B. Yankner

发表

Apoptosis in the nervous system

Junying Yuan, Bruce A. Yankner, Junying Yuan, 2000, Nature.

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Caine W. Wong, B. Yankner, J. Busciglio, 2002, Neuron.

Neural mechanisms of ageing and cognitive decline

B. Yankner, Nicholas A. Bishop, Tao Lu, 2010, Nature.

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

B. Yankner, 1996, Neuron.

Gene regulation and DNA damage in the ageing human brain

I. Kohane, Cheng Li, B. Yankner, 2004, Nature.

The aging brain.

Tao Lu, P. Loerch, B. Yankner, 2008, Annual review of pathology.

Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

Bruce A. Yankner, F. Lee, B. Yankner, 2002, Nature Medicine.

β‐Amyloid Neurotoxicity in Human Cortical Culture Is Not Mediated by Excitotoxins

B. Yankner, J. Busciglio, J. Yeh, 1993, Journal of neurochemistry.

Commentary and perspective on studies of beta amyloid neurotoxicity

B. Yankner, 1992, Neurobiology of Aging.

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

B. Yankner, L. Duffy, A. Cáceres, 1990, Proceedings of the National Academy of Sciences of the United States of America.

A γ-Secretase-independent Mechanism of Signal Transduction by the Amyloid Precursor Protein*

B. Yankner, Matthew R Hass, 2005, Journal of Biological Chemistry.

Inhibition of β‐Amyloid Production by Activation of Protein Kinase C

B. Yankner, J. Busciglio, D. Gabuzda, 1993 .

Expression of the IGF-II Gene in Brain and Muscle

N. Rosenthal, L. Villa-komaroff, E. Lamperti, 1989 .

Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease

B. Sommer, M. Staufenbiel, Caine W. Wong, 1997, The Journal of Neuroscience.

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

B. Sommer, M. Staufenbiel, B. Yankner, 2000, Nature neuroscience.

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.

B. Yankner, Matthew R Hass, 2005, The Journal of biological chemistry.

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Elizabeta Gjoneska, Li-Huei Tsai, Waseem K. Raja, 2018, Neuron.

Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

A. Bernstein, B. Yankner, M. Yuan, 2000, Nature Cell Biology.

Caspase activity sows the seeds of neuronal death

Junying Yuan, B. Yankner, 1999, Nature Cell Biology.

Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses

Conor K. Camplisson, Thomas C. Ferrante, G. Church, 2018, bioRxiv.

Inflammation and Alzheimer disease: The good, the bad, and the ugly

B. Yankner, S. Weninger, 2001, Nature Medicine.

An antibody to β amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types

B. Yankner, Ming Chen, 1991, Neuroscience Letters.

A century of cognitive decline

B. Yankner, 2000, Nature.

Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder

G. Church, J. Hirschhorn, S. Erdin, 2022, Nature Communications.

Amyloid and Alzheimer's disease—Cause or effect?

B. Yankner, 1989, Neurobiology of Aging.

The biology and mechanism of action of nerve growth factor.

E. Shooter, B. Yankner, 1982, Annual review of biochemistry.

Secretogranin I/Chromogranin B Is a Heparin‐Binding Adhesive Protein

P. Tempst, B. Yankner, M. Chen, 1992, Journal of neurochemistry.

REST and Stress Resistance in Ageing and Alzheimer’s Disease you. Your

B. Yankner, J. Zullo, Tao Lu, 2014 .

In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment.

M. Beal, A. McKee, N. Kowall, 1992, Neurobiology of aging.

Presenilin 1 and Presenilin 2 Have Differential Effects on the Stability and Maturation of Nicastrin in Mammalian Brain*

D. Westaway, P. Fraser, P. George-Hyslop, 2003, Journal of Biological Chemistry.

Neuronal Regulation of Presenilin-1 Processing

B. Yankner, J. Busciglio, H. Hartmann, 1998 .

Monster plaques: What they tell us about Alzheimer's disease

B. Yankner, 1998, Nature Medicine.

Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autism

G. Church, J. Hirschhorn, S. Erdin, 2020 .

Genetics and biology of the Alzheimer amyloid precursor.

R. Neve, G. Higgins, L. Benowitz, 1990, Progress in brain research.

Normal proteolytic processing of the presenilins.

B. Yankner, H. Hartmann, 2000, Methods in molecular medicine.

Developmental Regulation of Presenilin-1 Processing in the Brain Suggests a Role in Neuronal Differentiation*

M. Staufenbiel, B. Yankner, J. Busciglio, 1997, The Journal of Biological Chemistry.

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

M. Beal, N. Kowall, B. Yankner, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Intracellular Accumulation of β-Amyloid in Cells Expressing the Swedish Mutant Amyloid Precursor Protein (*)

B. Yankner, J. Busciglio, P. Paganetti, 1995, The Journal of Biological Chemistry.

Cerebral granulomatous angiitis associated with isolation of human T‐lymphotropic virus type III from the central nervous system

D. Ho, R. Sobel, B. Yankner, 1986, Annals of neurology.

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

P. Matsudaira, P. Matsudaira, B. Yankner, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.

A. Bernstein, B. Yankner, M. Yuan, 2000, Nature cell biology.

Negative Regulation of Vps 34 by Cdk Mediated Phosphorylation Citation

L. Tsai, M. Lipinski, Junying Yuan, 2012 .

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Junying Yuan, B. Yankner, Hong Zhu, 2000, Nature.

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

L. Villa-komaroff, R. Neve, M. Oster-Granite, 1989, Science.

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.

D. Kirschner, B. Yankner, L. Duffy, 1990, Science.

The aging stress response.

B. Yankner, M. Haigis, Marcia C Haigis, 2010, Molecular cell.

Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease*

B. Yankner, Tao Lu, Bruce A. Yankner, 2009, Journal of Biological Chemistry.

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

B. Yankner, J. Busciglio, 1995, Nature.

Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration.

L. Villa-komaroff, R. Neve, L. Benowitz, 1990, Brain research. Molecular brain research.

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

F. Alt, T. Prolla, P. Loerch, 2008, Cell.

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

Qikai Xu, Stephen J. Elledge, Bruce A. Yankner, 2015, Science.

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

R. Xavier, Aylwin Ng, M. Lipinski, 2010, Proceedings of the National Academy of Sciences.

The histone demethylase LSD1/KDM1A promotes the DNA damage response

S. Gygi, M. Sowa, H. Steen, 2013, The Journal of cell biology.

The histone demethylase LSD 1 / KDM 1 A promotes the DNA damage response

S. Gygi, M. Sowa, H. Steen, 2013 .

Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids

G. Church, C. Walsh, J. Hirschhorn, 2020, bioRxiv.

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

L. Tsai, Elizabeta Gjoneska, Fan Gao, 2018, Neuron.

Negative regulation of Vps34 by Cdk mediated phosphorylation.

L. Tsai, M. Lipinski, Junying Yuan, 2010, Molecular cell.

Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses

Andrew C. Pawlowski, Conor K. Camplisson, Thomas C. Ferrante, 2021, Nucleic acids research.

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.

B. Yankner, M. Yuan, P. Nadeau, 1999, Proceedings of the National Academy of Sciences of the United States of America.

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

Junying Yuan, Bruce A. Yankner, Xian Adiconis, 2018, Cell.

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Kara H. Woo, Cory C. Funk, Kelsey S. Montgomery, 2020, Scientific Data.

Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.

J. Harper, R. Bronson, B. Yankner, 2013, Molecular cell.

REST and Stress Resistance in Aging and Alzheimer’s Disease

David A. Bennett, Bruce A. Yankner, Tao Lu, 2014, Nature.

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1*

Alexei Degterev, Junying Yuan, Tao Lu, 2006, Journal of Biological Chemistry.

reticulum-specific apoptosis and cytotoxicity by amyloid-b

Junying Yuan, B. Yankner, Hong Zhu, 2000 .

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

B. Yankner, J. Busciglio, A. Lorenzo, 1995, Neuron.

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

Hans Clevers, Marc van de Wetering, Bruce A. Yankner, 1998, Nature.

Distinct Processing of Endogenous and Overexpressed Recombinant Presenilin 1

B. Sommer, M. Staufenbiel, B. Yankner, 1997, Neurobiology of Aging.

Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium*

J. Shine, B. Yankner, A. Isaacs, 2006, Journal of Biological Chemistry.

β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

Bruce A. Yankner, Yoichi Kato, Xi He, 1999 .

Regulation of Lifespan by Neural Excitation and REST

G. Church, D. Bennett, A. Rotenberg, 2019, Nature.

Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane.

E. Shooter, B. Yankner, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression

S. Yu, K. Ye, Xia Liu, 2022, Science advances.

Inflammation links ageing to the brain

Bruce A. Yankner, B. Yankner, Dana Gabuzda, 2013, Nature.

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.

P. Matsudaira, P. Matsudaira, B. Yankner, 1994, The Journal of biological chemistry.

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

G. Church, L. Tsai, B. Yankner, 2019, Cell reports.

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

Bruce A. Yankner, Chuang-Kuo Wu, Alfredo Lorenzo, 1998, Nature Medicine.

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.

Steven P Gygi, Joshua E Elias, Joshua E. Elias, 2005, Human molecular genetics.

Evolution of the Aging Brain Transcriptome and Synaptic Regulation

T. Prolla, P. Loerch, Cheng Li, 2008, PloS one.

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity.

C. Geula, B. Yankner, M. Yuan, 1998, Nature medicine.

In vivo neurotoxicity of beta-amyloid [β(1–40)] and the β(25–35) fragment

M. Beal, A. McKee, N. Kowall, 1992, Neurobiology of Aging.

Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

B. Sommer, M. Staufenbiel, B. Yankner, 2000, Nature Neuroscience.

β-Amyloid and the pathogenesis of alzheimer's disease

M. Mesulam, B. Yankner, 1991 .

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

P. Ghazal, G. McKenzie, R. Corriveau, 2008, Nature Neuroscience.

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

B. Yankner, A Lorenzo, B A Yankner, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

G. Feng, Kang Zhang, Zhigang He, 2011, Nature.

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

Bruce A. Yankner, Alfredo Lorenzo, G. Weir, 1994, Nature.

Slowing Down Aging.

B. Yankner, Katharina Meyer, 2017, Cell metabolism.

The adaptive aging brain

B. Yankner, Liviu Aron, J. Zullo, 2021, Current Opinion in Neurobiology.

Amyloid Fibril Toxicity in Alzheimer's Disease and Diabetes a

B. Yankner, A. Lorenzo, A. LORENZO, 1996, Annals of the New York Academy of Sciences.

beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation.

B. Yankner, Y. Kato, X. He, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Addendum: REST and stress resistance in ageing and Alzheimer’s disease

D. Bennett, Yiwen Chen, B. Yankner, 2016, Nature.

REST and Alzheimer disease

B. Yankner, 2015, Annals of neurology.

Neurodegenerative disorders: Neural synchronization in Alzheimer's disease

Bruce A. Yankner, B. Yankner, Liviu Aron, 2016, Nature.

MECHANISM OF ACTION OF NERVE GROWTH FACTOR1

E. Shooter, P. Gunning, A. Sutter, 1981 .

A RIP Tide in Neuronal Signal Transduction

B. Yankner, J. Ebinu, 2002, Neuron.

NGF and Alzheimer's disease—Considerations and caveats

B. Yankner, 1989, Neurobiology of Aging.

Biosynthesis and mechanism of action of nerve growth factor.

E. Shooter, G. Landreth, A. Sutter, 1981, Recent progress in hormone research.

574 Localization and functional significance of presenilin S182

M. Staufenbiel, B. Yankner, J. Busciglio, 1996, Neurobiology of Aging.

Methodological variables in the assessment of beta amyloid neurotoxicity

Bruce A. Yankner, Alfredo Lorenzo, B. Yankner, 1992, Neurobiology of Aging.

Inhibition of beta-amyloid production by activation of protein kinase C.

B. Yankner, J. Busciglio, D. Gabuzda, 1993, Journal of neurochemistry.

The Pathogenesis of Alzheimer's Disease: Is Amyloid β‐Protein the Beginning or the End?

B. Yankner, 2000, Annals of the New York Academy of Sciences.

Sorting Out Presenilins in Alzheimer’s Disease

M. Wolfe, B. Yankner, 2016, Cell.

Impaired neural stress resistance and loss of REST in bipolar disorder.

R. Perlis, B. Yankner, Tak Ko, 2023, Molecular psychiatry.

Amyloid (cid:1) -Protein Toxicity and the Pathogenesis of Alzheimer Disease

B. Yankner, Bruce A. Yankner, 2020 .