T. Malek

T. Malek, A. Bayer, C. Cabello-Kindelan, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Expansion of a restricted residual host Treg‐cell repertoire is dependent on IL‐2 following experimental autologous hematopoietic stem transplantation

T. Malek, A. Bayer, R. Levy, 2011, European journal of immunology.

The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation

T. Malek, A. Pugliese, A. Bayer, 2013, Immunologic Research.

Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment

O. Bathe, T. Malek, N. Dalyot-Herman, 2003, BMC Cancer.

Efficient Internalization of IL-2 Depends on the Distal Portion of the Cytoplasmic Tail of the IL-2R Common γ-Chain and a Lymphoid Cell Environment1

T. Malek, A. Yu, C. Y. Choi, 2000, The Journal of Immunology.

The Proteasome Regulates Receptor-mediated Endocytosis of Interleukin-2*

T. Malek, A. Yu, Aixin Yu, 2001, The Journal of Biological Chemistry.

Low-dose IL-2 as a therapeutic agent for tolerance induction.

T. Malek, A. Pugliese, 2011, Immunotherapy.

A Function for IL-7 R for CD 4 CD 25 Foxp 3 T Regulatory Cells 1

T. Malek, C. Surh, A. Bayer, 2008 .

Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family.

T. Malek, Margaret L. Fleming, M. L. Fleming, 1993, Journal of immunology.

Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT.

T. Malek, A. Bayer, R. Levy, 2009, Blood.

Cutting Edge: Allogeneic CD4+CD25+Foxp3+ T Regulatory Cells Suppress Autoimmunity while Establishing Transplantation Tolerance1

T. Malek, D. Adeegbe, A. Bayer, 2006, The Journal of Immunology.

This information is current as Tolerancewhile Establishing Transplantation T Regulatory Cells Suppress Autoimmunity + Foxp 3 + CD 25 + Cutting Edge : Allogeneic CD 4

T. Malek, D. Adeegbe, A. Bayer, 2006 .

Cells Competent to Develop into Memory T + Initial Antigen Encounter Programs CD 8

O. Bathe, T. Malek, R. Carrio, 2004 .

The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.

E. Shevach, T. Malek, R. Robb, 1984, Journal of immunology.

Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells.

T. Malek, Yuguang Ban, S. Hsiung, 2020, ImmunoHorizons.

Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance.

T. Malek, D. Adeegbe, R. Levy, 2010, Blood.

Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition

T. Malek, E. Rothenberg, J. Lugo, 1985, The Journal of experimental medicine.

Role of Ly-6 in lymphocyte activation. I. Characterization of a monoclonal antibody to a nonpolymorphic Ly-6 specificity.

E. Shevach, T. Malek, G. Ortega, 1986, Journal of immunology.

A delicate balance: tweaking IL-2 immunotherapy

T. Malek, J. Ferrara, 2012, Nature Medicine.

Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin 2 receptor: relationship to the interleukin 2‐binding site

E. Shevach, T. Malek, T. Diamantstein, 1987, European journal of immunology.

Non‐redundant role for IL‐7R signaling for the survival of CD8+ memory T cells

T. Malek, C. Rolle, R. Carrio, 2007, European journal of immunology.

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

E. Shevach, T. Malek, R. Robb, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Centrifugal Elutriation and PNA Panning Enrich for Dividing Cortical and Medullary Thymocytes

T. Malek, 2003 .

Interleukin 2 upregulates expression of its receptor on a T cell clone

J. Ashwell, T. Malek, Thomas R. Malek, 1985, The Journal of experimental medicine.

Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-I

W. Paul, E. Shevach, T. Malek, 1983, The Journal of experimental medicine.

Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody1

C. Ricordi, T. Berney, L. Inverardi, 2003, Transplantation.

Thymic Development Maturation of Regulatory T Cells during IL-2R Signaling Is Essential for Functional

T. Malek, Michael J. Dee, Aixin Yu, 2013 .

IL-2 During In Vitro Priming Promotes Subsequent Engraftment and Successful Adoptive Tumor Immunotherapy by Persistent Memory Phenotypic CD8+ T Cells1

O. Bathe, T. Malek, N. Dalyot-Herman, 2001, The Journal of Immunology.

Reversal of CD8+ T Cell Ignorance and Induction of Anti-Tumor Immunity by Peptide-Pulsed APC1

O. Bathe, T. Malek, N. Dalyot-Herman, 2000, The Journal of Immunology.

Control of T Cell Development In Vivo by Subdomains Within the IL-7 Receptor α-Chain Cytoplasmic Tail1

T. Malek, B. O. Porter, P. Scibelli, 2001, The Journal of Immunology.

Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammac-dependent cytokines IL-2, IL-7, and IL-15.

T. Malek, B. O. Porter, 2000, Seminars in immunology.

Multiple γc-dependent cytokines regulate T-cell development

You-Wen He, T. Malek, B. O. Porter, 1999 .

Monoclonal antibodies to the common γ‐chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development

You-Wen He, T. Malek, B. Adkins, 1998, Journal of leukocyte biology.

Transient Enhanced IL-2R Signaling Early during Priming Rapidly Amplifies Development of Functional CD8+ T Effector-Memory Cells

T. Malek, Michael J. Dee, I. Castro, 2012, The Journal of Immunology.

Distribution of Ly-6C on lymphocyte subsets: I. Influence of allotype on T lymphocyte expression.

P. Smith, T. Malek, T. Waldschmidt, 1997, Journal of immunology.

Blocking the Common g-Chain of Cytokine Receptors Induces T Cell Apoptosis and Long-Term Islet Allograft Survival

T. Strom, X. Li, A. Ima, 2000 .

Fueling Cancer Vaccines to Improve T Cell-Mediated Antitumor Immunity

T. Malek, Rosmely Hernandez, 2022, Frontiers in Oncology.

High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity

T. Malek, S. Hsiung, Rosmely Hernandez, 2021, Journal for ImmunoTherapy of Cancer.

Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors.

J. Allison, T. Malek, E. Podack, 1996, Journal of immunology.

The Murine Interleukin‐2 Receptor: Biochemical Structure and Regulation of Expression

R. Germain, E. Shevach, J. Ashwell, 1986, Immunological reviews.

Effector-Memory Cells T Development of Functional CD8 during Priming Rapidly Amplifies Transient Enhanced IL-2R Signaling Early

T. Malek, I. Castro, 2012 .

The Basis of Distinctive IL-2– and IL-15–Dependent Signaling: Weak CD122-Dependent Signaling Favors CD8+ T Central-Memory Cell Survival but Not T Effector-Memory Cell Development

T. Malek, Michael J. Dee, I. Castro, 2011, The Journal of Immunology.

CD 122-Dependent Signaling Favors CD 8 Dependent Signaling : Weak − and IL-15 − The Basis of Distinctive IL-2

T. Malek, I. Castro, Aixin Yu, 2011 .

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells

You-Wen He, T. Malek, Y. W. He, 1996, The Journal of experimental medicine.

Unusual expression of IL 2 receptors and both the c-myb and c-raf oncogenes in T cell lines and clones derived from autoimmune MRL-lpr/lpr mice.

A. Steinberg, J. Mountz, T. Malek, 1985, Journal of immunology.

Peptide-Pulsed APC Induction of Anti-Tumor Immunity by T Cell Ignorance and + Reversal of CD 8

O. Bathe, T. Malek, N. Dalyot-Herman, 2000 .

Selection of internalization‐deficient cells by interleukin‐2‐Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin‐2 receptor β chain does not contribute to internalization of interleukin‐2

T. Malek, R. Furse, Robert K. Furse, 1993, European journal of immunology.

Differentiated T Regulatory Cells Terminally + Development of Klrg1 IL-2 Receptor Signaling Is Essential for the

T. Malek, E. Podack, Guoyan Cheng, 2012 .

Legionella pneumophila protease inactivates interleukin-2 and cleaves CD4 on human T cells

R. Miller, T. Malek, N. Gutgsell, 1993, Infection and immunity.

The cellular compartmentalization of macrophage‐associated nominal antigen: immunologically relevant macrophage‐associated antigen may not require an intracellular phase of macrophage handling

E. Shevach, T. Malek, L. Clement, 1983, European journal of immunology.

T C E L L-A C T I V A T I N G P R O P E R T I E S OF AN ANTI -THY-1

E. Shevach, T. Malek, K. Gunter, 2003 .

On CD28/CD40 Ligand Costimulation, Common γ-Chain Signals, and the Alloimmune Response1

Wenda Gao, T. Strom, X. Li, 2002, The Journal of Immunology.

Alloimmune Response -Chain Signals, and the g Common On CD28/CD40 Ligand Costimulation,

Wenda Gao, T. Strom, X. Li, 2002 .

Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells1

T. Malek, E. Codias, P. Scibelli, 2001, The Journal of Immunology.

Antigen-Activated T Cells Cytokines and Functional Maturation of Signaling for Extended Growth to Multiple Broad Programming by IL-2 Receptor Lichtenheld

T. Malek, E. Codias, P. Scibelli, 2001 .

Enhancing the Anti-Tumor Activity of breast Cancer-Specific Cytotoxic T Lymphocytes

T. Malek, 2000 .

Redundant and unique regulation of activated mouse B lymphocytes by IL‐4 and IL‐21

T. Malek, Haoli Jin, 2006, Journal of leukocyte biology.

Expression of Ly-6A/E alloantigens in thymocyte and T-lymphocyte subsets: variability related to the Ly-6a and Ly-6b haplotypes

R. Baler, T. Malek, R. Levy, 1989, Immunogenetics.

Regulation of nuclear factor-kappa B and activator protein-1 activities after stimulation of T cells via glycosylphosphatidylinositol-anchored Ly-6A/E.

V. Ivanov, T. Malek, T. Fleming, 1994, Journal of immunology.

REVIEW Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions

T. Malek, S. Copsel, R. Levy, 2020 .

Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self

L. Glimcher, A. Singer, T. Malek, 1985, The Journal of experimental medicine.

Down-regulation of IL-2 production by activation of T cells through Ly-6A/E.

T. Malek, E. Codias, T. Fleming, 1990, Journal of immunology.

Tumor necrosis factor synergistically acts with IFN-gamma to regulate Ly-6A/E expression in T lymphocytes, thymocytes and bone marrow cells.

T. Malek, E. Codias, K. Danis, 1989, Journal of immunology.

Recombinant rabbit secretory immunoglobulin molecules: alpha chains with maternal (paternal) variable-region allotypes and paternal (maternal) constant-region allotypes.

T. Malek, W. Hanly, K. Knight, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Activated T Cells Inhibits IL-2 Production Cytokine-Dependent Blimp-1 Expression in

T. Malek, 2006 .

Identification of a membrane antigen that is distinct from the interleukin 2 receptor and that may be required for interleukin 2-driven proliferative responses.

E. Shevach, T. Malek, R. Robb, 1983, Journal of immunology.

The murine IL 2 receptor. II. Monoclonal anti-IL 2 receptor antibodies as specific inhibitors of T cell function in vitro.

E. Shevach, T. Malek, C. Chan, 1984, Journal of immunology.

Proliferation of T lymphocytes in response to interleukin 2 varies with their state of activation.

J. Ashwell, T. Malek, R. Robb, 1986, Journal of Immunology.

The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor.

You-Wen He, T. Malek, Y. W. He, 1995, Journal of immunology.

Factors in Allograft Rejection Allografts: A Role for Novel T Cell Growth IL-2 and IL-4 Double Knockout Mice Reject Islet

P. Nickerson, M. Zand, R. Manfro, 1998 .

Human immunoglobulins with a1 allotypic determinants of rabbit inuminoglobulin heavy chains

T. Malek, K. Knight, S. Dray, 1975, Nature.

Evidence for additional subunits associated to the mouse interleukin 2 receptor p55/p75 complex.

T. Malek, H. Saragovi, 1990, Proceedings of the National Academy of Sciences of the United States of America.

The murine interleukin 2 receptor. Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit.

T. Malek, H. Saragovi, 1987, Journal of immunology.

Prostaglandin E2 inhibits T cell activation‐induced apoptosis and Fas‐mediated cellular cytotoxicity by blockade of Fas‐ligand induction

T. Malek, B. O. Porter, 1999, European journal of immunology.

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors1

T. Malek, C. Bergmann, R. Levy, 2003, The Journal of Immunology.

Receptorsin the Absence of Functional IL-2 and IL-15 Vivo T Cell-Dependent Immune Responses In Efficient Induction of Primary and Secondary

T. Malek, C. Bergmann, R. Levy, 2002 .

Autoimmunitywith Limited TCR Diversity in Control of T Regulatory Cells + Foxp3 + CD25 + CD4

T. Malek, D. Adeegbe, T. Matsutani, 2009 .

IL-2Rβ/IL-7Rα Doubly Deficient Mice Recapitulate the Thymic and Intraepithelial Lymphocyte (IEL) Developmental Defects of γc−/− Mice: Roles for Both IL-2 and IL-15 in CD8αα IEL Development

T. Malek, B. O. Porter, 1999, The Journal of Immunology.

IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development.

T. Malek, B. O. Porter, 1999, Journal of immunology.

Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7.

T. Malek, R. Levy, Y. W. He, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.

T. Malek, B. Adkins, R. Furse, 1995, Journal of immunology.

Autoimmune Disease in New Zealand Mice

T. Malek, P. Baker, K. McCoy, 1987 .

Regulatory T cells in the treatment of disease

D. Klatzmann, A. Sharabi, T. Malek, 2018, Nature Reviews Drug Discovery.

Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus

M. Struthers, P. Mangan, C. Tovar, 2021, The Journal of Immunology.

Activation of T lymphocytes through the Ly-6 pathway is defective in A strain mice.

E. Shevach, T. Malek, K. Danis, 1989, Journal of immunology.

Structural Basis for Binding Multiple Ligands by the Common Cytokine Receptor γ-Chain*

T. Malek, Ferenc Olosz, 2002, The Journal of Biological Chemistry.

Three Loops of the Common γ Chain Ectodomain Required for the Binding of Interleukin-2 and Interleukin-7*

T. Malek, Ferenc Olosz, 2000, The Journal of Biological Chemistry.

T Regulatory Cell Adoptive Therapy for Tolerance Induction in Autoimmunity and Transplantation

T. Malek, A. Bayer, C. Cabello-Kindelan, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.

T. Malek, V. Vincek, P. Scibelli, 2002, Immunity.

Interleukin-2 receptor signaling: at the interface between tolerance and immunity.

T. Malek, I. Castro, 2010, Immunity.

IL-2R Signaling Is Essential for Functional Maturation of Regulatory T Cells during Thymic Development

T. Malek, Michael J. Dee, Guoyan Cheng, 2013, The Journal of Immunology.

T‐cell tolerance and the multi‐functional role of IL‐2R signaling in T‐regulatory cells

T. Malek, Guoyan Cheng, Aixin Yu, 2011, Immunological reviews.

Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to alpha-bungarotoxin and other neurotoxins.

T. Malek, C. O'huigin, T. Fleming, 1993, Journal of immunology.

Regulation of B lymphocyte responses to IL-4 and IFN-gamma by activation through Ly-6A/E molecules.

T. Malek, E. Codias, 1990, Journal of immunology.

T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4

E. Shevach, T. Malek, K. Gunter, 1984, The Journal of experimental medicine.

Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens

A. Singer, T. Malek, T. Mizuochi, 1986, The Journal of experimental medicine.

Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self

A. Singer, T. Malek, A. Rosenberg, 1985, The Journal of experimental medicine.

Engineering IL-2 for immunotherapy of autoimmunity and cancer

T. Malek, Rosmely Hernandez, Kathryn M LaPorte, 2022, Nature Reviews Immunology.

Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA.

R. Germain, W. Leonard, W. Greene, 1985, Journal of immunology.

IL-2Rβ–Dependent Signaling and CD103 Functionally Cooperate To Maintain Tolerance in the Gut Mucosa

T. Malek, Michael J. Dee, N. Altman, 2015, The Journal of Immunology.

IL-2 Receptor Signaling Is Essential for the Development of Klrg1+ Terminally Differentiated T Regulatory Cells

T. Malek, E. Podack, Matthew S Tsai, 2012, The Journal of Immunology.

The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.

W. Leonard, T. Malek, H. Nakajima, 1997, Journal of immunology.

IL-15 and IL-2: a matter of life and death for T cells in vivo

T. Strom, X. Li, T. Malek, 2001, Nature Medicine.

Initial Antigen Encounter Programs CD8+ T Cells Competent to Develop into Memory Cells That Are Activated in an Antigen-Free, IL-7- and IL-15-Rich Environment1

O. Bathe, T. Malek, R. Carrio, 2004, The Journal of Immunology.

Pleiotropic effects of Bcl-2 on transcription factors in T cells: potential role of NF-kappa B p50-p50 for the anti-apoptotic function of Bcl-2.

G. Deng, V. Ivanov, T. Malek, 1995, International immunology.

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

Paul D. Morton, T. Malek, C. Moraes, 2016, Cell Death and Differentiation.

Tolerance, not immunity, crucially depends on IL-2

T. Malek, A. Bayer, 2004, Nature Reviews Immunology.

Serologic and structural comparisons of rabbit IgA allotypes.

B. E. Peterson, T. Malek, B. Friedenson, 1978, Advances in experimental medicine and biology.

Digestion of the "proteolytic resistant" f-subclass of rabbit secretory IgA. Localization of f-subclass allotypic specificities to the Fc2alpha fragment.

T. Malek, K. Knight, 1977, Immunochemistry.

Papain‐resistant (f) and papain‐sensitive (g) subclasses of rabbit slgA. Allotypic specificities on different domains of the g subclass of α‐chains (αg)

T. Malek, W. Hanly, K. Knight, 1974, European journal of immunology.

The main function of IL‐2 is to promote the development of T regulatory cells

T. Malek, Thomas R. Malek, 2003, Journal of leukocyte biology.

Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation.

T. Malek, E. Podack, Matthew S Tsai, 2010, The Journal of clinical investigation.

Distribution of covalently bound and non-covalently bound secretory component on sbuclasses of rabbit secretory IgA.

T. Malek, M. L. Vetter, K. Knight, 1975, Journal of immunology.

Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis

W. Paul, Kendall A. Smith, E. Shevach, 1984, The Journal of experimental medicine.

In vivo and in vitro expression of an interleukin 2 receptor by murine B and T lymphocytes.

F. Finkelman, E. Shevach, T. Malek, 1986, Journal of immunology.

The biology of interleukin-2.

T. Malek, Thomas R Malek, 2008, Annual review of immunology.

Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens

T. Malek, S. Ono, Thomas R. Malek, 1986, The Journal of experimental medicine.

Promoting Immune Regulation in Type 1 Diabetes Using Low-Dose Interleukin-2

T. Malek, A. Pugliese, Natasha C. Ward, 2016, Current Diabetes Reports.

Treg amelioration of GVHD following allo/xeno-HSCT using mobilized mouse and human peripheral blood donors.

T. Malek, S. Copsel, G. Hill, 2023, Transplantation and cellular therapy.

Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets

T. Malek, Michael J. Dee, Jing Yang, 2016, The Journal of Immunology.

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

D. Klatzmann, A. Hartemann, T. Malek, 2015, Journal of autoimmunity.

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.

Linjiang Zhu, T. Malek, N. Altman, 2009, Immunity.

IL-2 Family of Cytokines in T Regulatory Cell Development and Homeostasis

Linjiang Zhu, T. Malek, D. Adeegbe, 2008, Journal of Clinical Immunology.

Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

D. Klatzmann, T. Malek, A. Pugliese, 2015, Diabetes.

The Role of IL-2 in the Development and Peripheral Homeostasis of Naturally Occurring CD4 + CD25 + Foxp3 + Regulatory T Cells

T. Malek, A. Bayer, 2008 .

Molecular Basis for Binding Multiple Cytokines by γc

T. Malek, Ferenc Olosz, 2003 .

IL-2R b/IL-7R a Doubly Deficient Mice Recapitulate the Thymic and Intraepithelial Lymphocyte (IEL) Developmental Defects ofgc Mice: Roles for Both IL-2 and IL-15 in CD8aa IEL Development

T. Malek, B. O. Porter, 1999 .

Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function.

M. Bachmann, P. Ohashi, T. Malek, 1999, International Immunology.

This information is current as Tolerance in the Gut Mucosa Functionally Cooperate To Maintain Dependent Signaling and CD 103 − β IL-2 R

T. Malek, Michael J. Dee, N. Altman, 2014 .

Cellular and molecular determinants for the development of natural and induced regulatory T cells.

T. Malek, Xiaomei Yuan, 2012, Human immunology.

Regulation and selective expression of Ly-6A/E, a lymphocyte activation molecule, in the central nervous system.

T. Malek, R. Levy, C. Cray, 1990, Brain research. Molecular brain research.

Distinct Activation Signals Determine whether IL-21 Induces B Cell Costimulation, Growth Arrest, or Bim-Dependent Apoptosis1

T. Malek, R. Carrio, Haoli Jin, 2004, The Journal of Immunology.

Measurement of lymphokine receptors.

J. Lowenthal, T. Malek, H. Saragovi, 2001, Current protocols in immunology.

Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies

E. Shevach, T. Malek, R. Kroczek, 1986, The Journal of experimental medicine.

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T 1 D patients Running head : dose-dependent low dose IL-2 immunoregulation

D. Klatzmann, A. Hartemann, T. Malek, 2017 .

The importance of regulatory T‐cell heterogeneity in maintaining self‐tolerance

T. Malek, Guoyan Cheng, Xiaomei Yuan, 2014, Immunological reviews.

Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling

X. Chen, T. Malek, Zhen Gao, 2022, Nature Immunology.

Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling

T. Malek, Zhen Gao, Yuguang Ban, 2022, Nature immunology.

Interleukin 2 receptors on cultured murine epidermal Langerhans cells.

K. Wolff, E. Tschachler, E. Shevach, 1986, Journal of Immunology.

Medical treatment can unintentionally alter the Treg compartment in patients with widespread pathophysiologic conditions.

T. Malek, S. Copsel, R. Levy, 2020, The American journal of pathology.

Low-dose Interleukin-2 in the Treatment of Autoimmune Disease

J. Ritz, D. Klatzmann, T. Malek, 2014 .

Activation of virus specific CTL clones: antigen-dependent regulation of interleukin 2 receptor expression.

T. Braciale, T. Malek, V. Braciale, 1985, Journal of immunology.

Multiple gamma c-dependent cytokines regulate T-cell development.

T. Malek, B. O. Porter, Y. W. He, 1999, Immunology today.

Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8+ T cells to enhance antitumor immunity

T. Malek, S. Hsiung, Rosmely Hernandez, 2020, Cancer Immunology, Immunotherapy.

Interleukin 2-driven T lymphocyte proliferation is dependent upon a surface antigen distinct from the interleukin 2 receptor: requirements for inhibition of T-cell proliferation by monoclonal antibody 5C3.

E. Shevach, T. Malek, 1984, Cellular immunology.

Antigen-specific murine T cell clones produce soluble interleukin 2 receptor on stimulation with specific antigens.

J. Berzofsky, T. Malek, D. Nelson, 1986, Journal of immunology.

Differential effect of cyclosporin A on the expression of T and B lymphocyte activation antigens.

E. Shevach, T. Malek, H. Lillehoj, 1984, Journal of immunology.

Regulation of T lymphocyte function by glycosylphosphatidylinositol (GPI)-anchored proteins.

T. Malek, E. Codias, T. Fleming, 1994, Seminars in immunology.

T helper cells, IL-2 and the generation of cytotoxic T-cell responses.

T. Malek, 2002, Trends in immunology.

The IL-2 receptor β chain gene (Il-2rb) is closely linked to the Pdgfb locus on mouse chromosome 15

M. Bucan, T. Malek, V. Vincek, 1993, Immunogenetics.

Growth Arrest , or Bim-Dependent Apoptosis whether IL-21 Induces B Cell Costimulation , Distinct Activation Signals Determine

T. Malek, R. Carrio, Haoli Jin, 2004 .

Interleukin 2 receptor dysfunction in mice undergoing a graft-vs-host reaction.

T. Malek, G. Shearer, T. Iwasaki, 1985, Journal of immunology.

Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits.

T. Malek, R. Furse, Y. W. He, 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Formation of high affinity IL-2 receptors is dependent on a nonligand binding region of the alpha subunit.

T. Malek, N. Gutgsell, 1994, Journal of immunology.

The murine interleukin 2 receptor. IV. Biochemical characterization.

T. Malek, P. E. Korty, 1986, Journal of Immunology.

CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells

T. Malek, Ying Ding, G. Tsokos, 2019, The Journal of Immunology.

Genomic organization and 5′ regulatory region of the mouse IL-2 receptor β-chain gene (IL-2Rb)

T. Malek, E. Codias, Ferenc Olosz, 2000, Immunogenetics.

IL7Rα Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages

T. Malek, R. Brambilla, J. Bethea, 2013, The Journal of Immunology.

Altered T Cell Responses and Autoimmune Encephalomyelitis through Contributes to Experimental α IL 7

T. Malek, R. Brambilla, J. Bethea, 2013 .

Nonhematopoietic Cell Lineages Altered T Cell Responses and Autoimmune Encephalomyelitis through Contributes to Experimental α IL 7 R

T. Malek, R. Brambilla, J. Bethea, 2013 .

The Lower Limit of Regulatory CD4+ Foxp3+ TCRβ Repertoire Diversity Required To Control Autoimmunity

T. Malek, D. Adeegbe, C. Dwyer, 2017, The Journal of Immunology.

CD4+ CD25+ Foxp3+ T Regulatory Cells with Limited TCR Diversity in Control of Autoimmunity

T. Malek, D. Adeegbe, T. Matsutani, 2009, The Journal of Immunology.

Signals required for activation and growth of autoimmune T lymphocytes.

A. Steinberg, T. Malek, H. Morse, 1984, The Journal of molecular and cellular immunology : JMCI.

T Cells IL-2R Signaling and the Proliferative Potential of Regulatory Acute Lipopolysaccharide-Induced Inflammation Lowers

T. Malek, Yuguang Ban, S. Hsiung, 2020 .

RejectionGrowth Factors in Allograft T Reject Islet Allografts: A Role for Novel IL-2 and IL-4 Double Knockout Mice

Terry B. Strom, Martin S. Zand, Yongsheng Li, 2010 .

Influence of accessory cell and T cell surface antigens on mitogen-induced IL 2 receptor expression.

R. Germain, L. Glimcher, E. Shevach, 1985, Journal of immunology.

Interleukin 2 as a proliferative signal for autoimmune B cells

T. Malek, B. Kotzin, T. Santoro, 1985 .

Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-κB

V. Ivanov, T. Malek, E. Podack, 1997, Oncogene.

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice

Zhibin Chen, Liping Yu, T. Malek, 2017, Science Signaling.

Differentiated T Regulatory Cells Terminally + Development of Klrg 1 IL-2 Receptor Signaling Is Essential for the Podack

T. Malek, E. Podack, Matthew S Tsai, 2012 .

Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8+ T cells

T. Malek, Rosmely Hernandez, Alicia Santos Savio, 2023, Journal for ImmunoTherapy of Cancer.

RESTRICTIONS ON MACROPHAGE-LYMPHOID CELL INTERACTIONS IN SECONDARY ANTIBODY RESPONSES TO FOWL GAMMA GLOBULIN IN VITRO1

T. Malek, C. Pierce, 1980 .

IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells.

T. Waldmann, I. Pastan, M. Willingham, 1990, Journal of immunology.

Multiple glycosylphosphatidylinositol-anchored Ly-6 molecules and transmembrane Ly-6E mediate inhibition of IL-2 production.

T. Malek, T J Fleming, T R Malek, 1994, Journal of immunology.

Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway.

J. Ashwell, T. Malek, C. Zacharchuk, 1992, Journal of immunology.

This information is current as Receptors Mature T Cells with Severely Impaired IL-2 Lethal Autoimmunity in Mice Containing Normal Lymphoid Homeostasis and Lack of Scibelli and Aixin

T. Malek, B. O. Porter, E. Codias, 2000 .

Interleukin-2 receptor signaling: at the interface between tolerance and immunity.

T. Malek, I. Castro, 2010, Immunity.

The importance of regulatory T‐cell heterogeneity in maintaining self‐tolerance

T. Malek, Guoyan Cheng, Xiaomei Yuan, 2014, Immunological reviews.

IL-2: fine-tuning the germinal center reaction.

T. Malek, W. Khan, 2012, Immunity.

Regulatory T cells in the treatment of disease

D. Klatzmann, A. Sharabi, T. Malek, 2018, Nature Reviews Drug Discovery.

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

D. Klatzmann, A. Hartemann, T. Malek, 2015, Journal of autoimmunity.

Persistent IL-2R signaling by IL-2/CD25 fusion protein controls diabetes in NOD mice by multiple mechanisms

M. Struthers, Liping Yu, T. Malek, 2020 .

Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance.

T. Malek, D. Adeegbe, R. Levy, 2010, Blood.

IL-2 Receptor Signaling Is Essential for the Development of Klrg1+ Terminally Differentiated T Regulatory Cells

T. Malek, E. Podack, Matthew S Tsai, 2012, The Journal of Immunology.

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

T. Malek, D. Adeegbe, A. Bayer, 2005, The Journal of experimental medicine.

This information is current as Regulatory Cells T + Foxp 3 + CD 25 + Peripheral CD 4 Function of the IL-2 R for Thymic and

T. Malek, A. Bayer, Aixin Yu, 2007 .

Alloreactive T cells from individual soft agar colonies specific for guinea pig Ia antigens. I. Production and initial characterization.

E. Shevach, T. Malek, R. Clark, 1981, Journal of immunology.

Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer.

T. Malek, Kathryn M LaPorte, Acacia N Shouse, 2024, Immunity.

Expansion of a restricted residual host Treg‐cell repertoire is dependent on IL‐2 following experimental autologous hematopoietic stem transplantation

T. Malek, A. Bayer, R. Levy, 2011, European journal of immunology.

Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment

O. Bathe, T. Malek, N. Dalyot-Herman, 2003, BMC Cancer.