitization of pineal alpha 1-adrenergic responses involves protein kinase-C.

D. Klein, D. Sugden, A. Ho, 1988, Endocrinology.

Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.

Michael J. Bailey, D. Klein, A. Ho, 2007, Endocrinology.

Effects on fluorine analogs of norepinephrine on stimulation of cyclic adenosine 3',5'-monophosphate and binding to beta-adrenergic receptors in intact pinealocytes.

D. Klein, K. Kirk, D. A. Auerbach, 1981, Biochemical pharmacology.

Effects of selected treatments on stability and activity of pineal serotonin N‐acetyltransferase

D. Klein, M. Namboodiri, C. Nakai, 1979, Journal of neurochemistry.

The pineal gene expression party: who's the surprise guest?

D. Klein, 2007, Endocrinology.

Dark induced increase in pineal serotonin N-acetyltransferase activity: A refractory period

D. Klein, J. Weller, S. Binkley, 1973, Experientia.

Ovine pineal alpha 1-adrenoceptors: characterization and evidence for a functional role in the regulation of serum melatonin.

D. Klein, D. Sugden, I. Mefford, 1985, Endocrinology.

Vasoactive intestinal peptide elevates pinealocyte intracellular calcium concentrations by enhancing influx: evidence for involvement of a cyclic GMP-dependent mechanism.

J. Vanecek, I. Rodriguez, D. Klein, 1995, Molecular pharmacology.

Cholera toxin-induced Gsα down-regulation in neural tissue: studies on the pineal gland

D. Klein, T. Babila, 1994, Brain Research.

A cholera toxin substrate regulates cyclic GMP content of rat pinealocytes.

D. Klein, D. Sugden, 1987, The Journal of biological chemistry.

Phospholipid-Protein Kinase C Involvement in the Adrenergic Regulation of Pinealocyte Cyclic AMP: A Model of How Modulators Act?

J. Vanecek, W. Anderson, D. Klein, 1986 .

A PROTECTIVE ROLE OF NERVE ENDINGS IN THE STRESS-STIMULATED INCREASE IN PINEAL N-ACETYLTRANSFERASE ACTIVITY

D. Klein, A. Parfitt, 1976 .

Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in the neonatal rat.

D. Klein, J. E. Martin, S. McKellar, 1980, Neuroendocrinology.

Pineal gland in organ culture. II. Role of adenosine 3',5'-monophosphate in the regulation of radiolabeled melatonin production.

D. Klein, G. R. Berg, 1971, Endocrinology.

Purification of sheep pineal N-acetyltransferase

D. Klein, M. Namboodiri, 1981 .

Benzodiazepines: rat pinealocyte binding sites and augmentation of norepinephrine-stimulated N-acetyltransferase activity.

E. Zimmerman, D. Klein, D. Sugden, 1984, The Journal of pharmacology and experimental therapeutics.

Taurine in the pineal gland.

D. Klein, J. Weller, G. H. Wheler, 1983, Progress in clinical and biological research.

Effects of damage to the suprachiasmatic area of the anterior hypothalamus on the daily melatonin and cortisol rhythms in the rhesus monkey

Leslie G. Ungerleider, M. Mishkin, D. Orloff, 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Characterization of alpha 2-adrenergic receptors on rat pinealocytes.

D. Klein, N. Schaad, 1992, Endocrinology.

Rat pineal Gsa, Gia and Goa: relative abundance and development

D. Klein, N. Schaad, T. Babila, 1992, Brain Research.

Stimulation of the paraventricular nucleus area of the hypothalamus elevates urinary 6-hydroxymelatonin during daytime

D. Klein, J. Yanovski, N. Adler, 1987, Brain Research Bulletin.

Seesaw signal processing in pineal cells: homologous sensitization of adrenergic stimulation of cyclic GMP accompanies homologous desensitization of beta-adrenergic stimulation of cyclic AMP.

D. Klein, J. Weller, D. A. Auerbach, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Rat Pineal α1-Adrenoceptors: Identification and Characterization Using [125I]Iodo-2-[β-(4-Hydroxyphenyl)-Ethylaminomethyl]Tetralone

D. Klein, D. Sugden, 1984 .

BETA-ADRENERGIC REGULATION OF INDOLE METABOLISM IN THE PINEAL GLAND

D. Klein, A. Yuwiler, 1973 .

Atypical synergistic alpha 1- and beta-adrenergic regulation of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in rat pinealocytes.

J. Vanecek, D. Klein, D. Sugden, 1985, Endocrinology.

Relation of the pineal gland and environmental lighting to thyroid function in the rat.

D. Klein, S. Reichlin, J. Rowe, 1970, Neuroendocrinology.

Presence of rhodopsin kinase in the rat pineal gland

D. Klein, R. Somers, 1984 .

Differential expression and enzymatic properties of the Na+,K(+)-ATPase alpha 3 isoenzyme in rat pineal glands.

D. Klein, V. Ceña, R. Levenson, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Cellular Stability of Serotonin N-Acetyltransferase Conferred by Phosphonodifluoromethylene Alanine (Pfa) Substitution for Ser-205*

D. Schwarzer, A. LeBeau, P. Cole, 2005, Journal of Biological Chemistry.

Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus

R. Baler, Y. Nakabeppu, D. Klein, 2000, Neuroscience.

Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum

D. Klein, M. Bernard, P. Voisin, 1996, Brain Research.

A neuroanatomical and physiological study of the non-image forming visual system of the cone-rod homeobox gene (Crx) knock out mouse

D. Klein, M. F. Rath, M. Møller, 2010, Brain Research.

Pineal transduction. Adrenergic----cyclic AMP-dependent phosphorylation of cytoplasmic 33-kDa protein (MEKA) which binds beta gamma-complex of transducin.

J. Reig, D. Klein, L. Yu, 1990, The Journal of biological chemistry.

Cellular and molecular regulation of serotonin N-acetyltransferase activity in chicken retinal photoreceptors.

V. Cassone, D. Klein, Á. Alonso-Gómez, 1997, Biological signals.

Daily rhythms in cortisol and melatonin in primate cerebrospinal fluid. Effects of constant light and dark.

S. Reppert, D. Klein, M. Perlow, 1981, Neuroendocrinology.

Transport of maternal[3H]melatonin to suckling rats and the fate of [3H]melatonin in the neonatal rat.

S. Reppert, D. Klein, 1978, Endocrinology.

Cerebrospinal Fluid Melatonin

S. Reppert, D. Klein, M. Perlow, 1980 .

Noradrenergic control of the synthesis of two rat pineal proteins

C. Merril, D. Klein, D. Goldman, 1990, Brain Research.

5-hydroxytryptophan elevates serum melatonin.

D. Klein, D. Sugden, I. Mefford, 1983, Science.

Development of MEKA (phosducin), G beta, G gamma and S-antigen in the rat pineal gland and retina.

W. Simonds, D. Klein, T. Shinohara, 1992, Brain Research.

Alpha 1-adrenergic potentiation of vasoactive intestinal peptide stimulation of rat pinealocyte adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate: evidence for a role of calcium and protein kinase-C.

D. Klein, A. Ho, C. Chik, 1988, Endocrinology.

Transmembrane receptor cross-talk: concurrent VIP and alpha 1-adrenergic activation rapidly elevates pinealocyte cGMP greater than 100-fold.

D. Klein, A. Ho, C. Chik, 1987, Biochemical and Biophysical Research Communications - BBRC.

Rat pineal alpha 1-adrenoceptors: identification and characterization using [125I]iodo-2-[beta-(4-hydroxyphenyl)-ethylaminomethyl]tetralone.

D. Klein, D. Sugden, 1984, Endocrinology.

Stress increases pineal epinephrine.

D. Klein, I. Kopin, R. Kvetňanský, 1979, Communications in psychopharmacology.

[3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland

J. Reig, P. Skolnick, A. Newman, 1989, FEBS letters.

The Perivascular Phagocyte of the Mouse Pineal Gland: an Antigen‐Presenting Cell

D. Klein, M. F. Rath, M. Møller, 2006, Chronobiology international.

Research report

D. Klein, M. Zylka, P. Roseboom, 1996, Brain Research.

Development of the rat pineal #x003B1;1-adrenoceptor

D. Klein, D. Sugden, 1985, Brain Research.

Genomic methods in profiling DNA accessibility and factor localization

D. Klein, Sarah J. Hainer, 2019, Chromosome Research.

Construction of a yeast artificial chromosome contig spanning the pseudoautosomal region and isolation of 25 new sequence-tagged sites.

D. Le Paslier, A. Bernheim, A. Billault, 1993, Genomics.

Pineal‐specific expression of green fluorescent protein under the control of the serotonin‐N‐acetyltransferase gene regulatory regions in transgenic zebrafish

R. Toyama, I. Dawid, D. Klein, 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

Pineal miRNAs and melatonin synthesis

D. Klein, P. Lau, S. Clokie, 2012 .

Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205.

D. Klein, S. Ganguly, B. Malpaux, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation

D. Klein, S. Coon, Surajit Ganguly, 2002, Cell and Tissue Research.

Non-Cartesian pineal function.

D. Klein, G. Berg, 1971, The New England journal of medicine.

Transcriptional Regulation of Arylalkylamine‐N‐Acetyltransferase‐2 Gene in the Pineal Gland of the Gilthead Seabream

L. Appelbaum, D. Vallone, N. Foulkes, 2007, Journal of neuroendocrinology.