J. Kopeček

J. Kopeček, T. Minko, K. Kunath, 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Synthesis of HPMA Copolymer Containing Adriamycin Bound via an Acid-Labile Spacer and its Activity toward Human Ovarian Carcinoma Cells

J. Kopeček, T. Minko, P. Kopec̆ková, 1999 .

Biodistribution of free and N-(2-hydroxypropyl)methacrylamide copolymer-bound mesochlorin e(6) and adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts.

J. Kopeček, Y. Sun, C. Peterson, 1999, Journal of Controlled Release.

Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line.

J. Kopeček, T. Minko, P. Kopec̆ková, 1999, Journal of controlled release : official journal of the Controlled Release Society.

High-molecular weight HPMA copolymer-adriamycin conjugates.

J. Kopeček, P. Kopec̆ková, M. Dvorák, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate.

J. Kopeček, C. Gentry, P. Kopec̆ková, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Influence of pH on aggregation and photoproperties of n-(2-hydroxypropyl)methacrylamide copolymer-meso-chlorin e6 conjugates.

J. Kopeček, J. Spikes, Č. Koňák, 1998, Drug delivery.

Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl)methacrylamide-based copolymers via lysosomal enzymes.

J. Kopeček, D. Putnam, David A. Putnam, 1995, Bioconjugate chemistry.

Biorecognizable polymers: Structure-properties relationship

J. Kopeček, P. Kopec̆ková, R. Rathi, 1995 .

New types of synthetic infusion solutions. I. Investigation of the effect of solutions of some hydrophilic polymers on blood.

J. Kopeček, L. Šprincl, D. Lïm, 1973, Journal of biomedical materials research.

Reactive copolymers of N‐(2‐hydroxypropyl)methacrylamide with N‐methacryloylated derivatives of L‐leucine and L‐phenylalanine, 1. Preparation, characterization, and reactions with diamines

J. Kopeček, 1977 .

Synthesis and activity of a polymer which contains insulin covalently bound on a copolymer of N-(2-hydroxypropyl)methacrylamide and N-methacryloyldiglycyl p-nitrophenyl ester

J. Kopeček, A. Vrána, V. Chytrý, 1978 .

Immunosuppressive effects of a synthetic polymer poly N-(2-hydroxypropyl)methacrylamide (Duxon).

J. Kopeček, J. Činátl, R. Staněk, 1980, Folia biologica.

BIODEGRADATION OF POLYMERS FOR BIOMEDICAL USE

J. Kopeček, 1982 .

Degradation of side-chains ofN-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases

J. Kopeček, R. Duncan, J. Lloyd, 1982, Bioscience reports.

Polymers containing enzymatically degradable bonds, 7. Design of oligopeptide side-chains in poly[N-(2-hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal enzymes†

J. Kopeček, R. Duncan, J. Lloyd, 1983 .

Targeting of N-(2-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues.

J. Kopeček, R. Duncan, J. Lloyd, 1983, Biochimica et biophysica acta.

Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity.

K. Ulbrich, J. Kopeček, M. V. Solovskij, 1983, Biomaterials.

Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers.

J. Kopeček, R. Duncan, J. Lloyd, 1984, Biochimica et biophysica acta.

Controlled biodegradability of polymers--a key to drug delivery systems.

J. Kopeček, 1984, Biomaterials.

Preparation of polymer-modified enzymes of prolonged circulation times. Poly[N-(2-hydroxypropyl) methacrylamide]-bound acetylcholinesterase

J. Kopeček, M. Haga, A. Aaviksaar, 1985 .

Immunogenicity of N‐(2‐hydroxypropyl) methacrylamide copolymers

K. Ulbrich, B. Říhová, J. Kopeček, 1985 .

Methods of targeting N‐(2‐hydroxypropyl) methacrylamide copolymers to particular cell types

J. Kopeček, R. Duncan, J. Lloyd, 1985 .

In vivo and in vitro immunogenicity of water-soluble haptenated copolymers for mouse and human lymphocytes

K. Ulbrich, J. Kopeček, F. Rypáček, 1985 .

Controlled Release of Drug Model from N‐(2‐Hydroxypropyl)‐methacrylamide Copolymers

J. Kopeček, R. Duncan, J. Lloyd, 1985, Annals of the New York Academy of Sciences.

Biological properties of targetable poly[N-(2-hydroxypropyl)-methacrylamide]-antibody conjugates☆

B. Říhová, J. Kopeček, 1985 .

Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers.

J. Kopeček, R. Duncan, J. Lloyd, 1985, Biomaterials.

Effect of a synthetic poly N-(2-hydroxypropyl)methacrylamide (Duxon) on haemopoiesis and graft-versus-host reaction.

J. Kopeček, O. Štěrba, A. Hrubá, 1986, Folia biologica.

Interaction of a Cationic N-(2-hydroxypropyl)methacrylamide Copolymer with Rat Visceral Yolk Sacs Cultured in vitro and Rat Liver in vivo

J. Kopeček, R. Duncan, L. Seymour, 1986 .

The Activity of Complement in the Presence of N-(2-hydroxypropyl)methacrylamide Copolymers

B. Říhová, J. Kopeček, D. Plocová, 1986 .

Poly(ethylene glycol)s containing enzymatically degradable bonds

K. Ulbrich, J. Kopeček, J. Strohalm, 1986 .

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats.

L. Scarlett, J. Kopeček, R. Duncan, 1986, Biochimica et biophysica acta.

Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers. 3. Targeting by incorporation of galactosamine residues. Effect of route of administration

J. Kopeček, R. Duncan, S. Cartlidge, 1987 .

Solution properties of drug carriers based on poly[N‐(2‐hydroxypropyl)methacrylamide] containing biodegradable bonds

K. Ulbrich, J. Kopeček, Č. Koňák, 1987 .

Polymer-bound derivatives of sarcolysin and their antitumour activity against mouse and human leukaemia in vitro

K. Ulbrich, J. Kopeček, R. Duncan, 1987 .

Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers: Pinocytosis by rat visceral yolk sacs and rat intestine cultured in vitro. Effect of molecular weight on uptake and intracellular degradation

J. Kopeček, R. Duncan, S. Cartlidge, 1987 .

Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers. 2. Effect of molecular weight on blood clearance and body distribution in the rat after intravenous administration. Distribution of unfractionated copolymer after intraperitoneal, subcutaneous or oral admin

J. Kopeček, R. Duncan, S. Cartlidge, 1987 .

Targetable polymeric prodrugs

J. Kopeček, R. Duncan, 1987 .

Potential of Sugar Residues Attached to N-(2- Hydroxypropyl)methacryl amide Copolymers as Targeting Groups for the Selective Delivery of Drugs

J. Kopeček, R. Duncan, L. Seymour, 1987 .

Cleavage of oligopeptide side-chains in N-(2-hydroxypropyl)meth-acrylamide copolymers by mixtures of lysosomal enzymes☆

V. Šubr, V. Kostka, J. Kopeček, 1988 .

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.

J. Kopeček, R. Duncan, J. Lloyd, 1988, British Journal of Cancer.

Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates.

J. Kopeček, R. Duncan, P. Kopec̆ková, 1989, Biochimica et biophysica acta.

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 3. Evaluation of adriamycin conjugates against mouse leukaemia L1210 in vivo

K. Ulbrich, J. Kopeček, R. Duncan, 1989 .

Effect of galactose on interaction of N‐(2‐hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: Preliminary application to an anticancer agent, daunomycin

L. Scarlett, J. Kopeček, R. Duncan, 1989, Hepatology.

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro.

K. Ulbrich, V. Vetvicka, B. Říhová, 1989, Biomaterials.

Action of polymeric prodrugs based on N-(2-hydroxypropyl)meth- acrylamide copolymers. I. Suppression of the antibody response and proliferation of mouse splenocytes in vitro

K. Ulbrich, V. Vetvicka, B. Říhová, 1989 .

Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model.

S. Kaye, J. Kopeček, J. Cassidy, 1989, Biochemical pharmacology.

Targetable photoactivatable drugs, 2. Synthesis of N‐(2‐hydroxypropyl)methacrylamide copolymeranti‐thy 1.2 antibody‐chlorin e6 conjugates and a preliminary study of their photodynamic effect on mouse splenocytes in vitro

N. L. Krinick, K. Ulbrich, B. Říhová, 1990 .

Immunogenicity of Protein-N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates in A/J and B10 Mice

V. Šubr, B. Říhová, J. Kopeček, 1990 .

Surface properties of copolymers of alkyl methacrylates with methoxy (polyethylene oxide) methacrylates and their application as protein-resistant coatings.

J. H. Lee, J. Andrade, J. Kopeček, 1990, Biomaterials.

The pharmacokinetics of polymer-bound adriamycin.

K. Ulbrich, J. Kopeček, R. Duncan, 1990, Biochemical pharmacology.

Targetable Polymeric Anticancer Drugs

J. Kopeček, 1991, Annals of the New York Academy of Sciences.

Targetable photoactivatable polymeric drugs

N. L. Krinick, B. Říhová, J. Kopeček, 1991 .

Photoregulated association of N-(2-hydroxypropyl)methacrylamide copolymers with azobenzene-containing side chains

J. Kopeček, P. Kopec̆ková, Č. Koňák, 1992 .

Synthesis and photoproperties of a substituted zinc(II) phthalocyanine-N-(2-hydroxypropyl)methacrylamide copolymer conjugate

J. Kopeček, P. Kopec̆ková, J. Spikes, 1993 .

Enzymatic activity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates.

J. Kopeček, P. Kopec̆ková, S. Zalipsky, 1993, Bioconjugate chemistry.

Enzymatic Degradation of Poly(ethylene glycol) Modified Dextrans

J. Kopeček, P. Kopec̆ková, Č. Koňák, 1994 .

A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light.

N. L. Krinick, R. Straight, J. Kopeček, 1994, Journal of biomaterials science. Polymer edition.

Super‐Resolution Imaging and Quantitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell‐Surface Self‐Assembly of Hybrid Nanoconjugates

Joel M. Harris, R. Zhang, J. Kopeček, 2015, Chembiochem : a European journal of chemical biology.

The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma.

J. Kopeček, P. Kopec̆ková, M. Tijerina, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Site-specific drug delivery and penetration enhancement in the gastrointestinal tract

W. Samowitz, J. Kopeček, P. Kopec̆ková, 1995 .

The Role of Galactose, Lactose, and Galactose Valency in the Biorecognition of N-(2-Hydroxypropyl)Methacrylamide Copolymers by Human Colon Adenocarcinoma Cells

J. Kopeček, A. David, P. Kopec̆ková, 2002, Pharmaceutical Research.

Equisorptic compositions in reverse osmosis

J. Kopeček, S. Sourirajan, 1969 .

Biodistribution of Fracture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Healing.

J. Kopeček, Jiyuan Yang, C. Galliford, 2015, Biomacromolecules.

Design of novel bioconjugates for targeted drug delivery.

Zheng-Rong Lu, J. Kopeček, S. Sakuma, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates.

J. Kopeček, P. Kopec̆ková, V. Cuchelkar, 2008, Macromolecular bioscience.

PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice.

J. Kopeček, U. Bakowsky, T. Kissel, 2005, Bioconjugate chemistry.

Release of prostaglandin E(1) from N-(2-hydroxypropyl)methacrylamide copolymer conjugates by bone cells.

M. Brandi, J. Kopeček, Jihua Liu, 2008, Macromolecular bioscience.

Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates.

J. Kopeček, Jihua Liu, P. Kopec̆ková, 2008, Molecular pharmaceutics.

Dendronized polymer conjugates with amplified immunogenic cell death for oncolytic immunotherapy.

J. Kopeček, Yachao Li, Z. Gu, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine.

M. Deininger, J. Kopeček, Jiyuan Yang, 2018, Nanomedicine : nanotechnology, biology, and medicine.

Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway.

J. Kopeček, Jiyuan Yang, Lian Li, 2018, Macromolecular bioscience.

Multimodality Imaging of Coiled‐Coil Mediated Self‐Assembly in a “Drug‐Free” Therapeutic System

R. Zhang, J. Kopeček, Jiyuan Yang, 2015, Advanced healthcare materials.

Combination treatment with immunogenic and anti-PD-L1 polymer-drug conjugates of advanced tumors in a transgenic MMTV-PyMT mouse model of breast cancer.

J. Kopeček, Jiyuan Yang, D. C. Radford, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells.

N. Nishiyama, J. Kopeček, A. Nori, 2003, Cancer research.

Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting.

J. Kopeček, P. Kopec̆ková, V. Cuchelkar, 2008, Molecular pharmaceutics.

Macromolecular therapeutics.

J. Kopeček, Jiyuan Yang, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Biorecognition of HPMA copolymer-lectin conjugates as an indicator of differentiation of cell-surface glycoproteins in development, maturation, and diseases of human and rodent gastrointestinal tissues.

J. Kopeček, P. Kopec̆ková, M. Berenson, 2000, Journal of biomedical materials research.

Preparation and properties of poly-(N-butylmethacrylamide) networks

K. Ulbrich, K. Dušek, J. Kopeček, 1978 .

Confocal-microscopy Studies of a Model Oligoribonucleotide HIV Inhibitor

J. Kopeček, K. Jensen, A. D. Broom, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy.

J. Kopeček, H. Pan, Jiyuan Yang, 2013, Macromolecular bioscience.

Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates.

J. Kopeček, Kui Luo, P. Kopec̆ková, 2011, Reactive & functional polymers.

Aminolyses of monomeric and polymeric 4‐nitrophenyl esters of N‐methacryloylamino acids

J. Labský, J. Kopeček, P. Rejmanová, 1977 .

Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells.

J. Kopeček, Kui Luo, Jiyuan Yang, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Targeting of multidrug-resistant human ovarian carcinoma cells with anti-P-glycoprotein antibody conjugates.

J. Kopeček, K. Fowers, 2012, Macromolecular bioscience.

Immunogenicity of N-(2-hydroxypropyl)-methacrylamide copolymers—Potential hapten or drug carriers

K. Ulbrich, B. Říhová, J. Kopeček, 2008, Folia Microbiologica.

Reactive copolymers of N‐(2‐hydroxypropyl) methacrylamide with N‐methacryloylated derivatives of l‐leucine and l‐phenylalanine. II. Reaction with the polymeric amine and stability of cross‐links towards chymotrypsin in vitro

J. Kopeček, P. Rejmanová, 2007 .

Preparation of polymerizable derivatives of N-(4-aminobenzenesulfonyl)-n′-butylurea

J. Kopeček, A. Vrána, B. Obereigner, 2007 .

Correlation of Subcellular Compartmentalization of HPMA Copolymer-Mce6 Conjugates with Chemotherapeutic Activity in Human Ovarian Carcinoma Cells

J. Kopeček, P. Kopec̆ková, M. Tijerina, 2003, Pharmaceutical Research.

Mechanisms of Cytotoxicity in Human Ovarian Carcinoma Cells Exposed to Free Mce6 or HPMA Copolymer–Mce6 Conjugates¶

J. Kopeček, P. Kopec̆ková, M. Tijerina, 2003 .

N-(2-Hydroxypropyl)methacrylamide Copolymer-9-Aminocamptothecin Conjugate: Colon-Specific Drug Delivery in Rats

J. Kopeček, S. Sakuma, P. Kopec̆ková, 2002 .

Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.

J. Kopeček, T. Minko, P. Kopec̆ková, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin.

Z. Lu, J. Kopeček, S. Sakuma, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.

J. Kopeček, T. Minko, P. Kopec̆ková, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Photodynamic Crosslinking of Proteins. III. Kinetics of the FMN‐ and Rose Bengal‐sensitized Photooxidation and Intermolecular Crosslinking of Model Tyrosine‐containing N‐(2‐Hydroxypropyl)methacrylamide Copolymers

J. Kopeček, P. Kopec̆ková, J. Spikes, 1999, Photochemistry and photobiology.

Bioadhesive N-(2-hydroxypropyl) methacrylamide copolymers for colon-specific drug delivery

B. Říhová, J. Kopeček, P. Kopec̆ková, 1994 .

Development of Tailor-Made Polymeric Prodrugs for Systemic and Oral Delivery

J. Kopeček, 1988 .

Soluble N-(2-hydroxypropyl) methacrylamide copolymers as a potential oral, controlled-release, drug delivery system. I. Bioadhesion to the rat intestine in vitro

J. Kopeček, R. Duncan, J. Woodley, 1988 .

Soluble Synthetic Polymers for Targeting and Controlled Release of Anticancer Agents, Particularly Anthracycline Antibiotics

K. Ulbrich, J. Kopeček, R. Duncan, 1988 .

Degradation of Oligopeptide Sequences Connecting Poly[N-(2- hydroxypropyl)methacrylamide] Chains by Lysosomal Cysteine Proteinases

V. Šubr, J. Kopeček, R. Duncan, 1986 .

Pinocytic capture and exocytosis of rat immunoglobulin IgG-N-(2-hydroxy-propyl)methacrylamide copolymer conjugates by rat visceral yolk sacs culturedin vitro

J. Kopeček, R. Duncan, J. Strohalm, 1986, Bioscience reports.

Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers.

B. Říhová, J. Kopeček, D. Plocová, 1986, Journal of chromatography.

Synthesis of Tailor-Made Soluble Polymeric Drug Carriers

J. Kopeček, 1984 .

An advantageous method for detection of Fc-receptors and for studying Fc-receptor-mediated phagocytosis.

V. Vetvicka, J. Kopeček, L. Fornusek, 1983, Immunology letters.

Development of N-(2-Hydroxypropyl)Methacrylamide Copolymers as Carriers of Therapeutic Agents

J. Kopeček, R. Duncan, J. Lloyd, 1983 .

Degradation and Aggregation of Human Calcitonin In Vitro

J. Kopeček, P. Kopec̆ková, R. H. Lu, 1999, Pharmaceutical Research.

Prostate-cancer-targeted N-(2-hydroxypropyl)methacrylamide copolymer/docetaxel conjugates.

J. Kopeček, Jihua Liu, P. Kopec̆ková, 2012, Macromolecular bioscience.

Poly[N-(2-hydroxypropyl)methacrylamide-block-n-butyl acrylate] micelles in water/DMF mixed solvents

K. Matyjaszewski, M. Teodorescu, J. Kopeček, 2002 .

Photodynamic crosslinking of proteins. II. Photocrosslinking of a model protein-ribonuclease A.

J. Kopeček, P. Kopec̆ková, J. Spikes, 1996, Journal of photochemistry and photobiology. B, Biology.

Two-step fluorescence screening of CD21-binding peptides with one-bead one-compound library and investigation of binding properties of N-(2-hydroxypropyl)methacrylamide copolymer-peptide conjugates.

J. Kopeček, W. Prodinger, Hui Ding, 2006, Biomacromolecules.

Exploration and Evaluation of Therapeutic Efficacy of Drug-Free Macromolecular Therapeutics in Collagen-Induced Rheumatoid Arthritis Mouse Model.

J. Kopeček, Yachao Li, Jiyuan Yang, 2020, Macromolecular bioscience.

Hybrid polymeric hydrogels via peptide nucleic acid (PNA)/DNA complexation.

J. Kopeček, Jiyuan Yang, Te-Wei Chu, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface.

J. Kopeček, Russell N. Johnson, Jihua Liu, 2010, Angewandte Chemie.

Indium-based and iodine-based labeling of HPMA copolymer-epirubicin conjugates: Impact of structure on the in vivo fate.

R. Zhang, J. Kopeček, Jiyuan Yang, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems.

Z. Lu, J. Kopeček, P. Kopec̆ková, 2001, Bioorganic & medicinal chemistry letters.

Efficiency of high molecular weight backbone degradable HPMA copolymer-prostaglandin E1 conjugate in promotion of bone formation in ovariectomized rats.

J. Kopeček, P. Kopec̆ková, H. Pan, 2013, Biomaterials.

Osteotropic Peptide that differentiates functional domains of the skeleton.

Y. Lyubchenko, L. Shlyakhtenko, J. Kopeček, 2007, Bioconjugate chemistry.

Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers.

J. Kopeček, P. Kopec̆ková, N. Tietze, 2006, Molecular pharmaceutics.

Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl) methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice.

R. Straight, C. Peterson, J. Kopeček, 1996, Cancer research.

Targeted drug delivery for musculoskeletal diseases.

J. Kopeček, S. Miller, Dong Wang, 2005, Advanced drug delivery reviews.

Effect of side-chains on solution properties of N-(2-hydroxypropyl)methacrylamide copolymers in aqueous solvents

J. Kopeček, P. Kopec̆ková, Č. Koňák, 1993 .

Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel.

R. Zhang, J. Kopeček, Kui Luo, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Differences in phagocytic activity of methacrylate copolymer particles in normal and stimulated macrophages

V. Vetvicka, J. Kopeček, L. Fornusek, 1981, Experientia.

Mechanisms of Cytotoxicity in Human Ovarian Carcinoma Cells Exposed to Free Mce6 or HPMA Copolymer–Mce6 Conjugates ¶

J. Kopeček, P. Kopec̆ková, M. Tijerina, 2003, Photochemistry and photobiology.

Separation of human lymphoid cells by affinity chromatography and cell surface labelling by hydroxyethyl methacrylate particles using monoclonal antibodies.

V. Vetvicka, J. Kopeček, H. Fiebig, 1986, Journal of chromatography.

Backbone Degradable N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates with Gemcitabine and Paclitaxel: Impact of Molecular Weight on Activity toward Human Ovarian Carcinoma Xenografts.

R. Zhang, J. Kopeček, H. Pan, 2017, Molecular pharmaceutics.

Phagocytosis of human blood leukocytes: a simple micromethod.

L. Kašpárek, V. Vetvicka, J. Kopeček, 1982, Immunology letters.

Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment.

A. Ray, J. Kopeček, H. Ghandehari, 2013, International journal of pharmaceutics.

Performance of Porous Cellulose Acetate Membranes for the Reverse Osmosis Separation of Mixtures of Organic Liquids

J. Kopeček, 1970 .

Development of a fibrinolytic surface: specific and non-specific binding of plasminogen☆

J. Kopeček, K. Fowers, 1997 .

Synthesis and characterization of poly(ε-caprolactone)-block-poly[N-(2-hydroxypropyl)methacrylamide] micelles for drug delivery.

J. Kopeček, Jihua Liu, H. Pan, 2011, Macromolecular bioscience.

Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model

J. Kopeček, D. Oupický, Ying Xie, 2022, Pharmaceutics.

Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates.

J. Kopeček, Russell N. Johnson, P. Kopec̆ková, 2012, Biomacromolecules.

Smart Polymer-Based Nanomedicines

J. Kopeček, Jonathan M. Hartley, 2016 .

Influence of medium and matrix composition on diffusivities in charged membranes.

H. Braselmann, J. Kopeček, J. Vacík, 1985, Biotechnology and bioengineering.

Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics

J. Kopeček, P. Kopec̆ková, S. Miller, 2009, Journal of Bone and Mineral Metabolism.

Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: potential drug carriers.

J. Kopeček, T. Minko, D. Wang, 2000, Biomacromolecules.

Drug‐free albumin‐triggered sensitization of cancer cells to anticancer drugs

J. Kopeček, P. Opanasopit, Jiyuan Yang, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Structure of porous cellulose acetate membranes and a method for improving their performance in reverse osmosis

J. Kopeček, S. Sourirajan, 1969 .

FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate.

R. Zhang, J. Kopeček, Jiyuan Yang, 2017, Macromolecular bioscience.

Novel Synthesis of HPMA Copolymers Containing Peptide Grafts and Their Self‐Assembly Into Hybrid Hydrogels

J. Kopeček, P. Kopec̆ková, Jiyuan Yang, 2008 .

Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer–9-AC Conjugate in Rats

C. Peterson, J. Kopeček, P. Kopec̆ková, 2007, Pharmaceutical Research.

Soluble biomedical polymers.

J. Kopeček, 1977, Polimery w medycynie.

Photoproperties of a mesochlorin e6—N-(2-hydroxypropyl)methacrylamide copolymer conjugate

N. L. Krinick, J. Kopeček, J. Spikes, 1993 .

Bioadhesive polymers for oral drug delivery.

B. Říhová, J. Kopeček, P. Kopec̆ková, 1995, Advances in experimental medicine and biology.

Adsorption and activation of zymogens at solid-liquid interfaces. I. Chymotrypsinogen on alkylamino modified silica derivatives.

K. Ulbrich, J. Kopeček, S. Oscarsson, 1994, Journal of biomedical materials research.

Peptide-directed self-assembly of hydrogels.

Jindrich Kopecek, Jiyuan Yang, J. Kopeček, 2009, Acta biomaterialia.

Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation.

Chunyu Xu, Jindrich Kopecek, Jiyuan Yang, 2006, Biomacromolecules.

Hybrid hydrogels cross-linked by genetically engineered coiled-coil block proteins.

R. Stewart, J. Kopeček, J Kopecek, 2001, Biomacromolecules.

Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains

Russell J. Stewart, R. Stewart, J. Kopeček, 1999, Nature.

Targeting polymer therapeutics to bone.

J. Kopeček, Stewart A. Low, S. Low, 2012, Advanced drug delivery reviews.

Lysosomal degradability of poly(α‐amino acids)

Jindřich Kopeček, J. Kopeček, P. Kopec̆ková, 1997 .

Coiled-Coil Hydrogels. Effect of Grafted Copolymer Composition and Cyclization on Gelation.

K. Dušek, J. Kopeček, Jiyuan Yang, 2009, Macromolecules.

Photodynamic crosslinking of proteins. I. Model studies using histidine- and lysine-containing N-(2-hydroxypropyl)methacrylamide copolymers.

J D Spikes, J. Kopeček, J. Spikes, 1996, Journal of photochemistry and photobiology. B, Biology.

Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry.

J. Kopeček, Kui Luo, P. Kopec̆ková, 2011, Macromolecules.

Photodynamic cross-linking of proteins: V. Nature of the tyrosine–tyrosine bonds formed in the FMN-sensitized intermolecular cross-linking of N-acetyl-l-tyrosine

J. Kopeček, J. Spikes, Cameron J. Smith, 2000 .

Photodynamic cross-linking of proteins: IV. Nature of the His–His bond(s) formed in the rose bengal-photosensitized cross-linking of N-benzoyl-L-histidine

J. Kopeček, J. Spikes, Cameron J. Smith, 2000 .

De novo design of biomedical polymers: Hybrids from synthetic macromolecules and genetically engineered protein domains

Russell J. Stewart, Jindřich Kopeček, R. Stewart, 2001 .

HPMA copolymer–anticancer drug–OV‐TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro

J. Kopeček, C. Gentry, P. Kopec̆ková, 1998, International journal of cancer.

Biological tolerance of poly(N-substituted methacrylamides).

L Sprincl, J. Kopeček, J. Vacík, 1971, Journal of biomedical materials research.

Hybrid hydrogels self-assembled from graft copolymers containing complementary β-sheets as hydroxyapatite nucleation scaffolds.

Larisa C Wu, J. Kopeček, Jiyuan Yang, 2011, Biomaterials.

Polymer-drug conjugates: origins, progress to date and future directions.

J. Kopeček, 2013, Advanced drug delivery reviews.

Bone-targeting macromolecular therapeutics.

J. Kopeček, P. Kopec̆ková, S. Miller, 2005, Advanced drug delivery reviews.

Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs.

J. Kopeček, P. Kopec̆ková, S. Prakongpan, 2008, International journal of pharmaceutics.

Preparation and properties of poly(N-ethylmethacrylamide) networks

K. Ulbrich, K. Dušek, J. Kopeček, 1977 .

N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia.

R. Zhang, J. Kopeček, Jiyuan Yang, 2016, Macromolecular bioscience.

Release of macromolecules and daunomycin from hydrophilic gels containing enzymatically degradable bonds.

V. Šubr, J. Kopeček, R. Duncan, 1990, Journal of biomaterials science. Polymer edition.

Enzymatic degradation and immunogenic properties of derivatized dextrans.

B. Říhová, J. Kopeček, J Kopecek, 1991, Biomaterials.

Soluble Polymers as Targetable Drug Carriers

N. L. Krinick, J. Kopeček, 1991 .

Intracellularly biorecognizable derivatives of 5-fluorouracil. Implications for site-specific delivery in the human condition.

J. Kopeček, J Kopecek, D A Putnam, 1996, Biochemical pharmacology.

Kinetics of the FMN-and Rose Bengal-sensitized Photooxidation and Intermolecular Crosslinking of Mode

J. Kopeček, P. Kopec̆ková, J. Spikes, 2007 .

Activation of poly[N‐(2‐hydroxypropyl)methacrylamide] for the binding of bioactive molecules, 1. Activation with 4‐nitrophenyl chloroformate

J. Kopeček, M. Haga, A. Aaviksaar, 1983 .

Optically controlled ligand delivery, 1. Synthesis of water-soluble copolymers containing photocleavable bonds

J. Andrade, J. Kopeček, H. Yen, 1989 .

Polymers containing enzymatically degradable bonds, 9. Chymotrypsm catalyzed hydrolysis of a p‐nitroanilide drug model, p bound via oligopeptides onto poly(vinylpyrrolidone‐co‐maleic anhydride)

K. Ulbrich, J. Pató, J. Kopeček, 1984 .

COPOLYMERS OF 6-O-METHACRYLOYL-D-GALACTOSE AND N-(2-HYDROXYPROPYL)METHACRYLAMIDE: TARGETING TO LIVER AFTER INTRAVENOUS ADMINISTRATION TO RATS.

L. Scarlett, J. Kopeček, R. Duncan, 1987 .

Self-Assembling Hydrogels

J. Kopeček, Chunyu Xu, 2007 .

Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells.

J. Kopeček, A. David, P. Kopec̆ková, 2001, Bioconjugate chemistry.

Intraperitoneal and subcutaneous retention of a soluble polymeric drug-carrier bearing galactose

K. Ulbrich, J. Kopeček, R. Duncan, 1991 .

Micellization of Graft Copolymers of Alkyl Methacrylates with α-Methyl-ω-hydroxypoly(oxyethylene) Methacrylates☆

J. Kopeček, P. Kopec̆ková, Č. Koňák, 1998 .

Radical polymerization of n-substituted methacrylamides

K. Ulbrich, J. Kopeček, 1976 .

Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus.

J. Kopeček, P. Kopec̆ková, K. Jensen, 2002, Bioconjugate chemistry.

Multifunctional Water-Soluble Polymers for Drug Delivery

J. Kopeček, H. Pan, 2008 .

Biological rationale for the design of polymeric anti-cancer nanomedicines

J. Kopeček, Yan Zhou, 2013, Journal of drug targeting.

Targeting Angiogenesis-Dependent Calcified Neoplasms Using Combined Polymer Therapeutics

P. Ofek, R. Satchi‐Fainaro, J. Kopeček, 2009, PloS one.

Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers.

Z. Lu, J. Kopeček, P. Kopec̆ková, 2001, Bioconjugate chemistry.

HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.

Z. Lu, J. Kopeček, T. Minko, 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Inhibition of Immunosuppressive Tumors by Polymer‐Assisted Inductions of Immunogenic Cell Death and Multivalent PD‐L1 Crosslinking

J. Kopeček, Yachao Li, Jiyuan Yang, 2020, Advanced functional materials.

Hydrogels for Site-Specific Drug Delivery to the Colon: In Vitro and in Vivo Degradation

Jindřich Kopeček, H. Brøndsted, J. Kopeček, 1992, Pharmaceutical Research.

Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair.

Yava L Jones-Hall, J. Kopeček, Jiyuan Yang, 2017, Nanomedicine.

HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function.

J. Kopeček, P. Kopec̆ková, A. Malugin, 2006, Molecular pharmaceutics.

Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.

C. Peterson, J. Kopeček, P. Kopec̆ková, 2009, Macromolecular bioscience.

Cancer stem cells: Potential target for anti-cancer nanomedicines

J. Kopeček, Jiyuan Yang, Yan Zhou, 2013 .

Hydrogels for site-specific oral drug delivery: synthesis and characterization.

H. Brøndsted, J. Kopeček, J Kopecek, 1991, Biomaterials.

The Influence of Cytotoxicity of Macromolecules and of VEGF Gene Modulated Vascular Permeability on the Enhanced Permeability and Retention Effect in Resistant Solid Tumors

J. Kopeček, T. Minko, P. Kopec̆ková, 2004, Pharmaceutical Research.

Effect of porosity of heterogeneous poly(glycol monomethacrylate) gels on the healing-in of test implants.

L Sprincl, J. Kopeček, D. Lím, 1971, Journal of biomedical materials research.

Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors.

J. Kopeček, D. Brömme, P. Kopec̆ková, 2002, Biochemistry.

Biodegradable and pH-sensitive hydrogels: Synthesis by crosslinking of N,N-dimethylacrylamide copolymer precursors

Jindrich Kopecek, J. Kopeček, P. Kopec̆ková, 1994 .

Co‐expression of different types of Fc receptors on murine peritoneal macrophages

V. Vetvicka, J. Kopeček, P. Kincade, 1986, European journal of immunology.

Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances.

Y. Shaked, R. Satchi‐Fainaro, J. Kopeček, 2011, Biomaterials.

Polymer nanomedicines.

J. Kopeček, Jiyuan Yang, 2020, Advanced drug delivery reviews.

Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels.

Dong Wang, Karel Dusek, Jindrich Kopecek, 2006, Biomaterials.

Photoregulated Adsorption and Association of Amphiphilic Copolymers Containing Azobenzene Side Chains

J. Kopeček, P. Kopec̆ková, Č. Koňák, 1994 .

Specific resistances of hydrophilic membranes containing ionogenic groups

J. Kopeček, J. Vacík, 1975 .

Permeability of membranes containing ionogenic groups

Jindřich Kopeček, J. Kopeček, J. Vacík, 1971 .

pH-Sensitive Hydrogels: Characteristics and Potential in Drug Delivery

H. Brøndsted, J. Kopeček, 1992 .

Tracking and quantifying polymer therapeutic distribution on a cellular level using 3D dSTORM.

R. Zhang, J. Kopeček, M. Gudheti, 2016, Journal of controlled release : official journal of the Controlled Release Society.

POLYMERIC BIOMATERIALS AND NANOMEDICINES.

J. Kopeček, Jiyuan Yang, 2015, Journal of drug delivery science and technology.

Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.

J. Kopeček, R. Duncan, L. Seymour, 1987, Cancer treatment reviews.

Nanomedicines in B Cell-Targeting Therapies.

J. Kopeček, Jiyuan Yang, Jiawei Wang, 2021, Acta biomaterialia.

The Light at the End of the Tunnel-Second Generation HPMA Conjugates for Cancer Treatment.

J. Kopeček, Jiyuan Yang, 2017, Current opinion in colloid & interface science.

Enhancing Accumulation and Penetration of HPMA Copolymer-Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer.

J. Kopeček, Zheng-Hong Peng, 2015, Journal of the American Chemical Society.

Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates

R. Zhang, J. Kopeček, Jiyuan Yang, 2014, Proceedings of the National Academy of Sciences.

Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis.

J. Kopeček, Jiyuan Yang, Monika Sima, 2014, ACS nano.

Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis.

J. Kopeček, Jiyuan Yang, Te‐Wei Chu, 2012, Biomaterials.

Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells.

J. Kopeček, Jiyuan Yang, Yan Zhou, 2012, Biomaterials.

Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.

Zheng-Rong Lu, J. Kopeček, P. Kopec̆ková, 2007, Journal of controlled release : official journal of the Controlled Release Society.

HPMA Copolymer-Anticancer Drug-OV-TL-TL16 Antibody Conjugates. 1. Influence of the Method of Synthesis on the Biding Affinity to OVCAR-3 Ovarian Carcinoma Cells In Vitro

J. Kopeček, C. Gentry, P. Kopec̆ková, 2003 .

HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro.

J. Kopeček, C. Gentry, P. Kopec̆ková, 1996, Journal of drug targeting.

Amplification of CD20 Cross-Linking in Rituximab-Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics.

J. Kopeček, Jiyuan Yang, Lian Li, 2018, ACS nano.

Prolonged Blood Circulation in Rats of Nanospheres Surface-Modified with Semitelechelic Poly[N-(2-Hydroxypropyl)methacrylamide]

Jindřich Kopeček, J. Kopeček, S. Kamei, 1995, Pharmaceutical Research.

Polymers containing enzymatically degradable bonds, 8. Degradation of oligopeptide sequences in N‐(2‐hydroxypropyl)methacrylamide copolymers by bovine spleen cathepsin B

Jindřich Kopeček, V. Kostka, J. Kopeček, 1983 .

Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.

J. Kopeček, R. Duncan, L. Seymour, 1987, Journal of biomedical materials research.

Antibody-directed affinity therapy applied to the immune system: in vivo effectiveness and limited toxicity of daunomycin conjugated to HPMA copolymers and targeting antibody.

V. Vetvicka, B. Říhová, J. Kopeček, 1988, Clinical immunology and immunopathology.

Mechanism of three‐dimensional polymerization of the system methyl methacrylate–glycol dimethacrylate. I. Determination of the structure of the three‐dimensional product

J. Kopeček, D. Lím, J. Jokl, 1968 .

Smart self-assembled hybrid hydrogel biomaterials.

Jiyuan Yang, Jindřich Kopeček, J. Kopeček, 2012, Angewandte Chemie.

The Influence of a Colonic Microbiota on HPMA Copolymer Lectin Conjugates Binding in Rodent Intestine

B. Říhová, J. Kopeček, P. Kopec̆ková, 2001, Journal of drug targeting.

Smart and genetically engineered biomaterials and drug delivery systems.

Jindrich Kopecek, J. Kopeček, 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Release of 5‐aminosalicylic acid from bioadhesive N‐(2‐hydroxypropyl)methacrylamide copolymers by azoreductases in vitro

J. Kopeček, P. Kopec̆ková, 1990 .

Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-Overexpressing Ovarian Carcinoma

J. Kopeček, A. David, Yosi Shamay, 2012, Pharmaceutical Research.

Biorecognition: A key to drug-free macromolecular therapeutics.

J. Kopeček, Jiyuan Yang, Lian Li, 2019, Biomaterials.

Human Serum Albumin-Based Drug-Free Macromolecular Therapeutics: Apoptosis Induction by Coiled-Coil-Mediated Cross-Linking of CD20 Antigens on Lymphoma B Cell Surface.

J. Kopeček, Jiyuan Yang, D. C. Radford, 2018, Macromolecular bioscience.

Drug‐free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells

J. Kopeček, Jiyuan Yang, Libin Zhang, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Drug-Free Macromolecular Therapeutics--A New Paradigm in Polymeric Nanomedicines.

J. Kopeček, Te‐Wei Chu, 2015, Biomaterials science.

Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells

J. Kopeček, P. Shami, Ken M. Kosak, 2014, Drug Delivery and Translational Research.

Coiled-coil based drug-free macromolecular therapeutics: in vivo efficacy.

J. Kopeček, Jihua Liu, Jiyuan Yang, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Long-term experience with poly(glycol monomethacrylate) gel in plastic operations of the nose.

Z Voldrich, J. Kopeček, J. Vacík, 1975, Journal of biomedical materials research.

Polymer chemistry: Swell gels

Jindřich Kopeček, J. Kopeček, 2002, Nature.

Phagocytosis of 2-hydroxyethylmethacrylate copolymer particles by different types of macrophages.

V. Vetvicka, J. Kopeček, L. Fornusek, 1983, Folia biologica.

Regulation of transport in artificial membranes by environmental hydrogen-ion concentration

H. Braselmann, J. Kopeček, J. Vacík, 1980 .

Concentration potentials of hydrophilic membranes containing ionogenic groups

J. Kopeček, J. Vacík, V. Kůdela, 1975 .

HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects.

J. Rhim, J. Kopeček, Jiyuan Yang, 2013, Journal of Controlled Release.

Multivalent HER2-binding polymer conjugates facilitate rapid endocytosis and enhance intracellular drug delivery.

Andrew S. Dixon, J. Kopeček, Jiyuan Yang, 2019, Journal of controlled release : official journal of the Controlled Release Society.

In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds.

J. Kopeček, H. Ghandehari, P. Kopec̆ková, 1997, Biomaterials.

Combination therapy of prostate cancer with HPMA copolymer conjugates containing PI3K/mTOR inhibitor and docetaxel.

R. Zhang, J. Kopeček, Jiyuan Yang, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Synthesis and activity of tumor-homing peptide iRGD and histone deacetylase inhibitor valproic acid conjugate.

J. Kopeček, Zheng-Hong Peng, 2014, Bioorganic & medicinal chemistry letters.

ENZYMATIC CLEAVAGE OF SIDE CHAINS OF SYNTHETIC WATER-SOLUBLE POLYMERS.

V. Saudek, J. Labský, J. Kálal, 1976 .

Multi-targeted immunotherapeutics to treat B cell malignancies.

J. Kopeček, Jiyuan Yang, M. T. Gambles, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells.

Jindrich Kopecek, J. Kopeček, Jihua Liu, 2009, Molecular pharmaceutics.

Simultaneous crosslinking of CD20 and CD38 receptors by drug-free macromolecular therapeutics enhances B cell apoptosis in vitro and in vivo.

J. Kopeček, Jiyuan Yang, D. Sborov, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates.

R. Straight, J. Kopeček, P. Kopec̆ková, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Mechanical Responses of 2-Hydroxyethyl Methacrylate-Methacrylonitrile and 2-Hydroxyethyl Methacrylate-Acrylonitrile Copolymer Networks

J. Kopeček, Ík, J. Kola, 1976 .

Solution and Photoproperties of N-(2-Hydroxypropyl)methacrylamide Copolymer−Meso-chlorin e6 Conjugates

J. Kopeček, J. Spikes, Č. Koňák, 1997 .

Hydrogels for site‐specific oral delivery. Poly[(acrylic acid)‐co‐(butyl acrylate)] crosslinked with 4,4′‐bis(methacryloylamino)azobenzene

J. Kopeček, M. Přádný, 1990 .

Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin.

K. Ulbrich, J. Kopeček, J Kopecek, 1982, Biomaterials.

Cross‐linked copolymers of N,N‐diethylacrylamide with improved mechanical properties

K. Ulbrich, J. Kopeček, 2007 .

Swelling pressure induced phase-volume transition in hybrid biopolymer gels caused by unfolding of folded crosslinks: a model.

R. Stewart, K. Dušek, J. Kopeček, 2003, Biomacromolecules.

Bone-Targeted Acid-Sensitive Doxorubicin Conjugate Micelles as Potential Osteosarcoma Therapeutics

J. Kopeček, Jiyuan Yang, S. Low, 2014, Bioconjugate chemistry.

Biological tolerance of ionogenic hydrophilic gels.

L Sprincl, J. Kopeček, J. Vacík, 1973, Journal of biomedical materials research.

Genetically Engineered Block Copolymers: Influence of the Length and Structure of the Coiled-Coil Blocks on Hydrogel Self-Assembly

J. Kopeček, Chunyu Xu, 2008, Pharmaceutical Research.

Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.

J. Kopeček, Jiyuan Yang, L. Radu, 2009, Macromolecular bioscience.

Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress.

J. Tarbell, J. Kopeček, P. Kopec̆ková, 2011, Biomaterials.

Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.

J. Kopeček, D. Brömme, P. Kopec̆ková, 2004, International journal of pharmaceutics.

Targeting and Lysosomal Handling of Polymethacrylamide-Oligopeptide Conjugates

J. Kopeček, R. Duncan, J. Lloyd, 1984 .

PINOCYTIC CAPTURE AND INTRACELLULAR DEGRADATION OF POLY N-(2-HYDROXYPROPYL)-METHACRYLAMIDE CHAINS CONNECTED BY OLIGOPEPTIDE SEQUENCES.

J. Kopeček, R. Duncan, S. Cartlidge, 1982 .

Reversible hydrogels from self-assembling genetically engineered protein block copolymers.

V. Breedveld, J. Kopeček, Chunyu Xu, 2005, Biomacromolecules.

Responsive hybrid hydrogels with volume transitions modulated by a titin immunoglobulin module.

R. Stewart, J. Kopeček, J Kopecek, 2000, Bioconjugate chemistry.

Osmotic opening of the blood-brain barrier permeability to N-(2-hydroxypropyl)methacrylamide copolymers. Effect of polymer -Mw charge and hydrophobicity

S. Rapoport, J. Kopeček, R. Duncan, 1989 .

Smart Self‐Assembled Hybrid Hydrogel Biomaterials

J. Kopeček, Jiyuan Yang, 2012 .

Targetable water-soluble polymeric anticancer drugs: Achievements and unsolved problems

J. Kopeček, P. Kopec̆ková, 1993 .

Immunogenicity of coiled-coil based drug-free macromolecular therapeutics.

J. Kopeček, Jiyuan Yang, M. Kverka, 2014, Biomaterials.

Permeability of hydrophilic membranes based on N-substituted (meth)acrylamides

K. Ulbrich, J. Kopeček, J. Vacík, 1978 .

Novel aromatic azo-containing pH-sensitive hydrogels: Synthesis and characterization

Dong Wang, Miroslava Dušková-Smrčková, Jindřich Kopeček, 2002 .

Novel pH-sensitive hydrogels with adjustable swelling kinetics.

J. Kopeček, P. Kopec̆ková, J Kopecek, 1998, Biomaterials.

Biodegradable and pH sensitive hydrogels: synthesis by a polymer-polymer reaction

Hamidreza Ghandehari, Jindřich Kopeček, J. Kopeček, 1996 .

Degradability of hydrogels containing azoaromatic crosslinks

J. Kopeček, P. Kopec̆ková, P. Yeh, 1995 .

Poly[N-(2-hydroxypropyl)methacrylamide]-iii. Crosslinking copolymerization

J. Kopeček, H. Baẑilová, 1974 .

Water Soluble Polymers for Medicine

J. Kálal, J. Kopeček, J. Drobník, 1978 .

Associative diblock copolymers of poly(ethylene glycol) and coiled-coil peptides

Lisa Joss, Jindřich Kopeček, J. Kopeček, 2002 .

Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels.

J. Kopeček, H. Pan, Jiyuan Yang, 2010, Macromolecular bioscience.

Water soluble polymers in tumor targeted delivery.

Z. Lu, J. Kopeček, T. Minko, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Hydrophilic polymeric microspheres : Their use in immunological methods

V. Vetvicka, J. Kopeček, J. Žídková, 1985 .

Targetable photoactivalable drugs. 3. In vitro efficacy of polymer bound chlorin e6 toward human hepatocarcinoma cell line (PLC/PRF/5) targeted with galactosamine and to mouse splenocytes targeted with anti-Thy 1.2 antibodies

N. L. Krinick, J. Kopeček, B. Říhová, 1993 .

Controlled release of LHRH-DT from bioerodible hydrogel microspheres

J. Kopeček, Manmohan J. Singh, J. Heller, 1991 .

Design of Polymer‐Drug Conjugates

J. Kopeček, P. Kopec̆ková, 2011 .

Backbone Degradable and Coiled‐Coil Based Macromolecular Therapeutics

J. Kopeček, Jiyuan Yang, 2014 .

Antigen Responsive Hydrogels Based on Polymerizable Antibody Fab′ Fragment

Jindřich Kopeček, J. Kopeček, P. Kopec̆ková, 2003 .

Binding and Cytotoxicity of HPMA Copolymer Conjugates to Lymphocytes Mediated by Receptor-Binding Epitopes

Jindřich Kopeček, J. Kopeček, P. Kopec̆ková, 2003, Pharmaceutical Research.

Macrophages of athymic nude mice: Fc receptors, C receptors, phagocytic and pinocytic activities.

V. Vetvicka, J. Kopeček, J. Žídková, 1984, European Journal of Cell Biology.

Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts.

Chunyu Xu, Jindrich Kopecek, Jiyuan Yang, 2006, Macromolecular bioscience.

Intracellular trafficking and subcellular distribution of a large array of HPMA copolymers.

J. Kopeček, Jon Callahan, Pavla Kopečkov, 2009, Biomacromolecules.

Effect of the structure of poly(glycol monomethacrylate) gel on the calcification of implants

J. Kopeček, D. Lím, D. Lím, 2005, Calcified Tissue Research.

Mechanism of the three‐dimensional polymerization of glycol methacrylates. II. The system glycol monomethacrylate–glycol dimethacrylates–solvents

Jindřich Kopeček, J. Kopeček, D. Lím, 1971 .

Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides.

J. Kopeček, Jiyuan Yang, Kuangshi Wu, 2009, Biomacromolecules.

Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers.

J. Kopeček, Jiyuan Yang, Č. Koňák, 2008, Biomacromolecules.

Protein-resistant surfaces prepared by PEO-containing block copolymer surfactants.

J. H. Lee, J. Andrade, J. Kopeček, 1989, Journal of biomedical materials research.

Polymerizable Fab′ antibody fragments for targeting of anticancer drugs

Jindrich Kopecek, J. Kopeček, P. Kopec̆ková, 1999, Nature Biotechnology.

Synthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates.

Z. Lu, J. Kopeček, P. Kopec̆ková, 2000, Bioconjugate chemistry.

Asimple test for immunogenicity of colloidal infusion solutions- the draining lymph node activation.

J. Kopeček, E. Paluska, L. Korčáková, 1976, Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie.

Mechanism of three-dimensional polymerization of glycol methacrylates. III. Contribution to the polymerization kinetics of the system diglycol monomethacrylate-glycol dimethacrylates-water

J. Kopeček, D. Lím, 1971 .

Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system.

Z. Lu, J. Kopeček, P. Kopec̆ková, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Drug targeting to lysosomes.

J. Kopeček, R. Duncan, J. Lloyd, 1984, Biochemical Society transactions.

Optically controlled ligand delivery: 3. Photocleavage of 2-nitrobenzyl bonds at solid-liquid interfaces

J. Andrade, J. Kopeček, H. Yen, 1992 .

Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions.

J. Kopeček, M. Berenson, S. Wroblewski, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion.

J. Kopeček, Jiyuan Yang, P. Kopečková, 2008, Journal of the American Chemical Society.

Hydrogel biomaterials: a smart future?

J. Kopeček, 2007, Biomaterials.

Design of smart HPMA copolymer-based nanomedicines.

J. Kopeček, Jiyuan Yang, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Solution Properties of Polymers Containing Zwitterionic Moieties in Side Chains

J. Kopeček, Č. Koňák, R. Rathi, 1994 .

Smart self-assembled hybrid hydrogel biomaterials.

J. Kopeček, Jiyuan Yang, 2012, Angewandte Chemie.

The Arthrotropism of Macromolecules in Adjuvant-Induced Arthritis Rat Model: A Preliminary Study

K. Craig Goodrich, Scott C. Miller, Dong Wang, 2004, Pharmaceutical Research.

Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells

J. Kopeček, P. Shami, Ken M. Kosak, 2014, Drug Delivery and Translational Research.

HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells

J. Kopeček, Zheng-Hong Peng, 2014, ACS macro letters.

The influence of fusion sequences on the thermal stabilities of coiled-coil proteins

Chunyu Xu, Lisa Joss, Jindřich Kopeček, 2002 .

Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis.

J. Kopeček, Jiyuan Yang, Monika Sima, 2014, ACS nano.

Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction.

J. Kopeček, H. Pan, Jiyuan Yang, 2011, Biomacromolecules.

Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-Overexpressing Ovarian Carcinoma

J. Kopeček, A. David, Yosi Shamay, 2012, Pharmaceutical Research.

HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway.

J. Kopeček, A. Malugin, P. Kopečková, 2004, Molecular pharmaceutics.

N‐(2‐hydroxypropyl) methacrylamide copolymers containing pendant saccharide moieties: Synthesis and bioadhesive properties

B. Říhová, J. Kopeček, R. Rathi, 1991 .

Synthetic polymers as targetable carries for drugs

J. Kopeček, R. Duncan, J. Lloyd, 1984 .

Performance of HPMA copolymer-drug conjugate antibody targeted to ovarian carcinoma cells

J. Kopeček, C. Gentry, V. Omelyanenko, 1996 .

Mechanisms of anticancer action of HPMA copolymer-bound doxorubicin

J. Kopeček, T. Minko, P. Kopečková, 2001 .

Cooperativity between free and N-(2-hydroxypropyl) methacrylamide copolymer bound adriamycin and meso-chlorin e6 monoethylene diamine induced photodynamic therapy in human epithelial ovarian carcinoma in vitro.

R. Straight, J. Kopeček, Z. Gu, 1999, International journal of oncology.

Biorecognizable Polymers: Design, Structure, and Bioactivity

J. Kopeček, P. Kopečková, Cestmár Konák, 1997 .

Covalent attachment of chymotrypsin to poly[N-(2-hydroxypropyl)methacrylamide]

J. Kopeček, P. Sikk, M. Haga, 1981 .

Drug-free macromolecular therapeutics exhibit amplified apoptosis in G2/M phase arrested cells

J. Kopeček, Jiyuan Yang, Lian Li, 2018, Journal of drug targeting.

Erratum: HPMA copolymer-anticancer drug OV-TL-TL16 antibody conjugates. 1. Influence of the method of synthesis on the biding affinity to OVCAR-3 ovarian carcinoma cells in vitro (Journal of Drug Targeting (1996) vol. 3 (357-373))

J. Kopeček, C. Gentry, V. Omelyanenko, 2003 .

Targetable polymeric drugs

J. Kopeček, P. Kopečková, 1990 .