D. Kamato

发表

Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2

Wenhua Zheng, P. Little, N. Osman, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling

P. Little, D. Kamato, Ying Zhou, 2021, Molecules.

Lysophosphatidic acid receptor 5 transactivation of TGFBR1 stimulates the mRNA expression of proteoglycan synthesizing genes XYLT1 and CHST3.

P. Little, D. Kamato, Yingnan Cao, 2020, Biochimica et biophysica acta. Molecular cell research.

Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation.

P. Little, N. Osman, D. Kamato, 2018, Cellular signalling.

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

Jihong Han, P. Little, D. Kamato, 2021, Pharmacological Reviews.

Targeted Molecular Imaging of Cardiovascular Diseases by Iron Oxide Nanoparticles.

P. Little, D. Kamato, Z. Xu, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Treatment of atherosclerotic plaque: perspectives on theranostics

P. Little, D. Kamato, H. Ta, 2019, The Journal of pharmacy and pharmacology.

Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis.

P. Little, D. Kamato, Z. Xu, 2018, Nanoscale.

Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes.

Wenhua Zheng, P. Little, N. Osman, 2019, Cellular signalling.

Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation

P. Little, N. Osman, D. Kamato, 2019, Journal of Cell Communication and Signaling.

The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle.

Wenhua Zheng, P. Little, N. Osman, 2016, Cellular signalling.

Peptidyl‐prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease

Wenhua Zheng, P. Little, N. Osman, 2015, Clinical and experimental pharmacology & physiology.

Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle

P. Little, N. Osman, D. Kamato, 2012, Clinical and experimental pharmacology & physiology.

Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic

D. Kamato, J. A. Roberts, J. Falconer, 2022, Materials Today Advances.

Transforming growth factor–β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells

P. Little, D. Kamato, Reyhaneh Niayesh Mehr, 2018, Journal of Cell Communication and Signaling.

Lipopolysaccharide acting via toll-like receptor 4 transactivates the TGF-β receptor in vascular smooth muscle cells

P. Little, D. Kamato, R. Afroz, 2022, Cellular and molecular life sciences : CMLS.

Lipopolysaccharide acting via toll-like receptor 4 transactivates the TGF-β receptor in vascular smooth muscle cells

P. Little, D. Kamato, R. Afroz, 2021, Cellular and Molecular Life Sciences.

Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics

P. Little, D. Kamato, S. Luo, 2021, Theranostics.

GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential

P. Little, D. Kamato, S. Luo, 2021, International journal of biological sciences.

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes.

M. Hollenberg, Wenhua Zheng, P. Little, 2016, Cellular signalling.

Artemisinin inhibits glycosaminoglycan chain synthesizing gene expression but not proliferation of human vascular smooth muscle cells.

P. Little, D. Kamato, Ying Zhou, 2020, Biochemical and biophysical research communications.

Suramin inhibits PDGF‐stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

YY-11, a camel milk-derived peptide, inhibits TGF-β-mediated atherogenic signaling in human vascular smooth muscle cells.

P. Little, D. Kamato, Yingnan Cao, 2021, Journal of food biochemistry.

Mouse models of atherosclerosis in translational research.

P. Little, D. Kamato, B. Berk, 2022, Trends in pharmacological sciences.

Endothelin‐1 (ET‐1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis

P. Little, D. Kamato, M. Ghaffari, 2016, The Journal of pharmacy and pharmacology.

25 years of endothelin research: the next generation.

M. Yanagisawa, D. Kamato, A. Ergul, 2014, Life Science.

Mouse models of atherosclerosis in translational research Trends in Pharmacological Sciences

P. Little, D. Kamato, B. Berk, 2022 .

Non-Mouse Models of Atherosclerosis: Approaches to Exploring the Translational Potential of New Therapies

P. Little, D. Kamato, Suowen Xu, 2022, International journal of molecular sciences.

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Wenhua Zheng, P. Little, N. Osman, 2014, Cellular and Molecular Life Sciences.

Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors

M. Hollenberg, P. Little, D. Kamato, 2017, Journal of Cell Communication and Signaling.

Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells

Wenhua Zheng, P. Little, N. Osman, 2016, International journal of biological sciences.

GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species

Wenhua Zheng, P. Little, D. Kamato, 2019, Vascular biology.

Gaq proteins: molecular pharmacology and therapeutic potential

Wenhua Zheng, P. Little, N. Osman, 2017, Cellular and Molecular Life Sciences.

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.

P. Little, D. Kamato, J. Pelisek, 2019, Pharmacology & therapeutics.

The Role of Toll-like Receptors in Atherothrombotic Cardiovascular Disease.

P. Little, D. Kamato, Ying Zhou, 2020, ACS pharmacology & translational science.

Toll-like Receptor 4 Stimulates Gene Expression via Smad2 Linker Region Phosphorylation in Vascular Smooth Muscle Cells.

P. Little, D. Kamato, J. Stow, 2020, ACS pharmacology & translational science.

Smad2 linker region phosphorylation is an autonomous cell signalling pathway: Implications for multiple disease pathologies.

P. Little, D. Kamato, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes.

P. Little, D. Kamato, Yingnan Cao, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Endothelial function and dysfunction: Impact of metformin

M. Barras, P. Little, D. Kamato, 2018, Pharmacology & therapeutics.

Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis

Wenhua Zheng, P. Little, N. Osman, 2018, Pharmacology & therapeutics.

Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease.

P. Little, D. Kamato, Ying Zhou, 2019, Pharmacology & therapeutics.

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2017, PloS one.

Integrating the GPCR transactivation‐dependent and biased signalling paradigms in the context of PAR1 signalling

M. Hollenberg, Wenhua Zheng, P. Little, 2016, British journal of pharmacology.

Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11

Wenhua Zheng, P. Little, N. Osman, 2015, Front. Cardiovasc. Med..

Therapeutic implications of endothelin and thrombin G‐protein‐coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Evaluation of the potential synergism of imatinib‐related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response

Wenhua Zheng, N. Osman, Robel Getachew, 2016, The Journal of pharmacy and pharmacology.

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation.

Wenhua Zheng, P. Little, N. Osman, 2013, Cellular signalling.

Transforming growth factor–β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells

P. Little, D. Kamato, Reyhaneh Niayesh Mehr, 2018, Journal of Cell Communication and Signaling.

G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors

P. Little, D. Kamato, H. B. Rezaei, 2018, Life sciences.

Transforming growth factor β‐mediated site‐specific Smad linker region phosphorylation in vascular endothelial cells

Wenhua Zheng, P. Little, N. Osman, 2014, The Journal of pharmacy and pharmacology.

Akt acts as a switch for GPCR transactivation of the TGF‐β receptor type 1

P. Little, Aravindra Shajimoon, D. Kamato, 2021, The FEBS journal.

Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease.

P. Little, D. Kamato, Ran Wang, 2023, Trends in cardiovascular medicine.

Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship

C. Askew, P. Little, D. Kamato, 2021, Biomedicines.

Animal Models for the Evaluation of the Cardiometabolic Therapeutic Potential of Traditional Chinese and Natural Product Medicines

P. Little, D. Kamato, Yingnan Cao, 2017 .

Methotrexate Inhibits Proliferation but not Proteoglycan Synthesis or Glycosaminoglycan Hyperelongation in Human Vascular Smooth Muscle Cells

P. Little, N. Osman, Robel Getachew, 2015 .

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle

Wenhua Zheng, P. Little, N. Osman, 2014, Cardiovascular Diabetology.

ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells.

M. Barras, Wenhua Zheng, P. Little, 2019, Biochimica et biophysica acta. General subjects.

(S)‐[6]‐Gingerol inhibits TGF‐β‐stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Assessing the role of Gαq/11 in cellular responses: an analysis of investigative tools

P. Little, N. Osman, D. Kamato, 2014 .

Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells

Wenhua Zheng, P. Little, N. Osman, 2022, International journal of molecular sciences.

Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor

P. Little, D. Kamato, Reyhaneh Niayesh Mehr, 2022, Molecular and Cellular Biochemistry.

Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling

P. Little, N. Osman, D. Kamato, 2019, Cellular and Molecular Life Sciences.

Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor

P. Little, D. Kamato, Reyhaneh Niayesh Mehr, 2022, Molecular and Cellular Biochemistry.

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Wenhua Zheng, P. Little, N. Osman, 2014, Cellular and Molecular Life Sciences.

Therapeutic implications of endothelin and thrombin G‐protein‐coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

25 years of endothelin research: the next generation.

M. Yanagisawa, D. Kamato, A. Ergul, 2014, Life sciences.

Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling

P. Little, N. Osman, D. Kamato, 2019, Cellular and Molecular Life Sciences.

Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis.

P. Little, D. Kamato, Z. Xu, 2018, Nanoscale.

Transforming growth factor-β receptors: versatile mechanisms of ligand activation

D. Kamato, Z. Chia, Ying-Nan Cao, 2024, Acta pharmacologica Sinica.

Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation

P. Little, N. Osman, D. Kamato, 2019, Journal of Cell Communication and Signaling.