J. Yen

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Coupling of Osteopontin and Its Cell Surface Receptor CD44 to the Cell Survival Response Elicited by Interleukin-3 or Granulocyte-Macrophage Colony-Stimulating Factor

Yi-hung Lin, Changyuan Huang, Jyh-Rong Chao, 2000, Molecular and Cellular Biology.

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

S. Ng, M. Jiang, Jyh-Rong Chao, 1995, Molecular and cellular biology.

MAPK-mediated Phosphorylation of GATA-1 Promotes Bcl-XL Expression and Cell Survival*

J. Yen, A. Skoultchi, Yung-Luen Yu, 2005, Journal of Biological Chemistry.

Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase

Kai-Ming Liu, Yen-Hui Chen, Yuan-Tsong Chen, 2010, PLoS genetics.

Restoring the apoptosis suppression response to IL-5 confers on erythroleukemic cells a phenotype of IL-5-dependent growth.

J. Yen, H. Yang-Yen, C. Chang, 1995, Journal of immunology.

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.

J. Yen, A. Poulsen, B. Dymock, 2016, Journal of medicinal chemistry.

Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer.

M. Hsiao, J. Yen, H. Yang-Yen, 2011, Journal of hepatology.

DNA Methyltransferase Inhibitor Promotes Human CD4+CD25hFOXP3+ Regulatory T Lymphocyte Induction under Suboptimal TCR Stimulation

J. Yen, Li-Chen Chen, M. Kuo, 2016, Front. Immunol..

The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

Min-Liang Kuo, M. Kuo, Jyh-Rong Chao, 1999, Molecular and Cellular Biology.

Promoter Knock-In Mutations Reveal a Role of Mcl-1 in Thymocyte-Positive Selection and Tissue or Cell Lineage-Specific Regulation of Mcl-1 Expression1

J. Yen, H. Yang-Yen, Ching‐Yu Huang, 2009, The Journal of Immunology.

Survival Factor Withdrawal-induced Apoptosis of TF-1 Cells Involves a TRB2-Mcl-1 Axis-dependent Pathway*

Shern-Fwu Lee, J. Yen, H. Yang-Yen, 2007, Journal of Biological Chemistry.

Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways.

J. Yen, H. M. Huang, C. J. Huang, 2000, Blood.

International Staging System predicts prognosis of Chinese patients with multiple myeloma across different calendar periods with application of novel agents

J. Yen, C. Tzeng, Jin-Hwang Liu, 2011, Annals of Hematology.

CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling

J. Yen, H. Yang-Yen, Yun-Jung Chiang, 2014, Cell Death and Disease.

Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells.

Jen-kun Lin, J. Lin, M. Jiang, 1996, Oncogene.

Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos.

J. Yen, C. Chou, Chang-jen Huang, 2003, Biochemical and biophysical research communications.

in NIH 3T3 cells. progression of cyclin D1 and acceleration of G1 Ras transformation results in an elevated level

S. Ng, M. Jiang, J. Yen, 2013 .

TCR-Mediated Proliferation of Peripheral T Tumor Protein in the Homeostasis and Critical Roles of Translationally Controlled

J. Yen, H. Yang-Yen, Sung-Ho Chen, 2009 .

Critical Roles of Translationally Controlled Tumor Protein in the Homeostasis and TCR-Mediated Proliferation of Peripheral T Cells1

J. Yen, H. Yang-Yen, Sung-Ho Chen, 2009, The Journal of Immunology.

Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver

Yu‐Ju Chen, J. Yen, Yuan-Tsong Chen, 2017, Scientific Reports.

Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation.

Yu‐Ju Chen, J. Yen, Yuan-Tsong Chen, 2015, The Journal of investigative dermatology.

Association of STAT6 genetic variants with childhood atopic dermatitis in Taiwanese population.

J. Yen, Fu-Tong Liu, Y. Lee, 2015, Journal of dermatological science.

Optimal proliferation of a hematopoietic progenitor cell line requires either costimulation with stem cell factor or increase of receptor expression that can be replaced by overexpression of Bcl-2.

J. Yen, H. Yang-Yen, Y. Hsieh, 1999, Blood.

Identification of a novel apolipoprotein that facilitates MTP-mediated lipid transport

J. Yen, H. Yang-Yen, T. Chiu, 2016 .

Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis.

J. Yen, H. Yang-Yen, Yuan-Tsong Chen, 2017, The Journal of investigative dermatology.

CBAP interacts with the un-liganded common β-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction

J. Yen, H. Yang-Yen, Yun-Jung Chiang, 2008, Oncogene.

IL‐5 Inhibits Apoptosis by Upregulation of c‐myc Expression in Human Hematopoietic Cells

Horng-mo Lee, J. Yen, S. Juan, 2005, Annals of the New York Academy of Sciences.

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

M. Downes, B. Beutler, P. Krebs, 2011, Proceedings of the National Academy of Sciences.

Cytokine Receptor Common β Chain as a Potential Activator of Cytokine Withdrawal-Induced Apoptosis

Jyh-Rong Chao, Shern-Fwu Lee, J. Yen, 1999, Molecular and Cellular Biology.

Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice

J. Yen, H. Yang-Yen, Wei-Hao Liao, 2016, Scientific Reports.

CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia

L. Shih, J. Yen, H. Yang-Yen, 2018, Oncogene.

Transcription factors mediating interleukin-3 survival signals.

J. Yen, H. Yang-Yen, 2006, Vitamins and hormones.

mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response

M. Kuo, Yi-hung Lin, Jyh-Rong Chao, 1998, Molecular and Cellular Biology.

GATA Factors Are Essential for Transcription of the Survival Gene E4bp4 and the Viability Response of Interleukin-3 in Ba/F3 Hematopoietic Cells*

J. Yen, Yun-Jung Chiang, Yung-Luen Yu, 2002, The Journal of Biological Chemistry.

CREB Is One Component of the Binding Complex of the Ces-2/E2A-HLF Binding Element and Is an Integral Part of the Interleukin-3 Survival Signal

Changyuan Huang, Jyh-Rong Chao, Shern-Fwu Lee, 2001, Molecular and Cellular Biology.

Constitutive Phosphorylation of GATA-1 at Serine26 Attenuates the Colony-Forming Activity of Erythrocyte-Committed Progenitors

J. Yen, H. Yang-Yen, Chung-Leung Li, 2013, PloS one.

Novel Transcriptional Regulatory Pathways of IL-3-Dependent Survival Responses

J. Yen, Yun-Jung Chiang, Wannhsin Chen, 2003 .

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.

J. Yen, A. Poulsen, B. Dymock, 2017, Journal of medicinal chemistry.

An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis.

J. Yen, Yun-Jung Chiang, S. Hung, 2007, Journal of biomedical science.

Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction

M. Hwang, J. Yen, H. Yang-Yen, 2017, Scientific Reports.

Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.

J. Yen, A. Poulsen, B. Dymock, 2018, European journal of medicinal chemistry.

Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.

Jen-kun Lin, M. Jiang, J. Yen, 1996, Nutrition and cancer.

Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver

J. Yen, Yuan-Tsong Chen, Jer-Yuarn Wu, 2017, Scientific Reports.

Molecular Mechanisms of Growth and Death Control of Hematopoietic Cells by Cytokines

Jyh-Rong Chao, Shern-Fwu Lee, J. Yen, 1997 .

Fracture risks in patients with atopic dermatitis: a nationwide matched cohort study.

J. Yen, Chun-Ying Wu, Yi-Ju Chen, 2021, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Identification of UAP1L1 as a critical factor for protein O-GlcNAcylation and cell proliferation in human hepatoma cells

J. Yen, H. Yang-Yen, Yun-Jung Chiang, 2018, Oncogene.

Palmitoyl acyltransferase activity of ZDHHC13 regulates skin barrier development partly by controlling PADi3 and TGM1 protein stability.

J. Yen, H. Yang-Yen, Yuan-Tsong Chen, 2020, The Journal of investigative dermatology.

Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2

F. Chien, J. Yen, H. Yang-Yen, 2012, Cell cycle.

CBAP Functions as a Novel Component in Chemokine-Induced ZAP70-Mediated T-Cell Adhesion and Migration

J. Yen, H. Yang-Yen, Yun-Jung Chiang, 2013, PloS one.

Palmitoyl Acyltransferase, Zdhhc13, Facilitates Bone Mass Acquisition by Regulating Postnatal Epiphyseal Development and Endochondral Ossification: A Mouse Model

J. Yen, Yuan-Tsong Chen, Jer-Yuarn Wu, 2014, PloS one.

PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport

Hsin-Chou Yang, M. Hwang, J. Yen, 2020, The Journal of biological chemistry.

Characterization of factor-independent variants derived from TF-1 hematopoietic progenitor cells: the role of the Raf/MAP kinase pathway in the anti-apoptotic effect of GM-CSF

M. Kuo, J. Yen, J. Tsai, 1997, Oncogene.