J. Heim

发表

Comparative microarray analysis of gene expression during apoptosis-induction by growth factor deprivation or protein kinase C inhibition

Jutta Heim, Adrian Brüngger, B. Pierrat, 2000, Oncogene.

Yeast Synthetic Biology Platform Generates Novel Chemical Structures as Scaffolds for Drug Discovery

J. Heim, J. Klein, W. Hamilton, 2014, ACS synthetic biology.

In-vitro cleavage of a fusion protein bound to cellulose using the soluble yscFs (Kex2) variant

J. Heim, R. Warren, P. Seeboth, 1992, Applied Microbiology and Biotechnology.

α-Factor-leader-directed secretion of recombinant human-insulin-like growth factor I from Saccharomyces cerevisiae

K. Steube, J. Heim, B. Chaudhuri, 1991 .

Physiological characterization of the yeast metallothionein (CUP1) promoter, and consequences of overexpressing its transcriptional activator, ACE1

J. Heim, P. Fürst, G. Pohlig, 1994, Yeast.

In-vitro processing of yeast α-factor leader fusion proteins using a soluble yscF (Kex2) variant

J. Heim, P. Seeboth, P. G. Seeboth, 1991, Applied Microbiology and Biotechnology.

In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs

P. Caspers, J. Heim, A. Schmitt-Hoffmann, 2009, Antimicrobial Agents and Chemotherapy.

Localization of Epitopes Recognized by Monoclonal Antibodies on Tissue-type and Urokinase-type Plasminogen Activators Using Recombinant Hybrid Enzymes

F. Asselbergs, J. Heim, B. Chaudhuri, 1993 .

Biogenesis of the yeast vacuole (lysosome). The precursor forms of the soluble hydrolase carboxypeptidase yscS are associated with the vacuolar membrane.

J. Heim, D. Wolf, D. Spormann, 1992, The Journal of biological chemistry.

Novel BNIP1 variants and their interaction with BCL2 family members

J. Heim, B. Meyhack, H. Zhang, 1999, FEBS letters.

A pure enzyme catalyzing penicillin biosynthesis.

A. Demain, J. Heim, I. Hollander, 1984, Science.

Functional expression of a mammalian acetylcholinesterase in Pichia pastoris: comparison to acetylcholinesterase, expressed and reconstituted from Escherichia coli.

C. Schmidt-Dannert, H. Atomi, J. Heim, 1998, Biochimica et biophysica acta.

The biosynthesis of sulfur-containing beta-lactam antibiotics.

J. Heim, J. Nüesch, H. Treichler, 1987, Annual review of microbiology.

Redistribution of Bax from cytosol to membranes is induced by apoptotic stimuli and is an early step in the apoptotic pathway.

H. Zhang, J. Heim, B. Meyhack, 1998, Biochemical and biophysical research communications.

Isolation and characterization of recombinant annexin V expressed in Saccharomyces cerevisiae.

J. Heim, H. Grossenbacher, R. Bürgi, 1994, Journal of biotechnology.

Regulation of isopenicillin N synthetase and deacetoxycephalosporin C synthetase by carbon source during the fermentation of Cephalosporium acremonium

A. Demain, J. Heim, S. Wolfe, 1984, Applied Microbiology and Biotechnology.

Carboxypeptidase yscS: gene structure and function of the vacuolar enzyme.

J. Heim, D. Wolf, D. Spormann, 1991, European journal of biochemistry.

Peptide and amino acid oxidation in the presence of thiosulfate by members of the genus Thermoanaerobacter

J. Heim, B. Ollivier, M. Magot, 1995, Current Microbiology.

Crinipellins, the First Natural Products with a Tetraquinane Skeleton

J. Heim, T. Anke, W. Steglich, 1985 .

Second-site NMR screening and linker design.

Wolfgang Jahnke, Marcel J J Blommers, Jutta Heim, 2003, Current topics in medicinal chemistry.

The Biosynthesis of Sulfur-Containing β-Lactam Antibiotics

J. Heim, J. Nüesch, Treichler Hj, 1987 .

Prospects for the next anti-Pseudomonas drug.

M. Page, J. Heim, 2009, Current opinion in pharmacology.

Repression of beta-lactam production in Cephalosporium acremonium by nitrogen sources.

A. Demain, J. Heim, S. Wolfe, 1984, The Journal of antibiotics.

C-terminal proteolytic degradation of recombinant desulfato-hirudin and its mutants in the yeast Saccharomyces cerevisiae.

J. Heim, G. Pohlig, K. Takabayashi, 1994, European journal of biochemistry.

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines

M. Unemo, W. Shafer, C. Deal, 2017, PLoS medicine.

Antibiotics from basidiomycetes. XXIX: Pilatin, a new antibiotically active marasmane derivative from cultures of Flagelloscypha pilatii agerer.

J. Heim, T. Anke, B. Steffan, 1988, The Journal of antibiotics.

Structural Basis of BFL-1 for Its Interaction with BAX and Its Anti-apoptotic Action in Mammalian and Yeast Cells*

W. Greenhalf, S. Cowan-Jacob, M. Simonen, 2000, The Journal of Biological Chemistry.

A microarray-based, integrated approach to identify novel regulators of cancer drug response and apoptosis

Jutta Heim, Adrian Brüngger, B. Pierrat, 2002, Oncogene.

In-vitro processing of yeast alpha-factor leader fusion proteins using a soluble yscF (Kex2) variant.

J. Heim, P. Seeboth, 1991, Applied microbiology and biotechnology.

Recombinant hirustasin: Production in yeast, crystallization, and interaction with serine proteases

M. Grütter, G. Fendrich, J. Priestle, 1997, Protein science : a publication of the Protein Society.

Thrombolytic Activity of Two Chimeric Recombinant Plasminogen Activators (FK2tu-PA and K2tu-PA) in Rabbits

J. Heim, G. Agnelli, A. Mele, 1992, Thrombosis and Haemostasis.

Survival and Distribution of Echinostoma caproni in the Small Intestine of ICR Mice up to 36 Hours after the Death of the Host

J. Heim, B. Fried, M. Rossi, 2000, The Journal of parasitology.

Orphan Nuclear Receptor HNF-4 Binds to the Human Coagulation Factor VII Promoter (*)

D. Erdmann, J. Heim, J. Heim, 1995, The Journal of Biological Chemistry.

Purification, characterization and biological evaluation of recombinant leech-derived tryptase inhibitor (rLDTI) expressed at high level in the yeast Saccharomyces cerevisiae.

G. Fendrich, J. Heim, C. Sommerhoff, 1996, European journal of biochemistry.

New molecules from old classes: revisiting the development of beta-lactams.

M. Page, J. Heim, 2009, IDrugs : the investigational drugs journal.

Properties of Chimeric (Tissue-Type/Urokinase-Type) Plasminogen Activators Obtained by Fusion at the Plasmin Cleavage Site

J. Heim, G. Agnelli, A. Mele, 1993, Thrombosis and Haemostasis.

Thrombolytic and Haemorrhagic Effects of Bolus Doses of Tissue-Type Plasminogen Activator and a Hybrid Plasminogen Activator with Prolonged Plasma Half-Life (K2tu-PA: CGP 42935)

J. Heim, G. Agnelli, A. Mele, 1993, Thrombosis and Haemostasis.

A Hybrid Plasminogen Activator Binds to the u-PA Receptor and Has a Reduced Thrombolytic Potency In Vivo

F. Asselbergs, J. Heim, G. Agnelli, 1993, Thrombosis and Haemostasis.

2‐μm vectors containing the Saccharomyces cerevisiae metallothionein gene as a selectable marker: Excellent stability in complex media, and high‐level expression of a recombinant protein from a CUP1‐promoter‐controlled expression cassette in cis

J. Heim, G. Pohlig, T. Hottiger, 1995, Yeast.

A new structural class of serine protease inhibitors revealed by the structure of the hirustasin-kallikrein complex.

M. Grütter, P. Mittl, G. Fendrich, 1997, Structure.

Isolation and structure of the pectin lyase D-encoding gene from Aspergillus niger.

J. Visser, J. Heim, H. Kester, 1990, Gene.

Factor X fusion proteins: improved production and use in the release in vitro of biologically active hirudin from an inactive alpha-factor-hirudin fusion protein.

D. Kilburn, J. Heim, E. Kwan, 2000, Protein expression and purification.

Heterologous gene expression in yeast.

A. Hinnen, J. Heim, A Hinnen, 1989, Biotechnology.

Recombinant Hirudin: Genetic Engineering and Structure Analysis

M. Grütter, J. Heim, W. Märki, 1991, Seminars in thrombosis and hemostasis.

Gene expression in recombinant yeast.

A. Hinnen, J. Heim, B. Chaudhuri, 1995, Bioprocess technology.

SH3GLB, a new endophilin-related protein family featuring an SH3 domain.

J. Mestan, P. Ferrigno, B. Pierrat, 2001, Genomics.

Prospects for the next anti-Pseudomonas drug.

M. Page, J. Heim, 2009, Current opinion in pharmacology.